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P. Kiepiela · SciRah

Researcher profile · Semantic Scholar

P. Kiepiela

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P. Kiepiela — researcher profile on SciRah

h-index: 35
Works: 82
Citations: 9,982

Most-cited papers

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
C. Day, D. Kaufmann, P. Kiepiela, Julia A. Brown +18 more
2006Nature2,869 citations
Semantic Scholar
CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
P. Kiepiela, K. Ngumbela, C. Thobakgale, D. Ramduth +26 more
2007Nature Medicine1,140 citations
Semantic Scholar
HIV evolution: CTL escape mutation and reversion after transmission
A. Leslie, K. Pfafferott, P. Chetty, R. Draenert +25 more
2004Nature Medicine937 citations
Semantic Scholar
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA
P. Kiepiela, A. Leslie, I. Honeyborne, Danni Ramduth +24 more
2004Nature891 citations
Semantic Scholar
Fitness Cost of Escape Mutations in p24 Gag in Association with Control of Human Immunodeficiency Virus Type 1
J. Martinez-Picado, J. Prado, E. Fry, K. Pfafferott +14 more
2006Journal of Virology518 citations Open access
Semantic Scholar
Immune Selection for Altered Antigen Processing Leads to Cytotoxic T Lymphocyte Escape in Chronic HIV-1 Infection
R. Draenert, S. Le Gall, K. Pfafferott, A. Leslie +19 more
2004Journal of Experimental Medicine335 citations Open access
Semantic Scholar
Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA
A. Leslie, D. Kavanagh, I. Honeyborne, K. Pfafferott +23 more
2005Journal of Experimental Medicine275 citations Open access
Semantic Scholar
Compensatory Mutation Partially Restores Fitness and Delays Reversion of Escape Mutation within the Immunodominant HLA-B*5703-Restricted Gag Epitope in Chronic Human Immunodeficiency Virus Type 1 Infection
H. Crawford, J. Prado, A. Leslie, S. Hué +15 more
2007Journal of Virology264 citations Open access
Semantic Scholar
Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes
N. Frahm, P. Kiepiela, S. Adams, C. Linde +22 more
2006Nature Immunology256 citations
Semantic Scholar
Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B*13 and Targeting of Multiple Gag-Specific CD8+ T-Cell Epitopes
I. Honeyborne, A. Prendergast, F. Pereyra, A. Leslie +15 more
2007Journal of Virology166 citations Open access
Semantic Scholar
Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression
A. J. Frater, H. Brown, A. Oxenius, H. Günthard +12 more
2007Journal of Virology122 citations Open access
Semantic Scholar
Vitamin A supplementation enhances specific IgG antibody levels and total lymphocyte numbers while improving morbidity in measles
A. Coutsoudis, P. Kiepiela, H. Coovadia, M. Broughton
1992The Pediatric Infectious Disease Journal120 citations
Semantic Scholar
Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes.
Christine M. Rousseau, B. Birditt, Angela McKay, Julia N. Stoddard +11 more
2006Journal of Virological Methods110 citations
Semantic Scholar
High frequency of rapid immunological progression in African infants infected in the era of perinatal HIV prophylaxis
Wendy P Mphatswe, N. Blanckenberg, G. Tudor-Williams, A. Prendergast +6 more
2007AIDS (London)106 citations Open access
Semantic Scholar
Proliferative Capacity of Epitope-Specific CD8 T-Cell Responses Is Inversely Related to Viral Load in Chronic Human Immunodeficiency Virus Type 1 Infection
C. Day, P. Kiepiela, A. Leslie, M. Vanderstok +8 more
2006Journal of Virology104 citations Open access
Semantic Scholar
Substantial Regional Differences in Human Herpesvirus 8 Seroprevalence in Sub-Saharan Africa: Insights on the Origin of the “KS Belt”
S. Dollard, L. M. Butler, Alison M. Graves Jones, Jonathan H. Mermin +8 more
2010International Journal of Cancer97 citations Open access
Semantic Scholar
Mutually Exclusive T-Cell Receptor Induction and Differential Susceptibility to Human Immunodeficiency Virus Type 1 Mutational Escape Associated with a Two-Amino-Acid Difference between HLA Class I Subtypes
