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M. Macielag · SciRah

Researcher profile · Semantic Scholar

M. Macielag

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M. Macielag — researcher profile on SciRah

h-index: 29
Works: 127
Citations: 3,480

Most-cited papers

Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase
A. Robicsek, J. Strahilevitz, G. Jacoby, M. Macielag +4 more
2006Nature Medicine1,016 citations
Semantic Scholar
Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria.
M. Macielag, J. P. Demers, Stephanie A. Fraga-Spano, Dennis J. Hlasta +11 more
1998Journal of Medicinal Chemistry130 citations Open access
Semantic Scholar
Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution
C. Schalk-Hihi, C. Schubert, R. Alexander, S. Bayoumy +18 more
2011Protein Science129 citations Open access
Semantic Scholar
Antibacterial agents that inhibit two-component signal transduction systems.
J. Barrett, R. Goldschmidt, L. Lawrence, B. Foleno +18 more
1998Proceedings of the National Academy of Sciences of the United States of America129 citations Open access
Semantic Scholar
New β-lactam antibiotics and β-lactamase inhibitors
K. Bush, M. Macielag
2010Expert Opinion on Therapeutic Patents112 citations
Semantic Scholar
Amidino benzimidazole inhibitors of bacterial two-component systems.
M. Weidner‐Wells, K. Ohemeng, Van N. Nguyen, S. A. Fraga-Spano +6 more
2001Bioorganic & Medicinal Chemistry Letters108 citations Open access
Semantic Scholar
Taking inventory: antibacterial agents currently at or beyond phase 1.
K. Bush, M. Macielag, M. Weidner‐Wells
2004Current Opinion in Microbiology102 citations
Semantic Scholar
Anti-MRSA β-lactams in development, with a focus on ceftobiprole: the first anti-MRSA β-lactam to demonstrate clinical efficacy
K. Bush, M. Heep, M. Macielag, G. Noel
200767 citations
Semantic Scholar
Novel inhibitors of bacterial two-component systems with gram positive antibacterial activity: pharmacophore identification based on the screening hit closantel.
Dennis J. Hlasta, J. P. Demers, B. Foleno, Stephanie A. Fraga-Spano +10 more
1998Bioorganic & Medicinal Chemistry Letters64 citations Open access
Semantic Scholar
Chemical Properties of Antimicrobials and Their Uniqueness
M. Macielag
201261 citations
Semantic Scholar
In Vitro Antibacterial Activities of JNJ-Q2, a New Broad-Spectrum Fluoroquinolone
B. Morrow, Wenping He, K. Amsler, B. Foleno +3 more
2010Antimicrobial Agents and Chemotherapy60 citations Open access
Semantic Scholar
A Long-Acting PYY3–36 Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates
S. M. Rangwala, Katharine D'Aquino, Yue-Mei Zhang, L. Bader +19 more
2019Cell Metabolism59 citations Open access
Semantic Scholar
Novel antibacterial agents for the treatment of serious Gram-positive infections.
D. Abbanat, M. Macielag, K. Bush
2003Expert Opinion on Investigational Drugs55 citations
Semantic Scholar
Inhibitors of bacterial two-component signalling systems
M. Macielag, R. Goldschmidt
2000Expert Opinion on Investigational Drugs54 citations
Semantic Scholar
Pyrroloquinolone PDE5 inhibitors with improved pharmaceutical profiles for clinical studies on erectile dysfunction.
Wei-Qin Jiang, Ji-Hua Guan, M. Macielag, Su-Ying Zhang +7 more
2005Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
Synthesis and antibacterial activity of pyrroloaryl-substituted oxazolidinones.
Steven D. Paget, B. Foleno, Christine M. Boggs, R. Goldschmidt +6 more
2003Bioorganic & Medicinal Chemistry Letters42 citations
Semantic Scholar
SAR studies of diaryltriazoles against bacterial two-component regulatory systems and their antibacterial activities.
Z. Sui, Ji-Hua Guan, Dennis J. Hlasta, M. Macielag +5 more
1998Bioorganic & Medicinal Chemistry Letters41 citations Open access
Semantic Scholar
New approaches in the treatment of bacterial infections.
K. Bush, M. Macielag
2000Current Opinion in Chemical Biology40 citations
Semantic Scholar
MurF Inhibitors with Antibacterial Activity: Effect on Muropeptide Levels
E. Baum, S. Crespo-Carbone, B. Foleno, L. Simon +3 more
2009Antimicrobial Agents and Chemotherapy39 citations Open access
Semantic Scholar
Isolation, sequence, and bioactivity of chicken motilin.
P. De Clercq, I. Depoortere, M. Macielag, A. Vandermeers +2 more
1996Peptides37 citations
Semantic Scholar
A MurF Inhibitor That Disrupts Cell Wall Biosynthesis in Escherichia coli
E. Baum, S. Crespo-Carbone, A. Klinger, B. Foleno +3 more
2007Antimicrobial Agents and Chemotherapy35 citations Open access
Semantic Scholar
A role for schwann cells in the neuroregenerative effects of a non-immunosuppressive fk506 derivative, jnj460.
Raymond B. Birge, Scott A. Wadsworth, R. Akakura, H. Abeysinghe +11 more
2004Neuroscience34 citations
Semantic Scholar
GPR120 agonists for the treatment of diabetes: a patent review (2014 present)
Xu-Qing Zhang, M. Macielag
2020Expert Opinion on Therapeutic Patents33 citations
Semantic Scholar
Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor
Ryan M. Wyatt, I. Fraser, Natalie Welty, Brian Lord +23 more
2019Journal of Pharmacology and Experimental Therapeutics32 citations Open access
Semantic Scholar
Motilin and OHM-11526 activate a calcium current in human and canine jejunal circular smooth muscle.
