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T. Hage · SciRah

Researcher profile · Semantic Scholar

T. Hage

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T. Hage — researcher profile on SciRah

h-index: 11
Works: 22
Citations: 892

Most-cited papers

Phosphodiesterase 10A Inhibitor Activity in Preclinical Models of the Positive, Cognitive, and Negative Symptoms of Schizophrenia
Steven M. Grauer, V. Pulito, Rachel L Navarra, M. P. Kelly +14 more
2009Journal of Pharmacology and Experimental Therapeutics259 citations
Semantic Scholar
Crystal Structure of the Interleukin-4/Receptor α Chain Complex Reveals a Mosaic Binding Interface
T. Hage, W. Sebald, P. Reinemer
1999206 citations Open access
Semantic Scholar
Inhibition of phoshodiesterase type 2 or type 10 reverses object memory deficits induced by scopolamine or MK-801.
O. Reneerkens, K. Rutten, E. Bollen, T. Hage +3 more
2013Behavioural Brain Research78 citations
Semantic Scholar
Global and Local Determinants for the Kinetics of Interleukin‐4/Interleukin‐4 Receptor α Chain Interaction
Bo-Jiang Shen, T. Hage, W. Sebald
199677 citations
Semantic Scholar
Highly potent, selective, and orally active phosphodiesterase 10A inhibitors.
M. Malamas, Y. Ni, J. Erdei, H. Stange +19 more
2011Journal of Medicinal Chemistry65 citations Open access
Semantic Scholar
Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors.
Norbert Höfgen, H. Stange, R. Schindler, H. Lankau +11 more
2010Journal of Medicinal Chemistry63 citations Open access
Semantic Scholar
Global and local determinants for the kinetics of interleukin-4/interleukin-4 receptor alpha chain interaction. A biosensor study employing recombinant interleukin-4-binding protein.
Bo-Jiang Shen, T. Hage, W. Sebald
1996European Journal of Biochemistry37 citations
Semantic Scholar
Phosphodiesterase 10 A Inhibitor Activity in Preclinical Models of the Positive , Cognitive , and Negative Symptoms of Schizophrenia
Steven M. Grauer, V. Pulito, Rachel L Navarra, M. P. Kelly +14 more
200928 citations
Semantic Scholar
Novel triazines as potent and selective phosphodiesterase 10A inhibitors.
M. Malamas, H. Stange, R. Schindler, H. Lankau +19 more
2012Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface.
T. Hage, W. Sebald, P. Reinemer
1999Cell22 citations
Semantic Scholar
Phosphodiesterase 2 Inhibitors Promote Axonal Outgrowth in Organotypic Slice Co-Cultures
C. Heine, Katja Sygnecka, Nico Scherf, A. Berndt +3 more
2012Neurosignals16 citations Open access
Semantic Scholar
Crystals of a 1:1 complex between human interleukin-4 and the extracellular domain of its receptor alpha chain.
T. Hage, P. Reinemer, W. Sebald
1998European Journal of Biochemistry9 citations Open access
Semantic Scholar
INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX
T. Hage, W. Sebald, P. Reinemer
20007 citations
Semantic Scholar
RNA-Based Drug Screening Using Automated RNA Purification and Real-time RT-PCR1
S. Ullmann, T. Hage, R. Draheim, U. Egerland +3 more
2004Journal of biomolecular screening3 citations Open access
Semantic Scholar
P.1.g.012 The pro-cognitive profile of the phosphodiesterase 2A inhibitor BCR909 highlights its utility as a novel treatment for diseases with cognitive decline
Barbara Langen, R. Dost, U. Egerland, T. Hage +2 more
20111 citations
Semantic Scholar
PDE10 INHIBITION FOR THE TREATMENT OF SCHIZOPHRENIA
N. Brandon, M. Malamas, N. Hoefgen, T. Hage
20081 citations
Semantic Scholar
Is There a Benefit of Metformin after Heart Transplantation?
D. Chang, J. Patel, M. Kittleson, E. Kransdorf +8 more
2019The Journal of Heart and Lung Transplantation0 citations
Semantic Scholar
Pyrazoles as NMDA NR2B receptor inhibitors and their preparation
R. Schindler, H. Lankau, Norbert Hifgen, C. Grunwald +5 more
20160 citations
Semantic Scholar
Inhibitors of the phosphodiesterase 2 increased axonal fibre growth in a dopaminergic organotypic ex vivo slice co-culture model
C. Heine, N. Scherf, Katja Sygnecka, U. Egerland +2 more
2011BMC Pharmacology0 citations Open access
Semantic Scholar
P.1.c.021 Effect of phosphodiesterase 2A inhibition on striatal dopamine in a microdialysis study and its reflection in dopamine-associated effects in animal models
Barbara Langen, R. Dost, Hans-Joachim Lankau, T. Hage +1 more
20110 citations
Semantic Scholar
P.3.d.005 Activity of phosphodiesterase 10A inhibitors in a novel animal model of negative symptoms of schizophrenia
B. Langen, D. Zschaber, H. Stange, T. Hage +2 more
20100 citations
Semantic Scholar
P.2.d.002 The phosphodiesterase 2 inhibitor BTT5001 demonstrates anxiolytic, anti-depressive and pro-cognitive efficacy in vivo
B. Langen, T. Hage, H. Stange
20090 citations
Semantic Scholar

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