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K. Trenholme · SciRah

Researcher profile · Semantic Scholar

K. Trenholme

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K. Trenholme — researcher profile on SciRah

h-index: 33
Works: 84
Citations: 3,195

Most-cited papers

Antigenic diversity and the transmission dynamics of Plasmodium falciparum.
Sunetra Gupta, K. Trenholme, Roy M. Anderson, Karen P. Day
1994Science188 citations
Semantic Scholar
A Pilot Randomised Trial of Induced Blood-Stage Plasmodium falciparum Infections in Healthy Volunteers for Testing Efficacy of New Antimalarial Drugs
J. McCarthy, S. Sekuloski, P. Griffin, S. Elliott +10 more
2011PLoS ONE146 citations Open access
Semantic Scholar
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase
S. McGowan, C. J. Porter, J. Lowther, Colin M. Stack +13 more
2009Proceedings of the National Academy of Sciences of the United States of America133 citations Open access
Semantic Scholar
Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials.
T. Skinner-Adams, Colin M. Stack, K. Trenholme, C. L. Brown +9 more
2010TIBS -Trends in Biochemical Sciences. Regular ed132 citations
Semantic Scholar
A cluster of ring stage-specific genes linked to a locus implicated in cytoadherence in Plasmodium falciparum codes for PEXEL-negative and PEXEL-positive proteins exported into the host cell.
T. Spielmann, Paula Hawthorne, Matthew W. A. Dixon, M. Hannemann +6 more
2006Molecular Biology of the Cell132 citations Open access
Semantic Scholar
clag9: A cytoadherence gene in Plasmodium falciparum essential for binding of parasitized erythrocytes to CD36.
K. Trenholme, D. L. Gardiner, D. Holt, E. Thomas +2 more
2000Proceedings of the National Academy of Sciences of the United States of America127 citations Open access
Semantic Scholar
Effect of antimalarial drugs on Plasmodium falciparum gametocytes.
Christopher L. Peatey, T. Skinner-Adams, Matthew W. A. Dixon, J. McCarthy +2 more
2009Journal of Infectious Diseases122 citations Open access
Semantic Scholar
Characterization of the Plasmodium falciparum M17 Leucyl Aminopeptidase
Colin M. Stack, J. Lowther, E. Cunningham, S. Donnelly +10 more
2007Journal of Biological Chemistry115 citations Open access
Semantic Scholar
A real-time, quantitative PCR method using hydrolysis probes for the monitoring of Plasmodium falciparum load in experimentally infected human volunteers
R. Rockett, S. Tozer, Christopher L. Peatey, S. Bialasiewicz +5 more
2011Malaria Journal106 citations Open access
Semantic Scholar
Selective permeabilization of the host cell membrane of Plasmodium falciparum-infected red blood cells with streptolysin O and equinatoxin II.
Katherine E. Jackson, T. Spielmann, E. Hanssen, A. Adisa +7 more
2007Biochemical Journal102 citations Open access
Semantic Scholar
Sex in Plasmodium: a sign of commitment.
Matthew W. A. Dixon, Joanne Thompson, D. L. Gardiner, K. Trenholme
2008Trends in Parasitology101 citations
Semantic Scholar
Experimentally induced blood-stage Plasmodium vivax infection in healthy volunteers.
J. McCarthy, P. Griffin, S. Sekuloski, A. Bright +7 more
2013Journal of Infectious Diseases99 citations Open access
Semantic Scholar
A novel Plasmodium falciparum ring stage protein, REX, is located in Maurer's clefts.
Paula Hawthorne, K. Trenholme, T. Skinner-Adams, T. Spielmann +6 more
2004Molecular and biochemical parasitology (Print)95 citations
Semantic Scholar
Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds.
T. Skinner-Adams, J. Lowther, F. Teuscher, Colin M. Stack +6 more
2007Journal of Medicinal Chemistry88 citations
Semantic Scholar
Anti-malarial drugs: how effective are they against Plasmodium falciparum gametocytes?
Christopher L. Peatey, D. Leroy, D. L. Gardiner, K. Trenholme
2012Malaria Journal82 citations Open access
Semantic Scholar
Fingerprinting the Substrate Specificity of M1 and M17 Aminopeptidases of Human Malaria, Plasmodium falciparum
M. Poręba, S. McGowan, T. Skinner-Adams, K. Trenholme +6 more
2012PLoS ONE74 citations Open access
Semantic Scholar
Lysine Acetylation in Sexual Stage Malaria Parasites Is a Target for Antimalarial Small Molecules
K. Trenholme, Linda Marek, Sandra Duffy, G. Pradel +13 more
2014Antimicrobial Agents and Chemotherapy64 citations Open access
Semantic Scholar
Aggregation and distribution of strains in microparasites.
