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V. Gelfanov · SciRah

Researcher profile · Semantic Scholar

V. Gelfanov

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V. Gelfanov — researcher profile on SciRah

h-index: 22
Works: 62
Citations: 4,501

Most-cited papers

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans
B. Finan, Tao Ma, Nickki Ottaway, T. Müller +29 more
2013Science Translational Medicine655 citations
Semantic Scholar
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.
Jonathan W. Day, Nickki Ottaway, James T. Patterson, V. Gelfanov +21 more
2009Nature Chemical Biology616 citations Open access
Semantic Scholar
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
B. Finan, Bin Yang, Nickki Ottaway, D. Smiley +25 more
2014Nature Medicine607 citations Open access
Semantic Scholar
Targeted estrogen delivery reverses the metabolic syndrome
B. Finan, Bin Yang, Nickki Ottaway, K. Stemmer +22 more
2012Nature Medicine313 citations Open access
Semantic Scholar
Paclitaxel sensitivity of breast cancer cells with constitutively active NF-κB is enhanced by IκBα super-repressor and parthenolide
N. Patel, S. Nozaki, N. H. Shortle, P. Bhat-Nakshatri +7 more
2000Oncogene282 citations
Semantic Scholar
Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions
K. Habegger, K. Stemmer, Christine C. Cheng, T. Müller +23 more
2013Diabetes229 citations Open access
Semantic Scholar
Unimolecular Polypharmacy for Treatment of Diabetes and Obesity.
M. Tschöp, B. Finan, Christoffer Clemmensen, V. Gelfanov +3 more
2016Cell Metabolism227 citations Open access
Semantic Scholar
Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism
P. Mroz, B. Finan, V. Gelfanov, Bin Yang +3 more
2018Molecular Metabolism202 citations Open access
Semantic Scholar
Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.
B. Finan, Christoffer Clemmensen, Zhimeng Zhu, K. Stemmer +38 more
2016Cell195 citations Open access
Semantic Scholar
Optimization of co‐agonism at GLP‐1 and glucagon receptors to safely maximize weight reduction in DIO‐rodents
Jonathan W. Day, V. Gelfanov, D. Smiley, P. Carrington +10 more
2012Biopolymers121 citations
Semantic Scholar
Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide.
N. Patel, S. Nozaki, N. H. Shortle, P. Bhat-Nakshatri +7 more
2000Oncogene120 citations
Semantic Scholar
Peptide lipidation stabilizes structure to enhance biological function.
B. Ward, Nickki Ottaway, D. Perez-Tilve, Dejian Ma +3 more
2013Molecular Metabolism89 citations Open access
Semantic Scholar
Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host–microbe interactions
E. Altindis, Weikang Cai, M. Sakaguchi, Fa Zhang +7 more
2018Proceedings of the National Academy of Sciences of the United States of America79 citations Open access
Semantic Scholar
Glucagon regulation of energy metabolism.
K. Heppner, K. Habegger, Jonathan W. Day, P. Pfluger +6 more
2010Physiology and Behavior76 citations
Semantic Scholar
Optimization of the Native Glucagon Sequence for Medicinal Purposes
Joseph R. Chabenne, Maria Dimarchi, V. Gelfanov, R. DiMarchi
2010Journal of Diabetes Science and Technology70 citations Open access
Semantic Scholar
IL-15 Promotes Survival But Not Effector Function Differentiation of CD8+ TCRαβ+ Intestinal Intraepithelial Lymphocytes
Y. Lai, V. Gelfanov, V. Gelfanova, L. Kulik +3 more
1999Journal of Immunology57 citations
Semantic Scholar
A novel human-based receptor antagonist of sustained action reveals body weight control by endogenous GLP-1.
James T. Patterson, Nickki Ottaway, V. Gelfanov, D. Smiley +4 more
2011ACS Chemical Biology53 citations Open access
