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P. Knerr · SciRah

Researcher profile · Semantic Scholar

P. Knerr

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P. Knerr — researcher profile on SciRah

h-index: 22
Works: 48
Citations: 2,223

Most-cited papers

Discovery, biosynthesis, and engineering of lantipeptides.
P. Knerr, W. A. van der Donk
2012Annual Review of Biochemistry313 citations
Semantic Scholar
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling
Qian Zhang, Challa Tenagne Delessa, R. Augustin, Mostafa Bakhti +32 more
2021Cell Metabolism276 citations Open access
Semantic Scholar
Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria
Bo Li, D. Sher, Libusha Kelly, Yanxiang Shi +6 more
2010Proceedings of the National Academy of Sciences of the United States of America263 citations Open access
Semantic Scholar
Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice
P. Knerr, Stephanie A. Mowery, J. Douros, B. Premdjee +7 more
2022Molecular Metabolism131 citations Open access
Semantic Scholar
Zinc-Triggered Hydrogelation of a Self-Assembling β-Hairpin Peptide
Christopher M. Micklitsch, P. Knerr, M. Branco, Radhika P. Nagarkar +2 more
2011Angewandte Chemie125 citations Open access
Semantic Scholar
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice
A. Liśkiewicz, Ahmed Khalil, D. Liśkiewicz, Aaron Novikoff +27 more
2023Nature Metabolism98 citations Open access
Semantic Scholar
In Vitro Mutasynthesis of Lantibiotic Analogues Containing Nonproteinogenic Amino Acids
M. Levengood, P. Knerr, Trent J. Oman, W. A. van der Donk
2009Journal of the American Chemical Society95 citations Open access
Semantic Scholar
Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists
Aaron Novikoff, S. O’Brien, Miriam Bernecker, Gerald Grandl +10 more
2021Molecular Metabolism87 citations Open access
Semantic Scholar
An Engineered Lantibiotic Synthetase That Does Not Require a Leader Peptide on Its Substrate
Trent J. Oman, P. Knerr, Noah A. Bindman, J. E. Velásquez +1 more
2012Journal of the American Chemical Society87 citations Open access
Semantic Scholar
Glucose-dependent insulinotropic polypeptide (GIP)
T. Müller, Alice E. Adriaenssens, Ah-Ren Bo, M. Blüher +35 more
2025Molecular Metabolism71 citations Open access
Semantic Scholar
Synthesis and Activity of Thioether-Containing Analogues of the Complement Inhibitor Compstatin
P. Knerr, Apostolia Tzekou, D. Ricklin, Hongchang Qu +3 more
2011ACS Chemical Biology70 citations Open access
Semantic Scholar
Heavy metal ion hydrogelation of a self-assembling peptideviacysteinyl chelation
P. Knerr, M. Branco, Radhika P. Nagarkar, D. Pochan +1 more
201263 citations
Semantic Scholar
Chemical Synthesis and Biological Activity of Analogues of the Lantibiotic Epilancin 15X
P. Knerr, W. A. van der Donk
2012Journal of the American Chemical Society62 citations Open access
Semantic Scholar
Chemical Synthesis of the Lantibiotic Lacticin 481 Reveals the Importance of Lanthionine Stereochemistry
P. Knerr, W. A. van der Donk
2013Journal of the American Chemical Society57 citations Open access
Semantic Scholar
GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice
Robert M. Gutgesell, Ahmed Khalil, A. Liśkiewicz, Gandhari Maity-Kumar +20 more
2025Nature Metabolism50 citations Open access
Semantic Scholar
Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes
Hüsün S. Kizilkaya, K. V. Sørensen, J. Madsen, Peter Lindquist +31 more
2024Nature Metabolism44 citations Open access
Semantic Scholar
Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems
Bin-jie Yang, V. Gelfanov, K. El, Alex F. Chen +9 more
2022Molecular Metabolism44 citations Open access
