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L. Malkowitz · SciRah

Researcher profile · Semantic Scholar

L. Malkowitz

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L. Malkowitz — researcher profile on SciRah

h-index: 24
Works: 36
Citations: 2,325

Most-cited papers

Cloning, expression, and characterization of the human eosinophil eotaxin receptor
Bruce L. Daugherty, S. Siciliano, J. DeMartino, L. Malkowitz +2 more
1996Journal of Experimental Medicine590 citations Open access
Semantic Scholar
Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors.
S. Siciliano, Thomas E. Rollins, J. DeMartino, Zenon Konteatis +5 more
1994Proceedings of the National Academy of Sciences of the United States of America235 citations Open access
Semantic Scholar
Mitochondrial benzodiazepine receptors mediate inhibition of mitochondrial respiratory control.
J. Hirsch, C. Beyer, L. Malkowitz, B. Beer +1 more
1989Molecular Pharmacology186 citations
Semantic Scholar
CCR5, CXCR4, and CD4 Are Clustered and Closely Apposed on Microvilli of Human Macrophages and T Cells
I. Singer, Solomon Scott, D. Kawka, J. Chin +13 more
2001Journal of Virology167 citations Open access
Semantic Scholar
Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties.
Dooseop Kim, Li-Ping Wang, J. Hale, C. L. Lynch +17 more
2005Bioorganic & Medicinal Chemistry Letters126 citations Open access
Semantic Scholar
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. part 1: discovery and initial structure-activity relationships for 1 -amino-2-phenyl-4-(piperidin-1-yl)butanes.
C. Dorn, P. Finke, Bryan D. Oates, R. Budhu +18 more
2001Bioorganic & Medicinal Chemistry Letters85 citations Open access
Semantic Scholar
Administration of 1,25-dihydroxyvitamin D3 results in the elevation of hippocampal seizure threshold levels in rats.
A. Siegel, L. Malkowitz, M. Moskovits, S. Christakos
1984Brain Research82 citations
Semantic Scholar
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure-activity relationships for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes.
P. Finke, Bryan D. Oates, S. Mills, M. Maccoss +14 more
2001Bioorganic & Medicinal Chemistry Letters81 citations Open access
Semantic Scholar
Isolation and structure of antagonists of chemokine receptor (CCR5).
H. Jayasuriya, K. Herath, J. Ondeyka, J. Polishook +11 more
2004Journal of Natural Products80 citations Open access
Semantic Scholar
Characterization of ligand binding to mitochondrial benzodiazepine receptors.
J. Hirsch, C. Beyer, L. Malkowitz, C. Loullis +1 more
1989Molecular Pharmacology71 citations
Semantic Scholar
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent anti-HIV activity.
J. Hale, R. Budhu, Edward J Holson, P. Finke +18 more
2001Bioorganic & Medicinal Chemistry Letters55 citations Open access
Semantic Scholar
Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection.
Dooseop Kim, Li-Ping Wang, C. G. Caldwell, Ping Chen +18 more
2001Bioorganic & Medicinal Chemistry Letters46 citations Open access
Semantic Scholar
Combinatorial synthesis of 3-(amidoalkyl) and 3-(aminoalkyl)-2-arylindole derivatives: discovery of potent ligands for a variety of G-protein coupled receptors.
C. A. Willoughby, S. Hutchins, K. Rosauer, Madhumeeta J. Dhar +9 more
2002Bioorganic & Medicinal Chemistry Letters41 citations
Semantic Scholar
Label-Free High-Throughput Screening via Mass Spectrometry: A Single Cystathionine Quantitative Method for Multiple Applications
Tom G. Holt, Bernard K. Choi, N. Geoghagen, Kristian K. Jensen +8 more
2009Assay and drug development technologies39 citations
Semantic Scholar
11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature.
M. Luo, R. Thieringer, M. Springer, S. Wright +21 more
2013Physiological Genomics38 citations
Semantic Scholar
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains.
C. L. Lynch, C. A. Willoughby, J. Hale, Edward J Holson +26 more
2003Bioorganic & Medicinal Chemistry Letters38 citations Open access
Semantic Scholar
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains.
