Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

Robert N. Helsley · SciRah

Researcher profile · Semantic Scholar

Robert N. Helsley

Share profile

Robert N. Helsley — researcher profile on SciRah

h-index: 23
Works: 67
Citations: 1,524

Most-cited papers

Gut microbiota-derived trimethylamine N-oxide contributes to abdominal aortic aneurysm through inflammatory and apoptotic mechanisms
Tyler W. Benson, K. Conrad, Xin-Min S. Li, Ze-Neng Wang +23 more
2023Circulation132 citations Open access
Semantic Scholar
Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease
Robert N. Helsley, Venkateshwari Varadharajan, Amanda L. Brown, Anthony D. Gromovsky +29 more
2019eLife111 citations Open access
Semantic Scholar
The Δ-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Pro-Inflammatory and Pro-Resolving Lipid Mediators
Anthony D. Gromovsky, R. Schugar, Amanda L. Brown, Robert N. Helsley +10 more
2017Arteriosclerosis, Thrombosis and Vascular Biology106 citations Open access
Semantic Scholar
Bisphenol A Increases Atherosclerosis in Pregnane X Receptor‐Humanized ApoE Deficient Mice
Yi-Peng Sui, Se-hyung Park, Robert N. Helsley, Manjula Sunkara +3 more
2014Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease94 citations Open access
Semantic Scholar
Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis
Taesik Gwag, Zhao-Jie Meng, Yi-Peng Sui, Robert N. Helsley +4 more
2019Journal of Hepatology85 citations Open access
Semantic Scholar
Small Molecule Inhibition of Gut Microbial Choline Trimethylamine Lyase Activity Alters Host Cholesterol and Bile Acid Metabolism.
P. Pathak, Robert N. Helsley, Amanda L. Brown, J. Buffa +11 more
2020American Journal of Physiology. Heart and Circulatory Physiology83 citations Open access
Semantic Scholar
IKKβ links vascular inflammation to obesity and atherosclerosis
Yi-Peng Sui, Se-hyung Park, Jin-Xian Xu, S. Monette +3 more
2014Journal of Experimental Medicine77 citations Open access
Semantic Scholar
Tissue-Specific Fructose Metabolism in Obesity and Diabetes
Robert N. Helsley, F. Moreau, Manoj K. Gupta, Aurelia Radulescu +2 more
2020Current Diabetes Reports71 citations Open access
Semantic Scholar
Coordinated Post-transcriptional Regulation of Hsp70.3 Gene Expression by MicroRNA and Alternative Polyadenylation*
M. Tranter, Robert N. Helsley, Waltke R. Paulding, M. McGuinness +5 more
2011Journal of Biological Chemistry70 citations Open access
Semantic Scholar
Mechanisms linking adipose tissue inflammation to cardiac hypertrophy and fibrosis
Sarah R. Anthony, Adrienne R. Guarnieri, Anamarie Gozdiff, Robert N. Helsley +2 more
2019Clinical science67 citations Open access
Semantic Scholar
Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms
R. Schugar, Christy M. Gliniak, Lucas J. Osborn, William J. Massey +29 more
2020bioRxiv58 citations Open access
Semantic Scholar
Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation
Robert N. Helsley, Se-hyung Park, Hemendra J. Vekaria, P. Sullivan +11 more
2023Journal of Hepatology53 citations Open access
Semantic Scholar
IKKβ Is Essential for Adipocyte Survival and Adaptive Adipose Remodeling in Obesity
Se-hyung Park, Zun Liu, Yi-Peng Sui, Robert N. Helsley +4 more
2016Diabetes51 citations Open access
Semantic Scholar
Myeloid-Specific IκB Kinase β Deficiency Decreases Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice
Se-hyung Park, Yi-Peng Sui, F. Gizard, Jin-Xian Xu +4 more
2012Arteriosclerosis, Thrombosis and Vascular Biology49 citations Open access
Semantic Scholar
Fructose impairs fat oxidation: Implications for the mechanism of western diet-induced NAFLD
Mustafa İnci, Se-hyung Park, Robert N. Helsley, S. Attia +1 more
2022Journal of Nutritional Biochemistry43 citations Open access
Semantic Scholar
Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice
Robert N. Helsley, T. Miyata, Anagha Kadam, Venkateshwari Varadharajan +32 more
2022bioRxiv42 citations Open access
Semantic Scholar
Epigenetic impact of endocrine disrupting chemicals on lipid homeostasis and atherosclerosis: a pregnane X receptor-centric view
Robert N. Helsley, Changcheng Zhou
2017Environmental epigenetics37 citations Open access
Semantic Scholar
