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A. Jalanko · SciRah

Researcher profile · Semantic Scholar

A. Jalanko

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A. Jalanko — researcher profile on SciRah

h-index: 46
Works: 136
Citations: 13K

Most-cited papers

FinnGen provides genetic insights from a well-phenotyped isolated population
M. Kurki, J. Karjalainen, P. Palta, Timo P. Sipilä +164 more
2023Nature3,914 citations Open access
Semantic Scholar
New insights into the genetic etiology of Alzheimer’s disease and related dementias
C. Bellenguez, F. Küçükali, I. Jansen, L. Kleineidam +496 more
2022Nature Genetics1,984 citations Open access
Semantic Scholar
Molecular genetics of the Finnish disease heritage.
L. Peltonen, A. Jalanko, T. Varilo
1999Human Molecular Genetics522 citations
Semantic Scholar
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice.
H. Tyynismaa, Katja Peltola Mjosund, Sjoerd Wanrooij, I. Lappalainen +5 more
2005Proceedings of the National Academy of Sciences of the United States of America360 citations Open access
Semantic Scholar
Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential
A. Kyttälä, Roksana Moraghebi, Cristina Valensisi, J. Kettunen +14 more
2016Stem Cell Reports257 citations Open access
Semantic Scholar
Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number.
H. Tyynismaa, H. Sembongi, M. Bokori-Brown, C. Granycome +6 more
2004Human Molecular Genetics248 citations Open access
Semantic Scholar
Neuronal ceroid lipofuscinoses.
A. Jalanko, T. Braulke
2009Biochimica et Biophysica Acta199 citations Open access
Semantic Scholar
Genetic architecture of human plasma lipidome and its link to cardiovascular disease
Rubina Tabassum, Joel T. Rämö, P. Ripatti, J. Koskela +255 more
2019Nature Communications167 citations Open access
Semantic Scholar
Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway.
K. Luiro, Kristiina Yliannala, L. Ahtiainen, H. Maunu +3 more
2004Human Molecular Genetics153 citations
Semantic Scholar
Palmitoyl protein thioesterase (PPT) localizes into synaptosomes and synaptic vesicles in neurons: implications for infantile neuronal ceroid lipofuscinosis (INCL).
M. Lehtovirta, A. Kyttälä, Eeva-Liisa Eskelinen, M. Hess +2 more
2001Human Molecular Genetics142 citations Open access
Semantic Scholar
Cell biology and function of neuronal ceroid lipofuscinosis-related proteins.
K. Kollmann, K. Uusi-Rauva, Enzo Scifo, J. Tyynelä +2 more
2013Biochimica et Biophysica Acta139 citations Open access
Semantic Scholar
Lysosomal localization of the neuronal ceroid lipofuscinosis CLN5 protein.
J. Isosomppi, J. Vesa, A. Jalanko, L. Peltonen
2002Human Molecular Genetics137 citations Open access
Semantic Scholar
Neuronal ceroid lipofuscinoses are connected at molecular level: interaction of CLN5 protein with CLN2 and CLN3.
J. Vesa, Mark H. Chin, Kathrin Oelgeschläger, J. Isosomppi +3 more
2002Molecular Biology of the Cell134 citations Open access
Semantic Scholar
CLN3 protein is targeted to neuronal synapses but excluded from synaptic vesicles: new clues to Batten disease.
K. Luiro, O. Kopra, M. Lehtovirta, A. Jalanko
2001Human Molecular Genetics132 citations
Semantic Scholar
Defective intracellular transport of CLN3 is the molecular basis of Batten disease (JNCL)
I. Järvelä, M. Lehtovirta, R. Tikkanen, A. Kyttälä +1 more
1999Human Molecular Genetics126 citations
Semantic Scholar
The neuronal ceroid lipofuscinosis CLN8 membrane protein is a resident of the endoplasmic reticulum.
Liina Lonka, A. Kyttälä, S. Ranta, A. Jalanko +1 more
2000Human Molecular Genetics124 citations
Semantic Scholar
Palmitoyl protein thioesterase 1 is targeted to the axons in neurons
L. Ahtiainen, O. V. van Diggelen, A. Jalanko, O. Kopra
2003The Journal of comparative neurology109 citations
Semantic Scholar