D. Shen, Min Shu, S. Mills, K. Chapman +16 more
2004Bioorganic & Medicinal Chemistry Letters35 citations Open access
Semantic Scholar
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment.
Min Shu, Jennifer L. Loebach, Kerry Parker, S. Mills +21 more
2004Bioorganic & Medicinal Chemistry Letters34 citations Open access
Semantic Scholar
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.
C. L. Lynch, J. Hale, R. Budhu, Amy L Gentry +19 more
2002Bioorganic & Medicinal Chemistry Letters33 citations Open access
Semantic Scholar
Combinatorial synthesis of CCR5 antagonists.
C. A. Willoughby, Scott C. Berk, Keith G. Rosauer, Silvia Degrado +14 more
2001Bioorganic & Medicinal Chemistry Letters33 citations Open access
Semantic Scholar
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds.
D. Shen, Min Shu, C. A. Willoughby, Shrenik K. Shah +22 more
2004Bioorganic & Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines.
C. L. Lynch, Amy L Gentry, J. Hale, S. Mills +18 more
2002Bioorganic & Medicinal Chemistry Letters30 citations Open access
Semantic Scholar
Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice.
Kristian K. Jensen, N. Geoghagen, Lan Jin, Tom G. Holt +9 more
2011European Journal of Pharmacology28 citations
Semantic Scholar
Synthesis and evaluation of CCR5 antagonists containing modified 4-piperidinyl-2-phenyl-1-(phenylsulfonylamino)-butane.
Shrenik K. Shah, N. Chen, R. Guthikonda, S. Mills +15 more
2005Bioorganic & Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
1,3,4 Trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains.
C. A. Willoughby, K. Rosauer, J. J. Hale, R. Budhu +19 more
2003Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Calcium Binding Protein in Squid Brain: Biochemical Similarity to the 28,000‐Mr Vitamin D‐Dependent Calcium Binding Protein (Calbindin‐D28k)
S. Christakos, L. Malkowitz, A. Sori, A. Sperduto +1 more
1987Journal of Neurochemistry22 citations
Semantic Scholar
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: polar functionality and its effect on anti-HIV-1 activity.
J. Hale, R. Budhu, S. Mills, M. Maccoss +15 more
2002Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Syntheses and SAR studies of 4-(heteroarylpiperdin-1-yl-methyl)-pyrrolidin-1-yl-acetic acid antagonists of the human CCR5 chemokine receptor.
K. Shankaran, K. Donnelly, Shrenik K. Shah, R. Guthikonda +15 more
2004Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
A nonpeptidic agonist ligand of the human C5a receptor: Synthesis, binding affinity optimization and functional characterization
S. E. deLaszlo, E. E. Allen, Bing Li, D. Ondeyka +7 more
199716 citations
Semantic Scholar
CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity.
C. L. Lynch, J. Hale, R. Budhu, Amy L Gentry +22 more
2003Organic Letters12 citations
Semantic Scholar
Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists.
K. Shankaran, K. Donnelly, Shrenik K. Shah, C. G. Caldwell +21 more
2004Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
1,3,4-Trisubstituted Pyrrolidine CCR5 Receptor Antagonists. Part 1. Discovery of the Pyrrolidine Scaffold and Determination of Its Stereochemical Requirements.
J. Hale, R. Budhu, S. Mills, M. Maccoss +5 more
20011 citations
Semantic Scholar
PCR Amplification and DNA Sequence Analysis of the ß-Actin Gene from a Scyphozoan Jellyfish (Chrysaora quinquecirrha)
L. Malkowitz, Montclair
20220 citations
Semantic Scholar
vasculatureproinflammatory gene expression in the -HSD1 inhibition reduces atherosclerosis in mice by
P. Lum, I-Ming Wang, Kenneth K. Wu, Jeffrey Yuan +16 more
20150 citations
Semantic Scholar
Expanding the Scope of HTMS Methods
Tom G. Holt, Jun Wang, Xun Chen, Bernard K. Choi +10 more
20110 citations
Semantic Scholar
A Nonpeptidic Agonist Ligand of the Human C5a Receptor: Synthesis, Binding Affinity Optimization and Functional Characterization.
S. E. deLaszlo, E. E. Allen, Bing Li, D. Ondeyka +7 more
19970 citations
Semantic Scholar

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