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G. Moiseyev · SciRah

Researcher profile · Semantic Scholar

G. Moiseyev

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G. Moiseyev — researcher profile on SciRah

h-index: 28
Works: 111
Citations: 3,190

Most-cited papers

RPE65 is the isomerohydrolase in the retinoid visual cycle.
G. Moiseyev, Ying Chen, Y. Takahashi, Bill X. Wu +1 more
2005Proceedings of the National Academy of Sciences of the United States of America555 citations Open access
Semantic Scholar
RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development.
L. L. Sandell, Brian W. Sanderson, G. Moiseyev, Teri Johnson +6 more
2007Genes & Development352 citations Open access
Semantic Scholar
Retinol-Binding Protein 4 Induces Inflammation in Human Endothelial Cells by an NADPH Oxidase- and Nuclear Factor Kappa B-Dependent and Retinol-Independent Mechanism
K. Farjo, R. Farjo, Stacey Halsey, G. Moiseyev +1 more
2012Molecular and Cellular Biology147 citations Open access
Semantic Scholar
RPE65 Is an Iron(II)-dependent Isomerohydrolase in the Retinoid Visual Cycle*
G. Moiseyev, Y. Takahashi, Ying Chen, S. Gentleman +3 more
2006Journal of Biological Chemistry130 citations Open access
Semantic Scholar
A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis.
N. Dobri, Qiong Qin, J. Kong, Kazunori Yamamoto +6 more
2013Investigative Ophthalmology and Visual Science97 citations Open access
Semantic Scholar
RPE65 gene delivery restores isomerohydrolase activity and prevents early cone loss in Rpe65-/- mice.
Ying Chen, G. Moiseyev, Y. Takahashi, Jian-Xing Ma
2006Investigative Ophthalmology and Visual Science81 citations
Semantic Scholar
RDH10 is the Primary Enzyme Responsible for the First Step of Embryonic Vitamin A Metabolism and Retinoic Acid Synthesis
K. Farjo, G. Moiseyev, O. Nikolaeva, L. L. Sandell +2 more
2011Developmental Biology76 citations Open access
Semantic Scholar
Light induces programmed cell death by activating multiple independent proteases in a cone photoreceptor cell line.
Y. Kanan, G. Moiseyev, N. Agarwal, Jian-Xing Ma +1 more
2007Investigative Ophthalmology and Visual Science75 citations Open access
Semantic Scholar
The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins.
K. Farjo, G. Moiseyev, Y. Takahashi, R. Crouch +1 more
2009Investigative Ophthalmology and Visual Science63 citations
Semantic Scholar
Identification of conserved histidines and glutamic acid as key residues for isomerohydrolase activity of RPE65, an enzyme of the visual cycle in the retinal pigment epithelium
Y. Takahashi, G. Moiseyev, Ying Chen, Jian-Xing Ma
2005FEBS Letters57 citations Open access
Semantic Scholar
Photoreceptor Degeneration and Retinal Inflammation Induced by Very Low-density Lipoprotein Receptor Deficiency
Ying Chen, Yang Hu, G. Moiseyev, Kevin K. Zhou +2 more
2009Microvascular Research56 citations Open access
Semantic Scholar
α-Phenyl-N-tert-butylnitrone (PBN) Prevents Light-induced Degeneration of the Retina by Inhibiting RPE65 Protein Isomerohydrolase Activity*
M. A. Mandal, G. Moiseyev, Michael H. Elliott, A. Kasus‐Jacobi +7 more
2011Journal of Biological Chemistry53 citations Open access
Semantic Scholar
Inhibition of the visual cycle by A2E through direct interaction with RPE65 and implications in Stargardt disease
G. Moiseyev, O. Nikolaeva, Ying Chen, K. Farjo +2 more
2010Proceedings of the National Academy of Sciences of the United States of America49 citations Open access
Semantic Scholar
Impaired Rhodopsin Generation in the Rat Model of Diabetic Retinopathy
Volha V. Malechka, G. Moiseyev, Y. Takahashi, Younghwa Shin +1 more
2017American Journal of Pathology43 citations Open access
Semantic Scholar
Purified RPE65 shows isomerohydrolase activity after re-association with a phospholipid membrane
O. Nikolaeva, Y. Takahashi, G. Moiseyev, Jian-Xing Ma
2009The FEBS Journal41 citations Open access
Semantic Scholar
Leukemia Inhibitory Factor Coordinates the Down-regulation of the Visual Cycle in the Retina and Retinal-pigmented Epithelium*
