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F. Urano · SciRah

Researcher profile · Semantic Scholar

F. Urano

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F. Urano — researcher profile on SciRah

h-index: 55
Works: 159
Citations: 20K

Most-cited papers

Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome
C. M. Oslowski, T. Hara, B. O'Sullivan-Murphy, Kohsuke Kanekura +10 more
2012Cell Metabolism674 citations Open access
Semantic Scholar
Wolfram Syndrome: Diagnosis, Management, and Treatment
F. Urano
2016Current Diabetes Reports283 citations Open access
Semantic Scholar
Program in Gene Function and Expression Publications and Presentations Program in Gene Function and Expression 1-1-2010 Transcriptional regulation of VEGF-A by the unfolded protein response pathway
Rajarshi Ghosh, K. Lipson, K. Sargent, A. Mercurio +3 more
2014192 citations
Semantic Scholar
Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway
Haiyan Liu, A. Javaheri, Rebecca J. Godar, John T. Murphy +11 more
2017Autophagy175 citations Open access
Semantic Scholar
Gene-edited human stem cell-derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice
Kristina G. Maxwell, Punn Augsornworawat, Leonardo Velazco-Cruz, Michelle H. Kim +5 more
2020Science Translational Medicine173 citations Open access
Semantic Scholar
FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress
R. R. K. Sama, C. Ward, Laura J. Kaushansky, Nathan Lemay +3 more
2013Journal of Cellular Physiology168 citations Open access
Semantic Scholar
Poly-dipeptides encoded by the C9ORF72 repeats block global protein translation.
Kohsuke Kanekura, T. Yagi, Alexander J Cammack, Jana Mahadevan +4 more
2016Human Molecular Genetics159 citations Open access
Semantic Scholar
A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome
Si-Min Lu, Kohsuke Kanekura, T. Hara, Jana Mahadevan +14 more
2014Proceedings of the National Academy of Sciences of the United States of America154 citations Open access
Semantic Scholar
Calcium efflux from the endoplasmic reticulum leads to β-cell death.
T. Hara, Jana Mahadevan, Kohsuke Kanekura, M. Hara +2 more
2014Endocrinology154 citations Open access
Semantic Scholar
Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation
L. Bonnycastle, P. Chines, T. Hara, J. Huyghe +14 more
2013Diabetes118 citations Open access
Semantic Scholar
The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma
D. Dadey, Vaishali Kapoor, Arpine Khudanyan, F. Urano +3 more
2015OncoTarget106 citations Open access
Semantic Scholar
Dominant ER Stress–Inducing WFS1 Mutations Underlie a Genetic Syndrome of Neonatal/Infancy-Onset Diabetes, Congenital Sensorineural Deafness, and Congenital Cataracts
E. De Franco, S. Flanagan, T. Yagi, Damien Abreu +12 more
2017Diabetes96 citations Open access
Semantic Scholar
Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells
Anthony N. Vomund, Bernd H. Zinselmeyer, Jing W. Hughes, B. Calderon +7 more
2015Proceedings of the National Academy of Sciences of the United States of America93 citations Open access
Semantic Scholar
Primary cilia control glucose homeostasis via islet paracrine interactions
Jing W. Hughes, Hoon-Cho Jung, H. Conway, M. Digruccio +5 more
2020Proceedings of the National Academy of Sciences of the United States of America90 citations Open access
Semantic Scholar
Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes
Beibei Xu, Camille Allard, Ana I. Alvarez-Mercado, Taylor T. Fuselier +9 more
2018Cell Reports82 citations Open access
Semantic Scholar
Rpl13a small nucleolar RNAs regulate systemic glucose metabolism.
Jiyeon Lee, Alexis N. Harris, C. Holley, Jana Mahadevan +12 more
2016Journal of Clinical Investigation81 citations Open access
Semantic Scholar
