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Jonathan D. Finn · SciRah

Researcher profile · Semantic Scholar

Jonathan D. Finn

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Jonathan D. Finn — researcher profile on SciRah

h-index: 20
Works: 50
Citations: 3,383

Most-cited papers

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing.
Jonathan D. Finn, A. R. Smith, Mihir Patel, L. Shaw +19 more
2018Cell Reports787 citations Open access
Semantic Scholar
In vivo genome editing restores hemostasis in a mouse model of hemophilia
Ho-Jun Li, V. Haurigot, Y. Doyon, Tian-Jian Li +16 more
2011Nature562 citations Open access
Semantic Scholar
X-linked thrombophilia with a mutant factor IX (factor IX Padua).
P. Simioni, D. Tormene, G. Tognin, S. Gavasso +6 more
2009New England Journal of Medicine358 citations Open access
Semantic Scholar
A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties
Kevin Dooley, Russell E. Mcconnell, Ke Xu, Nuruddeen D. Lewis +24 more
2021Molecular Therapy264 citations Open access
Semantic Scholar
Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors.
Gary C. Pien, E. Basner-Tschakarjan, Daniel J. Hui, Ashley N Mentlik +8 more
2009Journal of Clinical Investigation192 citations Open access
Semantic Scholar
Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells.
Ashley T. Martino, E. Basner-Tschakarjan, D. Markusic, Jonathan D. Finn +9 more
2013Blood164 citations Open access
Semantic Scholar
Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy.
Jonathan D. Finn, Margareth C. Ozelo, D. Sabatino, H. G. Franck +7 more
2010Blood154 citations Open access
Semantic Scholar
AAV liver expression of FIX-Padua prevents and eradicates FIX inhibitor without increasing thrombogenicity in hemophilia B dogs and mice.
Julie M. Crudele, Jonathan D. Finn, J. I. Siner, N. B. Martin +5 more
2015Blood151 citations Open access
Semantic Scholar
Proteasome inhibitors decrease AAV2 capsid derived peptide epitope presentation on MHC class I following transduction.
Jonathan D. Finn, Daniel J. Hui, H. Downey, Danielle Dunn +4 more
2010Molecular Therapy114 citations Open access
Semantic Scholar
The efficacy and the risk of immunogenicity of FIX Padua (R338L) in hemophilia B dogs treated by AAV muscle gene therapy.
Jonathan D. Finn, T. Nichols, Nikolaos Svoronos, E. Merricks +5 more
2012Blood112 citations Open access
Semantic Scholar
Strategies to modulate immune responses: a new frontier for gene therapy.
V. Arruda, P. Favaro, Jonathan D. Finn
2009Molecular Therapy73 citations Open access
Semantic Scholar
Persistence of Transgene Expression Influences CD8+ T-Cell Expansion and Maintenance following Immunization with Recombinant Adenovirus
Jonathan D. Finn, Jennifer D. Bassett, James B. Millar, Natalie Grinshtein +6 more
2009Journal of Virology67 citations Open access
Semantic Scholar
CD8+ T-cell expansion and maintenance after recombinant adenovirus immunization rely upon cooperation between hematopoietic and nonhematopoietic antigen-presenting cells.
Jennifer D. Bassett, Teng-Chih Yang, Dannie Bernard, James B. Millar +14 more
2011Blood49 citations Open access
Semantic Scholar
Timing of Intensive Immunosuppression Impacts Risk of Transgene Antibodies after AAV Gene Therapy in Nonhuman Primates
B. Samelson-Jones, Jonathan D. Finn, P. Favaro, J. F. Wright +1 more
2020Molecular Therapy: Methods & Clinical Development45 citations Open access
Semantic Scholar
Modulation of CD8+ T cell responses to AAV vectors with IgG-derived MHC class II epitopes
Daniel J. Hui, E. Basner-Tschakarjan, Yi-Feng Chen, R. Davidson +11 more
2013Molecular Therapy44 citations Open access
Semantic Scholar
T-cell immunity generated by recombinant adenovirus vaccines
Chih-Yang Teng, James B. Millar, Natalie Grinshtein, Jennifer D. Bassett +2 more
2007Expert Review of Vaccines41 citations
Semantic Scholar
Hyperactivity of factor IX Padua (R338L) depends on factor VIIIa cofactor activity.
B. Samelson-Jones, Jonathan D. Finn, Lindsey A. George, R. Camire +1 more
2019JCI Insight38 citations Open access
Semantic Scholar
Safety of Liver Gene Transfer Following Peripheral Intravascular Delivery of Adeno-Associated Virus (AAV)-5 and AAV-6 in a Large Animal Model