A. J. Chucair-Elliott, Michael H. Elliott, Jiangang Wang, G. Moiseyev +6 more
2012Journal of Biological Chemistry40 citations Open access
Semantic Scholar
Two Point Mutations of RPE65 from Patients with Retinal Dystrophies Decrease the Stability of RPE65 Protein and Abolish Its Isomerohydrolase Activity*
Y. Takahashi, Ying Chen, G. Moiseyev, Jian-Xing Ma
2006Journal of Biological Chemistry39 citations Open access
Semantic Scholar
Identification of a Novel Palmitylation Site Essential for Membrane Association and Isomerohydrolase Activity of RPE65*
Y. Takahashi, G. Moiseyev, Z. Ablonczy, Ying Chen +2 more
2009Journal of Biological Chemistry35 citations Open access
Semantic Scholar
Impacts of two point mutations of RPE65 from Leber's congenital amaurosis on the stability, subcellular localization and isomerohydrolase activity of RPE65
Ying Chen, G. Moiseyev, Y. Takahashi, Jian-Xing Ma
2006FEBS Letters35 citations
Semantic Scholar
Pigment epithelium-derived factor, a non-inhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway
Xuemin He, R. Cheng, Kyoungmin Park, S. Benyajati +7 more
2016Kidney International33 citations Open access
Semantic Scholar
Transgenic Mice Overexpressing Serum Retinol-Binding Protein Develop Progressive Retinal Degeneration through a Retinoid-Independent Mechanism
M. Du, Laura Otalora, Ashley Martin, G. Moiseyev +6 more
2015Molecular and Cellular Biology32 citations Open access
Semantic Scholar
Retinoid processing in cone and Müller cell lines.
Y. Kanan, A. Kasus‐Jacobi, G. Moiseyev, Kjell Sawyer +2 more
2008Experimental Eye Research28 citations Open access
Semantic Scholar
An Alternative Isomerohydrolase in the Retinal Müller Cells of a Cone-Dominant Species
Y. Takahashi, G. Moiseyev, Ying Chen, O. Nikolaeva +1 more
2011The FEBS Journal27 citations Open access
Semantic Scholar
A Dominant Mutation in Rpe65, D477G, Delays Dark Adaptation and Disturbs the Visual Cycle in the Mutant Knock-In Mice.
Younghwa Shin, G. Moiseyev, D. Chakraborty, Jian-Xing Ma
2017American Journal of Pathology26 citations Open access
Semantic Scholar
A Novel RPE65 Inhibitor CU239 Suppresses Visual Cycle and Prevents Retinal Degeneration
Younghwa Shin, G. Moiseyev, K. Petrukhin, C. Cioffi +3 more
2018Biochimica et Biophysica Acta - Molecular Basis of Disease24 citations Open access
Semantic Scholar
Identification of Active Retinaldehyde Dehydrogenase Isoforms in the Postnatal Human Eye
Angelica R. Harper, A. Wiechmann, G. Moiseyev, Jian-Xing Ma +1 more
2015PLoS ONE24 citations Open access
Semantic Scholar
Interphotoreceptor Retinol-Binding Protein Ameliorates Diabetes-Induced Retinal Dysfunction and Neurodegeneration Through Rhodopsin
Ada Admin, Jianglei Chen, Y. Shao, Temmy Sasore +5 more
2020Diabetes23 citations Open access
Semantic Scholar
RPE65 from Cone-dominant Chicken Is a More Efficient Isomerohydrolase Compared with That from Rod-dominant Species*
G. Moiseyev, Y. Takahashi, Ying Chen, Seoyoung Kim +1 more
2008Journal of Biological Chemistry23 citations Open access
Semantic Scholar
Characterization of Key Residues and Membrane Association Domains in RDH10
Y. Takahashi, G. Moiseyev, K. Farjo, Jian-Xing Ma
2009Biochemical Journal21 citations Open access
Semantic Scholar
PNPLA2 mobilizes retinyl esters from retinosomes and promotes the generation of 11-cis-retinal in the visual cycle
Miwa Hara, Wenjing Wu, Volha V. Malechka, Y. Takahashi +2 more
2023Cell Reports19 citations Open access
Semantic Scholar
The roles of three palmitoylation sites of RPE65 in its membrane association and isomerohydrolase activity.
Y. Takahashi, G. Moiseyev, Ying Chen, Jian-Xing Ma
2006Investigative Ophthalmology and Visual Science19 citations Open access
Semantic Scholar
Postnatal Chick Choroids Exhibit Increased Retinaldehyde Dehydrogenase Activity During Recovery From Form Deprivation Induced Myopia
Angelica R. Harper, Xiang Wang, G. Moiseyev, Jian-Xing Ma +1 more
2016Investigative Ophthalmology and Visual Science18 citations Open access
Semantic Scholar
Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration
M. Du, Eric D. Phelps, Michael J. Balangue, Aaron J Dockins +7 more
2017Investigative Ophthalmology and Visual Science16 citations Open access
Semantic Scholar
Negative charge of the glutamic acid 417 residue is crucial for isomerohydrolase activity of RPE65
O. Nikolaeva, Y. Takahashi, G. Moiseyev, Jian-Xing Ma
2009Biochemical and Biophysical Research Communications - BBRC15 citations Open access
Semantic Scholar
An Enzymatic Mechanism for Generating the Precursor of Endogenous 13-cis Retinoic Acid in the Brain
Y. Takahashi, G. Moiseyev, Ying Chen, K. Farjo +2 more
2011The FEBS Journal14 citations Open access
Semantic Scholar
Binding to lipid membrane induces conformational changes in RPE65: implications for its isomerohydrolase activity.
O. Nikolaeva, G. Moiseyev, K. Rodgers, Jian-Xing Ma
2011Biochemical Journal14 citations
Semantic Scholar
Comparison of ocular pathologies in vitamin A-deficient mice and RPE65 gene knockout mice.
Yang Hu, Ying Chen, G. Moiseyev, Y. Takahashi +2 more
2011Investigative Ophthalmology and Visual Science14 citations Open access
Semantic Scholar
Identification of the key residues determining the product specificity of isomerohydrolase
Y. Takahashi, G. Moiseyev, O. Nikolaeva, Jian-Xing Ma
2012Biochemistry13 citations Open access
Semantic Scholar
The interplay of environmental luminance and genetics in the retinal dystrophy induced by the dominant RPE65 mutation
Wenjing Wu, Y. Takahashi, H. Shin, Xiang Ma +2 more
2022Proceedings of the National Academy of Sciences of the United States of America11 citations Open access
Semantic Scholar
The novel visual cycle inhibitor (±)-RPE65-61 protects retinal photoreceptors from light-induced degeneration
Yuhong Wang, Xiang Ma, Parthasarathy Muthuraman, Arun Raja +5 more
2022PLoS ONE11 citations Open access
Semantic Scholar
PBN (Phenyl-N-Tert-Butylnitrone)-Derivatives Are Effective in Slowing the Visual Cycle and Rhodopsin Regeneration and in Protecting the Retina from Light-Induced Damage
Megan A. Stiles, G. Moiseyev, Madeline L. Budda, Annette Linens +8 more
2015PLoS ONE11 citations Open access
Semantic Scholar
Identification of Key Residues Determining Isomerohydrolase Activity of Human RPE65*
Y. Takahashi, G. Moiseyev, Jian-Xing Ma
2014Journal of Biological Chemistry8 citations Open access
Semantic Scholar
A Method for Real-Time Assessment of Mitochondrial Respiration Using Murine Corneal Biopsy
Wentao Liang, Li Huang, Tian Yuan, R. Cheng +4 more
2023Investigative Ophthalmology and Visual Science7 citations Open access
Semantic Scholar
The Single Administration of a Chromophore Alleviates Neural Defects in Diabetic Retinopathy.
Volha V. Malechka, Jianglei Chen, R. Cheng, Jian-Xing Ma +1 more
2020American Journal of Pathology7 citations Open access
Semantic Scholar
Telomerase-active urine-derived stem cells: Regenerative solutions for aging
Xi Cheng, Qiao-Yu Fu, Yun-Ling Zheng, G. Moiseyev +5 more
2025Ageing Research Reviews3 citations Open access
Semantic Scholar
Environmental Light Has an Essential Effect on the Disease Expression in a Dominant RPE65 Mutation.
Wenjing Wu, Y. Takahashi, Xiang Ma, G. Moiseyev +1 more
2023Advances in Experimental Medicine and Biology1 citations
Semantic Scholar
Fenofibrate is a competitive inhibitor of the RPE65 isomerase
G. Moiseyev, Younghwa Shin, Y. Takahashi, Jian-Xing Ma
20161 citations
Semantic Scholar
Iron Is Required for the Isomerohydrolase Activity in the Visual Cycle
G. Moiseyev, Ying Chen, R. Crouch, J.-X. Ma
20051 citations
Semantic Scholar
Retbindin Dynamically Redistributes to Preserve Retinal Flavin‐Dependent Homeostasis in Response to Riboflavin Availability and Circadian Demand
Xue Zhao, Mustafa S. Makia, G. Moiseyev, M. Naash +1 more
2026The FASEB Journal0 citations Open access
Semantic Scholar
Interdependent roles of PKM2 in photoreceptors and RPE: implications for retinal degeneration
A. Rajala, Rahul Rajala, Larissa J. Trevino, Tyler M. Black +3 more
2026Cell Death and Disease0 citations Open access
Semantic Scholar

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