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Yingjie Lai · SciRah

Researcher profile · Semantic Scholar

Yingjie Lai

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Yingjie Lai — researcher profile on SciRah

h-index: 9
Works: 17
Citations: 486

Most-cited papers

Lead identification of novel and selective TYK2 inhibitors.
Jun Liang, V. Tsui, A. V. van Abbema, Liang Bao +28 more
2013European journal of medicinal chemistry118 citations Open access
Semantic Scholar
A Restricted Role for TYK2 Catalytic Activity in Human Cytokine Responses Revealed by Novel TYK2-Selective Inhibitors
S. Sohn, K. Barrett, A. V. van Abbema, Christine Chang +20 more
2013Journal of Immunology117 citations Open access
Semantic Scholar
Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors.
Jun Liang, A. V. van Abbema, M. Balazs, K. Barrett +33 more
2013Journal of Medicinal Chemistry96 citations Open access
Semantic Scholar
The synthesis and structure-activity relationship of substituted N-phenyl anthranilic acid analogs as amyloid aggregation inhibitors.
Lloyd J. Simons, B. Caprathe, M. Callahan, James M. Graham +11 more
2009Bioorganic & Medicinal Chemistry Letters44 citations
Semantic Scholar
Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity.
Shu-Wen He, Zhi-Xiong Ye, Peter H. Dobbelaar, R. Bakshi +23 more
2010Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
Jun Liang, A. V. van Abbema, M. Balazs, K. Barrett +29 more
2017Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist.
Shu-Wen He, Zhi-Xiong Ye, Peter H. Dobbelaar, I. Sebhat +26 more
2010Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity.
Shu-Wen He, Zhi-Xiong Ye, Peter H. Dobbelaar, I. Sebhat +21 more
2010Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
A General Method for the Synthesis of 3-Substituted Tetrahydro- and 2,3-Dihydro-4H-thiopyran-4-ones
D. E. Ward, Yuan-Zhu Gai, Yingjie Lai
199610 citations
Semantic Scholar
Effect of residue substitution via site-directed mutagenesis on activity and steroselectivity of transaminase BpTA from Bacillus pumilus W3 for sitafloxacin hydrate intermediate.
Lixin Zhai, Shaolan Yang, Yingjie Lai, Di Meng +4 more
2019International Journal of Biological Macromolecules8 citations
Semantic Scholar
Mining of aminotransferase gene ota3 from Bacillus pumilus W3 via genome analysis, gene cloning and expressing for compound bioamination.
Lixin Zhai, Shaolan Yang, Yingjie Lai, Di Meng +4 more
2019Gene6 citations
Semantic Scholar
Melanocortin subtype 4 receptor agonists: structure-activity relationships about the 4-alkyl piperidine core.
I. Sebhat, Yingjie Lai, K. Barakat, Zhi-Xiong Ye +12 more
2007Bioorganic & Medicinal Chemistry Letters5 citations Open access
Semantic Scholar
Folate promotes colorectal cancer progression by impairing CD8+ T cell function and recruitment via SLC19A1/p-AKT/NOTCH1 axis and CCL5 downregulation
Shunjie Qing, Yunyan Ling, Yingjie Lai, Yating Hu +9 more
2026Journal of Translational Medicine3 citations Open access
Semantic Scholar
Steric and Electronic Factors Influence Regio‐isomeric Thiazole Formations Between Substituted Benzothioamides and Ethyl Bromopyruvate
Jun Liang, Valerie Dorman Soucy, Vickie Tusi, Yanzhou Liu +10 more
20141 citations
Semantic Scholar
A General Method for the Synthesis of 3‐Substituted Tetrahydro‐ and 2, 3‐Dihydro‐4H‐thiopyran‐4‐ones.
D. E. Ward, Yuan-Zhu Gai, Yingjie Lai
19961 citations
Semantic Scholar
Tyk2 (JH1) in complex with adenosine di-phosphate
Jun Liang, A. V. van Abbema, Liang Bao, K. Barrett +28 more
20130 citations
Semantic Scholar
CCDC 760573: Experimental Crystal Structure Determination
Shu-Wen He, Zhi-Xiong Ye, Peter H. Dobbelaar, I. Sebhat +26 more
20100 citations
Semantic Scholar

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