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J. Kuhle · SciRah

Researcher profile · Semantic Scholar

J. Kuhle

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J. Kuhle — researcher profile on SciRah

h-index: 74
Works: 462
Citations: 23K

Most-cited papers

Neurofilaments as biomarkers in neurological disorders — towards clinical application
M. Khalil, C. Teunissen, Sylvain Lehmann, M. Otto +19 more
2024Nature Reviews Neurology432 citations Open access
Semantic Scholar
Guidance for use of neurofilament light chain as a cerebrospinal fluid and blood biomarker in multiple sclerosis management
M. Freedman, S. Gnanapavan, Ronald A. Booth, P. Calabresi +4 more
2024EBioMedicine190 citations Open access
Semantic Scholar
Fluid biomarkers in multiple sclerosis: from current to future applications
M. Di Filippo, L. Gaetani, D. Centonze, H. Hegen +7 more
2024The Lancet Regional Health - Europe88 citations Open access
Semantic Scholar
Serum Glial Fibrillary Acidic Protein and Neurofilament Light Chain Levels Reflect Different Mechanisms of Disease Progression under B‐Cell Depleting Treatment in Multiple Sclerosis
P. Benkert, Aleksandra Maleska Maceski, S. Schaedelin, J. Oechtering +48 more
2024Annals of Neurology63 citations Open access
Semantic Scholar
Standardized Definition of Progression Independent of Relapse Activity (PIRA) in Relapsing-Remitting Multiple Sclerosis.
J. Müller, S. Sharmin, J. Lorscheider, S. Ozakbas +93 more
2025JAMA Neurology57 citations Open access
Semantic Scholar
Longitudinal Change in Serum Neurofilament Light Chain in Type 2 Diabetes and Early Diabetic Polyneuropathy: ADDITION-Denmark.
Laura L. Määttä, S. T. Andersen, T. Parkner, C. V. B. Hviid +8 more
2024Diabetes Care31 citations Open access
Semantic Scholar
B cell depletion with anti-CD20 promotes neuroprotection in a BAFF-dependent manner in mice and humans
Angela A. Wang, Felix Luessi, T. Neziraj, Elisabeth Pössnecker +19 more
2024Science Translational Medicine28 citations
Semantic Scholar
GFAP and NfL as predictors of disease progression and relapse activity in fingolimod-treated multiple sclerosis
A. Maceski, P. Benkert, M. Einsiedler, S. Schaedelin +47 more
2025Brain : a journal of neurology27 citations Open access
Semantic Scholar
Complement Activation Is Associated With Disease Severity in Multiple Sclerosis.
J. Oechtering, Kerstin Stein, S. Schaedelin, A. Maceski +26 more
2024Neurology(R) neuroimmunology & neuroinflammation27 citations Open access
Semantic Scholar
Prognostic Factors for Multiple Sclerosis Symptoms in Radiologically Isolated Syndrome.
N. Fissolo, S. Schaedelin, L. Villar, J. Lünemann +54 more
2025JAMA Neurology25 citations Open access
Semantic Scholar
Quantifying Remyelination Using χ-Separation in White Matter and Cortical Multiple Sclerosis Lesions
J. Müller, Po-Jui Lu, A. Cagol, E. Ruberte +15 more
2024Neurology22 citations Open access
Semantic Scholar
Efficacy and safety results after >3.5 years of treatment with the Bruton’s tyrosine kinase inhibitor evobrutinib in relapsing multiple sclerosis: Long-term follow-up of a Phase II randomised clinical trial with a cerebrospinal fluid sub-study
X. Montalban, Karolina Piasecka-Stryczynska, J. Kuhle, P. Benkert +10 more
2024Multiple Sclerosis22 citations Open access
Semantic Scholar
Effectiveness of cladribine compared to fingolimod, natalizumab, ocrelizumab and alemtuzumab in relapsing-remitting multiple sclerosis
Izanne Roos, S. Sharmin, C. Malpas, S. Ozakbas +42 more
2024Multiple Sclerosis21 citations Open access
Semantic Scholar
Development and multi-center validation of a fully automated digital immunoassay for neurofilament light chain: toward a clinical blood test for neuronal injury
David H. Wilson, D. Chan, Lei Chang, Robert Mathis +36 more
2023Clinical Chemistry and Laboratory Medicine21 citations Open access
Semantic Scholar
Blood Biomarkers for Predicting Disability Worsening in Progressive Multiple Sclerosis: A Multinational, Individual Participant-Level Analysis
A. Abdelhak, F. Bachhuber, Kiarra Ning, P. Benkert +72 more
2025Journal of Neurology Neurosurgery & Psychiatry20 citations Open access
Semantic Scholar
Blood-Based Biomarkers for Identifying Disease Activity in AQP4-IgG-Positive Neuromyelitis Optica Spectrum Disorder.
Su-Hyun Kim, A. B. A. G. R. Gomes, P. Schindler, Jae-Won Hyun +14 more
