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C. Nirschl · SciRah

Researcher profile · Semantic Scholar

C. Nirschl

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C. Nirschl — researcher profile on SciRah

h-index: 18
Works: 67
Citations: 3,647

Most-cited papers

Microenvironment and Immunology Immune InhibitoryMolecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape
Seng-Ryong Woo, Meghan E. Turnis, Monica V. Goldberg, Jaishree Bankoti +17 more
20121,414 citations
Semantic Scholar
Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Anti-Tumor Immune Responses via Cross-Presentation of Tumor Antigen
A. Sharabi, C. Nirschl, Christina M. Kochel, Thomas R. Nirschl +4 more
2014Cancer immunology research624 citations Open access
Semantic Scholar
Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia
F. McAllister, Jennifer M. Bailey, Janivette Alsina, C. Nirschl +14 more
2014Cancer Cell390 citations Open access
Semantic Scholar
Molecular Pathways Molecular Pathways : Coexpression of Immune Checkpoint Molecules : Signaling Pathways and Implications for Cancer Immunotherapy
C. Nirschl, C. Drake
2013223 citations
Semantic Scholar
Lymphocyte Activation Gene 3 (LAG-3) Modulates the Ability of CD4 T-cells to Be Suppressed In Vivo
N. Durham, C. Nirschl, Christopher M. Jackson, Jimmy Elias +3 more
2014PLoS ONE174 citations Open access
Semantic Scholar
Phenotypic and Functional Properties of Helios+ Regulatory T Cells
Daniel J. Zabransky, C. Nirschl, N. Durham, Ben Park +5 more
2012PLoS ONE166 citations Open access
Semantic Scholar
IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment
C. Nirschl, M. Suárez-Fariñas, B. Izar, S. Prakadan +25 more
2017Cell151 citations Open access
Semantic Scholar
Sustained CD4+ T cell-driven lymphopenia without a compensatory IL-7/IL-15 response among high-grade glioma patients treated with radiation and temozolomide
S. Ellsworth, A. Balmanoukian, F. Kos, C. Nirschl +4 more
2014Oncoimmunology72 citations Open access
Semantic Scholar
Systemic Tolerance Mediated by Melanoma Brain Tumors is Reversible by Radiotherapy and Vaccination
Christopher M. Jackson, Christina M. Kochel, C. Nirschl, N. Durham +16 more
2015Clinical Cancer Research66 citations Open access
Semantic Scholar
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T cell function to promote tumoral immune escape
Seng-Ryong Woo, Meghan E. Turnis, Monica V. Goldberg, Jaishree Bankoti +17 more
2011Cancer Research55 citations Open access
Semantic Scholar
An activation to memory differentiation trajectory of tumor infiltrating lymphocytes informs metastatic melanoma outcomes
A. Jaiswal, A. Verma, R. Dannenfelser, M. Melssen +16 more
2022Cancer Cell50 citations Open access
Semantic Scholar
Discovery of a Conditionally Activated IL-2 that Promotes Antitumor Immunity and Induces Tumor Regression
C. Nirschl, H. Brodkin, D. Hicklin, Nesreen Ismail +8 more
2022Cancer immunology research40 citations Open access
Semantic Scholar
Sorafenib combined with HER-2 targeted vaccination can promote effective T cell immunity in vivo
M. Sunay, J. Foote, J. Leatherman, J. Edwards +4 more
2017International Immunopharmacology34 citations Open access
Semantic Scholar
Near-infrared 1064 nm laser modulates migratory dendritic cells to adjuvant the immune response to intradermal influenza vaccine
K. Morse, Y. Kimizuka, Megan P. K. Chan, M. Shibata +20 more
2017Journal of Immunology29 citations Open access
Semantic Scholar
PPARγ Contributes to Immunity Induced by Cancer Cell Vaccines That Secrete GM-CSF
G. Goyal, Karrie K. Wong, C. Nirschl, N. Souders +3 more
2018Cancer immunology research28 citations Open access
Semantic Scholar
PD-1 is requisite for skin TRM cell formation and specification by TGFβ
K. S. Devi, Eric E. Wang, A. Jaiswal, Piotr Konieczny +26 more
2025Nature Immunology22 citations Open access
Semantic Scholar
Molecular Pathways: Co-Expression of Immune Checkpoint Molecules: Signaling Pathways and Implications for Cancer Immunotherapy
C. Nirschl, C. Drake
201321 citations
Semantic Scholar
mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity
C. Nirschl, H. Brodkin, C. Domonkos, Connor J. Dwyer +8 more
2023Cancer immunology research20 citations Open access
Semantic Scholar
Duality at the gate: Skin dendritic cells as mediators of vaccine immunity and tolerance
