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A. Tyner · SciRah

Researcher profile · Semantic Scholar

A. Tyner

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A. Tyner — researcher profile on SciRah

h-index: 49
Works: 133
Citations: 8,597

Most-cited papers

The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.
A. Gartel, A. Tyner
2002Molecular Cancer Therapeutics1,005 citations
Semantic Scholar
Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3
A. Gartel, Xin Ye, E. Goufman, Pavel Shianov +3 more
2001Proceedings of the National Academy of Sciences of the United States of America435 citations Open access
Semantic Scholar
FoxM1, a critical regulator of oxidative stress during oncogenesis
H. Park, Janai R. Carr, Ze-Bin Wang, Veronique Nogueira +5 more
2009EMBO Journal248 citations Open access
Semantic Scholar
Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin.
D. Lim, Y. Jeong, A. Tyner, J. Park
2007American Journal of Physiology - Gastrointestinal and Liver Physiology192 citations
Semantic Scholar
Sik (BRK) Phosphorylates Sam68 in the Nucleus and Negatively Regulates Its RNA Binding Ability
J. Derry, S. Richard, Héctor Valderrama Carvajal, Xin Ye +4 more
2000Molecular and Cellular Biology161 citations Open access
Semantic Scholar
Deregulation of FoxM1b leads to tumour metastasis
H. Park, G. Gusarova, Ze-Bin Wang, Janai R. Carr +10 more
2011EMBO Molecular Medicine152 citations Open access
Semantic Scholar
FoxM1 Regulates Transcription of JNK1 to Promote the G1/S Transition and Tumor Cell Invasiveness*
I-Ching Wang, Yi-Ju Chen, D. Hughes, Timothy Ackerson +6 more
2008Journal of Biological Chemistry147 citations Open access
Semantic Scholar
Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells
J. Derry, G. Prins, Vera H. Ray, A. Tyner
2003Oncogene146 citations Open access
Semantic Scholar
Conjugated linoleic acid inhibits cell proliferation and ErbB3 signaling in HT-29 human colon cell line.
Cho J. Han, W. Kim, E. Kim, K. Jung +4 more
2003American Journal of Physiology - Gastrointestinal and Liver Physiology143 citations
Semantic Scholar
Tyrosine Phosphorylation of Sam68 by Breast Tumor Kinase Regulates Intranuclear Localization and Cell Cycle Progression*
K. Lukong, D. Larocque, A. Tyner, S. Richard
2005Journal of Biological Chemistry139 citations Open access
Semantic Scholar
Functional analysis and intracellular localization of p53 modified by SUMO-1
S. Kwek, J. Derry, A. Tyner, Zhi-Yuan Shen +1 more
2001Oncogene133 citations Open access
Semantic Scholar
Anaphase-Promoting Complex/Cyclosome-Cdh1-Mediated Proteolysis of the Forkhead Box M1 Transcription Factor Is Critical for Regulated Entry into S Phase
H. Park, R. Costa, L. Lau, A. Tyner +1 more
2008Molecular and Cellular Biology131 citations Open access
Semantic Scholar
Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases.
M. Serfas, A. Tyner
2003Oncology Research126 citations Open access
Semantic Scholar
Constitutive expression of E2F-1 leads to p21-dependent cell cycle arrest in S phase of the cell cycle
Senthil K. Radhakrishnan, Claudine Feliciano, F. Najmabadi, A. Haegebarth +3 more
2004Oncogene117 citations
Semantic Scholar
Building a better understanding of the intracellular tyrosine kinase PTK6 – BRK by BRK
Patrick M. Brauer, A. Tyner
2010Biochimica et Biophysica Acta115 citations Open access
Semantic Scholar
A Conserved Phosphorylation Site within the Forkhead Domain of FoxM1B Is Required for Its Activation by Cyclin-CDK1*
Yi-Ju Chen, Carmen Dominguez-Brauer, Ze-Bin Wang, J. Asara +4 more
2009Journal of Biological Chemistry106 citations Open access
Semantic Scholar
