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I. Leav · SciRah

Researcher profile · Semantic Scholar

I. Leav

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I. Leav — researcher profile on SciRah

h-index: 35
Works: 69
Citations: 4,349

Most-cited papers

ERβ Impedes Prostate Cancer EMT by Destabilizing HIF-1α and Inhibiting VEGF-Mediated Snail Nuclear Localization: Implications for Gleason Grading
Paul Mak, I. Leav, Bryan M. Pursell, Donggoo Bae +5 more
2010Cancer Cell403 citations Open access
Semantic Scholar
Comparative Studies of the Estrogen Receptors β and α and the Androgen Receptor in Normal Human Prostate Glands, Dysplasia, and in Primary and Metastatic Carcinoma
I. Leav, Kin-Mang Lau, J. Y. Adams, J. Mcneal +4 more
2001377 citations Open access
Semantic Scholar
Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis.
Xue-Gong Zhu, I. Leav, Y. Leung, Meng-Chu Wu +4 more
2004American Journal of Pathology235 citations Open access
Semantic Scholar
Comparative studies of the estrogen receptors beta and alpha and the androgen receptor in normal human prostate glands, dysplasia, and in primary and metastatic carcinoma.
I. Leav, Kin-Mang Lau, J. Y. Adams, J. Mcneal +4 more
2001American Journal of Pathology207 citations
Semantic Scholar
Biochemical alterations in sex hormone-induced hyperplasia and dysplasia of the dorsolateral prostates of Noble rats.
I. Leav, S. Ho, P. Ofner, F. B. Merk +2 more
1988Journal of the National Cancer Institute190 citations
Semantic Scholar
Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium
Michael Stanbrough, I. Leav, Paul W. L. Kwan, G. Bubley +1 more
2001Proceedings of the National Academy of Sciences of the United States of America172 citations Open access
Semantic Scholar
SOX9 is expressed in human fetal prostate epithelium and enhances prostate cancer invasion.
Hong-Yun Wang, I. Leav, S. Ibaragi, M. Wegner +4 more
2008Cancer Research170 citations
Semantic Scholar
Adenomas and carcinomas of the canine and feline thyroid.
I. Leav, A. Schiller, A. Rijnberk, M. A. Legg +1 more
1976American Journal of Pathology170 citations
Semantic Scholar
Androgen‐supported estrogen‐enhanced epithelial proliferation in the prostates of intact noble rats
I. Leav, Frederick B. Merk, Paul Kwan, S. Ho
1989The Prostate155 citations
Semantic Scholar
Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer.
I. Leav, J. Plescia, H. Goel, Jing Li +4 more
2010American Journal of Pathology138 citations Open access
Semantic Scholar
Adenocarcinoma of the canine prostate
I. Leav, Gerald V. Ling
1968Cancer120 citations Open access
Semantic Scholar
Workgroup I: Rodent models of prostate cancer
M. Lucia, D. Bostwick, M. Bosland, A. Cockett +6 more
1998The Prostate108 citations
Semantic Scholar
VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-1R Define a Novel Mechanism of Aggressive Prostate Cancer
H. Goel, Cheng Chang, Bryan M. Pursell, I. Leav +11 more
2012Cancer Discovery101 citations Open access
Semantic Scholar
Rat Estrogen Receptor-α and -β, and Progesterone Receptor mRNA Expression in Various Prostatic Lobes and Microdissected Normal and Dysplastic Epithelial Tissues of the Noble Rats.
Kin-Mang Lau, I. Leav, S. Ho
1998Endocrinology100 citations
Semantic Scholar
Expression of estrogen receptor beta in the fetal, neonatal, and prepubertal human prostate
J. Y. Adams, I. Leav, Kin-Mang Lau, S. Ho +1 more
2002The Prostate98 citations
Semantic Scholar
Androgen-driven prostate epithelial cell proliferation and differentiation in vivo involve the regulation of p27.
D. Waltregny, I. Leav, Sabina Signoretti, Peggy Soung +6 more
2001Molecular Endocrinology89 citations Open access
Semantic Scholar
Immunohistochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the human fetal and adult male reproductive tracts.
A. Kirschenbaum, Dara R. Liotta, Shen Yao, Xin-Hua Liu +5 more
2000Journal of Clinical Endocrinology and Metabolism80 citations
Semantic Scholar
Immunohistochemical evidence for impaired cell differentiation in the premalignant phase of prostate carcinogenesis.
J. Mcneal, J. Alroy, I. Leav, E. Redwine +2 more
1988American Journal of Clinical Pathology79 citations
Semantic Scholar
Endogenous Tumor Suppression Mediated by PTEN Involves Survivin Gene Silencing