C. Nirschl, N. Anandasabapathy
2016Human Vaccines & Immunotherapeutics14 citations Open access
Semantic Scholar
Characterization of ASP8374, a fully-human, antagonistic anti-TIGIT monoclonal antibody.
Kenna Shirasuna, G. Koelsch, C. Seidel-Dugan, A. Salmeron +11 more
2021Cancer Treatment and Research Communications13 citations Open access
Semantic Scholar
Role of Radiation Therapy in Inducing Antigen Specific Antitumor Immune Responses When Combined With Anti-PD1 Checkpoint Blockade: Mechanism and Clinical Implications
A. Sharabi, C. Nirschl, T. Ceccato, Thomas R. Nirschl +5 more
20149 citations Open access
Semantic Scholar
Conditionally Activated IL-12 or IFNα Indukine™ Molecules Inhibit Syngeneic Lymphoma Tumor Growth in Mice, Induce Anti-Tumor Immune Responses and Are Tolerated in Non-Human Primates
P. Steiner, H. Brodkin, Josue Canales, D. Hicklin +10 more
2021Blood8 citations Open access
Semantic Scholar
A phase 1/1b study of the IL-2 prodrug WTX-124 in patients with locally advanced or metastatic solid tumors after checkpoint inhibitor therapy: Initial results of the combination dose escalation with pembrolizumab.
Justin C. Moser, Mateusz Opyrchal, I. Rodriguez Rivera, B. Curti +12 more
2024Journal of Clinical Oncology4 citations
Semantic Scholar
718 WTX-124 is a novel IL-2 pro-drug that is conditionally activated in tumors and drives antitumor immunity in murine syngeneic cancer models
C. Nirschl, H. Brodkin, D. Hicklin, Nesreen Ismail +7 more
2021Journal for ImmunoTherapy of Cancer4 citations Open access
Semantic Scholar
723 WTX-613, a conditionally activated IFNα INDUKINE™ molecule, induces anti-tumor immune responses resulting in strong tumor growth control in syngeneic mouse tumor models
E. Tyagi, H. Brodkin, Josue Canales, D. Hicklin +9 more
2021Journal for ImmunoTherapy of Cancer3 citations Open access
Semantic Scholar
Core skin DC signatures control immune tolerance to skin cancer and limit anti-tumor immunity
C. Nirschl, Yong Liu, K. Sarin, M. Suárez-Fariñas +4 more
2015Journal of Immunotherapy for Cancer3 citations Open access
Semantic Scholar
Expression of neuropilin-1 on in vivo induced regulatory T cells
C. Nirschl, Christina M. Ceccato, Angela Alme, Brian J. Francica +1 more
2013Journal of Immunotherapy for Cancer3 citations Open access
Semantic Scholar
Abstract 4074: Discovery of WTX-518, an IL-18 pro-drug that is conditionally activated within the tumor microenvironment and induces regressions in mouse tumor models
K. Morris, H. Brodkin, Kyriakos D. Economides, Daniel J. Hicklin +8 more
2024Cancer Research2 citations
Semantic Scholar
715 WTX-330 is an IL-12 pro-drug that is conditionally activated within the tumor microenvironment and induces regressions in mouse tumor models
K. Morris, H. Brodkin, D. Hicklin, Nesreen Ismail +6 more
2021Journal for ImmunoTherapy of Cancer2 citations Open access
Semantic Scholar
Abstract 1716: WTX-330, a conditionally activated IL-12 INDUKINE, releases IL-12 selectively in the tumor microenvironment to activate anti-tumor immune responses and induce regressions in mouse tumor models
P. Steiner, H. Brodkin, D. Hicklin, Nesreen S Ismail +7 more
2021Immunology2 citations
Semantic Scholar
Insecure by design? A human-centric security perspective on AI-assisted software development
M. Glas, C. Nirschl, Bar Lanyado, Johan F. Van Niekerk
2026Computers & security1 citations Open access
Semantic Scholar
964 Development of conditional T cell engagers (INDUCER™ molecules) with a highly effective masking approach to reduce dose-limiting cytokine release and off-target peripheral toxicity
T. Cafarelli, Pamela A. Aderhold-Camiré, H. Brodkin, Olivia G. Donovan +14 more
2025Regular and Young Investigator Award Abstracts1 citations Open access
Semantic Scholar
737 A phase 1/1b study of the tumor-activated IL-2 prodrug WTX-124 alone or in combination with pembrolizumab in patients with immunotherapy-sensitive locally advanced or metastatic solid tumors
Justin C. Moser, M. Opyrchal, Ildefonso Rodriguez Rivera, M. Bilen +10 more
2023Regular and Young Investigator Award Abstracts1 citations Open access
Semantic Scholar
Abstract 1723: WTX-124 is an IL-2 pro-drug conditionally activated in tumors and able to induce complete regressions in mouse tumor models
A. Salmeron, H. Brodkin, D. Hicklin, Nesreen Ismail +7 more
2021Immunology1 citations
Semantic Scholar