C. C. Lord, B. Barnard, K. Day, J. Hargrove +4 more
1999Philosophical transactions of the Royal Society of London. Series B, Biological sciences63 citations Open access
Semantic Scholar
Inhibition of Plasmodium falciparum clag9 gene function by antisense RNA.
D. L. Gardiner, D. Holt, E. Thomas, D. J. Kemp +1 more
2000Molecular and biochemical parasitology (Print)62 citations
Semantic Scholar
The cytoadherence linked asexual gene family of Plasmodium falciparum: are there roles other than cytoadherence?
D. Holt, D. L. Gardiner, E. Thomas, M. Mayo +6 more
1999International Journal of Parasitology61 citations
Semantic Scholar
Anti-Giardia drug discovery: Current status and gut feelings.
A. Riches, Christopher J. S. Hart, K. Trenholme, T. Skinner-Adams
2020Journal of Medicinal Chemistry59 citations Open access
Semantic Scholar
The M18 Aspartyl Aminopeptidase of the Human Malaria Parasite Plasmodium falciparum*
F. Teuscher, J. Lowther, T. Skinner-Adams, T. Spielmann +9 more
2007Journal of Biological Chemistry58 citations Open access
Semantic Scholar
Overexpression of Leucyl Aminopeptidase in Plasmodium falciparum Parasites
D. L. Gardiner, K. Trenholme, T. Skinner-Adams, Colin M. Stack +1 more
2006Journal of Biological Chemistry54 citations Open access
Semantic Scholar
Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development
J. McCarthy, L. Marquart, S. Sekuloski, K. Trenholme +15 more
2016Antimicrobial Agents and Chemotherapy45 citations Open access
Semantic Scholar
Development of cultured Plasmodium falciparum blood-stage malaria cell banks for early phase in vivo clinical trial assessment of anti-malaria drugs and vaccines
D. Stanisic, Xue Q. Liu, S. De, M. Batzloff +11 more
2015Malaria Journal45 citations Open access
Semantic Scholar
A green fluorescent protein-based assay for determining gametocyte production in Plasmodium falciparum.
Matthew W. A. Dixon, Christopher L. Peatey, D. L. Gardiner, K. Trenholme
2009Molecular and biochemical parasitology (Print)44 citations
Semantic Scholar
The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: importance of active site metal ions in the binding of substrates and inhibitors.
S. Maric, S. Donnelly, M. Robinson, T. Skinner-Adams +5 more
2009Biochemistry41 citations
Semantic Scholar
Implication of a Plasmodium falciparum gene in the switch between asexual reproduction and gametocytogenesis.
D. L. Gardiner, Matthew W. A. Dixon, T. Spielmann, T. Skinner-Adams +4 more
2005Molecular and biochemical parasitology (Print)41 citations
Semantic Scholar
The Aminopeptidase Inhibitor CHR-2863 Is an Orally Bioavailable Inhibitor of Murine Malaria
T. Skinner-Adams, Christopher L. Peatey, K. Anderson, K. Trenholme +8 more
2012Antimicrobial Agents and Chemotherapy39 citations Open access
Semantic Scholar
Plasmodium falciparum: new molecular targets with potential for antimalarial drug development
D. L. Gardiner, T. Skinner-Adams, C. L. Brown, K. Andrews +4 more
2009Expert Review of Anti-Infective Therapy38 citations
Semantic Scholar
Plasmodium gametocyte inhibition identified from a natural-product-based fragment library.
H. Vu, C. Roullier, M. Campitelli, K. Trenholme +6 more
2013ACS Chemical Biology35 citations
Semantic Scholar
Plasmodium falciparum gametocytes: with a view to a kill
Alice S. Butterworth, T. Skinner-Adams, D. L. Gardiner, K. Trenholme
2013Parasitology33 citations Open access
Semantic Scholar
Antimalarial Asexual Stage-Specific and Gametocytocidal Activities of HIV Protease Inhibitors
Christopher L. Peatey, K. Andrews, Nina Eickel, T. Macdonald +5 more
2009Antimicrobial Agents and Chemotherapy33 citations Open access
Semantic Scholar
Diversity in repeat-containing surface proteins of Leishmania major.
P. McKean, K. Trenholme, D. Rangarajan, J. Keen +1 more
1997Molecular and biochemical parasitology (Print)33 citations
Semantic Scholar
Dual stage synthesis and crucial role of cytoadherence-linked asexual gene 9 in the surface expression of malaria parasite var proteins
Suchi Goel, M. Valiyaveettil, R. Achur, A. Goyal +5 more
2010Proceedings of the National Academy of Sciences of the United States of America32 citations Open access
Semantic Scholar
Aminopeptidases of malaria parasites: new targets for chemotherapy.
K. Trenholme, C. L. Brown, T. Skinner-Adams, Colin M. Stack +6 more
2010Infectious Diseases - Drug Targets32 citations
Semantic Scholar
