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G. Le · SciRah

Researcher profile · Semantic Scholar

G. Le

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G. Le — researcher profile on SciRah

h-index: 20
Works: 40
Citations: 1,724

Most-cited papers

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll‐like receptor 4 agonist LPS
M. Halili, Melanie R. Andrews, Larisa I. Labzin, K. Schroder +10 more
2010Journal of Leukocyte Biology199 citations
Semantic Scholar
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome
N. Jiménez-Vargas, Luke A. Pattison, Pei-Shen Zhao, T. Lieu +23 more
2018Proceedings of the National Academy of Sciences of the United States of America156 citations Open access
Semantic Scholar
Antifibrotic activity of an inhibitor of histone deacetylases in DOCA‐salt hypertensive rats
A. Iyer, A. Fenning, Jun-Xian Lim, G. Le +4 more
2010British Journal of Pharmacology135 citations Open access
Semantic Scholar
Potent Antimalarial Activity of Histone Deacetylase Inhibitor Analogues
K. Andrews, T. N. Tran, A. J. Lucke, P. Kahnberg +5 more
2008Antimicrobial Agents and Chemotherapy118 citations Open access
Semantic Scholar
Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110)
J. Suen, G. Barry, R. Lohman, M. Halili +3 more
2012British Journal of Pharmacology114 citations Open access
Semantic Scholar
Carbohydrates as Scaffolds in Drug Discovery
W. Meutermans, G. Le, B. Becker
2006ChemMedChem104 citations
Semantic Scholar
Novel agonists and antagonists for human protease activated receptor 2.
Grant D. Barry, J. Suen, G. Le, Adam J. Cotterell +2 more
2010Journal of Medicinal Chemistry101 citations Open access
Semantic Scholar
Nonpeptidic ligands for peptide-activated G protein-coupled receptors.
Jade S. Blakeney, R. Reid, G. Le, D. Fairlie
2007Chemical Reviews78 citations
Semantic Scholar
Histone deacetylase inhibitors and periodontal bone loss.
M. Cantley, P. Bartold, V. Marino, D. Fairlie +3 more
2011Journal of Periodontal Research74 citations
Semantic Scholar
Inhibitors of histone deacetylases in class I and class II suppress human osteoclasts in vitro
M. Cantley, D. Fairlie, P. Bartold, K. Rainsford +4 more
2011Journal of Cellular Physiology74 citations
Semantic Scholar
Molecular diversity through sugar scaffolds.
G. Le, G. Abbenante, B. Becker, Matthias Grathwohl +4 more
2003Drug Discovery Today70 citations
Semantic Scholar
Agonists and antagonists of protease activated receptors (PARs).
Grant D. Barry, G. Le, D. Fairlie
2006Current Medicinal Chemistry69 citations
Semantic Scholar
Inhibitors of TACE and Caspase-1 as anti-inflammatory drugs.
G. Le, G. Abbenante
2005Current Medicinal Chemistry58 citations
Semantic Scholar
Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design
T. Peat, D. Rhodes, N. Vandegraaff, G. Le +12 more
2012PLoS ONE55 citations Open access
Semantic Scholar
Structural Basis for a New Mechanism of Inhibition of H I V-1 Integrase Identified by Fragment Screening and Structure-Based Design
D. Rhodes, T. Peat, N. Vandegraaff, D. Jeevarajah +12 more
2011Antiviral Chemistry & Chemotherapy48 citations
Semantic Scholar
Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: selection of the scaffold.
E. D. Jones, N. Vandegraaff, G. Le, N. Choi +11 more
2010Bioorganic & Medicinal Chemistry Letters40 citations Open access
Semantic Scholar
Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: azoles: effective metal chelators.
G. Le, N. Vandegraaff, D. Rhodes, E. D. Jones +8 more
2010Bioorganic & Medicinal Chemistry Letters34 citations Open access
Semantic Scholar
Organic azide inhibitors of cysteine proteases.
G. Le, G. Abbenante, P. Madala, H. N. Hoang +1 more
2006Journal of the American Chemical Society26 citations
Semantic Scholar
Profiling the Enzymatic Properties and Inhibition of Human Complement Factor B*