Abstract 635: Antigen-specific immune responses in melanoma using stereotactic radiotherapy combined with anti-PD1 checkpoint blockade
A. Sharabi, C. Nirschl, T. Ceccato, Brian J. Francica +5 more
20141 citations
Semantic Scholar
TH17 cells and early pancreatic tumorigenesis.
F. McAllister, Jennifer M. Bailey, Janivette Alsina, C. Nirschl +9 more
20131 citations
Semantic Scholar
Abstract 1437: Prostate cancer cells up-regulate PD-L1 in response to pro-inflammatory cytokines.
S. Boikos, C. Nirschl, Allison M. Martin, Angela Alme +2 more
20131 citations
Semantic Scholar
Chat First, Worry Later: Understanding Individuals'Privacy Perceptions Using ChatGPT in a Work Context
C. Nirschl, M. Glas, Gerhard Messmann, Günther Pernul
20260 citations
Semantic Scholar
WTX-124, a Conditionally Activated Wild-Type IL2, Maximizes the Therapeutic Index of IL2, Unlike "Non-Alpha" Muteins.
C. Nirschl, K. Subramanian, H. Brodkin, C. Domonkos +13 more
2026Cancer immunology research0 citations
Semantic Scholar
861 Sequential administration of WTX-124 and mWTX-330, IL-2 and IL-12 INDUKINE™ molecules, enhanced antitumor activity in mice bearing poorly immunogenic EMT6 tumors without systemic toxicity
Julie LePrevost, Kristin Morris, Sameer S. Chopra, Daniel J. Hicklin +5 more
2025Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
862 Pharmacokinetic insight into the IL-2 INDUKINE prodrug WTX-124: Real-time assessment of tumor-specific activation and immune modulation
Celesztina Nagy-Domonkos, H. Brodkin, Daniel J. Hicklin, Jennifer Ngo +4 more
2025Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
Development of WTX-921, a conditionally activated IL-10 INDUKINETM molecule for the treatment of Inflammatory Bowel Disease 2679
Jenna M. Sullivan, Pamela A. Aderhold-Camiré, H. Brodkin, Celesztina Nagy-Domonkos +9 more
2025Journal of Immunology0 citations
Semantic Scholar
672 The tumor-activated IL-12 prodrug WTX-330 expanded/activated tumor infiltrating lymphocytes and caused tumor regression in patients with refractory solid tumors: interim data from an ongoing Ph1 study
D. Mahalingam, M. Opyrchal, Justin C. Moser, Ildefonso Rodriguez Rivera +13 more
2024Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
955 INDUKINE™ molecules delivering various cytokines utilize unique mechanisms of action to drive anti-tumor efficacy in murine syngeneic tumor models
C. Nirschl, Pam Aderhold, H. Brodkin, Olivia G. Donovan +7 more
2024Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
1059 Spatial analysis of tumor infiltrating lymphocyte populations in syngeneic mouse tumor models after treatment with IL-12 (mWTX-330) and IL-2 (WTX-124) INDUKINETMmolecules
C. Nirschl, H. Brodkin, Daniel J. Hicklin, C. Seidel-Dugan +3 more
2023Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
172 Spatiotemporal architecting of skin dendritic cell directed immunity and tolerance
Q. Huang, A. Doane, Y. Liu, J. Valencia +14 more
2023Journal of Investigative Dermatology0 citations Open access
Semantic Scholar
Abstract 1817: WTX-613, (JZP898) a selectively activated IFNα INDUKINE™ molecule, reprograms the tumor microenvironment and generates robust anti-tumor immunity as a monotherapy and in combination with checkpoint inhibitors
C. Nirschl, H. Brodkin, C. Domonkos, Kyriakos D. Economides +7 more
2023Cancer Research0 citations
Semantic Scholar
1074 PK/RO modeling of WTX-124, a tumor-activated IL-2 prodrug, highlights the potential for a substantially improved therapeutic index compared to other IL-2 molecules
K. Subramanian, Sameer S. Chopra, Kristin Morris, C. Nirschl +6 more
2023Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
Abstract A074: Discovery of WTX-330, a clinical stage conditionally activated IL-12 INDUKINETM therapeutic with potent antitumor activity in murine syngeneic tumor models resistant to checkpoint blockade
C. Nirschl, H. Brodkin, Sameer S. Chopra, Connor J. Dwyer +8 more
2023Molecular Cancer Therapeutics0 citations
Semantic Scholar
1058 Optimal antitumor immunity triggered by WTX-124, a clinical stage conditionally activated INDUKINETMmolecule that releases fully potent IL-2 in the tumor microenvironment
C. Nirschl, H. Brodkin, Daniel J. Hicklin, Nesreen Ismail +6 more
2023Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar

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