Xu G. Yu, M. Lichterfeld, Senica Chetty, K. Williams +22 more
2006Journal of Virology97 citations Open access
Semantic Scholar
Kaposi Sarcoma–Associated Herpesvirus (KSHV) Seroprevalence in Population-Based Samples of African Children: Evidence for At Least 2 Patterns of KSHV Transmission
Lisa M. Butler, G. Dorsey, W. Hladik, P. Rosenthal +9 more
2009Journal of Infectious Diseases94 citations Open access
Semantic Scholar
Kaposi's sarcoma-associated herpesvirus-specific immune reconstitution and antiviral effect of combined HAART/chemotherapy in HIV clade C-infected individuals with Kaposi's sarcoma
F. Bihl, A. Mosam, Leah N Henry, John V. Chisholm +10 more
2007AIDS (London)92 citations Open access
Semantic Scholar
Targeting of a CD8 T Cell Env Epitope Presented by HLA-B*5802 Is Associated with Markers of HIV Disease Progression and Lack of Selection Pressure
K. Ngumbela, C. Day, Z. Mncube, Kriebashnie Nair +21 more
2008AIDS Research and Human Retroviruses80 citations
Semantic Scholar
HLA-B63 Presents HLA-B57/B58-Restricted Cytotoxic T-Lymphocyte Epitopes and Is Associated with Low Human Immunodeficiency Virus Load
N. Frahm, S. Adams, P. Kiepiela, C. Linde +18 more
2005Journal of Virology79 citations Open access
Semantic Scholar
Extensive Intrasubtype Recombination in South African Human Immunodeficiency Virus Type 1 Subtype C Infections
Christine M. Rousseau, G. Learn, Tanmoy Bhattacharya, D. Nickle +8 more
2007Journal of Virology75 citations Open access
Semantic Scholar
Trends in Pretreatment HIV-1 Drug Resistance in Antiretroviral Therapy-naive Adults in South Africa, 2000–2016: A Pooled Sequence Analysis
B. Chimukangara, R. Lessells, S. Rhee, Jennifer Giandhari +27 more
2019EClinicalMedicine72 citations Open access
Semantic Scholar
Human Immunodeficiency Virus-Specific CD8+ T-Cell Activity Is Detectable from Birth in the Majority of In Utero-Infected Infants
C. Thobakgale, D. Ramduth, S. Reddy, Nompumelelo P. Mkhwanazi +15 more
2007Journal of Virology70 citations Open access
Semantic Scholar
Rapid screening of Mycobacterium tuberculosis for susceptibility to rifampicin and streptomycin.
R. McNerney, P. Kiepiela, K. Bishop, P. Nye +1 more
2000The International Journal of Tuberculosis and Lung Disease67 citations
Semantic Scholar
Differential immunogenicity of HIV-1 clade C proteins in eliciting CD8+ and CD4+ cell responses.
Danni Ramduth, P. Chetty, Nolwandle Cyloria Mngquandaniso, N. Nene +14 more
2005Journal of Infectious Diseases64 citations
Semantic Scholar
Type II Human Complement C2 Deficiency
R. Wetsel, J. Kulics, M. Lokki, P. Kiepiela +4 more
1996Journal of Biological Chemistry61 citations Open access
Semantic Scholar
HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory.
E. J. Wherry, C. Day, R. Draenert, Joseph D. Miller +7 more
2006Virology60 citations Open access
Semantic Scholar
Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype
A. Leslie, D. Price, P. Mkhize, K. Bishop +16 more
2006Journal of Immunology60 citations Open access
Semantic Scholar
Impact of HLA in Mother and Child on Disease Progression of Pediatric Human Immunodeficiency Virus Type 1 Infection
C. Thobakgale, A. Prendergast, H. Crawford, Nompumelelo P. Mkhwanazi +17 more
2009Journal of Virology55 citations Open access
Semantic Scholar
Differential Selection Pressure Exerted on HIV by CTL Targeting Identical Epitopes but Restricted by Distinct HLA Alleles from the Same HLA Supertype1
A. Leslie, D. Price, P. Mkhize, K. Bishop +16 more
2006Journal of Immunology55 citations Open access
Semantic Scholar
Growth and cultural characteristics of Calymmatobacterium granulomatis--the aetiological agent of granuloma inguinale (Donovanosis).
A. Kharsany, A. Hoosen, P. Kiepiela, T. Naicker +1 more
1997Journal of Medical Microbiology43 citations Open access
Semantic Scholar
Immunodominant HIV-1 Cd4+ T Cell Epitopes in Chronic Untreated Clade C HIV-1 Infection
Danni Ramduth, C. Day, C. Thobakgale, Nompumelelo P. Mkhwanazi +12 more
2009PLoS ONE42 citations Open access
