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H. Clewell · SciRah

Researcher profile · Semantic Scholar

H. Clewell

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H. Clewell — researcher profile on SciRah

h-index: 71
Works: 368
Citations: 16K

Most-cited papers

Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing
B. Wetmore, J. Wambaugh, B. Allen, S. Ferguson +10 more
2015Toxicological Sciences245 citations Open access
Semantic Scholar
Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK)
M. Verner, A. Loccisano, N. Morken, M. Yoon +11 more
2015Environmental Health Perspectives209 citations Open access
Semantic Scholar
Why is elevation of serum cholesterol associated with exposure to perfluoroalkyl substances (PFAS) in humans? A workshop report on potential mechanisms
M. Andersen, B. Hagenbuch, U. Apte, J. Corton +7 more
2021Toxicology89 citations Open access
Semantic Scholar
Dose-response for assessing the cancer risk of inorganic arsenic in drinking water: the scientific basis for use of a threshold approach
J. Tsuji, E. Chang, P. Gentry, H. Clewell +2 more
2019Critical Reviews in Toxicology78 citations Open access
Semantic Scholar
Can the observed association between serum perfluoroalkyl substances and delayed menarche be explained on the basis of puberty-related changes in physiology and pharmacokinetics?
Huali Wu, M. Yoon, M. Verner, J. Xue +4 more
2015Environment International53 citations
Semantic Scholar
Developing context appropriate toxicity testing approaches using new alternative methods (NAMs).
M. Andersen, P. McMullen, M. B. Phillips, M. Yoon +6 more
2019ALTEX52 citations Open access
Semantic Scholar
New Framework for a Non-Animal Approach Adequately Assures the Safety of Cosmetic Ingredients - A Case Study on Caffeine.
D. Bury, Camilla Alexander-White, H. Clewell, M. Cronin +13 more
2021Regulatory toxicology and pharmacology : RTP51 citations Open access
Semantic Scholar
Current Approaches and Techniques in Physiologically Based Pharmacokinetic (PBPK) Modelling of Nanomaterials
W. Utembe, H. Clewell, N. Sanabria, P. Doganis +1 more
2020Nanomaterials49 citations Open access
Semantic Scholar
Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment - A case study with parabens.
G. Ouedraogo, Camilla Alexander-White, D. Bury, H. Clewell +23 more
2022Regulatory toxicology and pharmacology : RTP48 citations Open access
Semantic Scholar
Quantitative bias analysis for epidemiological associations of perfluoroalkyl substance serum concentrations and early onset of menopause.
Christopher D. Ruark, Gina Song, M. Yoon, M. Verner +3 more
2017Environment International46 citations
Semantic Scholar
Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans
Pankajini Mallick, Marjory Moreau, Gina Song, A. Efremenko +8 more
2019Toxicological Sciences45 citations Open access
Semantic Scholar
Quantitative in vitro to in vivo extrapolation (QIVIVE): An essential element for in vitro-based risk assessment.
M. Yoon, B. Blaauboer, H. Clewell
2015Toxicology44 citations Open access
Semantic Scholar
Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop
C. Ellison, K. Blackburn, P. Carmichael, H. Clewell +14 more
2019Regulatory toxicology and pharmacology : RTP40 citations Open access
Semantic Scholar
Excretion of Di-2-ethylhexyl phthalate (DEHP) metabolites in urine is related to body mass index because of higher energy intake in the overweight and obese.
Jerry L. Campbell, M. Yoon, Peyton L Ward, H. Fromme +5 more
2018Environment International40 citations
Semantic Scholar
The application of PBPK models in estimating human brain tissue manganese concentrations
Siva Ramoju, D. Mattison, Brittany Milton, Doreen McGough +6 more
2017Neurotoxicology38 citations
Semantic Scholar
PBPK Model for Atrazine and Its Chlorotriazine Metabolites in Rat and Human
Jerry L. Campbell, M. Andersen, P. Hinderliter, K. D. Yi +3 more
2016Toxicological Sciences36 citations Open access
Semantic Scholar
Use of in vitro data in developing a physiologically based pharmacokinetic model: Carbaryl as a case study.
M. Yoon, G. L. Kedderis, Grace Zhixia Yan, H. Clewell
