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T. Takeuchi · SciRah

Researcher profile · Semantic Scholar

T. Takeuchi

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T. Takeuchi — researcher profile on SciRah

h-index: 37
Works: 80
Citations: 6,780

Most-cited papers

Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement.
Ikuhiko Nakase, M. Niwa, T. Takeuchi, K. Sonomura +9 more
2004Molecular Therapy770 citations Open access
Semantic Scholar
Interaction of arginine-rich peptides with membrane-associated proteoglycans is crucial for induction of actin organization and macropinocytosis.
Ikuhiko Nakase, A. Tadokoro, N. Kawabata, T. Takeuchi +6 more
2007Biochemistry431 citations
Semantic Scholar
Experimental evidence for the functional relevance of anion-pi interactions.
R. Dawson, A. Hennig, D. P. Weimann, Daniel Emery +8 more
2010Nature Chemistry419 citations Open access
Semantic Scholar
High-resolution multi-dimensional NMR spectroscopy of proteins in human cells
Kohsuke Inomata, A. Ohno, H. Tochio, Shin Isogai +7 more
2009Nature419 citations
Semantic Scholar
Cellular internalization and distribution of arginine-rich peptides as a function of extracellular peptide concentration, serum, and plasma membrane associated proteoglycans.
Michie Kosuge, T. Takeuchi, Ikuhiko Nakase, A. Jones +1 more
2008Bioconjugate chemistry359 citations Open access
Semantic Scholar
Methodological and cellular aspects that govern the internalization mechanisms of arginine-rich cell-penetrating peptides.
Ikuhiko Nakase, T. Takeuchi, Gen Tanaka, S. Futaki
2008Advanced Drug Delivery Reviews341 citations
Semantic Scholar
Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide.
Misao Akishiba, T. Takeuchi, Y. Kawaguchi, K. Sakamoto +6 more
2017Nature Chemistry300 citations Open access
Semantic Scholar
Direct and rapid cytosolic delivery using cell-penetrating peptides mediated by pyrenebutyrate.
T. Takeuchi, Michie Kosuge, A. Tadokoro, Y. Sugiura +5 more
2006ACS Chemical Biology287 citations Open access
Semantic Scholar
Temperature-, concentration- and cholesterol-dependent translocation of L- and D-octa-arginine across the plasma and nuclear membrane of CD34+ leukaemia cells.
M. Fretz, Neal A Penning, S. Al-Taei, S. Futaki +4 more
2007Biochemical Journal233 citations Open access
Semantic Scholar
Arginine-rich peptides and their internalization mechanisms.
S. Futaki, Ikuhiko Nakase, A. Tadokoro, T. Takeuchi +1 more
2007Biochemical Society Transactions228 citations
Semantic Scholar
Transient focal membrane deformation induced by arginine-rich peptides leads to their direct penetration into cells.
Hisaaki Hirose, T. Takeuchi, Hiroko Osakada, Silvia Pujals +5 more
2012Molecular Therapy211 citations Open access
Semantic Scholar
Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level
T. Takeuchi, Mari Suzuki, N. Fujikake, H. Popiel +4 more
2015Proceedings of the National Academy of Sciences of the United States of America198 citations Open access
Semantic Scholar
Quality and Safety Considerations for Therapeutic Products Based on Extracellular Vesicles
Y. Takakura, R. Hanayama, Kazunari Akiyoshi, S. Futaki +11 more
2024Pharmaceutical Research168 citations Open access
Semantic Scholar
Elucidating cell-penetrating peptide mechanisms of action for membrane interaction, cellular uptake, and translocation utilizing the hydrophobic counter-anion pyrenebutyrate.
P. Guterstam, F. Madani, Hisaaki Hirose, T. Takeuchi +4 more
2009Biochimica et Biophysica Acta139 citations Open access
Semantic Scholar
Enhanced intracellular delivery using arginine-rich peptides by the addition of penetration accelerating sequences (Pas).
Kentaro Takayama, Ikuhiko Nakase, H. Michiue, T. Takeuchi +3 more
2009Journal of Controlled Release133 citations Open access
Semantic Scholar
Anionic fullerenes, calixarenes, coronenes, and pyrenes as activators of oligo/polyarginines in model membranes and live cells.
F. Perret, Masamichi Nishihara, T. Takeuchi, S. Futaki +4 more
2005Journal of the American Chemical Society130 citations Open access
Semantic Scholar