2024JAMA Neurology19 citations Open access
Semantic Scholar
Serum Neurofilament Light Chain in Multiple Sclerosis: Superiority of Age‐ and BMI‐Corrected Z Scores/Percentiles Over Absolute Cutoff Values for Prediction of Treatment Response
M. Einsiedler, A. Maceski, S. Sandgren, J. Oechtering +39 more
2025Annals of Clinical and Translational Neurology18 citations Open access
Semantic Scholar
Aberrant Complement Activation Is Associated With Structural Brain Damage in Multiple Sclerosis
J. Oechtering, S. Schaedelin, Kerstin Stein, Aleksandra Maleska Maceski +34 more
2025Neurology(R) neuroimmunology & neuroinflammation18 citations Open access
Semantic Scholar
Validation and generation of age-specific reference intervals for a new blood neurofilament light chain assay.
Ronald A. Booth, D. Beriault, R. Schneider, P. Benkert +5 more
2025Clinica chimica acta; international journal of clinical chemistry17 citations Open access
Semantic Scholar
Comparative Performances of 4 Serum NfL Assays, pTau181, and GFAP in Patients With Amyotrophic Lateral Sclerosis
E. Mondésert, C. Delaby, E. de la Cruz, J. Kuhle +9 more
2025Neurology16 citations Open access
Semantic Scholar
A novel imaging marker of cortical “cellularity” in multiple sclerosis patients
M. Barakovic, Matthias Weigel, A. Cagol, S. Schaedelin +12 more
2024Scientific Reports16 citations Open access
Semantic Scholar
Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview
C. Delaby, A. Ladang, Jose Martinez-Yriarte, Chiara Zecca +71 more
2025Alzheimer's & Dementia15 citations Open access
Semantic Scholar
Personalized treatment decision algorithms for the clinical application of serum neurofilament light chain in multiple sclerosis: A modified Delphi Study
Ö. Yaldizli, P. Benkert, L. Achtnichts, Amit Bar-Or +39 more
2025Multiple Sclerosis15 citations Open access
Semantic Scholar
Markers of axonal injury in blood and tissue triggered by acute and chronic demyelination
A. Abdelhak, C. Cordano, Greg J. Duncan, Katie Emberley +17 more
2025Brain : a journal of neurology15 citations Open access
Semantic Scholar
Disentangling Neurodegeneration From Aging in Multiple Sclerosis Using Deep Learning
G. Pontillo, F. Prados, J. Colman, B. Kanber +56 more
2024Neurology14 citations Open access
Semantic Scholar
Personalized federated learning for predicting disability progression in multiple sclerosis using real-world routine clinical data
A. Pirmani, E. De Brouwer, A. Arany, M. Oldenhof +69 more
2025npj Digital Medicine12 citations Open access
Semantic Scholar
Retinal neuronal loss and progression independent of relapse activity in multiple sclerosis
Federico Burguet Villena, N. Cerdá-Fuertes, Lisa Hofer, S. Schädelin +13 more
2025Journal of Neurology12 citations Open access
Semantic Scholar
Advanced Quantitative MRI Unveils Microstructural Thalamic Changes Reflecting Disease Progression in Multiple Sclerosis
A. Cagol, M. Ocampo-Pineda, Po-Jui Lu, Matthias Weigel +9 more
2024Neurology(R) neuroimmunology & neuroinflammation12 citations
Semantic Scholar
Treatment De-escalation in Relapsing-Remitting Multiple Sclerosis: An Observational Study
J. Müller, S. Sharmin, J. Lorscheider, D. Horáková +29 more
2025CNS Drugs11 citations Open access
Semantic Scholar
Clinical trial evidence of quality-of-life effects of disease-modifying therapies for multiple sclerosis: a systematic analysis
J. Hirt, Kinga Dembowska, T. Woelfle, C. Axfors +5 more
2024Journal of Neurology11 citations Open access
Semantic Scholar
Serum Neurofilament Light Chain as a Biomarker for CIDP Diagnosis, Severity, and Treatment Outcome
R. Klimas, Felix Kohle, L. Horstkemper, P. Benkert +16 more
2025Neurology(R) neuroimmunology & neuroinflammation9 citations Open access
Semantic Scholar
Plasma CHI3L1 associates with brain volume loss and glial activation in multiple sclerosis
Venla Ahola, M. Saraste, M. Nylund, M. Matilainen +10 more
2025Journal of Neurology Neurosurgery & Psychiatry9 citations Open access
Semantic Scholar
White Matter Tract Degeneration in Multiple Sclerosis Patients With Progression Independent of Relapse Activity
M. Ocampo-Pineda, A. Cagol, P. Benkert, M. Barakovic +9 more
2025Neurology(R) neuroimmunology & neuroinflammation9 citations
Semantic Scholar
Effects of obstructive sleep apnea treatment on neurodegenerative biomarker neurofilament light chain and cognitive performance