2015Toxicology35 citations
Semantic Scholar
Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment.
R. Clewell, C. Thompson, H. Clewell
2019Chemico-Biological Interactions34 citations Open access
Semantic Scholar
Evaluating opportunities for advancing the use of alternative methods in risk assessment through the development of fit-for-purpose in vitro assays.
P. McMullen, M. Andersen, Brian D. Cholewa, H. Clewell +9 more
2018Toxicology in Vitro32 citations Open access
Semantic Scholar
Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates.
R. Clewell, J. Leonard, Chantel I. Nicolas, Jerry L. Campbell +7 more
2020Toxicology in Vitro29 citations Open access
Semantic Scholar
Using exposure prediction tools to link exposure and dosimetry for risk-based decisions: A case study with phthalates
Marjory Moreau, J. Leonard, Katherine A. Phillips, Jerry L. Campbell +9 more
2017Chemosphere29 citations Open access
Semantic Scholar
A case study on quantitative in vitro to in vivo extrapolation for environmental esters: Methyl-, propyl- and butylparaben.
Jerry L. Campbell, M. Yoon, H. Clewell
2015Toxicology28 citations
Semantic Scholar
High-throughput in-silico prediction of ionization equilibria for pharmacokinetic modeling.
Cory L. Strope, K. Mansouri, H. Clewell, J. Rabinowitz +2 more
2018Science of the Total Environment26 citations Open access
Semantic Scholar
Development of an integrated multi-species and multi-dose route PBPK model for volatile methyl siloxanes - D4 and D5.
T. McMullin, Yu-Ching Yang, Jerry L. Campbell, H. Clewell +2 more
2016Regulatory toxicology and pharmacology : RTP26 citations Open access
Semantic Scholar
Considerations for Improving Metabolism Predictions for In Vitro to In Vivo Extrapolation
Marjory Moreau, Pankajini Mallick, Marci G. Smeltz, Saad Haider +8 more
2022Frontiers in Toxicology24 citations Open access
Semantic Scholar
Evaluation of Age-Related Pyrethroid Pharmacokinetic Differences in Rats: Physiologically-Based Pharmacokinetic Model Development Using In Vitro Data and In Vitro to In Vivo Extrapolation.
Gina Song, Marjory Moreau, A. Efremenko, B. Lake +8 more
2019Toxicological Sciences22 citations Open access
Semantic Scholar
Considerations for refining the risk assessment process for formaldehyde: Results from an interdisciplinary workshop.
M. Andersen, P. Gentry, J. Swenberg, K. A. Mundt +10 more
2019Regulatory toxicology and pharmacology : RTP22 citations Open access
Semantic Scholar
A tissue dose‐based comparative exposure assessment of manganese using physiologically based pharmacokinetic modeling—The importance of homeostatic control for an essential metal
R. Gentry, C. V. Van Landingham, William G. Fuller, S. Sulsky +6 more
2017Toxicology and Applied Pharmacology19 citations Open access
Semantic Scholar
Modeling the effect of succimer (DMSA; dimercaptosuccinic acid) chelation therapy in patients poisoned by lead
J. V. van Eijkeren, J. D. N. Olie, S. Bradberry, J. Vale +4 more
2017Clinical toxicology19 citations Open access
Semantic Scholar
Pharmacokinetic bias analysis of the epidemiological associations between serum polybrominated diphenyl ether (BDE-47) and timing of menarche.
Gina Song, C. R. Peeples, M. Yoon, Huali Wu +4 more
2016Environmental Research19 citations
Semantic Scholar
Fluid Dynamic Modeling to Support the Development of Flow-Based Hepatocyte Culture Systems for Metabolism Studies
Jenny M. Pedersen, Yoo-Sik Shim, Vaibhav Hans, M. B. Phillips +5 more
2016Frontiers in Bioengineering and Biotechnology19 citations Open access
Semantic Scholar
Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment
Yu-Mei Tan, H. Barton, A. Boobis, R. Brunner +23 more
2021Regulatory toxicology and pharmacology : RTP18 citations Open access
Semantic Scholar
Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver
M. Andersen, Michael B. Black, Jerry L. Campbell, S. Pendse +6 more
2017Toxicology and Applied Pharmacology18 citations Open access
Semantic Scholar
A preliminary regional PBPK model of lung metabolism for improving species dependent descriptions of 1,3-butadiene and its metabolites.