Direct Observation of Anion‐Mediated Translocation of Fluorescent Oligoarginine Carriers into and across Bulk Liquid and Anionic Bilayer Membranes
N. Sakai, T. Takeuchi, S. Futaki, S. Matile
2005ChemBioChem127 citations Open access
Semantic Scholar
Current Understanding of Direct Translocation of Arginine-Rich Cell-Penetrating Peptides and Its Internalization Mechanisms.
T. Takeuchi, S. Futaki
2016Chemical and pharmaceutical bulletin122 citations Open access
Semantic Scholar
Syndecan-4 Is a Receptor for Clathrin-Mediated Endocytosis of Arginine-Rich Cell-Penetrating Peptides.
Y. Kawaguchi, T. Takeuchi, K. Kuwata, Junya Chiba +3 more
2016Bioconjugate chemistry119 citations
Semantic Scholar
Intracellular traffic and fate of protein transduction domains HIV-1 TAT peptide and octaarginine. Implications for their utilization as drug delivery vectors.
S. Al-Taei, Neal A Penning, Jeremy C. Simpson, S. Futaki +3 more
2006Bioconjugate chemistry117 citations
Semantic Scholar
Arginine magic with new counterions up the sleeve.
Masamichi Nishihara, F. Perret, T. Takeuchi, S. Futaki +4 more
2005Organic and biomolecular chemistry117 citations Open access
Semantic Scholar
Cell-surface accumulation of flock house virus-derived peptide leads to efficient internalization via macropinocytosis.
Ikuhiko Nakase, Hisaaki Hirose, Gen Tanaka, A. Tadokoro +3 more
2009Molecular Therapy113 citations Open access
Semantic Scholar
Alternative mitochondrial quality control mediated by extracellular release
Chi-Jing Choong, Tatsusada Okuno, K. Ikenaka, Kousuke Baba +12 more
2020Autophagy106 citations Open access
Semantic Scholar
Effects of Na+/H+ exchanger inhibitors on subcellular localisation of endocytic organelles and intracellular dynamics of protein transduction domains HIV-TAT peptide and octaarginine.
M. Fretz, Jing Jin, Robin Conibere, Neal A Penning +6 more
2006Journal of Controlled Release96 citations
Semantic Scholar
Guanidine-containing molecular transporters: sorbitol-based transporters show high intracellular selectivity toward mitochondria.
K. Maiti, W. Lee, T. Takeuchi, C. Watkins +6 more
2007Angewandte Chemie90 citations
Semantic Scholar
Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease.
Mari Suzuki, N. Fujikake, T. Takeuchi, A. Kohyama-Koganeya +4 more
2015Human Molecular Genetics87 citations
Semantic Scholar
Comparison of serum and plasma as a source of blood extracellular vesicles: Increased levels of platelet-derived particles in serum extracellular vesicle fractions alter content profiles from plasma extracellular vesicle fractions
Xiaoman Zhang, T. Takeuchi, Akiko Takeda, H. Mochizuki +1 more
2022PLoS ONE70 citations Open access
Semantic Scholar
Protein Misfolding and Aggregation as a Therapeutic Target for Polyglutamine Diseases
T. Takeuchi, Y. Nagai
2017Brain Science67 citations Open access
Semantic Scholar
Acid wash in determining cellular uptake of Fab/cell-permeating peptide conjugates.
S. Kameyama, M. Horie, T. Kikuchi, T. Omura +5 more
2007Biopolymers63 citations Open access
Semantic Scholar
Pattern generation with synthetic sensing systems in lipid bilayer membranes
T. Takeuchi, J. Montenegro, A. Hennig, S. Matile
201153 citations Open access
Semantic Scholar
Sensing applications of synthetic transport systems.
T. Takeuchi, S. Matile
2013Chemical Communications45 citations Open access
Semantic Scholar
Hsp40 Gene Therapy Exerts Therapeutic Effects on Polyglutamine Disease Mice via a Non-Cell Autonomous Mechanism
H. Popiel, T. Takeuchi, Hiromi Fujita, Kazuhiro Yamamoto +6 more
2012PLoS ONE44 citations Open access
Semantic Scholar
Amphiphilic Counterion Activators for DNA: Stimuli‐Responsive Cation Transporters and Biosensors in Bulk and Lipid Bilayer Membranes
T. Takeuchi, V. Bagnacani, F. Sansone, S. Matile
2009ChemBioChem42 citations Open access
Semantic Scholar
Effects of cell-permeating peptide binding on the distribution of 125I-labeled Fab fragment in rats.
S. Kameyama, M. Horie, T. Kikuchi, T. Omura +4 more
2006Bioconjugate chemistry40 citations
Semantic Scholar
Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson’s disease
M. Hideshima, Y. Kimura, C. Aguirre, K. Kakuda +12 more