P. Favaro, Jonathan D. Finn, J. I. Siner, J. Wright +2 more
2011Human Gene Therapy27 citations Open access
Semantic Scholar
Transfection reagent artefact likely accounts for some reports of extracellular vesicle function
Russell E. Mcconnell, Madeleine R. Youniss, Bhargavee Gnanasambandam, Palak Shah +2 more
2022Journal of Extracellular Vesicles24 citations Open access
Semantic Scholar
Evolutionary insights into coagulation factor IX Padua and other high-specific-activity variants.
B. Samelson-Jones, Jonathan D. Finn, L. Raffini, E. Merricks +3 more
2021Blood Advances22 citations Open access
Semantic Scholar
Empty Capsids and Macrophage Inhibition/Depletion Increase rAAV Transgene Expression in Joints of Both Healthy and Arthritic Mice
C. Aalbers, N. Broekstra, M. van Geldorp, E. Kramer +4 more
2017Human Gene Therapy15 citations Open access
Semantic Scholar
Characterization of Naturally-Occurring Humoral Immunity to AAV in Sheep
J. Tellez, K. van Vliet, Yu-Shan Tseng, Jonathan D. Finn +5 more
2013PLoS ONE13 citations Open access
Semantic Scholar
Cytoplasmic expression systems triggered by mRNA yield increased gene expression in post-mitotic neurons
Paul Farrow, Lee B. Barrett, M. Stevenson, K. Fisher +7 more
2006Nucleic Acids Research11 citations Open access
Semantic Scholar
Factors limiting autogene‐based cytoplasmic expression systems
Jonathan D. Finn, I. Maclachlan, P. Cullis
2005The FASEB Journal11 citations
Semantic Scholar
Induction of Immune Tolerance to Canine FVIII in Hemophilia a Dogs with Inhibitors Using AAV-Mediated Expression of Canine FVIII
Jonathan D. Finn, D. Sabatino, Margareth C. Ozelo, Shang-Zhen Zhou +4 more
20088 citations
Semantic Scholar
Suppression of CTL Responses against AAV-Capsid Epitopes by Peptide-Induced Regulatory T Cells.
Daniel J. Hui, Gary C. Pien, E. Basner-Tschakarjan, F. Mingozzi +5 more
20096 citations
Semantic Scholar
Exosome-based therapeutics: ready for prime time
Jonathan D. Finn, K. Konstantinov
2020Cell and Gene Therapy Insights5 citations
Semantic Scholar
New Hyperactive Factor IX Variants Bioengineered Based upon Biochemical Studies of Factor IX Padua
B. Samelson-Jones, Jonathan D. Finn, R. Camire, V. Arruda
20164 citations
Semantic Scholar
A8.14 CD39 and CD73 transgenic exosomes and recombinant fusion protein as novel therapeutics for the treatment of inflammatory disease
Jonathan D. Finn, J. van Ittersum, Niels Broekstra, P. Tak +1 more
20154 citations
Semantic Scholar
FIX-R338L (FIX Padua) as a Successful Alternative for the Treatment of Canine Severe Hemophilia B.
Jonathan D. Finn, P. Simioni, Nicholas P. Iacobelli, Shang-Zhen Zhou +3 more
20094 citations
Semantic Scholar
Rabbit Anti-Thymocyte Globulin (rATG) Administrated Concomitantly with Liver Delivery of AAV2-hFIX Can Promote Inhibitor Formation In Rhesus Macaques.
Jonathan D. Finn, P. Favaro, J. F. Wright, F. Mingozzi +2 more
20103 citations
Semantic Scholar
A8.12 AAV mediated expression of CD39 and CD73 is effective in reducing inflammation in the air pouch synovial inflammation model
Jonathan D. Finn, S. Snoek, J. van Ittersum, Niels Broekstra +5 more
20152 citations
Semantic Scholar
A1.39 Modulation of atp:adenosine balance by exosome and rain (Recombinant Anti-Inflammatory Fusion Protein) delivery of CD39 and CD73 is effective in reducing pro-inflammatory cytokine and chemokine production
Jonathan D. Finn, S. Snoek, J. van Ittersum, N. Broekstra +3 more
20142 citations
Semantic Scholar
T-cell expansion and maintenance after recombinant adenovirus immunization rely upon cooperation between hematopoietic and nonhematopoietic antigen-presenting cells
Jennifer D. Bassett, Teng-Chih Yang, Dannie Bernard, James B. Millar +14 more
20112 citations
Semantic Scholar
The decrease of JAK2 V617F allele burden in leukemia transformation of an elderly patient with myelofibrosis.
Su-jiang Zhang, Jian-Yong Li, Jian-fu Zhang, Jonathan D. Finn +4 more
2009Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis2 citations
Semantic Scholar
703 Engineered exosomes with altered cellular tropism achieve targeted STING agonist delivery and single-agent tumor control in vivo