T. Sehr, Katja Akgün, P. Benkert, J. Kuhle +2 more
2024Journal of Sleep Research9 citations Open access
Semantic Scholar
Contrast-Enhancing Lesion Segmentation in Multiple Sclerosis: A Deep Learning Approach Validated in a Multicentric Cohort
Martina Greselin, Po-Jui Lu, L. Melie-García, M. Ocampo-Pineda +34 more
2024Bioengineering9 citations Open access
Semantic Scholar
Longitudinal change of serum NfL as disease activity biomarker candidate in MOGAD: A descriptive cohort study.
P. Schindler, J. Bellmann-Strobl, J. Kuhle, B. Wildemann +3 more
2024Multiple Sclerosis and Related Disorders9 citations Open access
Semantic Scholar
Granulocyte and astrocyte markers distinguish MOG-antibody disease and neuromyelitis optica from multiple sclerosis
Roberto Furlan, S. Schaedelin, J. Frederiksen, Mitsuru Watanabe +24 more
2025Brain : a journal of neurology8 citations Open access
Semantic Scholar
Comparative analysis of three platforms for serum NfL quantification in healthy controls and MS patients
J. Dargvainiene, A. Torge, Klaus-Peter Wandinger, R. Junker +11 more
2025Clinical Chemistry and Laboratory Medicine8 citations Open access
Semantic Scholar
Comparative effectiveness of teriflunomide and ocrelizumab on smoldering activity in multiple sclerosis: an observational study in the Swiss Multiple Sclerosis Cohort
A. Cagol, S. Schaedelin, M. Ocampo-Pineda, P. Benkert +30 more
2025Journal of Neurology8 citations Open access
Semantic Scholar
Routine CSF parameters as predictors of disease course in multiple sclerosis: an MSBase cohort study
C. Dekeyser, M. Hautekeete, Melissa Cambron, V. van Pesch +45 more
2024Journal of Neurology Neurosurgery & Psychiatry8 citations Open access
Semantic Scholar
Neurofilament Light Chain as Biomarker in Encephalitis
S. Wellmann, T. Geis, J. Kuhle, V. Lehnerer
2024Journal of Clinical Medicine8 citations Open access
Semantic Scholar
Persistent progression independent of relapse activity in multiple sclerosis
Chao Zhu, Zhen Zhou, T. Kalincik, Izanne Roos +41 more
2025Brain Communications7 citations Open access
Semantic Scholar
Investigation of the association of serum GFAP and NfL with brain and upper cervical MRI volumes in AQP4-IgG-positive NMOSD and MOGAD
P. Schindler, U. Grittner, R. Rust, S. Asseyer +11 more
2025Therapeutic Advances in Neurological Disorders7 citations Open access
Semantic Scholar
Predictors of risk of secondary progression in multiple sclerosis
S. Laaksonen, M. Sucksdorff, A. Vuorimaa, J. Kuhle +6 more
2025Therapeutic Advances in Neurological Disorders7 citations Open access
Semantic Scholar
Neurofilament Light Chain as a Discriminator of Disease Activity Status in MOG Antibody-Associated Disease
A. B. A. G. R. Gomes, Su-Hyun Kim, R. Pretzsch, L. Kulsvehagen +19 more
2024Neurology(R) neuroimmunology & neuroinflammation7 citations
Semantic Scholar
MultiSCRIPT-Cycle 1—a pragmatic trial embedded within the Swiss Multiple Sclerosis Cohort (SMSC) on neurofilament light chain monitoring to inform personalized treatment decisions in multiple sclerosis: a study protocol for a randomized clinical trial
P. Janiaud, C. Zecca, A. Salmen, P. Benkert +25 more
2024Trials7 citations Open access
Semantic Scholar
Modulator of VRAC Current 1 Is a Potential Target Antigen in Multiple Sclerosis
J. Dahl, Alicia Weier, Christopher Winter, Maik Hintze +13 more
2025Neurology(R) neuroimmunology & neuroinflammation6 citations Open access
Semantic Scholar
Extracellular Vesicle Marker Changes Associated With Disease Activity in Relapsing-Remitting Multiple Sclerosis
Victoria Lim Falk, Nicole Mueller-Wirth, D. Karathanasis, M. Evangelopoulos +8 more
2025Neurology(R) neuroimmunology & neuroinflammation6 citations Open access
Semantic Scholar
Natural language processing analysis of the theories of people with multiple sclerosis about causes of their disease
C. Haag, Nina Steinemann, V. Ajdacic-Gross, J. Schlomberg +13 more
2024Communications Medicine6 citations Open access
Semantic Scholar
Emulating randomised clinical trials in relapsing-remitting multiple sclerosis with non-randomised real-world evidence: an application using data from the MSBase Registry
A. Signori, M. Ponzano, T. Kalincik, S. Ozakbas +16 more
2024Journal of Neurology Neurosurgery & Psychiatry6 citations
Semantic Scholar

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