2022Scientific Reports39 citations Open access
Semantic Scholar
Inhibition of Protein Misfolding/Aggregation Using Polyglutamine Binding Peptide QBP1 as a Therapy for the Polyglutamine Diseases
H. Popiel, T. Takeuchi, James R. Burke, Warren J. Strittmatter +3 more
2013Neurotherapeutics38 citations Open access
Semantic Scholar
Design, synthesis, and membrane-translocation studies of inositol-based transporters.
K. Maiti, Ock-Youm Jeon, W. Lee, Dong-Chan Kim +4 more
2006Angewandte Chemie38 citations
Semantic Scholar
DNA aptamers as analyte-responsive cation transporters in fluorogenic vesicles: signal amplification by supramolecular polymerization.
T. Takeuchi, S. Matile
2009Journal of the American Chemical Society37 citations Open access
Semantic Scholar
FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD
Yuzo Fujino, M. Ueyama, T. Ishiguro, Daisaku Ozawa +25 more
2023bioRxiv30 citations Open access
Semantic Scholar
The Aggregation Inhibitor Peptide QBP1 as a Therapeutic Molecule for the Polyglutamine Neurodegenerative Diseases
H. Popiel, J. Burke, W. Strittmatter, S. Oishi +5 more
2011Journal of Amino Acids30 citations Open access
Semantic Scholar
Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism
Chi-Jing Choong, C. Aguirre, K. Kakuda, Goichi Beck +21 more
2023Acta Neuropathologica28 citations Open access
Semantic Scholar
Arginine is a disease modifier for polyQ disease models that stabilizes polyQ protein conformation.
Eiko N. Minakawa, H. Popiel, M. Tada, Toshiaki Takahashi +23 more
2020Brain : a journal of neurology27 citations Open access
Semantic Scholar
Oligoarginine-Bearing Tandem Repeat Penetration-Accelerating Sequence Delivers Protein to Cytosol via Caveolae-Mediated Endocytosis.
A. Okuda, Shinya Tahara, Hisaaki Hirose, T. Takeuchi +5 more
2019Biomacromolecules27 citations
Semantic Scholar
Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice
T. Takeuchi, K. Maeta, Xin Ding, Yukako Oe +12 more
2023Molecular Therapy: Nucleic Acids24 citations Open access
Semantic Scholar
Pathogenic and protective roles of extracellular vesicles in neurodegenerative diseases.
T. Takeuchi
2020Journal of Biochemistry (Tokyo)24 citations Open access
Semantic Scholar
Dynamic octopus amphiphiles as powerful activators of DNA transporters: differential fragrance sensing and beyond.
J. Montenegro, Pauline Bonvin, T. Takeuchi, S. Matile
2010Chemistry23 citations Open access
Semantic Scholar
Increased Hydrophobic Block Length of PTDMs Promotes Protein Internalization
Coralie M Backlund, Federica Sgolastra, R. Otter, L. Minter +3 more
2016Polymer Chemistry16 citations Open access
Semantic Scholar
Relating Structure and Internalization for ROMP-based Protein Mimics
Coralie M Backlund, T. Takeuchi, S. Futaki, G. Tew
2016Biochimica et Biophysica Acta16 citations Open access
Semantic Scholar
E46K mutant α-synuclein is more degradation resistant and exhibits greater toxic effects than wild-type α-synuclein in Drosophila models of Parkinson's disease
Ryusuke Sakai, Mari Suzuki, M. Ueyama, T. Takeuchi +5 more
2019PLoS ONE15 citations Open access
Semantic Scholar
Distribution of immunoglobulin Fab fragment conjugated with HIV-1 REV peptide following intravenous administration in rats.
S. Kameyama, Ritsuko Okada, T. Kikuchi, T. Omura +4 more
2006Molecular Pharmaceutics15 citations
Semantic Scholar

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S. Futaki×30
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S. Futaki — researcher profile on SciRah
Ikuhiko Nakase×18
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Ikuhiko Nakase — researcher profile on SciRah
Y. Nagai×14
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S. Matile×10
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H. Mochizuki — researcher profile on SciRah

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Y. Sugiura — researcher profile on SciRah

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A. Tadokoro — researcher profile on SciRah

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N. Sakai — researcher profile on SciRah

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