Intestinal pregnane X receptor links xenobiotic exposure and hypercholesterolemia.
Yi-Peng Sui, Robert N. Helsley, Se-hyung Park, Xiulong Song +2 more
2015Molecular Endocrinology36 citations Open access
Semantic Scholar
Pregnane X Receptor Mediates Dyslipidemia Induced by the HIV Protease Inhibitor Amprenavir in Mice
Robert N. Helsley, Yi-Peng Sui, Ni Ai, Se-hyung Park +2 more
2013Molecular Pharmacology34 citations Open access
Semantic Scholar
Fructose Induced KHK-C Can Increase ER Stress Independent of its Effect on Lipogenesis to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD
Se-hyung Park, Robert N. Helsley, Taghreed Fadhul, Jennifer L. S. Willoughby +19 more
2023Metabolism: Clinical and Experimental32 citations Open access
Semantic Scholar
The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis
D. Ferguson, Jun Zhang, Matthew A. Davis, Robert N. Helsley +7 more
2017Journal of Lipid Research32 citations Open access
Semantic Scholar
FOXS1 is increased in liver fibrosis and regulates TGFβ responsiveness and proliferation pathways in human hepatic stellate cells
Evelyn A. Bates, Zachary A. Kipp, Wang-Hsin Lee, Genesee J. Martinez +10 more
2024Journal of Biological Chemistry27 citations Open access
Semantic Scholar
Dietary Choline Supplementation Attenuates High-Fat-Diet-Induced Hepatocellular Carcinoma in Mice.
Amanda L. Brown, K. Conrad, D. Allende, Anthony D. Gromovsky +5 more
2019Journal of NutriLife27 citations Open access
Semantic Scholar
Efficacy of supermarket and web-based interventions for improving dietary quality: a randomized, controlled trial
D. Steen, Robert N. Helsley, D. Bhatt, E. King +5 more
2022Nature Medicine20 citations Open access
Semantic Scholar
Loss of carnitine palmitoyltransferase 1a reduces docosahexaenoic acid-containing phospholipids and drives sexually dimorphic liver disease in mice
Mikala M Zelows, Corissa Cady, Nikitha Dharanipragada, Anna E. Mead +16 more
2023Molecular Metabolism17 citations Open access
Semantic Scholar
Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury
Venkateshwari Varadharajan, Iyappan Ramachandiran, William J. Massey, Raghav Jain +20 more
2024eLife13 citations Open access
Semantic Scholar
HuR expression in adipose tissue mediates energy expenditure and acute thermogenesis independent of UCP1 expression
Sarah R. Anthony, Adrienne R. Guarnieri, Lindsey Lanzillotta, Anamarie Gozdiff +5 more
2020Adipocyte13 citations Open access
Semantic Scholar
A luminescence-based protocol for assessing fructose metabolism via quantification of ketohexokinase enzymatic activity in mouse or human hepatocytes
Se-hyung Park, Robert N. Helsley, L. Noetzli, Ho-Chou Tu +5 more
2021STAR Protocols9 citations Open access
Semantic Scholar
Non-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae
Michelle S. M. A. Damen, T. Stankiewicz, Se-hyung Park, Robert N. Helsley +7 more
2021International Journal of Obesity9 citations Open access
Semantic Scholar
Design and Rationale for the Supermarket and Web-Based Intervention Targeting Nutrition (SuperWIN) for Cardiovascular Risk Reduction Trial.
S. Couch, Robert N. Helsley, Francesca Siegel, B. Saelens +7 more
2022American Heart Journal8 citations
Semantic Scholar
Hepatic Inactivation of Carnitine Palmitoyltransferase 1a Lowers Apolipoprotein B Containing Lipoproteins in Mice
Robert N. Helsley, Mikala M Zelows, Victoria P. Noffsinger, G. Anspach +10 more
2025Arteriosclerosis, Thrombosis and Vascular Biology5 citations
Semantic Scholar
Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD.
Se-hyung Park, Robert N. Helsley, Taghreed Fadhul, Jennifer L. S. Willoughby +19 more
2023bioRxiv4 citations Open access
Semantic Scholar
The nonvesicular sterol transporter Aster-C plays a minor role in whole body cholesterol balance
Rakhee Banerjee, Rachel C. Hohe, Shijie Cao, Bryan M. Jung +20 more
2024Frontiers in Physiology3 citations Open access
Semantic Scholar
Fructose metabolism by the guts cuts liver fat
Robert N. Helsley, S. Softic
2020Journal of molecular medicine3 citations
Semantic Scholar
ABCG5/ABCG8-independent mechanisms fail to maintain sterol balance in mice fed a high-cholesterol diet
G. Anspach, Rupinder Kaur, Isha Chauhan, Erika L. Savage +9 more