M. Guha, J. Plescia, I. Leav, Jing Li +2 more
2009Cancer Research72 citations Open access
Semantic Scholar
Branched fatty acids in dairy and beef products markedly enhance alpha-methylacyl-CoA racemase expression in prostate cancer cells in vitro.
J. Mobley, I. Leav, P. Zielie, Chad Wotkowitz +5 more
2003Cancer Epidemiology, Biomarkers and Prevention66 citations
Semantic Scholar
Increased survival in experimental dog heatstroke after reduction of gut flora.
G. Bynum, J. Brown, D. Dubose, M. Marsili +5 more
1979Aviation Space and Environmental Medicine63 citations
Semantic Scholar
BMP‐5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures
G. Mailhot, Meiheng Yang, A. Mason‐Savas, C. Mackay +2 more
2008Journal of Cellular Physiology55 citations Open access
Semantic Scholar
Canine Prostate Carcinomas Express Markers of Urothelial and Prostatic Differentiation
B. E. LeRoy, Murali V. P. Nadella, Ramiro E. Toribio, I. Leav +1 more
2004Veterinary Pathology-Supplement54 citations
Semantic Scholar
Sex hormones induce direct epithelial and inflammation-mediated oxidative/nitrosative stress that favors prostatic carcinogenesis in the noble rat.
Neville N. C. Tam, I. Leav, S. Ho
2007American Journal of Pathology53 citations Open access
Semantic Scholar
Androgen Receptor Expression in Prostatic Dysplasia (Prostatic lntraepithelial Neoplasia) in the Human Prostate: An Immunohistochemical and In Situ Hybridization Study
I. Leav, John E. Mcneal, Paul W. L. Kwan, P. Komminoth +1 more
1996The Prostate53 citations
Semantic Scholar
β1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1
H. Goel, A. Sayeed, Michael J. Breen, Matthew J. Zarif +10 more
2013Journal of Cellular Physiology50 citations Open access
Semantic Scholar
The laboratory rat as a model for hyperthermic syndromes in humans.
R. Hubbard, W. T. Matthew, J. D. Linduska, F. C. Curtis +3 more
1976American Journal of Physiology48 citations Open access
Semantic Scholar
Gene Expression Profiling of Testosterone and Estradiol-17β-Induced Prostatic Dysplasia in Noble Rats and Response to the Antiestrogen ICI 182,780.
C. J. Thompson, Neville N. C. Tam, Jennifer M Joyce, I. Leav +1 more
2002Endocrinology47 citations
Semantic Scholar
Estrogen receptor-beta expression in human testicular germ cell tumors.
V. Pais, I. Leav, Kin-Mang Lau, Zhong Jiang +1 more
2003Clinical Cancer Research45 citations
Semantic Scholar
Alpha-methylacyl-CoA racemase (P504S) expression in evolving carcinomas within benign prostatic hyperplasia and in cancers of the transition zone.
I. Leav, J. Mcneal, S. Ho, Zhong Jiang
2003Human Pathology45 citations
Semantic Scholar
Frequent activation of the Ki‐ras oncogene at codon 12 in N‐methyl‐N‐nitrosourea‐induced rat prostate adenocarcinomas and neurogenic sarcomas
S. Sukumar, B. Armstrong, Joost P. Bruyntjes, I. Leav +1 more
1991Molecular Carcinogenesis44 citations
Semantic Scholar
Characterization of a human, sex steroid-responsive transitional cell carcinoma maintained as a tumor line (R198) in athymic nude mice.
L. Reid, I. Leav, Paul W. L. Kwan, P. Russell +1 more
1984Cancer Research43 citations
Semantic Scholar
Role of canine basal cells in postnatal prostatic development, induction of hyperplasia, and sex hormone‐stimulated growth; and the ductal origin of carcinoma *
I. Leav, K. Schelling, J. Y. Adams, Frederick B. Merk +1 more
2001The Prostate42 citations
Semantic Scholar
Functional interaction of the retinoblastoma and Ini1/Snf5 tumor suppressors in cell growth and pituitary tumorigenesis.
Cynthia J. Guidi, Rajini R. Mudhasani, Kathleen Hoover, A. Koff +3 more
2006Cancer Research35 citations Open access
Semantic Scholar
An anesthetized dog heatstroke model.
G. Bynum, J. Patton, W. Bowers, I. Leav +3 more
1977Journal of applied physiology: respiratory, environmental and exercise physiology35 citations
Semantic Scholar
Role of canine basal cells in prostatic post natal development, induction of hyperplasia, sex hormone‐stimulated growth; and the ductal origin of carcinoma
I. Leav, K. Schelling, J. Y. Adams, Frederick B. Merk +1 more
35 citations
Semantic Scholar
Prostate Cancer Regulatory Networks
Dario C. Altieri, Lucia R. Languino, Jane B. Lian, J. Stein +4 more
2009Journal of Cellular Biochemistry34 citations Open access