Semantic Scholar
GLP-1 and GIP agonism has no direct actions in human hepatocytes or hepatic stellate cells
N. da Silva Lima, A. Cabaleiro, Eva Novoa, C. Riobello +12 more
2024Cellular and Molecular Life Sciences41 citations Open access
Semantic Scholar
GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice
C. Quarta, K. Stemmer, Aaron Novikoff, Bin Yang +36 more
2022Nature Metabolism40 citations Open access
Semantic Scholar
Selection and progression of unimolecular agonists at the GIP, GLP-1, and glucagon receptors as drug candidates.
P. Knerr, Stephanie A. Mowery, B. Finan, D. Perez-Tilve +2 more
2019Peptides39 citations
Semantic Scholar
Non-proteinogenic Amino Acids in Lacticin 481 Analogues Result in More Potent Inhibition of Peptidoglycan Transglycosylation
P. Knerr, Trent J. Oman, Chantal V. Garcia De Gonzalo, Tania J. Lupoli +2 more
2012ACS Chemical Biology35 citations Open access
Semantic Scholar
Optimization of peptide-based polyagonists for treatment of diabetes and obesity.
P. Knerr, B. Finan, V. Gelfanov, D. Perez-Tilve +2 more
2017Bioorganic & Medicinal Chemistry23 citations Open access
Semantic Scholar
A GLP-1 analogue optimized for cAMP-biased signaling improves weight loss in obese mice
J. Douros, Aaron Novikoff, B. Dubois, Rebecca Rohlfs +18 more
2025Molecular Metabolism21 citations Open access
Semantic Scholar
A once-daily GLP-1/GIP/glucagon receptor tri-agonist (NN1706) lowers body weight in rodents, monkeys and humans
B. Finan, J. Douros, R. Goldwater, Ann Maria Kruse Hansen +14 more
2025Molecular Metabolism17 citations Open access
Semantic Scholar
The agony and the efficacy: central mechanisms of GLP-1 induced adverse events and their mitigation by GIP
J. Douros, Jonathan N. Flak, P. Knerr
2025Frontiers in Endocrinology14 citations
Semantic Scholar
Conjugation to Albumin-Binding Molecule Tags as a Strategy to Improve Both Efficacy and Pharmacokinetic Properties of the Complement Inhibitor Compstatin
Yijun Huang, E. Reis, P. Knerr, W. A. van der Donk +2 more
2014ChemMedChem13 citations Open access
Semantic Scholar
The Premise of the Paradox: Examining the Evidence That Motivated GIPR Agonist and Antagonist Drug Development Programs
J. Douros, Stephanie A. Mowery, P. Knerr
2025Journal of Clinical Medicine11 citations
Semantic Scholar
GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice
D. Liśkiewicz, Aaron Novikoff, Ahmed Khalil, Seun Akindehin +49 more
2026Nature10 citations Open access
Semantic Scholar
Acute exogenous acyl-GIP treatment enhances lipid handling and fatty acid oxidation by involving brown fat
S. A. Lyons, Micah B S Lea, Mihir Parikh, Zhengzhang Guo +15 more
2025EMBO Reports9 citations Open access
Semantic Scholar
Estrogenic activity of E2-conjugated GLP-1 is mediated by intracellular endolysosomal acidification and estrone metabolism
Callum Coupland, N. Sun, Ahmed Khalil, Özüm Ezgi Karaoğlu +14 more
2025Molecular Metabolism4 citations Open access
Semantic Scholar
Zinc-triggered hydrogelation of designed {beta}-hairpin peptides
P. Knerr, Christopher M. Micklitsch, C. Thorpe, J. Schneider
20073 citations
Semantic Scholar
Distinct brain regions mediate regulation of food intake in response to GIPR agonism or antagonism
Jo Edward Lewis, Mireia Montaner, Danaé Nuzzaci, Paula-Peace James-Okoro +7 more
2026Nature Metabolism2 citations Open access
Semantic Scholar
Improving Incretin-Mediated Body Weight Loss via Energy Expenditure
Andrew J. Elmendorf, J. Douros, P. Knerr, Jon N. Flak
2026Trends in endocrinology and metabolism2 citations Open access
Semantic Scholar
GCGR agonism requires GABAergic signaling in the medial basal hypothalamus to promote weight loss in obese mice