A repeat sequence domain of the ring-exported protein-1 of Plasmodium falciparum controls export machinery architecture and virulence protein trafficking
Emma McHugh, Steven Batinovic, E. Hanssen, Paul J. McMillan +7 more
2015Molecular Microbiology30 citations Open access
Semantic Scholar
X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP.
K. Sivaraman, C. A. Oellig, Kitmun Huynh, Sarah C Atkinson +9 more
2012Journal of Molecular Biology30 citations Open access
Semantic Scholar
Enhanced gametocyte formation in erythrocyte progenitor cells: a site-specific adaptation by Plasmodium falciparum.
Christopher L. Peatey, J. Watson, K. Trenholme, C. L. Brown +5 more
2013Journal of Infectious Diseases29 citations
Semantic Scholar
Malaria transfection and transfection vectors.
D. L. Gardiner, T. Skinner-Adams, T. Spielmann, K. Trenholme
2003Trends in Parasitology27 citations
Semantic Scholar
Enhanced invasion of blood group A1 erythrocytes by Plasmodium falciparum.
Wendy Y. Chung, D. L. Gardiner, C. Hyland, M. Gatton +2 more
2005Molecular and biochemical parasitology (Print)25 citations
Semantic Scholar
CLAG 9 is located in the rhoptries of Plasmodium falciparum
D. L. Gardiner, T. Spielmann, Matthew W. A. Dixon, Paula Hawthorne +5 more
2004Parasitology Research22 citations
Semantic Scholar
Plasmodium falciparum gametocytes: playing hide and seek.
D. L. Gardiner, K. Trenholme
2015Annals of Translational Medicine20 citations
Semantic Scholar
Malaria in the post-genomics era: light at the end of the tunnel or just another train?
D. L. Gardiner, J. Mccarthy, K. Trenholme
2005Postgraduate medical journal20 citations Open access
Semantic Scholar
An improved method for undertaking limiting dilution assays for in vitro cloning of Plasmodium falciparum parasites
Alice S. Butterworth, Alan J. Robertson, Mei-Fong Ho, M. Gatton +2 more
2011Malaria Journal19 citations Open access
Semantic Scholar
Temporal evaluation of commitment to sexual development in Plasmodium falciparum
Christopher L. Peatey, Matthew W. A. Dixon, D. L. Gardiner, K. Trenholme
2013Malaria Journal16 citations Open access
Semantic Scholar
A bioreactor system for the manufacture of a genetically modified Plasmodium falciparum blood stage malaria cell bank for use in a clinical trial
Rebecca Pawliw, R. Farrow, S. Sekuloski, Helen Jennings +10 more
2018Malaria Journal15 citations Open access
Semantic Scholar
A Plasmodium falciparum S33 proline aminopeptidase is associated with changes in erythrocyte deformability.
F. L. da Silva, Matthew W. A. Dixon, Colin M. Stack, F. Teuscher +9 more
2016Experimental parasitology14 citations Open access
Semantic Scholar
Identification of Potent and Selective Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) of Human Malaria via High Throughput Screening
T. Spicer, V. Fernandez-Vega, P. Chase, L. Scampavia +13 more
2014Journal of biomolecular screening14 citations Open access
Semantic Scholar
Resistance of Plasmodium falciparum to amodiaquine in Papua New Guinea.
K. Trenholme, D. E. Kum, A. Raiko, N. Gibson +2 more
1993Transactions of the Royal Society of Tropical Medicine and Hygiene14 citations
Semantic Scholar

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D. L. Gardiner×37
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D. L. Gardiner — researcher profile on SciRah
T. Skinner-Adams×23
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T. Skinner-Adams — researcher profile on SciRah
J. Dalton×14
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Colin M. Stack×11
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Colin M. Stack — researcher profile on SciRah

Matthew W. A. Dixon

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Matthew W. A. Dixon — researcher profile on SciRah

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J. McCarthy — researcher profile on SciRah

Christopher L. Peatey×9

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J. Lowther — researcher profile on SciRah

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C. L. Brown — researcher profile on SciRah

T. Spielmann×7

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T. Spielmann — researcher profile on SciRah

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D. Kemp — researcher profile on SciRah

S. Sekuloski×5

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S. Sekuloski — researcher profile on SciRah