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W. Ferlin · SciRah

Researcher profile · Semantic Scholar

W. Ferlin

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W. Ferlin — researcher profile on SciRah

h-index: 37
Works: 118
Citations: 4,782

Most-cited papers

IL-6 Trans-Signaling Modulates TLR4-Dependent Inflammatory Responses via STAT3
Claire J. Greenhill, S. Rose-John, R. Lissilaa, W. Ferlin +4 more
2011Journal of Immunology273 citations Open access
Semantic Scholar
Elevated circulating levels of interferon-γ and interferon-γ-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
C. Bracaglia, K. D. de Graaf, Denise Pires Marafon, F. Guilhot +9 more
2016Annals of the Rheumatic Diseases262 citations
Semantic Scholar
Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor*
Christoph Garbers, Wolfgang M. Thaiss, Gareth W. Jones, G. H. Waetzig +8 more
2011Journal of Biological Chemistry182 citations Open access
Semantic Scholar
Neutralization of IFNγ defeats haemophagocytosis in LCMV-infected perforin- and Rab27a-deficient mice
J. P. Schmid, Chen-Hsuan Ho, F. Chrétien, Juliette M. Lefebvre +6 more
2009EMBO Molecular Medicine181 citations Open access
Semantic Scholar
CC chemokine CCL5 plays a central role impacting infarct size and post-infarction heart failure in mice.
F. Montecucco, V. Braunersreuther, S. Lenglet, B. Delattre +10 more
2012European Heart Journal150 citations Open access
Semantic Scholar
The IL-27 p28 Subunit Binds Cytokine-Like Factor 1 to Form a Cytokine Regulating NK and T Cell Activities Requiring IL-6R for Signaling1
S. Crabé, Angélique Guay-Giroux, A. Tormo, D. Duluc +9 more
2009Journal of Immunology140 citations Open access
Semantic Scholar
Selective Blockade of the Ubiquitous Checkpoint Receptor CD47 Is Enabled by Dual-Targeting Bispecific Antibodies
E. Dheilly, V. Moine, Lucile Broyer, S. Salgado-Pires +11 more
2017Molecular Therapy133 citations Open access
Semantic Scholar
TLR4/MD-2 Monoclonal Antibody Therapy Affords Protection in Experimental Models of Septic Shock
B. Daubeuf, J. Mathison, Stephan Spiller, S. Hugues +7 more
2007Journal of Immunology131 citations
Semantic Scholar
Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG
N. Fischer, G. Elson, G. Magistrelli, E. Dheilly +28 more
2015Nature Communications112 citations Open access
Semantic Scholar
Blocking interferon γ reduces expression of chemokines CXCL9, CXCL10 and CXCL11 and decreases macrophage infiltration in ex vivo cultured arteries from patients with giant cell arteritis
M. Corbera-Bellalta, E. Planas-Rigol, E. Lozano, Nekane Terrades-García +12 more
2015Annals of the Rheumatic Diseases112 citations Open access
Semantic Scholar
IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis.
G. Brooks, L. McLeod, S. Alhayyani, A. Miller +5 more
2016Cancer Research108 citations Open access
Semantic Scholar
ADAM17 selectively activates the IL‐6 trans‐signaling/ERK MAPK axis in KRAS‐addicted lung cancer
Mohamed I. Saad, S. Alhayyani, L. McLeod, Liang Yu +20 more
2019EMBO Molecular Medicine100 citations Open access
Semantic Scholar
Preclinical development of a bispecific antibody that safely and effectively targets CD19 and CD47 for the treatment of B cell lymphoma and leukemia
V. Buatois, Z. Johnson, S. S. Pires, Anne Papaioannou +27 more
2018Molecular Cancer Therapeutics99 citations Open access
Semantic Scholar
Blockade of the IL-6 trans-signalling/STAT3 axis suppresses cachexia in Kras-induced lung adenocarcinoma
A. Miller, L. McLeod, S. Alhayyani, A. Szczepny +6 more
2017Oncogene95 citations
Semantic Scholar
Neutralization of IFN‐&ggr; reverts clinical and laboratory features in a mouse model of macrophage activation syndrome
G. Prencipe, I. Caiello, A. Pascarella, A. Grom +7 more
2017Journal of Allergy and Clinical Immunology81 citations Open access
Semantic Scholar
Role of interferon-γ in immune-mediated graft failure after allogeneic hematopoietic stem cell transplantation
P. Merli, I. Caruana, R. De Vito, L. Strocchio +15 more
2019Haematologica68 citations Open access
Semantic Scholar
A Novel Targeted Approach to the Treatment of Hemophagocytic Lymphohistiocytosis (HLH) with an Anti-Interferon Gamma (IFNγ) Monoclonal Antibody (mAb), NI-0501: First Results from a Pilot Phase 2 Study in Children with Primary HLH