Tumor suppressor functions for the Cdk inhibitor p21 in the mouse colon
A. Poole, Darien Heap, R. Carroll, A. Tyner
2004Oncogene102 citations
Semantic Scholar
Protein Tyrosine Kinase 6 Negatively Regulates Growth and Promotes Enterocyte Differentiation in the Small Intestine
A. Haegebarth, W. Bie, Ruyan Yang, S. Crawford +3 more
2006Molecular and Cellular Biology93 citations
Semantic Scholar
FoxM1 in Tumorigenicity of the Neuroblastoma Cells and Renewal of the Neural Progenitors
Ze-Bin Wang, H. Park, Janai R. Carr, Yi-Ju Chen +6 more
2011Cancer Research91 citations Open access
Semantic Scholar
An N-terminal inhibitory domain modulates activity of FoxM1 during cell cycle
Hyun-Jung Park, Ze-Bin Wang, R. Costa, A. Tyner +2 more
2008Oncogene91 citations Open access
Semantic Scholar
The Nuclear Tyrosine Kinase BRK/Sik Phosphorylates and Inhibits the RNA-binding Activities of the Sam68-like Mammalian Proteins SLM-1 and SLM-2*
A. Haegebarth, Darien Heap, W. Bie, J. Derry +2 more
2004Journal of Biological Chemistry91 citations Open access
Semantic Scholar
PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer
D. Wozniak, A. Kajdacsy-Balla, V. Macias, S. Ball-Kell +3 more
2017Nature Communications76 citations Open access
Semantic Scholar
Sp1 and Sp3 activate p21 (WAF1/CIP1) gene transcription in the Caco-2 colon adenocarcinoma cell line
A. Gartel, E. Goufman, F. Najmabadi, A. Tyner
2000Oncogene75 citations
Semantic Scholar
Protein Tyrosine Kinase 6 Directly Phosphorylates AKT and Promotes AKT Activation in Response to Epidermal Growth Factor
Yu Zheng, M. Peng, Ze-Bin Wang, J. Asara +1 more
2010Molecular and Cellular Biology74 citations Open access
Semantic Scholar
Inhibition of colon cancer cell proliferation by the dietary compound conjugated linoleic acid is mediated by the CDK inhibitor p21CIP1/WAF1
Donna Y. Lim, A. Tyner, Jae-Bong Park, Jae-Yong Lee +2 more
2005Journal of Cellular Physiology71 citations
Semantic Scholar
Identification of β-catenin as a target of the intracellular tyrosine kinase PTK6
H. Palka-Hamblin, Jessica J. Gierut, W. Bie, Patrick M. Brauer +3 more
2010Journal of Cell Science67 citations Open access
Semantic Scholar
A new method for determining the status of p53 in tumor cell lines of different origin.
A. Gartel, Claudine Feliciano, A. Tyner
2003Oncology Research64 citations Open access
Semantic Scholar
Protein Tyrosine Kinase 6 Protects Cells from Anoikis by Directly Phosphorylating Focal Adhesion Kinase and Activating AKT
Yu Zheng, Jessica J. Gierut, Ze-Bin Wang, Jianjun Miao +2 more
2012Oncogene63 citations Open access
Semantic Scholar
FoxM1 Regulates Growth Factor-induced Expression of Kinase-interacting Stathmin (KIS) to Promote Cell Cycle Progression*
V. Petrovic, R. Costa, L. Lau, P. Raychaudhuri +1 more
2008Journal of Biological Chemistry63 citations Open access
Semantic Scholar
A role for E2F1 in Ras activation of p21(WAF1/CIP1) transcription
A. Gartel, F. Najmabadi, E. Goufman, A. Tyner
2000Oncogene54 citations Open access
Semantic Scholar
Induction of Protein Tyrosine Kinase 6 in Mouse Intestinal Crypt Epithelial Cells Promotes DNA-Damage Induced Apoptosis
A. Haegebarth, Ansu Perekatt, W. Bie, Jessica J. Gierut +1 more
2009Gastroenterology51 citations Open access
Semantic Scholar
PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer
Yu Zheng, Ze-Bin Wang, W. Bie, Patrick M. Brauer +9 more
2013Cancer Research49 citations Open access
Semantic Scholar
Differential expression of the non-receptor tyrosine kinase BRK in oral squamous cell carcinoma and normal oral epithelium.
B. Petro, R. Tan, A. Tyner, M. Lingen +1 more
