J. Tykvart

Most-cited papers

1. Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein

   M. Klíma, Dániel J. Tóth, R. Hexnerová, A. Baumlová +11 more

   2016Scientific Reports85 citations Open access

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2. Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery.

   J. Tykvart, J. Schimer, Jitka Bařinková, P. Pachl +4 more

   2014Bioorganic & Medicinal Chemistry43 citations Open access

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3. iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties

   P. Šácha, Tomáš Knedlík, J. Schimer, J. Tykvart +9 more

   2016Angewandte Chemie36 citations Open access

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4. Design of highly potent urea-based, exosite-binding inhibitors selective for glutamate carboxypeptidase II.

   J. Tykvart, J. Schimer, A. Jančařík, Jitka Bařinková +6 more

   2015Journal of Medicinal Chemistry31 citations Open access

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5. Mouse glutamate carboxypeptidase II (GCPII) has a similar enzyme activity and inhibition profile but a different tissue distribution to human GCPII

   Tomáš Knedlík, Barbora Vorlová, V. Navrátil, J. Tykvart +5 more

   2017FEBS Open Bio25 citations Open access

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6. Comparison of human glutamate carboxypeptidases II and III reveals their divergent substrate specificities

   M. Navrátil, J. Tykvart, J. Schimer, P. Pachl +5 more

   2016The FEBS Journal24 citations

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7. Prostate‐specific membrane antigen and its truncated form PSM′

   P. Mlcochova, C. Bařinka, J. Tykvart, P. Šácha +1 more

   2009The Prostate20 citations

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8. GCPII variants, paralogs and orthologs.

   Klára Hlouchová, V. Navrátil, J. Tykvart, P. Šácha +1 more

   2012Current Medicinal Chemistry19 citations

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9. DNA-linked Inhibitor Antibody Assay (DIANA) for sensitive and selective enzyme detection and inhibitor screening

   V. Navrátil, J. Schimer, J. Tykvart, Tomáš Knedlík +4 more

   2016Nucleic Acids Research17 citations Open access

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10. Structural and Biochemical Characterization of a Novel Aminopeptidase from Human Intestine*

    J. Tykvart, C. Bařinka, M. Svoboda, V. Navrátil +6 more

    2015Journal of Biological Chemistry17 citations Open access

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11. GCPII and its close homolog GCPIII: from a neuropeptidase to a cancer marker and beyond.

    Barbora Vorlová, Tomáš Knedlík, J. Tykvart, J. Konvalinka

    2019Frontiers in Bioscience11 citations

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12. Identification of Novel Carbonic Anhydrase IX Inhibitors Using High-Throughput Screening of Pooled Compound Libraries by DNA-Linked Inhibitor Antibody Assay (DIANA)

    J. Tykvart, V. Navrátil, M. Kugler, P. Šácha +12 more

    2020SLAS discovery : advancing life sciences R & D10 citations Open access

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13. Factors, associated with elevated concentration of soluble carbonic anhydrase IX in plasma of women with cervical dysplasia

    S. Grinceviciene, D. Vaitkienė, Daiva Kanopiene, Rasa Vansevičiūtė +21 more

    2022Scientific Reports2 citations Open access

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14. Characterization of Glutamate Carboxypeptidase II, its Close Homologs and their Interaction with Ligands

    J. Tykvart

    20150 citations

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15. Avi-GCPII structure in complex with FITC-conjugated GCPII-specific inhibitor

    J. Tykvart, J. Konvalinka

    20150 citations

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16. Crystal Structure of Glutamate Carboxypeptidase II in a complex with urea-based inhibitor

    J. Tykvart, P. Pachl

    20140 citations

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17. N-terminally AviTEV-tagged Human Glutamate Carboxypeptidase II in complex with 2-PMPA

    J. Tykvart, P. Šácha, C. Bařinka, J. Štarková +3 more

    20120 citations

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18. Prostate-SpecificMembraneAntigen and ItsTruncated FormPSM 0

    P. Mlcochova, C. Bařinka, J. Tykvart, P. Šácha +1 more

    20090 citations

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