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A. Zelent · SciRah

Researcher profile · Semantic Scholar

A. Zelent

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A. Zelent — researcher profile on SciRah

h-index: 58
Works: 191
Citations: 13K

Most-cited papers

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
T. Schenk, W. Chen, Stefanie Göllner, L. Howell +16 more
2012Nature Medicine631 citations Open access
Semantic Scholar
Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia
Jiong Hu, Yuan-Fang Liu, Chuanfeng Wu, Fang Xu +15 more
2009Proceedings of the National Academy of Sciences of the United States of America422 citations Open access
Semantic Scholar
Role of the proto-oncogene Pokemon in cellular transformation and ARF repression
Takahiro Maeda, R. Hobbs, T. Merghoub, I. Guernah +4 more
2005Nature353 citations
Semantic Scholar
Regulation of B Versus T Lymphoid Lineage Fate Decision by the Proto-Oncogene LRF
Takahiro Maeda, T. Merghoub, R. Hobbs, Lin Dong +9 more
2007Science227 citations Open access
Semantic Scholar
Loss of the Histone Methyltransferase EZH2 induces Resistance to Multiple Drugs in Acute Myeloid Leukemia
S. Göllner, T. Oellerich, Shuchi Agrawal-Singh, T. Schenk +24 more
2016Nature Medicine221 citations Open access
Semantic Scholar
Retinoic Acid and Its Derivatives in Skin
Łukasz Szymański, Rafał Skopek, Małgorzata Palusińska, T. Schenk +5 more
2020Cells200 citations Open access
Semantic Scholar
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia
A. Zelent, M. Greaves, T. Enver
2004Oncogene183 citations
Semantic Scholar
Differentiation therapy of acute myeloid leukemia: past, present and future.
K. Petrie, A. Zelent, S. Waxman
2009Current opinion in hematology170 citations
Semantic Scholar
Unlocking the potential of retinoic acid in anticancer therapy
T. Schenk, S. Stengel, A. Zelent
2014British Journal of Cancer152 citations Open access
Semantic Scholar
LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis
Takahiro Maeda, Keisuke Ito, T. Merghoub, L. Poliseno +10 more
2009Developmental Cell120 citations Open access
Semantic Scholar
Histone Deacetylase 9 Promotes Angiogenesis by Targeting the Antiangiogenic MicroRNA-17–92 Cluster in Endothelial Cells
David Kaluza, J. Kroll, Sabine Gesierich, Yosif Manavski +8 more
2013Arteriosclerosis, Thrombosis and Vascular Biology117 citations Open access
Semantic Scholar
Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor.
L. Altucci, A. Rossin, O. Hirsch, A. Nebbioso +9 more
2005Cancer Research116 citations
Semantic Scholar
Histone Acetyltransferase Activity of p300 Is Required for Transcriptional Repression by the Promyelocytic Leukemia Zinc Finger Protein
F. Guidez, L. Howell, M. Isalan, M. Cebrat +8 more
2004Molecular and Cellular Biology105 citations Open access
Semantic Scholar
PLZF is a regulator of homeostatic and cytokine-induced myeloid development.
S. Doulatov, F. Notta, K. Rice, L. Howell +3 more
2009Genes & Development99 citations Open access
Semantic Scholar
Recruitment of RXR by homotetrameric RARalpha fusion proteins is essential for transformation.
B. Zeisig, C. Kwok, A. Zelent, P. Shankaranarayanan +3 more
2007Cancer Cell97 citations Open access
Semantic Scholar
Histone Deacetylases 9 and 10 Are Required for Homologous Recombination*
Shweta Kotian, S. Liyanarachchi, A. Zelent, J. Parvin
2011Journal of Biological Chemistry81 citations Open access
Semantic Scholar
Retinoids and myelomonocytic growth factors cooperatively activate RARA and induce human myeloid leukemia cell differentiation via MAP kinase pathways.
A. Glasow, Natalia V. Prodromou, Ke Xu, M. von Lindern +1 more
2005Blood76 citations
Semantic Scholar
Selective inhibition of SIN3 corepressor with avermectins as a novel therapeutic strategy in triple negative breast cancer