Mice with Ppt1 Δex4 mutation replicate the INCL phenotype and show an inflammation-associated loss of interneurons
A. Jalanko, J. Vesa, Tuula Manninen, C. von Schantz +7 more
2005Neurobiology of Disease100 citations Open access
Semantic Scholar
Author Correction: FinnGen provides genetic insights from a well-phenotyped isolated population
M. Kurki, J. Karjalainen, P. Palta, Timo P. Sipilä +164 more
2023Nature95 citations Open access
Semantic Scholar
A mouse model for Finnish variant late infantile neuronal ceroid lipofuscinosis, CLN5, reveals neuropathology associated with early aging.
O. Kopra, J. Vesa, C. von Schantz, Tuula Manninen +7 more
2004Human Molecular Genetics94 citations Open access
Semantic Scholar
Batten disease (JNCL) is linked to disturbances in mitochondrial, cytoskeletal, and synaptic compartments
K. Luiro, O. Kopra, T. Blom, Massimiliano Gentile +4 more
2006Journal of Neuroscience Research86 citations
Semantic Scholar
Expression of palmitoyl protein thioesterase in neurons.
Outi Heinonen, A. Kyttälä, Elina Lehmus, T. Paunio +2 more
2000Molecular Genetics and Metabolism84 citations
Semantic Scholar
Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins
A. Lyly, C. von Schantz, C. Heine, M. Schmiedt +3 more
2009BMC Cell Biology82 citations Open access
Semantic Scholar
The mouse ortholog of the neuronal ceroid lipofuscinosis CLN5 gene encodes a soluble lysosomal glycoprotein expressed in the developing brain.
Ville Holmberg, A. Jalanko, J. Isosomppi, A. Fabritius +2 more
2004Neurobiology of Disease80 citations Open access
Semantic Scholar
USF1 deficiency activates brown adipose tissue and improves cardiometabolic health
P. Laurila, J. Soronen, S. Kooijman, S. Forsström +43 more
2016Science Translational Medicine77 citations Open access
Semantic Scholar
Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments
K. Uusi-Rauva, A. Kyttälä, R. van der Kant, J. Vesa +4 more
2012Cellular and Molecular Life Sciences76 citations
Semantic Scholar
Deficiency of the INCL protein Ppt1 results in changes in ectopic F1-ATP synthase and altered cholesterol metabolism.
A. Lyly, Sanna K Marjavaara, A. Kyttälä, K. Uusi-Rauva +8 more
2008Human Molecular Genetics75 citations
Semantic Scholar
Mice with inactivation of aryl hydrocarbon receptor-interacting protein (Aip) display complete penetrance of pituitary adenomas with aberrant ARNT expression.
A. Raitila, Heli J. Lehtonen, J. Arola, E. Heliövaara +6 more
2010American Journal of Pathology71 citations Open access
Semantic Scholar
Developmental expression of palmitoyl protein thioesterase in normal mice.
J. Isosomppi, Outi Heinonen, J. Hiltunen, N. Greene +6 more
1999Brain research. Developmental brain research67 citations
Semantic Scholar
AP-1 and AP-3 Facilitate Lysosomal Targeting of Batten Disease Protein CLN3 via Its Dileucine Motif*
A. Kyttälä, Kristiina Yliannala, P. Schu, A. Jalanko +1 more
2005Journal of Biological Chemistry64 citations Open access
Semantic Scholar
Expression and lysosomal targeting of CLN7, a major facilitator superfamily transporter associated with variant late-infantile neuronal ceroid lipofuscinosis.
A. Sharifi, M. Kousi, C. Sagné, G. C. Bellenchi +11 more
2010Human Molecular Genetics60 citations Open access
Semantic Scholar
Proteomic analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells.
Enzo Scifo, Agnieszka Szwajda, R. Soliymani, F. Pezzini +11 more
2015Journal of Proteomics59 citations
Semantic Scholar
Brain gene expression profiles of Cln1 and Cln5 deficient mice unravels common molecular pathways underlying neuronal degeneration in NCL diseases
C. von Schantz, J. Saharinen, O. Kopra, J. Cooper +4 more
2008BMC Genomics59 citations Open access
Semantic Scholar
Molecular pathogenesis of a disease: structural consequences of aspartylglucosaminuria mutations.