Andrew J. Elmendorf, E. C. Furber, Betty Lorentz, Connor A. Mahler +6 more
2026Molecular Metabolism1 citations Open access
Semantic Scholar
Ectopic, hepatic GLP-1R agonism enhances the weight loss efficacy of GLP-1 analogues
J. Douros, M. Capozzi, Aaron Novikoff, Jacek Mokrosiński +21 more
2025bioRxiv1 citations Open access
Semantic Scholar
Experimental colonization with H. hepaticus, S. aureus and R. pneumotropicus does not influence the metabolic response to high-fat diet or incretin-analogues in wildtype SOPF mice
Margit Wunderlich, Manuel Miller, Bärbel Ritter, Ronan Le Gleut +6 more
2024Molecular Metabolism1 citations Open access
Semantic Scholar
The Glucose-Dependent Insulinotropic Polypeptide (GIP) Regulates Body Weight and Food Intake Via CNS-GIPR Signaling
Qian Zhang, Challa Tenagne Delessa, Robert Augustin, Mostafa Bakhti +28 more
2020Social Science Research Network1 citations Open access
Semantic Scholar
The Importance of Ethical Conduct in Scientific Researchf
L. Doemeny, P. Knerr
20171 citations
Semantic Scholar
2839-LB: A Long-Acting Quintuple Agonist for the GLP-1, GIP, Glucagon, Amylin, and Calcitonin Receptors Induces Greater Weight Loss than Retatrutide in Obese Rats
J. Douros, Stephanie A. Mowery, Michael A. Kalwat, Scott Dodson +2 more
2026Diabetes0 citations
Semantic Scholar
Publisher Correction: GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice
D. Liśkiewicz, Aaron Novikoff, Ahmed Khalil, Seun Akindehin +49 more
2026Nature0 citations Open access
Semantic Scholar
1684-P: A GLP-1 Analogue Optimized for cAMP-Biased Signaling Improves Weight Loss in Obese Mice
J. Douros, Diego Perez-Tilve, Megan Capozzi, B. Dubois +6 more
2025Diabetes0 citations
Semantic Scholar
Publisher Correction: GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice
Robert M. Gutgesell, Ahmed Khalil, A. Liśkiewicz, Gandhari Maity-Kumar +20 more
2025Nature Metabolism0 citations Open access
Semantic Scholar
1685-P: Ectopic Hepatic GLP-1R Agonism Enhances the Weight Loss Efficacy of GLP-1 Analogues
J. Douros, Megan Capozzi, Jacek Mokrosiński, B. Dubois +9 more
2025Diabetes0 citations
Semantic Scholar
Case of a Day Early and Grade Short
P. Knerr
20160 citations
Semantic Scholar
Cover Picture: Conjugation to Albumin‐Binding Molecule Tags as a Strategy to Improve Both Efficacy and Pharmacokinetic Properties of the Complement Inhibitor Compstatin (ChemMedChem 10/2014)
Yijun Huang, E. Reis, P. Knerr, W. Donk +2 more
20140 citations Open access
Semantic Scholar
Chemical and chemoenzymatic syntheses of lantibiotics and other bioactive cyclic peptides
P. Knerr
20130 citations
Semantic Scholar
Metal‐triggered hydrogelation of self‐assembling β‐hairpin peptides for bioremediation
P. Knerr, Radhika P. Nagarkar, J. Schneider
20080 citations
Semantic Scholar
Zinc‐triggered hydrogelation of designed β‐hairpin peptides
P. Knerr, Christopher M. Micklitsch, C. Thorpe, J. Schneider
0 citations
Semantic Scholar

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J. Douros×24
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B. Finan×19
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T. Müller×16
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Stephanie A. Mowery×15
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D. Perez-Tilve×11

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Aaron Novikoff×11

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Gerald Grandl×10

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W. A. van der Donk×9

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A. Liśkiewicz×8

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