2004Oral Oncology49 citations
Semantic Scholar
Caveolin-1 regulates cancer cell metabolism via scavenging Nrf2 and suppressing MnSOD-driven glycolysis
Peter C. Hart, B. Ratti, Mao Mao, Kristine Ansenberger-Fricano +4 more
2015OncoTarget47 citations Open access
Semantic Scholar
RAKing in AKT: A Tumor Suppressor Function for the Intracellular Tyrosine Kinase FRK
Patrick M. Brauer, A. Tyner
2009Cell Cycle47 citations Open access
Semantic Scholar
The Cdk Inhibitor p21 Is Required for Necrosis, but It Inhibits Apoptosis following Toxin-induced Liver Injury*
Y. H. Kwon, A. Jovanović, M. Serfas, A. Tyner
2003Journal of Biological Chemistry47 citations Open access
Semantic Scholar
p21 Functions to Maintain Quiescence of p27-deficient Hepatocytes*
Y. H. Kwon, A. Jovanović, M. Serfas, H. Kiyokawa +1 more
2002Journal of Biological Chemistry47 citations Open access
Semantic Scholar
Brk/Protein Tyrosine Kinase 6 Phosphorylates p27KIP1, Regulating the Activity of Cyclin D–Cyclin-Dependent Kinase 4
P. Patel, B. Asbach, Elina Shteyn, C. Gomez +5 more
2015Molecular and Cellular Biology43 citations Open access
Semantic Scholar
Context Specific Protein Tyrosine Kinase 6 (PTK6) Signaling in Prostate Cancer
Yu Zheng, A. Tyner
2013European Journal of Clinical Investigation42 citations Open access
Semantic Scholar
Protein-tyrosine Kinase 6 Promotes Peripheral Adhesion Complex Formation and Cell Migration by Phosphorylating p130 CRK-associated Substrate*
Yu Zheng, J. Asara, A. Tyner
2011Journal of Biological Chemistry42 citations Open access
Semantic Scholar
Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin
V. Petrovic, R. Costa, L. Lau, P. Raychaudhuri +1 more
2010Cancer Biology & Therapy42 citations Open access
Semantic Scholar
The Intracellular Tyrosine Kinase Brk Sensitizes Nontransformed Cells to Inducers of Apoptosis
A. Haegebarth, R. Nuñez, A. Tyner
2005Cell Cycle41 citations Open access
Semantic Scholar
PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors
M. Peng, R. Emmadi, Ze-Bin Wang, E. Wiley +8 more
2014OncoTarget37 citations Open access
Semantic Scholar
Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells
Patrick M. Brauer, Yu Zheng, Lin Wang, A. Tyner
2010Cell Cycle33 citations Open access
Semantic Scholar
Conditionally immortalized colonic epithelial cell line from a Ptk6 null mouse that polarizes and differentiates in vitro
R. H. Whitehead, Pamela S. Robinson, Janice A. Williams, W. Bie +2 more
2008Journal of Gastroenterology and Hepatology31 citations Open access
Semantic Scholar
Differential Regulation of D-Type Cyclins in the Mouse Intestine
Ruyan Yang, W. Bie, A. Haegebarth, A. Tyner
2006Cell Cycle31 citations Open access
Semantic Scholar
Kinase-Dependent and Independent Roles for PTK6 in Colon Cancer
Priya S. Mathur, Jessica J. Gierut, G. Guzman, Hui Xie +5 more
2016Molecular Cancer Research30 citations Open access
Semantic Scholar
The Alternative Splice Variant of Protein Tyrosine Kinase 6 Negatively Regulates Growth and Enhances PTK6-Mediated Inhibition of β-Catenin
Patrick M. Brauer, Yu Zheng, M. Evans, Carmen Dominguez-Brauer +2 more
2011PLoS ONE29 citations Open access
Semantic Scholar
Targeting Protein Tyrosine Kinase 6 in Cancer
Milica B. Gilic, A. Tyner
2020Biochimica et biophysica acta. Reviews on cancer27 citations Open access
Semantic Scholar
Disruption of the Mouse Protein Tyrosine Kinase 6 Gene Prevents STAT3 Activation and Confers Resistance to Azoxymethane
Jessica J. Gierut, Yu Zheng, W. Bie, R. Carroll +3 more
2011Gastroenterology27 citations Open access
Semantic Scholar

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