J. Saarela, Minna Laine, C. Oinonen, C. von Schantz +3 more
2001Human Molecular Genetics57 citations
Semantic Scholar
The neuronal ceroid lipofuscinosis protein CLN5: new insights into cellular maturation, transport, and consequences of mutations
M. Schmiedt, C. Bessa, C. Heine, M. G. Ribeiro +2 more
2010Human Mutation54 citations
Semantic Scholar
Cln5-deficiency in mice leads to microglial activation, defective myelination and changes in lipid metabolism.
M. Schmiedt, Tea Blom, T. Blom, O. Kopra +7 more
2012Neurobiology of Disease51 citations Open access
Semantic Scholar
Novel interactions of CLN3 protein link Batten disease to dysregulation of fodrin-Na+, K+ ATPase complex.
K. Uusi-Rauva, K. Luiro, K. Tanhuanpää, O. Kopra +3 more
2008Experimental Cell Research51 citations
Semantic Scholar
Palmitoyl protein thioesterase 1 (Ppt1)-deficient mouse neurons show alterations in cholesterol metabolism and calcium homeostasis prior to synaptic dysfunction.
L. Ahtiainen, Julia Kolikova, A. Mutka, K. Luiro +5 more
2007Neurobiology of Disease51 citations Open access
Semantic Scholar
Localization of wild‐type and mutant neuronal ceroid lipofuscinosis CLN8 proteins in non‐neuronal and neuronal cells
Liina Lonka, Tarja Salonen, E. Siintola, O. Kopra +2 more
2004Journal of Neuroscience Research49 citations
Semantic Scholar
Progressive thalamocortical neuron loss in Cln5 deficient mice: distinct effects in Finnish variant late infantile NCL
C. von Schantz, C. Kielar, Stine N. Hansen, Charlie C. Pontikis +4 more
2009Neurobiology of Disease48 citations Open access
Semantic Scholar
Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach.
Enzo Scifo, Agnieszka Szwajda, J. Debski, K. Uusi-Rauva +7 more
2013Journal of Proteome Research47 citations Open access
Semantic Scholar
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells
Erik L. Bao, Satish K. Nandakumar, Xiaotian Liao, A. Bick +335 more
2020Nature44 citations Open access
Semantic Scholar
Activation and Oligomerization of Aspartylglucosaminidase*
J. Saarela, M. Laine, R. Tikkanen, C. Oinonen +3 more
1998Journal of Biological Chemistry44 citations Open access
Semantic Scholar
CLN‐1 and CLN‐5, genes for infantile and variant late infantile neuronal ceroid lipofuscinoses, are expressed in the embryonic human brain
O. Heinonen, Tarja Salonen, A. Jalanko, L. Peltonen +1 more
2000The Journal of comparative neurology42 citations
Semantic Scholar
Sialin expression in the CNS implicates extralysosomal function in neurons.
N. Aula, O. Kopra, A. Jalanko, L. Peltonen
2004Neurobiology of Disease41 citations Open access
Semantic Scholar
Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing.
L. Ahtiainen, K. Luiro, Maria Kauppi, J. Tyynelä +2 more
2006Experimental Cell Research40 citations
Semantic Scholar
Unraveling the molecular pathogenesis of free sialic acid storage disorders: altered targeting of mutant sialin.
N. Aula, A. Jalanko, P. Aula, L. Peltonen
2002Molecular Genetics and Metabolism38 citations
Semantic Scholar
Advanced Feeder‐Free Generation of Induced Pluripotent Stem Cells Directly From Blood Cells
R. Trokovic, J. Weltner, K. Nishimura, M. Ohtaka +5 more
2014Stem Cells Translational Medicine37 citations Open access
Semantic Scholar
Adenovirus-mediated gene transfer results in decreased lysosomal storage in brain and total correction in liver of aspartylglucosaminuria (AGU) mouse
Minna Peltola, A. Kyttälä, Outi Heinonen, J. Rapola +4 more
1998Gene Therapy37 citations Open access
Semantic Scholar
Mice with an aspartylglucosaminuria mutation similar to humans replicate the pathophysiology in patients.
A. Jalanko, Kai Tenhunen, C. McKinney, M. Lamarca +9 more
1998Human Molecular Genetics36 citations
Semantic Scholar

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