Jerry L. Campbell, C. V. Van Landingham, S. Crowell, R. Gentry +4 more
2015Chemico-Biological Interactions18 citations Open access
Semantic Scholar
EFSA's 21st Scientific Colloquium on Harmonisation of human and ecological risk assessment of combined exposure to multiple chemicals
D. Benford, D. Spurgeon, J. Kleiner, B. Meek +19 more
201518 citations Open access
Semantic Scholar
Paraquat pharmacokinetics in primates and extrapolation to humans.
Alexander J. Stevens, Jerry L. Campbell, K. Travis, H. Clewell +5 more
2021Toxicology and Applied Pharmacology16 citations Open access
Semantic Scholar
Quantitative bias analysis of the association between subclinical thyroid disease and two perfluoroalkyl substances in a single study.
Michael W. Dzierlenga, Marjory Moreau, Gina Song, Pankajini Mallick +7 more
2019Environmental Research16 citations Open access
Semantic Scholar
Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system.
B. Wetmore, R. Clewell, Brian D. Cholewa, Bethany B. Parks +12 more
2019Toxicology in Vitro16 citations Open access
Semantic Scholar
Quantitative bias analysis of a reported association between perfluoroalkyl substances (PFAS) and endometriosis: The influence of oral contraceptive use.
G. Ngueta, M. Longnecker, M. Yoon, Christopher D. Ruark +3 more
2017Environment International15 citations
Semantic Scholar
Incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene
H. Clewell, Jerry L. Campbell, C. V. Van Landingham, A. Franzen +4 more
2019Inhalation Toxicology13 citations Open access
Semantic Scholar
Assessing children's exposure to manganese in drinking water using a PBPK model.
M. Yoon, Caroline L Ring, C. V. Van Landingham, Mina Suh +7 more
2019Toxicology and Applied Pharmacology13 citations Open access
Semantic Scholar
Refinement of the oral exposure description in the cyclic siloxane PBPK model for rats and humans: Implications for exposure assessment.
Jerry L. Campbell, M. Andersen, C. V. Van Landingham, R. Gentry +3 more
2017Toxicology Letters13 citations Open access
Semantic Scholar
Predicting lung dosimetry of inhaled particleborne benzo[a]pyrene using physiologically based pharmacokinetic modeling
Jerry L. Campbell, A. Franzen, C. V. Van Landingham, Michael H. Lumpkin +5 more
2016Inhalation Toxicology13 citations Open access
Semantic Scholar
PBPK-Based Probabilistic Risk Assessment for Total Chlorotriazines in Drinking Water
C. Breckenridge, Jerry L. Campbell, H. Clewell, M. Andersen +2 more
2016Toxicological Sciences13 citations Open access
Semantic Scholar
Using quantitative modeling tools to assess pharmacokinetic bias in epidemiological studies showing associations between biomarkers and health outcomes at low exposures.
M. Andersen, Pankajini Mallick, H. Clewell, M. Yoon +2 more
2021Environmental Research12 citations Open access
Semantic Scholar
Integration of Evidence to Evaluate the Potential for Neurobehavioral Effects Following Exposure to USFDA-Approved Food Colors.
R. Gentry, Tracy B. Greene, G. Chappell, Isabel A. Lea +8 more
2021Food and Chemical Toxicology12 citations Open access
Semantic Scholar
An evaluation of the USEPA Proposed Approaches for applying a biologically based dose‐response model in a risk assessment for perchlorate in drinking water
H. Clewell, R. Gentry, E. Hack, Tracy B. Greene +1 more
2019Regulatory toxicology and pharmacology : RTP12 citations Open access
Semantic Scholar
An updated mode of action and human relevance framework evaluation for Formaldehyde-Related nasal tumors
C. Thompson, R. Gentry, S. Fitch, Kun Lu +1 more
2020Critical Reviews in Toxicology11 citations Open access
Semantic Scholar
The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene.
H. Yoo, J. Cichocki, Sungkyoon Kim, Abhishek Venkatratnam +11 more
2015Toxicological Sciences11 citations Open access
Semantic Scholar
Pharmacokinetic bias analysis of an association between clinical thyroid disease and two perfluoroalkyl substances.
Michael W. Dzierlenga, B. Allen, H. Clewell, M. Longnecker
2020Environment International9 citations Open access
Semantic Scholar

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