Gianrico Farrugia, M. Macielag, T. Peeters, M. Sarr +2 more
1997American Journal of Physiology29 citations
Semantic Scholar
Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists.
Bin Zhu, Mingde Xia, Xiao-Qing Xu, D. Ludovici +12 more
2013Bioorganic & Medicinal Chemistry Letters28 citations Open access
Semantic Scholar
Synthesis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives.
Bin Zhu, Brett A Marinelli, D. Abbanat, B. Foleno +2 more
2007Bioorganic & Medicinal Chemistry Letters26 citations
Semantic Scholar
Anti-MRSA beta-lactams in development, with a focus on ceftobiprole: the first anti-MRSA beta-lactam to demonstrate clinical efficacy.
K. Bush, M. Heep, M. Macielag, G. Noel
2007Expert Opinion on Investigational Drugs26 citations
Semantic Scholar
Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements.
Steven D. Paget, Christine M. Boggs, B. Foleno, R. Goldschmidt +5 more
2006Bioorganic & Medicinal Chemistry Letters25 citations
Semantic Scholar
Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes.
Xu-Qing Zhang, C. Cai, Z. Sui, M. Macielag +11 more
2017ACS Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Preparation of Erythromycin Analogs Having Functional Groups at C-15
G. Ashley, Mark A. Burlingame, Ruchir P. Desai, Hong Fu +6 more
2006Journal of antibiotics (Tokyo. 1968)22 citations
Semantic Scholar
The motilin antagonist ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit.
T. Peeters, I. Depoortere, M. Macielag, R. Dharanipragada +3 more
1994Biochemical and Biophysical Research Communications - BBRC22 citations
Semantic Scholar
Synthesis and antibacterial activity of 7-(1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-7-yl) quinolones.
Bin Zhu, Brett A Marinelli, R. Goldschmidt, B. Foleno +3 more
2009Bioorganic & Medicinal Chemistry Letters21 citations
Semantic Scholar
The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones.
M. Weidner‐Wells, H. Werblood, R. Goldschmidt, K. Bush +5 more
2004Bioorganic & Medicinal Chemistry Letters21 citations
Semantic Scholar
Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.
Guo-Zhang Xu, Zhijie Liu, Xin-Kang Wang, Tian-Bao Lu +21 more
2022Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Tetrahydroindazole derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists.
Jay M. Matthews, J. Mcnally, P. Connolly, Mingde Xia +7 more
2016Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes.
Xiao-Dong Xu, T. Henninger, D. Abbanat, K. Bush +3 more
2005Bioorganic & Medicinal Chemistry Letters20 citations
Semantic Scholar
Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics.
T. Henninger, Xiao-Dong Xu, D. Abbanat, E. Baum +5 more
2004Bioorganic & Medicinal Chemistry Letters20 citations
Semantic Scholar
Antagonistic properties of [Phe3,Leu13]porcine motilin.
I. Depoortere, M. Macielag, Alphonse Galdes, T. Peeters
1995European Journal of Pharmacology20 citations
Semantic Scholar
In Vitro Antibacterial Activity of the Pyrrolopyrazolyl-Substituted Oxazolidinone RWJ-416457
B. Foleno, D. Abbanat, R. Goldschmidt, R. Flamm +5 more
2006Antimicrobial Agents and Chemotherapy19 citations Open access
Semantic Scholar
Structure-activity relationships of N-acyl pyrroloquinolone PDE-5 inhibitors.
James C. Lanter, Z. Sui, M. Macielag, James J. Fiordeliso +8 more
2004Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Furoyl and benzofuroyl pyrroloquinolones as potent and selective PDE5 inhibitors for treatment of erectile dysfunction.
Wei-Qin Jiang, Z. Sui, M. Macielag, Shawn P. Walsh +10 more
2003Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Pyrimidinylpyrroloquinolones as highly potent and selective PDE5 inhibitors for treatment of erectile dysfunction.
Z. Sui, Ji-Hua Guan, M. Macielag, Wei-Qin Jiang +7 more
2002Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
In Vivo Activity of the Pyrrolopyrazolyl-Substituted Oxazolidinone RWJ-416457
J. Hilliard, Jeffrey Fernandez, J. Melton, M. Macielag +3 more
2009Antimicrobial Agents and Chemotherapy16 citations Open access
Semantic Scholar
Characterization of a novel phosphodiesterase type 5 inhibitor: JNJ-10258859.
Yu-Hong Qiu, S. Bhattacharjee, P. Kraft, T. John +8 more
2003European Journal of Pharmacology16 citations
Semantic Scholar
Synthesis and antibacterial activity of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives.
Bin Zhu, Brett A Marinelli, D. Abbanat, B. Foleno +3 more
2006Bioorganic & Medicinal Chemistry Letters13 citations
Semantic Scholar
6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB1) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity.
Yue-Mei Zhang, M. Greco, M. Macielag, C. Teleha +12 more
2018Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar
Synthesis and biological activities of novel beta-carbolines as PDE5 inhibitors.
Z. Sui, Ji-Hua Guan, M. Macielag, Wei-Qin Jiang +7 more
2003Bioorganic & Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors.
Bin Zhu, P. Connolly, Yue-Mei Zhang, M. McDonnell +9 more
2020Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolides.
E. Grant, D. Guiadeen, D. Abbanat, B. Foleno +2 more
2006Bioorganic & Medicinal Chemistry Letters10 citations
Semantic Scholar

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