Semantic Scholar
Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems
Bin-jie Yang, V. Gelfanov, K. El, Alex F. Chen +9 more
2022Molecular Metabolism44 citations Open access
Semantic Scholar
Chemical synthesis of insulin analogs through a novel precursor.
A. Zaykov, J. Mayer, V. Gelfanov, R. DiMarchi
2014ACS Chemical Biology43 citations
Semantic Scholar
A glucagon analog chemically stabilized for immediate treatment of life-threatening hypoglycemia
Joseph R. Chabenne, Maria DiMarchi Chabenne, Yan Zhao, J. Levy +3 more
2014Molecular Metabolism42 citations Open access
Semantic Scholar
Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation.
Fangzhou Wu, J. Mayer, V. Gelfanov, Fa Liu +1 more
2017Journal of Organic Chemistry33 citations Open access
Semantic Scholar
Optimization of peptide-based polyagonists for treatment of diabetes and obesity.
P. Knerr, B. Finan, V. Gelfanov, D. Perez-Tilve +2 more
2017Bioorganic & Medicinal Chemistry23 citations Open access
Semantic Scholar
Differential requirement of CD28 costimulation for activation of murine CD8+ intestinal intraepithelial lymphocyte subsets and lymph node cells.
V. Gelfanov, Yen-Gei Lai, V. Gelfanova, Jien-Yee Dong +2 more
1995Journal of Immunology22 citations
Semantic Scholar
Biomimetic Synthesis of Insulin Enabled by Oxime Ligation and Traceless "C-Peptide" Chemical Excision.
Kishore Thalluri, Bin-Bin Kou, V. Gelfanov, J. Mayer +2 more
2017Organic Letters21 citations
Semantic Scholar
Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist
Francois Moreau, N. S. Kirk, Fa Zhang, V. Gelfanov +10 more
2022Nature Communications20 citations Open access
Semantic Scholar
Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists.
Bin Yang, V. Gelfanov, D. Perez-Tilve, Barent Dubois +6 more
2021Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Pyridyl-alanine as a Hydrophilic, Aromatic Element in Peptide Structural Optimization.
P. Mroz, D. Perez-Tilve, Fa Liu, V. Gelfanov +2 more
2016Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
A viral insulin-like peptide is a natural competitive antagonist of the human IGF-1 receptor
Fa Zhang, E. Altindis, C. Kahn, R. DiMarchi +1 more
2021Molecular Metabolism16 citations Open access
Semantic Scholar
Efficacy of glucagon-like peptide-1 and estrogen dual agonist in pancreatic islets protection and pre-clinical models of insulin-deficient diabetes
Taylor T. Fuselier, Paula Mota de Sá, Fahd Qadir, Beibei Xu +8 more
2022Cell Reports Medicine15 citations Open access
Semantic Scholar
Synthetic Advances in Insulin-like Peptides Enable Novel Bioactivity.
Fa Liu, Peng-Yun Li, V. Gelfanov, J. Mayer +1 more
2017Accounts of Chemical Research15 citations
Semantic Scholar
Synthetic Route to Human Relaxin-2 via Iodine-Free Sequential Disulfide Bond Formation.
Xu Yang, V. Gelfanov, Fa Liu, R. DiMarchi
2016Organic Letters15 citations
Semantic Scholar
Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence.
Daniel E K Kabotso, D. Smiley, J. Mayer, V. Gelfanov +4 more
2020Journal of Medicinal Chemistry14 citations
Semantic Scholar
Insulin-like Peptide 5 Fails to Improve Metabolism or Body Weight in Obese Mice.
A. Zaykov, V. Gelfanov, D. Perez-Tilve, B. Finan +1 more
2019Peptides14 citations
Semantic Scholar
Synthesis of relaxin‐2 and insulin‐like peptide 5 enabled by novel tethering and traceless chemical excision
Kishore Thalluri, Bin-Bin Kou, Xu Yang, A. Zaykov +4 more
2017Journal of Peptide Science14 citations
Semantic Scholar
A hydrophobic site on the GLP-1 receptor extracellular domain orients the peptide ligand for signal transduction.