Monique J. Kauke, N. Ross, Dalia Burzyn, Shelly Martin +9 more
20201 citations Open access
Semantic Scholar
GENE THERAPY Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-speci fi c CD 8 1 T cells
Ashley T. Martino, E. Basner-Tschakarjan, D. Markusic, Jonathan D. Finn +9 more
20131 citations
Semantic Scholar
Naturally-Occurring Antibodies to Human AAV In Sheep: A New Large Animal Model for Immune Aspects of AAV Gene Transfer.
J. Tellez, Jonathan D. Finn, Nicholas Tschernia, G. Almeida-Porada +2 more
20101 citations
Semantic Scholar
Proteasome Inhibitors Decrease AAV2 Capsid-Derived Peptide Epitope Presentation On MHC Class I Following Transduction.
Jonathan D. Finn, Daniel J. Hui, Downey Harre, Danielle Dunn +3 more
20091 citations
Semantic Scholar
Modulation of CD8 Modulation of CD8 ++ T cell responses to AAV vectors with IgG-T cell responses to AAV vectors with IgG-derived MHC class II epitopes derived MHC class II epitopes
Daniel J. Hui, E. Basner-Tschakarjan, Yi-Feng Chen, Robert J. Davidson +11 more
20230 citations
Semantic Scholar
Modulation of CD8 Modulation of CD8 ++ T cell responses to AAV vectors with IgG- T cell responses to AAV vectors with IgG-derived MHC class II epitopes derived MHC class II epitopes
Daniel J. Hui, E. Basner-Tschakarjan, Yi-Feng Chen, Robert J. Davidson +11 more
20220 citations
Semantic Scholar
The Complete Dependence of Factor IX Padua (R338L) Hyperactivity on Factor VIIIa Cofactor Activity Supports Its Safety As a Transgene for Hemophilia B Gene Therapy
B. Samelson-Jones, Jonathan D. Finn, R. Camire, V. Arruda
2018Blood0 citations
Semantic Scholar
645. Improving RAAV Gene Expression Inflammatory Conditions Using Empty Capsids and an Immunosuppressive Compound
C. Aalbers, N. Broekstra, M. van Geldorp, P. Tak +2 more
20150 citations Open access
Semantic Scholar
A6.39 Dynamic regulation of adenosine receptors determines responses to adenosine in primary cells from healthy donors and rheumatoid arthritis patients
S. Snoek, C. Braam, R. Brunekreef, Niels Broekstra +4 more
20150 citations
Semantic Scholar
93. Macrophages Are a Barrier to AAV5 Mediated Gene Expression in the Air Pouch Synovial Inflammation (APSI) Model
S. Snoek, E. Kramer, M. van Geldorp, R. Brunekreef +5 more
20150 citations Open access
Semantic Scholar
Tolerance Induction To FIX Padua With AAV Liver Gene Transfer In Inhibitor-Prone Hemophilia B Dogs
Julie M. Crudele, Jonathan D. Finn, N. B. Martin, J. I. Siner +7 more
20130 citations
Semantic Scholar
A9.6 Identification of New Potential Therapeutic Targets for the Treatment of Rheumatoid Arthritis: ENTPD1 (CD39) and 5NTE1 (CD73)
Jonathan D. Finn, L. V. van Baarsen, J. van Ittersum, C. Braam +3 more
20130 citations Open access
Semantic Scholar
314. mRNA Production is the Major Factor Limiting Autogene-Based Cytoplasmic Expression
Jonathan D. Finn, I. Maclachlan, P. Cullis
20040 citations Open access
Semantic Scholar
The development and characterization of a novel autogene based, dual promoter cytoplasmic expression system
Jonathan D. Finn
20040 citations
Semantic Scholar
American Society of Gene Therapy - Fifth Annual Meeting.
Jonathan D. Finn
2002IDrugs : the investigational drugs journal0 citations Open access
Semantic Scholar

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Shang-Zhen Zhou×15
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V. Arruda×15
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F. Mingozzi×12
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K. High×11
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M. Vervoordeldonk

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E. Basner-Tschakarjan×7

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Daniel J. Hui×7

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Gary C. Pien×6

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Gary C. Pien — researcher profile on SciRah

J. van Ittersum×6

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T. Nichols — researcher profile on SciRah

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P. Tak — researcher profile on SciRah

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V. Haurigot — researcher profile on SciRah