G. Le, G. Abbenante, D. Fairlie
2007Journal of Biological Chemistry22 citations Open access
Semantic Scholar
Protein α-turns recreated in structurally stable small molecules.
H. N. Hoang, Russell W. Driver, Renée L. Beyer, A. Malde +4 more
2011Angewandte Chemie21 citations
Semantic Scholar
Noncovalent tripeptidyl benzyl- and cyclohexyl-amine inhibitors of the cysteine protease caspase-1.
Reik Löser, G. Abbenante, P. Madala, M. Halili +2 more
2010Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Discovery of potent HIV integrase inhibitors active against raltegravir resistant viruses.
G. Le, N. Vandegraaff, D. Rhodes, E. D. Jones +6 more
2010Bioorganic & Medicinal Chemistry Letters20 citations
Semantic Scholar
A refined agonist pharmacophore for protease activated receptor 2.
Grant D. Barry, J. Suen, Heng Boon Low, Bernhard Pfeiffer +4 more
2007Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Carbohydrate-based scaffolds in drug discovery.
B. Becker, G. Condie, G. Le, W. Meutermans
2006Mini-Reviews in Medical Chemistry20 citations
Semantic Scholar
Structure-activity relationships for substrate-based inhibitors of human complement factor B.
Gloria Ruiz-Gómez, Jun-Xian Lim, M. Halili, G. Le +3 more
2009Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Unexpected photolytic decomposition of alkyl azides under mild conditions.
G. Abbenante, G. Le, D. Fairlie
2007Chemical Communications14 citations
Semantic Scholar
Complement component C2, inhibiting a latent serine protease in the classical pathway of complement activation.
M. Halili, Gloria Ruiz-Gómez, G. Le, G. Abbenante +1 more
2009Biochemistry9 citations
Semantic Scholar
Microwave-promoted synthesis of 3-amino-substituted 1,2-benzisoxazoles.
J. A. Smith, G. Le, E. D. Jones, J. Deadman
2010Future Medicinal Chemistry5 citations
Semantic Scholar
Nonpeptidic Ligands for Peptide-Activated G Protein-Coupled Receptors
Jade S. Blakeney, R. Reid, G. Le, D. Fairlie
20075 citations
Semantic Scholar
Correction: Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design
T. Peat, D. Rhodes, N. Vandegraaff, G. Le +12 more
2013PLoS ONE1 citations Open access
Semantic Scholar
Novel agonists and antagonists for protease activated receptor 2
Annika Yau, Li-Gong Liu, R. Reid, Grant D. Barry +5 more
20111 citations
Semantic Scholar
Derivatives of synthesis of monosaccharides for drug discovery
M. West, P. Andrews, T. Ramsdale, W. Meutermans +4 more
20041 citations
Semantic Scholar
Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
T. Peat, J. Newman, D. Rhodes, N. Vandergraaff +10 more
20120 citations
Semantic Scholar
New HIV integrase inhibitors discovered through fragment screening
T. Peat, J. Deadman, D. Rhodes, J. Newman +7 more
20110 citations Open access
Semantic Scholar
MEDI 256-Activation and inhibition of latent serine proteases, complement factors B and C2
D. Fairlie, G. Le, M. Halili, Gloria Ruiz-Gómez +1 more
20080 citations
Semantic Scholar
Organic Azide Inhibitors of Cysteine Proteases [J. Am. Chem. Soc. 2006, 128, 12396−12397].
G. Le, G. Abbenante, P. Madala, H. N. Hoang +1 more
20070 citations Open access
Semantic Scholar
MEDI 181-Alpha helix induction in HIV REV34-50 by N-terminal nucleators
Renée L. Beyer, Michael J. Kelso, R. Reid, G. Le +1 more
20060 citations Open access
Semantic Scholar
MEDI 180-Effects of cyclization constraints on helix/turn peptide structures
Renée L. Beyer, H. N. Hoang, G. Le, D. Fairlie
20060 citations
Semantic Scholar
Disaccarides for drug discovery
G. Abbenante, G. Adamson, B. Becker, N. Drinnan +6 more
20030 citations
Semantic Scholar
SUGARS AS SCAFFOLDS FOR DRUG DESIGN
G. Le, C. Clark, M. Broadhurst, Li-Gong Liu +7 more
20020 citations
Semantic Scholar

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