2025Journal of Lipid Research2 citations Open access
Semantic Scholar
The Lipid Hydrolase ABHD6 is a Therapeutic Target in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-Related Hepatocellular Carcinoma
D. Orabi, William J. Massey, Kevin K. Fung, Venkateshwari Varadharajan +29 more
2025bioRxiv1 citations
Semantic Scholar
Abstract 128: Blood TMAO Predicts Abdominal Aortic Aneurysm Growth Rate And Need For Surgical Intervention
S. Cameron, Xin-Min S. Li, T. Benson, K. Conrad +18 more
2024Arteriosclerosis, Thrombosis and Vascular Biology1 citations
Semantic Scholar
Author response: Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease
Robert N. Helsley, Venkateshwari Varadharajan, Amanda L. Brown, Anthony D. Gromovsky +29 more
20191 citations Open access
Semantic Scholar
Abstract 105: Increased Circulating Trimethylamine N-oxide (TMAO) Augments the Incidence of Abdominal Aortic Aneurysm in Low Penetrant C57BL/6J Mice
K. Conrad, Shannon M. Jones, Robert N. Helsley, R. Schugar +4 more
20181 citations
Semantic Scholar
THE ROLE OF PXR AND IKKβ SIGNALING IN CARDIOMETABOLIC DISEASE
Robert N. Helsley
20161 citations
Semantic Scholar
Abstract 270: IκB Kinase β Signaling in Adipose Progenitor Cells Promotes Obesity and Metabolic Disorders
Robert N. Helsley, Yi-Peng Sui, Zun Liu, Se-hyung Park +1 more
2015Arteriosclerosis, Thrombosis and Vascular Biology1 citations
Semantic Scholar
Abstract 12115: Phthalate Substitute Plasticizers Activate PXR and Induce Dyslipidemia in Mice
Yi-Peng Sui, Robert N. Helsley, Se-hyung Park, Zun Liu +1 more
20141 citations
Semantic Scholar
A ubiquitous organophosphate flame retardant disrupts energy and glucose homeostasis in mice
Krystal M Sewell, Kelly Oriakhi, Sara Y. Ngo Tenlep, Megan Weaver +7 more
2026Ecotoxicology and Environmental Safety0 citations Open access
Semantic Scholar
ABCG5 ABCG8-independent mechanisms fail to maintain sterol balance in mice fed a high cholesterol diet
G. Anspach, Isha Chauhan, Erika L. Savage, Brittney Poole +7 more
2025bioRxiv0 citations
Semantic Scholar
Hepatic Inactivation of Carnitine Palmitoyltransferase 1a Lowers Apolipoprotein B Containing Lipoproteins in Mice
Robert N. Helsley, Mikala M Zelows, Victoria P. Noffsinger, G. Anspach +10 more
2024bioRxiv0 citations
Semantic Scholar
Abstract 399: Carnitine Palmitoyltransferase 1a Modulates Hepatic And Lipoprotein Metabolism
Mikala M Zelows, Rupinder Kaur, Douglas A Harrison, Qing-Lin Wu +4 more
2023Arteriosclerosis, Thrombosis and Vascular Biology0 citations
Semantic Scholar
Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in Mice
Mikala M Zelows, Corissa Cady, Nikitha Dharanipragada, Anna E. Mead +16 more
2023bioRxiv0 citations Open access
Semantic Scholar
Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury
Venkateshwari Varadharajan, Iyappan Ramachandiran, William J. Massey, Raghav Jain +20 more
2023bioRxiv0 citations Open access
Semantic Scholar
Abstract 437: Carnitine Palmitoyltransferase 1a Modulates Lipoprotein Metabolism
Mikala M Zelows, Rupinder Kaur, Kori S. Williams, G. Graf +1 more
2022Arteriosclerosis, Thrombosis and Vascular Biology0 citations
Semantic Scholar
Author response: Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice
Robert N. Helsley, T. Miyata, Anagha Kadam, Venkateshwari Varadharajan +32 more
20220 citations Open access
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

Se-hyung Park×16
Invite
Se-hyung Park — researcher profile on SciRah
Rakhee Banerjee×11
Invite
Rakhee Banerjee — researcher profile on SciRah
R. Schugar×10
Invite
R. Schugar — researcher profile on SciRah
Venkateshwari Varadharajan×10
Invite
Venkateshwari Varadharajan — researcher profile on SciRah

Changcheng Zhou×10

Invite

Changcheng Zhou — researcher profile on SciRah

Invite

Yi-Peng Sui — researcher profile on SciRah

Invite

S. Softic — researcher profile on SciRah

Amanda L. Brown×8

Invite

Amanda L. Brown — researcher profile on SciRah

Ze-Neng Wang×7

Invite

Ze-Neng Wang — researcher profile on SciRah

Chase K. A. Neumann×7

Invite

Chase K. A. Neumann — researcher profile on SciRah

Invite

S. Hazen — researcher profile on SciRah

Iyappan Ramachandiran×6

Invite

Iyappan Ramachandiran — researcher profile on SciRah