Franco Locatelli Prof, C. Allen, F. de Benedetti, A. Grom +3 more
201567 citations
Semantic Scholar
Although IL-6 Trans-Signaling Is Sufficient To Drive Local Immune Responses, Classical IL-6 Signaling Is Obligate for the Induction of T Cell-Mediated Autoimmunity
R. Lissilaa, V. Buatois, G. Magistrelli, A. Williams +10 more
2010Journal of Immunology67 citations
Semantic Scholar
Therapeutic Effects of Treatment with Anti-TLR2 and Anti-TLR4 Monoclonal Antibodies in Polymicrobial Sepsis
C. X. Lima, D. G. Souza, F. Amaral, C. T. Fagundes +7 more
2015PLoS ONE62 citations Open access
Semantic Scholar
Novel Insights into Interleukin 6 (IL-6) Cis- and Trans-signaling Pathways by Differentially Manipulating the Assembly of the IL-6 Signaling Complex*
M. Lacroix, F. Rousseau, F. Guilhot, P. Malinge +10 more
2015Journal of Biological Chemistry60 citations Open access
Semantic Scholar
Use of a mouse model to identify a blood biomarker for IFNγ activity in pediatric secondary hemophagocytic lymphohistiocytosis
V. Buatois, L. Chatel, Laura Cons, Sabrina Lory +8 more
2016Translational Research: The Journal of Laboratory and Clinical Medicine57 citations Open access
Semantic Scholar
The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis
M. Stacey, S. Clare, M. Clement, M. Marsden +18 more
2017Journal of Clinical Investigation50 citations Open access
Semantic Scholar
Epstein-Barr virus-induced gene 3 (EBI3) can mediate IL-6 trans-signaling
Salma Chehboun, Jérémie Labrecque-Carbonneau, S. Pasquin, Y. Meliani +6 more
2017Journal of Biological Chemistry49 citations Open access
Semantic Scholar
NI‐0801, an anti‐chemokine (C‐X‐C motif) ligand 10 antibody, in patients with primary biliary cholangitis and an incomplete response to ursodeoxycholic acid
K. D. de Graaf, G. Lapeyre, F. Guilhot, W. Ferlin +12 more
2018Hepatology Communications44 citations Open access
Semantic Scholar
Anti-CD79 Antibody Induces B cell Anergy That Protects Against Autoimmunity
Ian R. Hardy, N. Anceriz, F. Rousseau, Matthew B. Seefeldt +16 more
2014Journal of Immunology42 citations Open access
Semantic Scholar
IL-6 trans-signalling mediates trabecular, but not cortical, bone loss after ovariectomy.
Leah Lazzaro, Brett A. Tonkin, Ingrid J. Poulton, Narelle E. McGregor +2 more
2018Bone41 citations
Semantic Scholar
A specific anti-citrullinated protein antibody profile identifies a group of rheumatoid arthritis patients with a toll-like receptor 4-mediated disease
E. Hatterer, L. Shang, P. Simonet, S. Herren +12 more
2016Arthritis Research & Therapy41 citations Open access
Semantic Scholar
Evaluation of Multiple Immunoassay Technology Platforms to Select the Anti-Drug Antibody Assay Exhibiting the Most Appropriate Drug and Target Tolerance
Justine Collet-Brose, Pierre Couble, M. Deehan, R. Nelson +2 more
2016Journal of Immunological Research39 citations Open access
Semantic Scholar
Co-engaging CD47 and CD19 with a bispecific antibody abrogates B-cell receptor/CD19 association leading to impaired B-cell proliferation
E. Hatterer, L. Barba, N. Noraz, B. Daubeuf +7 more
2019mAbs37 citations Open access
Semantic Scholar
Selective Antibody Intervention of Toll-like Receptor 4 Activation through Fc γ Receptor Tethering
L. Shang, B. Daubeuf, M. Triantafilou, Robin Olden +20 more
2014Journal of Biological Chemistry37 citations Open access
Semantic Scholar
Pan–CC Chemokine Neutralization Restricts Splenocyte Egress and Reduces Inflammation in a Model of Arthritis
V. Buatois, Séverine Fagète, G. Magistrelli, L. Chatel +3 more
2010Journal of Immunology26 citations Open access
Semantic Scholar
Spatiotemporal expression of endogenous TLR4 ligands leads to inflammation and bone erosion in mouse collagen‐induced arthritis
Gaëlle Wambiekele Kiyeko, E. Hatterer, S. Herren, I. Ceglie +5 more
2016European Journal of Immunology23 citations Open access
Semantic Scholar
Immunological analysis of the murine anti‐CD3‐induced cytokine release syndrome model and therapeutic efficacy of anti‐cytokine antibodies
L. Nouveau, V. Buatois, Laura Cons, L. Chatel +3 more
2021European Journal of Immunology22 citations Open access
