Wolfram Syndrome: Diagnosis, Management, and Treatment
Fumihiko Uranoa b c✉
- aDepartment of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, MO, 63110, USA. urano@dom.wustl.edu
- bDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA. urano@dom.wustl.edu
- cDepartment of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, MO, 63110, USA
- ✉Corresponding author
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Abstract
Wolfram syndrome is a rare genetic disorder characterized by juvenile-onset diabetes mellitus, diabetes insipidus, optic nerve atrophy, hearing loss, and neurodegeneration. Although there are currently no effective treatments that can delay or reverse the progression of Wolfram syndrome, the use of careful clinical monitoring and supportive care can help relieve the suffering of patients and improve their quality of life. The prognosis of this syndrome is currently poor, and many patients die prematurely with severe neurological disabilities, raising the urgency for developing novel treatments for Wolfram syndrome. In this article, we describe natural history and etiology, provide recommendations for diagnosis and clinical management, and introduce new treatments for Wolfram syndrome.
TL;DRThe natural history and etiology of Wolfram syndrome is described, recommendations for diagnosis and clinical management are provided, and new treatments for the syndrome are introduced. (Semantic Scholar)