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N. Fujikake · SciRah

Researcher profile · Semantic Scholar

N. Fujikake

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N. Fujikake — researcher profile on SciRah

h-index: 23
Works: 44
Citations: 2,452

Most-cited papers

A toxic monomeric conformer of the polyglutamine protein
Y. Nagai, T. Inui, H. Popiel, N. Fujikake +5 more
2007Nature Structural &Molecular Biology332 citations
Semantic Scholar
Heat Shock Transcription Factor 1-activating Compounds Suppress Polyglutamine-induced Neurodegeneration through Induction of Multiple Molecular Chaperones*
N. Fujikake, Y. Nagai, H. Popiel, Y. Okamoto +2 more
2008Journal of Biological Chemistry216 citations Open access
Semantic Scholar
Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level
T. Takeuchi, Mari Suzuki, N. Fujikake, H. Popiel +4 more
2015Proceedings of the National Academy of Sciences of the United States of America198 citations Open access
Semantic Scholar
VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease.
E. Miura, T. Hasegawa, M. Konno, Mari Suzuki +11 more
2014Neurobiology of Disease182 citations Open access
Semantic Scholar
Association Between Autophagy and Neurodegenerative Diseases
N. Fujikake, M. Shin, S. Shimizu
2018Frontiers in Neuroscience166 citations Open access
Semantic Scholar
Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila.
Y. Nagai, N. Fujikake, K. Ohno, H. Higashiyama +6 more
2003Human Molecular Genetics146 citations Open access
Semantic Scholar
Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31
T. Ishiguro, Nozomu Sato, M. Ueyama, N. Fujikake +15 more
2017Neuron117 citations Open access
Semantic Scholar
Detection of Polyglutamine Protein Oligomers in Cells by Fluorescence Correlation Spectroscopy*
Yasuo Takahashi, Y. Okamoto, H. Popiel, N. Fujikake +3 more
2007Journal of Biological Chemistry90 citations Open access
Semantic Scholar
Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease.
Mari Suzuki, N. Fujikake, T. Takeuchi, A. Kohyama-Koganeya +4 more
2015Human Molecular Genetics87 citations
Semantic Scholar
Residual laminin-binding activity and enhanced dystroglycan glycosylation by LARGE in novel model mice to dystroglycanopathy
M. Kanagawa, Akemi Nishimoto, T. Chiyonobu, S. Takeda +15 more
2008Human Molecular Genetics85 citations Open access
Semantic Scholar
Alternative splicing regulates the transcriptional activity of Drosophila heat shock transcription factor in response to heat/cold stress
N. Fujikake, Y. Nagai, H. Popiel, Hiroki Kano +2 more
2005FEBS Letters84 citations
Semantic Scholar
Induction of molecular chaperones as a therapeutic strategy for the polyglutamine diseases.
Y. Nagai, N. Fujikake, H. Popiel, K. Wada
2010Current Pharmaceutical Biotechnology79 citations
Semantic Scholar
Knockdown of the Drosophila Fused in Sarcoma (FUS) Homologue Causes Deficient Locomotive Behavior and Shortening of Motoneuron Terminal Branches
H. Sasayama, Mai Shimamura, T. Tokuda, Yumiko Azuma +6 more
2012PLoS ONE77 citations Open access
Semantic Scholar
Normalization of Overexpressed α-Synuclein Causing Parkinson's Disease By a Moderate Gene Silencing With RNA Interference.
Masaki Takahashi, Mari Suzuki, Masashi Fukuoka, N. Fujikake +5 more
2015Molecular Therapy: Nucleic Acids74 citations Open access
Semantic Scholar
Molecular interaction between fukutin and POMGnT1 in the glycosylation pathway of alpha-dystroglycan.
H. Xiong, Kazuhiro Kobayashi, Masaji Tachikawa, H. Manya +10 more
2006Biochemical and Biophysical Research Communications - BBRC70 citations
Semantic Scholar
Protein transduction domain-mediated delivery of QBP1 suppresses polyglutamine-induced neurodegeneration in vivo.
H. Popiel, Y. Nagai, N. Fujikake, T. Toda
2007Molecular Therapy62 citations Open access
Semantic Scholar
p62 Plays a Protective Role in the Autophagic Degradation of Polyglutamine Protein Oligomers in Polyglutamine Disease Model Flies*
Y. Saitoh, N. Fujikake, Y. Okamoto, H. Popiel +7 more
2014Journal of Biological Chemistry54 citations Open access
Semantic Scholar
α-Synuclein Transgenic Drosophila As a Model of Parkinson's Disease and Related Synucleinopathies
Hideya Mizuno, N. Fujikake, K. Wada, Y. Nagai
2010Parkinson's Disease51 citations Open access
Semantic Scholar
Delivery of the aggregate inhibitor peptide QBP1 into the mouse brain using PTDs and its therapeutic effect on polyglutamine disease mice.
H. Popiel, Y. Nagai, N. Fujikake, T. Toda
2009Neuroscience Letters49 citations
Semantic Scholar
Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration
Hirofumi Yamaguchi, S. Honda, Satoru Torii, Kimiko Shimizu +7 more
2020Nature Communications45 citations Open access
Semantic Scholar
Identification of ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS.
Yumiko Azuma, T. Tokuda, Mai Shimamura, Akane Kyotani +9 more
2014Human Molecular Genetics38 citations
Semantic Scholar
Humanin attenuates apoptosis induced by DRPLA proteins with expanded polyglutamine stretches
S. Kariya, M. Hirano, Y. Nagai, Y. Furiya +3 more
2007Journal of Molecular Neuroscience38 citations
Semantic Scholar
Disruption of the toxic conformation of the expanded polyglutamine stretch leads to suppression of aggregate formation and cytotoxicity.
