Researcher profile · Semantic Scholar

Xu Hou

h-index: 15
Works: 27
Citations: 1,275

Most-cited papers

Autophagy in Parkinson’s disease
Xu Hou, J. Watzlawik, Fabienne C. Fiesel, W. Springer
2020Journal of Molecular Biology320 citations Open access
Semantic Scholar
PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson’s Disease Pathobiology?
Dominika Truban, Xu Hou, T. Caulfield, Fabienne C. Fiesel +1 more
2016Journal of Parkinson's Disease217 citations Open access
Semantic Scholar
Heterozygous PINK1 p.G411S increases risk of Parkinson’s disease via a dominant-negative mechanism
A. Puschmann, Fabienne C. Fiesel, T. Caulfield, R. Hudec +29 more
2016Brain : a journal of neurology137 citations Open access
Semantic Scholar
Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease
Xu Hou, Fabienne C. Fiesel, Dominika Truban, Monica Castanedes Casey +20 more
2018Autophagy125 citations Open access
Semantic Scholar
Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology
Xu Hou, J. Watzlawik, C. Cook, Chia-Chen Liu +17 more
2020Alzheimer's & Dementia65 citations Open access
Semantic Scholar
Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples
J. Watzlawik, Xu Hou, Dominika Fricova, Chloe Ramnarine +13 more
2020Autophagy57 citations Open access
Semantic Scholar
Hexokinases link DJ-1 to the PINK1/parkin pathway
D. Hauser, A. Mamais, M. Conti, C. Primiani +13 more
2017Molecular Neurodegeneration54 citations Open access
Semantic Scholar
Allopregnanolone Reinstates Tyrosine Hydroxylase Immunoreactive Neurons and Motor Performance in an MPTP-Lesioned Mouse Model of Parkinson's Disease
S. Adeosun, Xu Hou, Y. Jiao, B. Zheng +14 more
2012PLoS ONE53 citations Open access
Semantic Scholar
Cognitive Deficits and Disruption of Neurogenesis in a Mouse Model of Apolipoprotein E4 Domain Interaction*
S. Adeosun, Xu Hou, B. Zheng, C. Stockmeier +5 more
2013Journal of Biological Chemistry43 citations Open access
Semantic Scholar
A Dominant Negative ERβ Splice Variant Determines the Effectiveness of Early or Late Estrogen Therapy after Ovariectomy in Rats
Jun-Ming Wang, Xu Hou, S. Adeosun, R. Hill +8 more
2012PLoS ONE43 citations Open access
Semantic Scholar
Alpha‐synuclein‐associated changes in PINK1‐PRKN‐mediated mitophagy are disease context dependent
Xu Hou, Taylor Hsuan-Yu Chen, Shunsuke Koga, Jenny M. Bredenberg +11 more
2023Brain Pathology40 citations Open access
Semantic Scholar
Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer’s disease
Xu Hou, S. Adeosun, Qin-Li Zhang, B. Barlow +3 more
2015Frontiers in Aging Neuroscience26 citations Open access
Semantic Scholar
Substitution of PINK1 Gly411 modulates substrate receptivity and turnover
Fabienne C. Fiesel, Dominika Fričová, Caleb S Hayes, Matt Coban +21 more
2022Autophagy24 citations Open access
Semantic Scholar
Systematic Functional Analysis of PINK1 and PRKN Coding Variants
Benjamin J Broadway, Paige K Boneski, Jenny M. Bredenberg, Ana Kolicheski +5 more
2022Cells23 citations Open access
Semantic Scholar
Cathepsin B p.Gly284Val Variant in Parkinson’s Disease Pathogenesis
L. Milanowski, Xu Hou, Jenny M. Bredenberg, Fabienne C. Fiesel +34 more
2022International Journal of Molecular Sciences15 citations Open access
Semantic Scholar
Human LRRK2 G2019S mutation represses post-synaptic protein PSD95 and causes cognitive impairment in transgenic mice
S. Adeosun, Xu Hou, B. Zheng, H. Melrose +2 more
2017Neurobiology of Learning and Memory14 citations Open access
Semantic Scholar
Female Mice with Apolipoprotein E4 Domain Interaction Demonstrated Impairments in Spatial Learning and Memory Performance and Disruption of Hippocampal Cyto-Architecture
S. Adeosun, Xu Hou, Li-Ge Shi, C. Stockmeier +5 more
2019Neurobiology of Learning and Memory11 citations Open access
Semantic Scholar
ERβ agonist alters RNA splicing factor expression and has a longer window of antidepressant effectiveness than estradiol after long-term ovariectomy.
Xu Hou, S. Adeosun, Xueying Zhao, R. Hill +6 more
2019Journal of Psychiatry & Neuroscience5 citations Open access
Semantic Scholar
ERβ agonist alters RNA splicing factor expression and has a longer window of antidepressant effectiveness than estradiol after long-term ovariectomy
Xu Hou, S. Adeosun, Xueying Zhao, R. Hill +6 more
2019Journal of Psychiatry & Neuroscience1 citations
Semantic Scholar
P2‐330: The High Prevalence of Alzheimer's Disease in Female APOE4 Allele Carriers is Contributed from a Combination of APOE4 Increased Activity and Female Sex Related High Expression of Bace1
Jun-Ming Wang, Xu Hou, B. Zheng, T. Mosley
20161 citations
Semantic Scholar
P4‐110: Motor deficits in mouse models of Alzheimer's disease
S. Adeosun, Xu Hou, B. Zheng, I. Paul +3 more
20121 citations Open access
Semantic Scholar
P2‐028: Apolipoprotein e ε4 domain interaction in size of hippocampal subregions, density of newborn neurons, and cognitive behaviors
S. Adeosun, Xu Hou, Xueying Zhao, C. Stockmeier +6 more
20150 citations
Semantic Scholar
P1‐249: Effects of chronic alcohol feeding on learning and memory in mice carrying risk mutations for Alzheimer's disease
Qin-Li Zhang, Xu Hou, Taylor J Moehling, B. Zheng +3 more
20150 citations
Semantic Scholar
P3–027: Overexpressing human wild‐ LRRK2 increases spatial recognition and working memory performance in mice
Jun-Ming Wang, S. Adeosun, Xu Hou, B. Zheng
20130 citations
Semantic Scholar
P2–040: Both human and rodent ERbeta2 repress estradiol‐mediated cell proliferation
Jun-Ming Wang, B. Zheng, Xu Hou, S. Adeosun
20130 citations
Semantic Scholar
3.243 INCREASING ENDOGENOUS NEUROGENESIS USING NEUROSTEROIDS: A NOVEL THERAPEUTIC STRATEGY TO TREAT PARKINSON'S DISEASE
S. Adeosun, Xu Hou, Y. Jiao, B. Zheng +7 more
20120 citations
Semantic Scholar
P3‐476: Preclinical efficacy of 2‐Deoxyglucose to sustain mitochondrial metabolic function and delay progression of Alzheimer's pathology
Jun-Ming Wang, S. Adeosun, Y. Jiao, B. Zheng +11 more
20110 citations Open access
Semantic Scholar

W. Springer

×11

O. Ross×8

T. Mosley×8

C. Stockmeier×8

Z. Wszolek×6

I. Paul×6

J. Watzlawik×4

M. Heckman×4