Semantic Scholar
CD47xCD19 bispecific antibody triggers recruitment and activation of innate immune effector cells in a B-cell lymphoma xenograft model
X. Chauchet, Laura Cons, L. Chatel, B. Daubeuf +9 more
2022Experimental Hematology & Oncology21 citations Open access
Semantic Scholar
Safety and Efficacy of Emapalumab in Pediatric Patients with Primary Hemophagocytic Lymphohistiocytosis
F. Locatelli, M. Jordan, C. Allen, S. Cesaro +14 more
2018Blood21 citations Open access
Semantic Scholar
Tumor-Directed Blockade of CD47 with Bispecific Antibodies Induces Adaptive Antitumor Immunity
E. Dheilly, S. Majocchi, V. Moine, Gérard Didelot +8 more
2018Antibodies21 citations Open access
Semantic Scholar
AB0451 NI-0101, a Monoclonal Antibody Targeting Toll Like Receptor 4 (TLR4) Being Developed for Rheumatoid Arthritis (RA) Treatment with a Potential for Personalized Medicine
E. Monnet, L. Shang, G. Lapeyre, K. DeGraaf +11 more
201519 citations
Semantic Scholar
P156 Investigating the novel mechanism of action for NI-0501, a human interferon gamma monoclonal antibody
E. Hatterer, F. Richard, P. Malinge, A. Serge +5 more
201218 citations
Semantic Scholar
Antibody Neutralization of CXCL10 in Vivo Is Dependent on Binding to Free and Not Endothelial-bound Chemokine
Pauline Bonvin, F. Gueneau, V. Buatois, Maud Charreton-Galby +9 more
2017Journal of Biological Chemistry17 citations Open access
Semantic Scholar
The cytokines cardiotrophin-like cytokine/cytokine-like factor-1 (CLC/CLF) and ciliary neurotrophic factor (CNTF) differ in their receptor specificities.
A. Tormo, M. Letellier, R. Lissilaa, Laurie-Anne Batraville +5 more
2012Cytokine17 citations
Semantic Scholar
Persistently active interferon‐γ pathway and expansion of T‐bet+ B cells in a subset of patients with childhood‐onset systemic lupus erythematosus
G. Moneta, C. Bracaglia, I. Caiello, C. Farroni +12 more
2023European Journal of Immunology12 citations Open access
Semantic Scholar
High levels of interferon-gamma (IFNγ) in macrophage activation syndrome (MAS) and CXCL9 levels as a biomarker for IFNγ production in MAS
C. Bracaglia, D. Marafon, Ivan Caiello, K. D. de Graaf +9 more
2015Pediatric Rheumatology Online Journal12 citations Open access
Semantic Scholar
Interferon-gamma (IFNy) in macrophage activation syndrome (MAS) associated with systemic juvenile idiopathic arthritis (sJIA). High levels in patients and a role in a murine mas model
C. Bracaglia, I. Caiello, K. D. de Graaf, G. d'Ario +10 more
2014Pediatric Rheumatology Online Journal12 citations Open access
Semantic Scholar
NI-3201 Is a Bispecific Antibody Mediating PD-L1–Dependent CD28 Co-stimulation on T Cells for Enhanced Tumor Control
Sara Majocchi, Pauline Lloveras, L. Nouveau, M. Legrand +18 more
2025Cancer immunology research11 citations Open access
Semantic Scholar
CC chemokine CCL 5 plays a central role impacting infarct size and post-infarction heart failure in mice
F. Montecucco, V. Braunersreuther, S. Lenglet, B. Delattre +10 more
20129 citations
Semantic Scholar
Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part one
F. Debenedetti, J. Antón, M. Gattorno, H. Lachmann +496 more
2017Pediatric Rheumatology Online Journal8 citations Open access
Semantic Scholar
Bispecific antibody targeting of CD47/CD19 to promote enhanced phagocytosis of patient B lymphoma cells.
Z. Johnson, Anne Papaioannou, L. Bernard, E. Cosimo +12 more
20158 citations
Semantic Scholar
Selective CD47 targeting with a bispecific antibody
W. Ferlin, K. Masternak, L. Shang
2021Cancer Immunology and Immunotherapy6 citations
Semantic Scholar
707 A Phase 1, open-label, dose finding study of NI-1801, a bispecific mesothelin x CD47 engaging antibody, in patients with mesothelin expressing solid cancers
E. Romano, J. Medioni, T. de la Motte Rouge, N. Fischer +6 more
2022Regular and Young Investigator Award Abstracts4 citations Open access
Semantic Scholar
Abstract 546: Selectively targeting CD47 with bispecific antibody to efficiently eliminate mesothelin-positive solid tumors
L. Shang, V. Buatois, E. Hatterer, X. Chauchet +6 more
2019Clinical research4 citations
Semantic Scholar

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