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T. Irie · SciRah

Researcher profile · Semantic Scholar

T. Irie

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T. Irie — researcher profile on SciRah

h-index: 19
Works: 39
Citations: 2,763

Most-cited papers

Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments.
S. Kumagai, S. Koyama, K. Itahashi, T. Tanegashima +42 more
2022Cancer Cell836 citations Open access
Semantic Scholar
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies
S. Kumagai, Yosuke Togashi, Takahiro Kamada, E. Sugiyama +27 more
2020Nature Immunology663 citations
Semantic Scholar
Identification of hundreds of novel UPF1 target transcripts by direct determination of whole transcriptome stability
Hidenori Tani, Naoto Imamachi, K. Salam, Rena Mizutani +5 more
2012RNA Biology170 citations Open access
Semantic Scholar
Highly immunogenic cancer cells require activation of the WNT pathway for immunological escape
Yoshiko Takeuchi, T. Tanegashima, E. Sato, T. Irie +23 more
2021Science immunology125 citations
Semantic Scholar
Massive transcriptional start site analysis of human genes in hypoxia cells
K. Tsuchihara, Yutaka Suzuki, H. Wakaguri, T. Irie +9 more
2009Nucleic Acids Research123 citations Open access
Semantic Scholar
PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T cell clonotypes.
Joji Nagasaki, T. Inozume, N. Sax, R. Ariyasu +22 more
2022Cell Reports109 citations Open access
Semantic Scholar
BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors
K. Itahashi, T. Irie, J. Yuda, S. Kumagai +15 more
2022Science immunology101 citations
Semantic Scholar
Immune Suppression by PD-L2 against Spontaneous and Treatment-Related Antitumor Immunity
T. Tanegashima, Yosuke Togashi, Koichi Azuma, A. Kawahara +11 more
2019Clinical Cancer Research81 citations Open access
Semantic Scholar
Microbiota-driven antitumour immunity mediated by dendritic cell migration
Nina Yi-Tzu Lin, S. Fukuoka, Shohei Koyama, D. Motooka +32 more
2025Nature80 citations Open access
Semantic Scholar
BRIC-seq: a genome-wide approach for determining RNA stability in mammalian cells.
Naoto Imamachi, Hidenori Tani, Rena Mizutani, Katsutoshi Imamura +3 more
2014Methods76 citations
Semantic Scholar
Regulatory T‐cell development in the tumor microenvironment
K. Itahashi, T. Irie, Hiroyoshi Nishikawa
2022European Journal of Immunology67 citations
Semantic Scholar
Analysis of RNA decay factor mediated RNA stability contributions on RNA abundance
Sho Maekawa, Naoto Imamachi, T. Irie, Hidenori Tani +8 more
2015BMC Genomics45 citations Open access
Semantic Scholar
Depletion of central memory CD8+ T cells might impede the antitumor therapeutic effect of Mogamulizumab
Y. Maeda, H. Wada, D. Sugiyama, Takuro Saito +16 more
2021Nature Communications44 citations Open access
Semantic Scholar
Importance of lymph node immune responses in MSI-H/dMMR colorectal cancer
K. Inamori, Yosuke Togashi, S. Fukuoka, K. Akagi +12 more
2021JCI Insight41 citations Open access
Semantic Scholar
Low conservation and species-specific evolution of alternative splicing in humans and mice: comparative genomics analysis using well-annotated full-length cDNAs
Jun-ichi Takeda, Yutaka Suzuki, Ryuichi Sakate, Yoshiharu Sato +8 more
2008Nucleic Acids Research34 citations Open access
Semantic Scholar
Diverse DNA methylation statuses at alternative promoters of human genes in various tissues.
Ji-Sook Cheong, Yoichi Yamada, Riu Yamashita, T. Irie +7 more
2006DNA Research33 citations Open access
Semantic Scholar
Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes.
K. Tsuritani, T. Irie, Riu Yamashita, Y. Sakakibara +6 more
2007Genome Research32 citations Open access
Semantic Scholar
Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer
K. Masuhiro, M. Tamiya, K. Fujimoto, S. Koyama +21 more
2022JCI Insight30 citations Open access
Semantic Scholar
Potentiality of multiple modalities for single-cell analyses to evaluate the tumor microenvironment in clinical specimens
Y. Kashima, Yosuke Togashi, S. Fukuoka, Takahiro Kamada +19 more
2021Scientific Reports23 citations Open access
Semantic Scholar
Atezolizumab following definitive chemoradiotherapy in patients with unresectable locally advanced esophageal squamous cell carcinoma – a multicenter phase 2 trial (EPOC1802)
H. Bando, S. Kumagai, D. Kotani, S. Mishima +25 more
2025Nature Cancer17 citations Open access
Semantic Scholar
Coactivation of innate immune suppressive cells induces acquired resistance against combined TLR agonism and PD-1 blockade.