Y. Kwon, K. Petrie, B. Leibovitch, L. Zeng +17 more
2015Molecular Cancer Therapeutics71 citations Open access
Semantic Scholar
Interference with Sin3 function induces epigenetic reprogramming and differentiation in breast cancer cells
E. Farias, K. Petrie, B. Leibovitch, Janice Murtagh +4 more
2010Proceedings of the National Academy of Sciences of the United States of America68 citations Open access
Semantic Scholar
Synthesis and evaluation of a potent and selective cell-permeable p300 histone acetyltransferase inhibitor.
Y. Zheng, K. Balasubramanyam, M. Cebrat, Donnie Buck +4 more
2005Journal of the American Chemical Society65 citations
Semantic Scholar
Ex-vivo Sensitivity Profiling to Guide Clinical Decision Making in Acute Myeloid Leukemia: A Pilot Study
R. Swords, Diana J Azzam, H. Al-Ali, I. Lohse +17 more
2017Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis58 citations Open access
Semantic Scholar
LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling
Zhaoyuan Hou, Hongzhuang Peng, David E. White, D. Negorev +6 more
2010Proceedings of the National Academy of Sciences of the United States of America53 citations Open access
Semantic Scholar
Cross Talk between Retinoic Acid Signaling and Transcription Factor GATA-2
S. Tsuzuki, K. Kitajima, T. Nakano, A. Glasow +2 more
2004Molecular and Cellular Biology47 citations Open access
Semantic Scholar
Deregulated expression of HDAC9 in B cells promotes development of lymphoproliferative disease and lymphoma in mice
V. Gil, G. Bhagat, L. Howell, Jiyuan Zhang +5 more
2016Disease Models & Mechanisms45 citations Open access
Semantic Scholar
DNA methylation-independent loss of RARA gene expression in acute myeloid leukemia.
A. Glasow, A. Barrett, K. Petrie, Rajeev Gupta +9 more
2008Blood42 citations Open access
Semantic Scholar
Clinical responsiveness to All-trans Retinoic Acid is potentiated by LSD1 inhibition and associated with a quiescent transcriptome in myeloid malignancies
M. Tayari, H. G. Dos Santos, D. Kwon, T. Bradley +10 more
2021Clinical Cancer Research40 citations Open access
Semantic Scholar
Looking into the Eyes—In Vitro Models for Ocular Research
Krystyna Lieto, Rafał Skopek, Aneta Lewicka, M. Stelmasiak +4 more
2022International Journal of Molecular Sciences39 citations Open access
Semantic Scholar
The acetyltransferase GCN5 maintains ATRA-resistance in non-APL AML
M. Kahl, A. Brioli, M. Bens, F. Perner +16 more
2019Leukemia35 citations
Semantic Scholar
Marked for death
K. Petrie, A. Zelent
2008Nature Cell Biology34 citations
Semantic Scholar
Targeting the SIN3A-PF1 interaction inhibits epithelial to mesenchymal transition and maintenance of a stem cell phenotype in triple negative breast cancer
Nidhi Bansal, K. Petrie, R. Christova, Chi Y. Chung +14 more
2015OncoTarget32 citations Open access
Semantic Scholar
Suppression of MYC by PI3K/AKT/mTOR pathway inhibition in combination with all‐trans retinoic acid treatment for therapeutic gain in acute myeloid leukaemia
S. Stengel, K. Petrie, Y. Sbirkov, Clara Stanko +8 more
2022British Journal of Haematology25 citations Open access
Semantic Scholar
Inhibiting estrogen responses in breast cancer cells using a fusion protein encoding estrogen receptor-α and the transcriptional repressor PLZF
Lakjaya Buluwela, J. Pike, D. Mazhar, T. Kamalati +16 more
2005Gene Therapy21 citations Open access
Semantic Scholar
State of the Translational Science
A. Zelent, S. Waxman, M. Carducci, J. Wright +2 more
2004Clinical Cancer Research21 citations
Semantic Scholar
Molecular target-based treatment of human cancer: summary of the 10th international conference on differentiation therapy.
A. Zelent, K. Petrie, Zhu Chen, R. Lotan +5 more