Semantic Scholar
Phylogenetic analysis of Calymmatobacterium granulomatis based on 16S rRNA gene sequences.
A. Kharsany, A. Hoosen, P. Kiepiela, R. Kirby +1 more
1999Journal of Medical Microbiology41 citations Open access
Semantic Scholar
HIGH-FREQUENCY failure of combination antiretroviral therapy in paediatric HIV infection is associated with unmet maternal needs causing maternal NON-ADHERENCE
J. Millar, N. Bengu, Rowena Fillis, K. Sprenger +24 more
2020EClinicalMedicine38 citations Open access
Semantic Scholar
Prevalence of HIV-1 Drug Resistance among Women Screening for HIV Prevention Trials in KwaZulu-Natal, South Africa (MTN-009)
Urvi M. Parikh, P. Kiepiela, S. Ganesh, Kailazarid Gomez +8 more
2013PLoS ONE33 citations Open access
Semantic Scholar
Suppressor cells assayed by numerical and functional tests in chronic renal failure.
Jennifer E. Lortan, P. Kiepiela, H. Coovadia, Yackoob K. Seedat
1982Kidney International33 citations Open access
Semantic Scholar
Characterisation of the pncA gene in Mycobacterium tuberculosis isolates from Gauteng, South Africa.
K. Bishop, L. Blumberg, A. Trollip, A. Smith +3 more
2001The International Journal of Tuberculosis and Lung Disease32 citations
Semantic Scholar
Effect of co-trimoxazole prophylaxis on morbidity and mortality of HIV-exposed, HIV-uninfected infants in South Africa: a randomised controlled, non-inferiority trial.
B. Daniels, A. Coutsoudis, Eshia Moodley-Govender, H. Mulol +7 more
2019Lancet Global Health30 citations Open access
Semantic Scholar
Role of HIV-specific CD8+ T cells in pediatric HIV cure strategies after widespread early viral escape
E. Leitman, C. Thobakgale, E. Adland, M. Ansari +19 more
2017Journal of Experimental Medicine28 citations Open access
Semantic Scholar
HIV-specific CD 8 T cells express low levels of IL-7 R alpha : Implications for HIV-specific T cell memory
E. Wherry, C. Day, R. Draenert, Joseph D. Miller +7 more
28 citations
Semantic Scholar
Impact of select immunologic and virologic biomarkers on CD4 decline in chronic HIV-1 subtype C infection: Results from Sinikithemba longitudinal population-based cohort, Durban, South Africa
Z. Brumme, Bingxia Wang, K. Nair, C. Brumme +20 more
2009Clinical Infectious Diseases26 citations Open access
Semantic Scholar
Motif Inference Reveals Optimal CTL Epitopes Presented by HLA Class I Alleles Highly Prevalent in Southern Africa1
I. Honeyborne, A. Rathod, R. Buchli, D. Ramduth +9 more
2006Journal of Immunology26 citations Open access
Semantic Scholar
Detecting Mycobacterium tuberculosis using the loop-mediated isothermal amplification test in South Africa.
S. Reddy, S. Ntoyanto, Y. Sakadavan, T. Reddy +9 more
2017The International Journal of Tuberculosis and Lung Disease18 citations
Semantic Scholar
Measles, histocompatibility leukocyte antigen polymorphism, and natural selection in humans.
H. Coovadia, A. Wesley, M. G. Hammond, P. Kiepiela
1981Journal of Infectious Diseases17 citations
Semantic Scholar
Culture of Calymmatobacterium granulomatis.
A. Kharsany, A. Hoosen, P. Kiepiela, T. Naicker +1 more
1996Clinical Infectious Diseases15 citations
Semantic Scholar
Further predictive indices of clinical severity of measles.
A. Wesley, H. Coovadia, P. Kiepiela
1982South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde13 citations
Semantic Scholar
HIV Drug Resistance Patterns at the Epicentre of the HIV-1 Epidemic in Kwazulu-Natal, South Africa 2003-2013
P. Kiepiela, Justen Manasa, M. Moosa, P. Moodley +5 more
201412 citations
Semantic Scholar
Detection of HIV Type 1 Gag-Specific CD4+ T Cell Responses in Acutely Infected Infants
Danni Ramduth, C. Thobakgale, Nompumelelo P. Mkhwanazi, C. DePierres +15 more
2008AIDS Research and Human Retroviruses12 citations
Semantic Scholar
Slow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype
V. Vieira, N. Lim, Alveera Singh, E. Leitman +22 more
2023JCI Insight11 citations Open access
Semantic Scholar

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