Blocking CHOP-dependent TXNIP shuttling to mitochondria attenuates albuminuria and mitigates kidney injury in nephrotic syndrome
Sun-Ji Park, Yeawon Kim, Chuang Li, Junwoo Suh +7 more
2022Proceedings of the National Academy of Sciences of the United States of America67 citations Open access
Semantic Scholar
Neuroplastin Modulates Anti-inflammatory Effects of MANF
T. Yagi, Rie Asada, Kohsuke Kanekura, Ave Eesmaa +3 more
2020iScience66 citations Open access
Semantic Scholar
Endoplasmic Reticulum Stress In Beta Cells and Autoimmune Diabetes
A. Clark, F. Urano
2016Current Opinion in Immunology64 citations Open access
Semantic Scholar
Palmitoylation couples insulin hypersecretion with β-cell failure in diabetes
Gui-Mei Dong, Sangeeta Adak, Georges Spyropoulos, Qiang Zhang +14 more
2023Cell Metabolism58 citations Open access
Semantic Scholar
Discovery of endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome
Sun-Ji Park, Yeawon Kim, Shyh-Ming Yang, M. Henderson +4 more
2019Proceedings of the National Academy of Sciences of the United States of America58 citations Open access
Semantic Scholar
Mesencephalic Astrocyte-Derived Neurotrophic Factor as a Urine Biomarker for Endoplasmic Reticulum Stress-Related Kidney Diseases.
Yeawon Kim, Heedoo Lee, Scott R. Manson, Maria Lindahl +4 more
2016Journal of the American Society of Nephrology54 citations Open access
Semantic Scholar
Monogenic diabetes syndromes: Locus‐specific databases for Alström, Wolfram, and Thiamine‐responsive megaloblastic anemia
D. Astuti, A. Sabir, P. Fulton, M. Zatyka +30 more
2017Human Mutation53 citations Open access
Semantic Scholar
c-Abl Inhibition Delays Motor Neuron Degeneration in the G93A Mouse, an Animal Model of Amyotrophic Lateral Sclerosis
R. Katsumata, Shinsuke Ishigaki, M. Katsuno, Kaori Kawai +6 more
2012PLoS ONE49 citations Open access
Semantic Scholar
Current landscape of treatments for Wolfram syndrome
Damien Abreu, F. Urano
2019TIPS - Trends in Pharmacological Sciences48 citations Open access
Semantic Scholar
Cytoplasmic Polyadenylation Element Binding Protein Deficiency Stimulates PTEN and Stat3 mRNA Translation and Induces Hepatic Insulin Resistance
I. Alexandrov, M. Ivshina, D. Jung, Randall H. Friedline +8 more
2012PLoS Genetics48 citations Open access
Semantic Scholar
Calpain inhibitor and ibudilast rescue β cell functions in a cellular model of Wolfram syndrome
Lien D. Nguyen, Tom T. Fischer, Damien Abreu, Alfredo Arroyo +2 more
2020Proceedings of the National Academy of Sciences of the United States of America47 citations Open access
Semantic Scholar
IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions
Kohsuke Kanekura, Xiu-Cui Ma, John T. Murphy, L. Zhu +2 more
2015Science Signaling46 citations Open access
Semantic Scholar
Wolfram syndrome 1 gene regulates pathways maintaining beta cell health and survival
Damien Abreu, Rie Asada, J. Revilla, Z. Lavagnino +3 more
2020Laboratory Investigation45 citations Open access
Semantic Scholar
KLF15 Is a Molecular Link between Endoplasmic Reticulum Stress and Insulin Resistance
D. Jung, UmaDevi Chalasani, Ning Pan, Randall H. Friedline +13 more
2013PLoS ONE44 citations Open access
Semantic Scholar
Nrf2/antioxidant pathway mediates β cell self-repair after damage by high-fat diet-induced oxidative stress.
Tsehay B. Abebe, Jana Mahadevan, Lindsey D. Bogachus, S. Hahn +5 more
2017JCI Insight43 citations Open access
Semantic Scholar
Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations
B. Mollereau, N. Rzechorzek, B. D. Roussel, M. Sedru +20 more
2016Brain Research43 citations Open access
Semantic Scholar
Neuroimaging evidence of deficient axon myelination in Wolfram syndrome
H. Lugar, J. M. Koller, J. Rutlin, Bess A. Marshall +5 more
2016Scientific Reports42 citations Open access