2005Cancer Research17 citations Open access
Semantic Scholar
Targeted interference of SIN3A-TGIF1 function by SID decoy treatment inhibits Wnt signaling and invasion in triple negative breast cancer cells
Y. Kwon, B. Leibovitch, Nidhi Bansal, L. Pereira +5 more
2016OncoTarget15 citations Open access
Semantic Scholar
Clinical translation of epigenetics in cancer: eN-CORe—a report on the second workshop
A. Zelent, K. Petrie, R. Lotan, S. Waxman +1 more
2005Molecular Cancer Therapeutics14 citations Open access
Semantic Scholar
Inhibition of the PI3K/AKT/mTOR Pathway Leads to Down-Regulation of c-Myc and Overcomes Resistance to ATRA in Acute Myeloid Leukemia
R. Swords, T. Schenk, S. Stengel, V. Gil +7 more
201513 citations Open access
Semantic Scholar
Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression.
Ke Xu, F. Guidez, A. Glasow, D. Chung +7 more
2005Cancer Research13 citations Open access
Semantic Scholar
A Case of AML Characterized by a Novel t(4;15)(q31;q22) Translocation That Confers a Growth-Stimulatory Response to Retinoid-Based Therapy
J. Watts, Aymee Perez, L. Pereira, Yao-Shan Fan +5 more
2017International Journal of Molecular Sciences12 citations Open access
Semantic Scholar
Blocking the PAH2 domain of Sin3A inhibits tumorigenesis and confers retinoid sensitivity in triple negative breast cancer
Nidhi Bansal, Almudena Bosch, B. Leibovitch, L. Pereira +9 more
2016OncoTarget12 citations Open access
Semantic Scholar
Post transcriptional control of the epigenetic stem cell regulator PLZF by sirtuin and HDAC deacetylases
M. McConnell, L. Durand, E. Langley, Lise Coste-Sarguet +5 more
2015Epigenetics & Chromatin12 citations Open access
Semantic Scholar
State of the Translational Science: Summary of Baltimore Workshop on Gene Re-expression As a Therapeutic Target in Cancer January 2003
A. Zelent, S. Waxman, M. Carducci, John Wright +2 more
200412 citations
Semantic Scholar
The Lysine-Specific Demethylase 1 (LSD1) Inhibitor Tranylcypromine (TCP) in Combination with ATRA Is Tolerable and Has Anti-Leukemic Activity in Adult Patients with Relapsed/Refractory AML and MDS
J. Watts, T. Bradley, A. Thomassen, Y. Dinh +14 more
2018Blood11 citations
Semantic Scholar
AML1/ETO, a promiscuous fusion oncoprotein
K. Petrie, A. Zelent
200711 citations Open access
Semantic Scholar
Rexinoid-triggered differentiation and tumor-selective apoptosis of AML by protein kinase A-mediated de-subordination of RXR
E. M. Schiavone, L. Altucci, M. De Simone, F. Ferrara +9 more
200611 citations
Semantic Scholar
Semi-Quantitative Mass Spectrometry in AML Cells Identifies New Non-Genomic Targets of the EZH2 Methyltransferase
Y. Sbirkov, C. Kwok, Amandeep Bhamra, A. Thompson +3 more
2017International Journal of Molecular Sciences10 citations Open access
Semantic Scholar
Silencing of androgen-regulated genes using a fusion of AR with the PLZF transcriptional repressor
J. Pike, David I. R. Holmes, T. Kamalati, D. Davies +9 more
2004Oncogene10 citations
Semantic Scholar
Benzodithiophenes induce differentiation and apoptosis in human leukemia cells.
Y. Jing, N. Hellinger, Lijuan Xia, A. Monks +3 more
2005Cancer Research9 citations Open access
Semantic Scholar
The Small Molecule Img-98, a Potent and Selective Inhibitor of the Lysine Demethylase Lsd-1, Effectively Augments the Pro-Differentiation Effects of ATRA in a Pre-Clinical Model of AML
R. Swords, Aymee Perez, Ana Rodriguez, J. Watts +4 more
20158 citations
Semantic Scholar
Derepression in the Desert: The Third Workshop on Clinical Translation of Epigenetics in Cancer Therapeutics
A. Zelent, K. Petrie, M. Boix-Chornet, A. Melnick +2 more
2008Cancer Research8 citations Open access
Semantic Scholar

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