James T. Patterson, Peng-Yun Li, Jonathan W. Day, V. Gelfanov +1 more
2013Molecular Metabolism14 citations Open access
Semantic Scholar
A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression
Martina Chrudinová, N. S. Kirk, A. Chuard, Hari Venugopal +10 more
2024Molecular Metabolism13 citations Open access
Semantic Scholar
The islet-expressed Lhx1 transcription factor interacts with Islet-1 and contributes to glucose homeostasis.
M. Bethea, Yan-Ping Liu, Alexa K. Wade, R. Mullen +7 more
2019American Journal of Physiology. Endocrinology and Metabolism12 citations Open access
Semantic Scholar
A disulfide-scan of insulin by [3+1] methodology exhibits site-specific influence on bioactivity.
F. Brunel, J. Mayer, V. Gelfanov, A. Zaykov +3 more
2019ACS Chemical Biology10 citations
Semantic Scholar
Synthesis of disulfide-rich heterodimeric peptides through an auxiliary N, N-crosslink
Kishore Thalluri, J. Mayer, Joseph R. Chabenne, V. Gelfanov +1 more
2018Communications Chemistry10 citations Open access
Semantic Scholar
Controlled intramolecular antagonism as a regulator of insulin receptor maximal activity
S. Brandt, J. Mayer, James Ford, V. Gelfanov +1 more
2018Peptides10 citations
Semantic Scholar
IL-15 promotes survival but not effector function differentiation of CD8+ TCRalphabeta+ intestinal intraepithelial lymphocytes.
Y. Lai, V. Gelfanov, V. Gelfanova, L. Kulik +3 more
1999Journal of Immunology10 citations
Semantic Scholar
Distinct actions of interleukin-9 and interleukin-4 on a hematopoietic stem cell line, EMLC1.
X. Wang, V. Gelfanov, H. B. Sun, S. Tsai +1 more
1999Experimental Hematology9 citations Open access
Semantic Scholar
High-Yield Synthesis of Human Insulin-Like Peptide 5 Employing a Nonconventional Strategy.
A. Zaykov, V. Gelfanov, Fa Liu, R. DiMarchi
2018Organic Letters8 citations
Semantic Scholar
Efficacy of a Glucagon-Like Peptide-1 and Estrogen Dual Agonist in Pancreatic Islets Protection and Pre-Clinical Models of Insulin-Deficient Diabetes
Taylor T. Fuselier, Paula Mota de Sa, Fahd Qadir, Beibei Xu +7 more
2022Social Science Research Network7 citations
Semantic Scholar
Discovery of high potency, single-chain insulin analogs with a shortened B-chain and nonpeptide linker.
Zach Kaur, Alexander R. Ochman, J. Mayer, V. Gelfanov +1 more
2013ACS Chemical Biology5 citations
Semantic Scholar
Synthesis and Characterization of the R27S Genetic Variant of Insulin‐like Peptide 5
A. Zaykov, V. Gelfanov, Fa Liu, R. DiMarchi
2018ChemMedChem4 citations
Semantic Scholar
Toward once-monthly insulin therapy via synergy in two pharmacokinetic protractors: Fc-conjugation and fatty acid acylation
Alexander N. Zaykov, V. Gelfanov, T. Tagmose, Damien Demozay +6 more
2024RSC Chemical Biology3 citations Open access
Semantic Scholar
Discovery and Structural Optimization of High Affinity Co- Agonists at the Glucagon and GLP-1 Receptors
V. Gelfanov, D. Smiley, Wesleyne Whittaker, R. DiMarchi
20063 citations
Semantic Scholar
New virus-specific T-helper epitopes of foot-and-mouth disease viral VP1 protein.
O. Volpina, V. Gelfanov, A. V. Yarov, Surovoy AYu +2 more
1993FEBS Letters3 citations Open access
Semantic Scholar
Max Bergmann award lecture:Macromolecular medicinal chemistry as applied to metabolic diseases
R. DiMarchi, J. Mayer, V. Gelfanov, M. Tschöp
2018Journal of Peptide Science2 citations
Semantic Scholar

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D. Perez-Tilve×19
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M. Tschöp×14
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J. Mayer×13
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