Semantic Scholar
Effects of estrogen and androgen on the ultrastructure of secretory granules and intercellular junctions in regressed canine prostate
F. B. Merk, I. Leav, Paul W. L. Kwan, P. Ofner
1980The Anatomical Record34 citations
Semantic Scholar
Gene expression profiling of testosterone and estradiol-17 beta-induced prostatic dysplasia in Noble rats and response to the antiestrogen ICI 182,780.
C. J. Thompson, Neville N. C. Tam, Jennifer M Joyce, I. Leav +1 more
2002Endocrinology32 citations
Semantic Scholar
Multistage prostate carcinogenesis: the role of hormones.
M. Bosland, H. C. D. der Meulen, S. Sukumar, P. Ofner +3 more
1991Princess Takamatsu symposia31 citations
Semantic Scholar
Deletion Hotspots in AMACR Promoter CpG Island Are cis-Regulatory Elements Controlling the Gene Expression in the Colon
Xiang Zhang, I. Leav, M. Revelo, R. Deka +3 more
2009PLoS Genetics28 citations Open access
Semantic Scholar
Rat estrogen receptor-alpha and -beta, and progesterone receptor mRNA expression in various prostatic lobes and microdissected normal and dysplastic epithelial tissues of the Noble rats.
Kin-Mang Lau, I. Leav, S. Ho
1998Endocrinology27 citations
Semantic Scholar
Diagnostic significance of selected serum enzymes in a rat heatstroke model.
R. Hubbard, R. Criss, L. P. Elliott, C. Kelly +4 more
1979Journal of applied physiology: respiratory, environmental and exercise physiology24 citations
Semantic Scholar
Alterations of rat liver subsequent to heat overload.
W. Bowers, R. Hubbard, I. Leav, R. Daum +4 more
1975Archives of Pathology & Laboratory Medicine23 citations
Semantic Scholar
Prostate Tumorigenesis Induced by PTEN Deletion Involves Estrogen Receptor beta Repression
Jianrong Li, Sanjoy Samanta, Cheng Chang, D. Jerry +3 more
201522 citations
Semantic Scholar
Peritoneal lavage cooling in an anesthetized dog heatstroke model.
G. Bynum, J. Patton, W. Bowers, I. Leav +3 more
1978Aviation Space and Environmental Medicine22 citations
Semantic Scholar
Use of polyestradiol phosphate and anti‐17β estradiol antibodies for the localization of estrogen receptors in target tissues: A critique
B. Morrow, I. Leav, R. A. Delellis, S. Raam
1980Cancer19 citations Open access
Semantic Scholar
Role of canine basal cells in postnatal prostatic development, induction of hyperplasia, and sex hormone-stimulated growth; and the ductal origin of carcinoma.
I. Leav, K. Schelling, J. Y. Adams, F. B. Merk +1 more
2001The Prostate18 citations
Semantic Scholar
Testosterone-mediated increase in 5 alpha-dihydrotestosterone content, nuclear androgen receptor levels, and cell division in an androgen-independent prostate carcinoma of Noble rats.
S. Ho, I. Leav, D. Damassa, Paul Kwan +2 more
1988Cancer Research17 citations
Semantic Scholar
Effect of low-potassium diet on rat exercise hyperthermia and heatstroke mortality.
R. Hubbard, M. Mager, W. Bowers, I. Leav +3 more
1981Journal of applied physiology: respiratory, environmental and exercise physiology17 citations
Semantic Scholar

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S. Ho×16
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S. Ho — researcher profile on SciRah
Kin-Mang Lau×6
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Zhong Jiang×6
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Zhong Jiang — researcher profile on SciRah
W. Bowers×6
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W. Bowers — researcher profile on SciRah

×5

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J. Y. Adams — researcher profile on SciRah

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J. Mcneal — researcher profile on SciRah

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F. B. Merk — researcher profile on SciRah

Paul W. L. Kwan×5

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Paul W. L. Kwan — researcher profile on SciRah

Frederick B. Merk×5

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Frederick B. Merk — researcher profile on SciRah

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J. Alroy — researcher profile on SciRah

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M. Hamlet — researcher profile on SciRah

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R. Hubbard — researcher profile on SciRah