Semantic Scholar
Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells
C. Liew, A. Assmann, Andrew T. Templin, J. C. Raum +13 more
2014Proceedings of the National Academy of Sciences of the United States of America42 citations Open access
Semantic Scholar
A phase Ib/IIa clinical trial of dantrolene sodium in patients with Wolfram syndrome
Damien Abreu, Stephen I. Stone, Toni S. Pearson, Robert C. Bucelli +13 more
2021JCI Insight40 citations Open access
Semantic Scholar
Pathologic Endoplasmic Reticulum Stress Mediated by the IRE1 Pathway Contributes to Pre-insulitic Beta Cell Apoptosis in a Virus Induced Rat Model of Type 1 Diabetes
Chaoxing Yang, Philip Diiorio, Agata Jurczyk, B. O'Sullivan-Murphy +2 more
2013Diabetologia38 citations Open access
Semantic Scholar
Wolframin is a novel regulator of tau pathology and neurodegeneration
Shuo Chen, Diana Acosta, Liangping Li, Jiawen Liang +26 more
2022Acta Neuropathologica37 citations
Semantic Scholar
Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death
A. Clark, Kohsuke Kanekura, Z. Lavagnino, Larry D. Spears +6 more
2017Scientific Reports36 citations Open access
Semantic Scholar
Novel Treatment of Chronic Graft-Versus-Host Disease in Mice Using the ER Stress Reducer 4-Phenylbutyric Acid
S. Mukai, Y. Ogawa, F. Urano, C. Kudo-Saito +2 more
2017Scientific Reports35 citations Open access
Semantic Scholar
Monogenic and Syndromic Diabetes due to Endoplasmic Reticulum Stress
Stephen I. Stone, Damien Abreu, J. McGill, F. Urano
2020Journal of diabetes and its complications33 citations Open access
Semantic Scholar
Wolfram Syndrome iPS Cells: The First Human Cell Model of Endoplasmic Reticulum Disease
F. Urano
2014Diabetes33 citations Open access
Semantic Scholar
Loss of Function of WFS1 Causes ER Stress-Mediated Inflammation in Pancreatic Beta-Cells
Shuntaro Morikawa, L. Blacher, Chinyere Onwumere, F. Urano
2022Frontiers in Endocrinology31 citations Open access
Semantic Scholar
Low serum osteocalcin concentration is associated with incident type 2 diabetes mellitus in Japanese women
T. Urano, M. Shiraki, T. Kuroda, Shiro Tanaka +3 more
2018Journal of Bone and Mineral Metabolism31 citations
Semantic Scholar
Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function*
Benjamin D Moore, Ramon U. Jin, Hei-Yong G Lo, M. Jung +5 more
2016Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Multidimensional analysis and therapeutic development using patient iPSC–derived disease models of Wolfram syndrome
R. Kitamura, Kristina G. Maxwell, W. Ye, Kelly Kries +13 more
2022JCI Insight25 citations Open access
Semantic Scholar
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum resident proteome
M. Henderson, Kathleen A. Trychta, Shyh-Ming Yang, Susanne Bäck +22 more
2021Cell Reports25 citations Open access
Semantic Scholar
Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2rγnull mice treated with alogliptin
Agata Jurczyk, Philip Diiorio, Dean Brostowin, Linda Leehy +6 more
2013Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy24 citations Open access
Semantic Scholar
The Role of ER Stress in Diabetes: Exploring Pathological Mechanisms Using Wolfram Syndrome
Shuntaro Morikawa, F. Urano
2022International Journal of Molecular Sciences21 citations Open access
Semantic Scholar
DIABETES
F. Urano
2014Nature Reviews Endocrinology20 citations Open access
Semantic Scholar
Altered neuronal physiology, development, and function associated with a common chromosome 15 duplication involving CHRNA7
K. Meganathan, Ramachandran Prakasam, Dustin Baldridge, P. Gontarz +8 more
2021BMC Biology17 citations Open access
Semantic Scholar

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Bess A. Marshall — researcher profile on SciRah