H. Popiel, Y. Nagai, O. Onodera, T. Inui +6 more
2004Biochemical and Biophysical Research Communications - BBRC28 citations
Semantic Scholar
Surface plasmon resonance characterization of specific binding of polyglutamine aggregation inhibitors to the expanded polyglutamine stretch.
Y. Okamoto, Y. Nagai, N. Fujikake, H. Popiel +3 more
2009Biochemical and Biophysical Research Communications - BBRC21 citations
Semantic Scholar
Synthesis of Novel Polymers with Biodegradability by Main-Chain Editing of Chiral Polyketones.
Haobo Yuan, Kohei Takahashi, S. Hayashi, Miwa Suzuki +8 more
2024Journal of the American Chemical Society17 citations
Semantic Scholar
Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD
T. Ueda, Toshihide Takeuchi, N. Fujikake, Mari Suzuki +11 more
2024Acta Neuropathologica Communications15 citations Open access
Semantic Scholar
ER stress is the initial response to polyglutamine toxicity in PC12 cells.
H. Nakayama, M. Hamada, N. Fujikake, Y. Nagai +6 more
2008Biochemical and Biophysical Research Communications - BBRC14 citations
Semantic Scholar
Cytoprotective effect of novel histone deacetylase inhibitors against polyglutamine toxicity.
S. Kariya, M. Hirano, S. Uesato, Y. Nagai +6 more
2006Neuroscience Letters11 citations
Semantic Scholar
HSF1 Activation by Small Chemical Compounds for the Treatment of Neurodegenerative Diseases
N. Fujikake, T. Takeuchi, Y. Nagai
20164 citations
Semantic Scholar
[Therapeutic strategies for the polyglutamine diseases].
Y. Nagai, H. Popiel, N. Fujikake, T. Toda
2007Brain and nerve = Shinkei kenkyu no shinpo4 citations
Semantic Scholar
DHX8 regulates degradation of RNA by RNautophagy
Ryohei Sakai, Eigo Takeda, Chihana Kabuta, Viorica Raluca Contu +5 more
2025Nucleic Acids Research1 citations Open access
Semantic Scholar
Genetic Testing for Huntington's Disease in Parkinsonism.
M. Rahman, Yoshitaka Nagai, H. Popiel, N. Fujikake +12 more
2010Mymensingh Medical Journal1 citations
Semantic Scholar
P2-n27 Loss of DJ-1 affects mitochondrial functions
Kimi Sakai, H. Maita, K. Takahashi-Niki, Sanae +22 more
20180 citations
Semantic Scholar
P 2r 21 AbnormalGluR 2 RNAeditingandTDP-43 pathology in ALS motor neurons
T. Tamura, Masaki Sone, Sam Barclay, Hikaru Ito +26 more
20180 citations
Semantic Scholar
Balance between RNA binding proetin TDP-43 and an RNA UGGAA repeat underlies pathogenesis of spinocerebellar ataxia type 31 (SCA31) and motor neuron disease fly models
Taro Ishiguro, N. Sato, M. Ueyama, N. Fujikake +14 more
20170 citations
Semantic Scholar
The role of the Atg5/Atg7-independent autophagy in the brain
N. Fujikake, Hirofumi Yamaguchi, Satoko Arakawa, S. Shimizu
20160 citations
Semantic Scholar
NPM-hMLF1 prevents the formation of FUS aggregates for Drosophila ALS model
Itaru Yamamoto, Yumiko Azuma, Y. Okada, H. Yoshida +7 more
20160 citations
Semantic Scholar
Identification of modifier to prevent formation of aggregates in Drosophila induced Amyotrophic Lateral Screlosis (ALS) causing gene FUS
Itaru Yamamoto, Yumiko Azuma, Akane Kyotami, H. Yoshida +6 more
20150 citations
Semantic Scholar
α-Synuclein Transgenic Drosophila As aModel of Parkinson ’ s Disease and Related
Synucleinopathies, HideyaMizuno, N. Fujikake, K. Wada +1 more
20140 citations
Semantic Scholar
Guided Poster Tour
Y. Nagai, N. Fujikake, A. Kikuchi, K. Fender
20130 citations
Semantic Scholar
P2-r20Aggravation of neurodegeneration by high-nutrient diet in Drosophila models of neurodegenerative diseases
Mari Suzuki, N. Fujikake, K. Wada, Y. Nagai
20110 citations
Semantic Scholar
Amelioration of neurological phenotypes and inclusion body formation in polyglutamine disease mice upon AAV5-mediated expression of aggregate inhibitor molecules
H. Popiel, Hiromi Fujita, Kazuhiro Yamamoto, N. Fujikake +4 more
20100 citations
Semantic Scholar
Establishment of novel Drosophila models of ALS expressing TDP-43, and analyses of its pathomechanisms
N. Fujikake, Y. Saitoh, A. Yokoseki, O. Onodera +2 more
20100 citations
Semantic Scholar
Induction of Multiple Molecular Polyglutamine-induced Neurodegeneration 1-activating Compounds Suppress Heat Shock Transcription Factor Protein Structure and Folding :
N. Fujikake, Y. Nagai, H. Popiel, Y. Okamoto +2 more
20080 citations
Semantic Scholar

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Y. Nagai×32
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Y. Nagai — researcher profile on SciRah
H. Popiel×16
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H. Popiel — researcher profile on SciRah
T. Toda×16
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K. Wada×12
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M. Yamaguchi — researcher profile on SciRah

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Mari Suzuki — researcher profile on SciRah

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M. Ueyama — researcher profile on SciRah

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Y. Okamoto — researcher profile on SciRah

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Yumiko Azuma×4

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Yumiko Azuma — researcher profile on SciRah

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T. Inui — researcher profile on SciRah