Hitomi Nishinakamura, Sayoko Shinya, T. Irie, S. Sakihama +10 more
2025Science Translational Medicine14 citations
Semantic Scholar
Predicting promoter activities of primary human DNA sequences
T. Irie, Sung-Joon Park, Riu Yamashita, M. Seki +4 more
2011Nucleic Acids Research10 citations Open access
Semantic Scholar
A phase Ib study of photoimmunotherapy with ASP-1929 in combination with nivolumab for advanced gastric cancer (GE-PIT, EPOC1901)
T. Kadota, Rika Fujii, Shohei Koyama, D. Kotani +13 more
2025Gastric Cancer7 citations
Semantic Scholar
Intrinsic Promoter Activities of Primary DNA Sequences in the Human Genome
Y. Sakakibara, T. Irie, Yutaka Suzuki, Riu Yamashita +8 more
2007DNA Research5 citations Open access
Semantic Scholar
KRAS mutations disrupt interactions between CD8+ T cells and antigen-presenting cells in the tumor microenvironment of biliary tract cancer.
Fumihiro Terasaki, S. Kumagai, Akito Fukuda, Yosuke Tanaka +10 more
2025International Immunology2 citations Open access
Semantic Scholar
Abstract 6686: The mechanism of gut microbiome-mediated immune activation on the clinical efficacy of PD-1 blocking treatment in solid tumors
Nina Yi-Tzu Lin, S. Fukuoka, D. Motooka, Yuko Shigeno +17 more
2024Cancer Research2 citations
Semantic Scholar
Linear regression models predicting strength of transcriptional activity of promoters.
T. Yada, Keigo Yoshida, Masao Morita, Takeaki Taniguchi +2 more
2011Genome informatics. International Conference on Genome Informatics2 citations
Semantic Scholar
Clinical utility of precision immunoprofiling and monitoring of the tumour microenvironment using flow cytometry and CyTOF in patients with advanced NSCLC treated with atezolizumab: Results from a phase II study for biomarker analysis (EPOC1702)
K. Kirita, E. Sugiyama, Yosuke Togashi, H. Udagawa +12 more
2019Annals of Oncology1 citations Open access
Semantic Scholar
A new computational method to predict transcriptional activity of a DNA sequence from diverse datasets of massively parallel reporter assays
Ying Liu, T. Irie, T. Yada, Yutaka Suzuki
2017Nucleic Acids Research1 citations Open access
Semantic Scholar
Multi-omic paired analysis reveals chemotherapy-associated immunosuppressive changes and therapeutic insights in recurrent endometrial carcinoma
Yuki Koike, S. Kumagai, M. Kamii, Suguru Odajima +16 more
2026npj Precision Oncology0 citations Open access
Semantic Scholar
Lenvatinib combined with PD-1 blockade therapy benefits gastric cancers through immunosuppressive macrophage modulation.
Nina Yi-Tzu Lin, H. Machiyama, A. Kawazoe, A. Sai +10 more
2026Cancer immunology research0 citations Open access
Semantic Scholar
Abstract 6134: Identifying the mechanism of acquired resistance against cancer immunotherapy targeting innate immunity
Hitomi Nishinakamura, Sayoko Shinya, T. Irie, S. Sakihama +11 more
2025Cancer Research0 citations
Semantic Scholar
First-line regorafenib with nivolumab and FOLFOX or CapeOX in patients with advanced gastric, gastroesophageal junction, and esophageal adenocarcinoma: A single-arm, phase Ib/II trial (REGONIVOCTx, EPOC2104).
A. Kawazoe, T. Hashimoto, K. Itahashi, T. Irie +13 more
2024Journal of Clinical Oncology0 citations
Semantic Scholar
Abstract 2697: Simultaneous activation of innate immune suppressive components impairs antitumor efficacy of immunotherapy against the innate immune system
Hitomi Nishinakamura, Sayoko Shinya, T. Irie, S. Sakihama +12 more
2024Cancer Research0 citations
Semantic Scholar
PD-1 Blockade Therapy Promotes Novel Infiltration of Tumor-Specific T-Cell Clonotypes
Joji Nagasaki, T. Inozume, Nirolas Sax, R. Ariyasu +20 more
20210 citations Open access
Semantic Scholar
Su116 DISSECTING TRANSCROPTOMIC HETEROGENEITY IN PRIMARY ESOPHAGEAL SQUAMOUS CELL CARCINOMA BY SINGLE-CELL RNA SEQUENCING
T. Minamide, Y. Kashima, T. Irie, Syohei Koyama +19 more
20210 citations
Semantic Scholar
Unexpected central-memory CD8+ T cell reduction hampers the antitumor efficacy of mogamulizumab (anti-CC chemokine receptor 4 mAb) treatment
Y. Maeda, H. Wada, Takuro Saito, D. Sugiyama +15 more
20200 citations Open access
Semantic Scholar
High-throughput analysis for mutant promoter using massively parallel sequencer
T. Irie, Ying Liu, Y. Sakakibara, Taku Monjo +4 more
20160 citations
Semantic Scholar
Analysis of RNA decay factor mediated RNA stability contributions on RNA abundance
Sho Maekawa, Naoto Imamachi, T. Irie, Hidenori Tani +8 more
2015BMC Genomics0 citations Open access
Semantic Scholar

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T. Tanegashima — researcher profile on SciRah