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J. Kessl · SciRah

Researcher profile · Semantic Scholar

J. Kessl

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J. Kessl — researcher profile on SciRah

h-index: 26
Works: 50
Citations: 2,590

Most-cited papers

Nuclear Export of 60S Ribosomal Subunits Depends on Xpo1p and Requires a Nuclear Export Sequence-Containing Factor, Nmd3p, That Associates with the Large Subunit Protein Rpl10p
Olivier Gadal, D. Strauss, J. Kessl, B. Trumpower +2 more
2001Molecular and Cellular Biology328 citations Open access
Semantic Scholar
Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation
K. Jurado, Hao Wang, Alison Slaughter, Lei Feng +8 more
2013Proceedings of the National Academy of Sciences of the United States of America211 citations Open access
Semantic Scholar
Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors*
J. Kessl, Nivedita Jena, Y. Koh, Humeyra Taskent-Sezgin +8 more
2012Journal of Biological Chemistry185 citations Open access
Semantic Scholar
BET proteins promote efficient murine leukemia virus integration at transcription start sites
Amit Sharma, Ross C. Larue, Matthew R. Plumb, Nirav Malani +11 more
2013Proceedings of the National Academy of Sciences of the United States of America179 citations Open access
Semantic Scholar
Molecular Basis for Atovaquone Binding to the Cytochrome bc1 Complex*
J. Kessl, Benjamin B. Lange, Torsten Merbitz-Zahradnik, K. Zwicker +6 more
2003Journal of Biological Chemistry147 citations Open access
Semantic Scholar
HIV-1 integrase binds the viral RNA genome and is essential during virion morphogenesis
J. Kessl, S. Kutluay, Dana Townsend, Stephanie V. Rebensburg +7 more
2016Cell142 citations Open access
Semantic Scholar
Dynamic Modulation of HIV-1 Integrase Structure and Function by Cellular Lens Epithelium-derived Growth Factor (LEDGF) Protein*
Christopher J. McKee, J. Kessl, Nikoloz Shkriabai, Mohd Jamal Dar +2 more
2008Journal of Biological Chemistry128 citations Open access
Semantic Scholar
A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase
Amit Sharma, Alison Slaughter, Nivedita Jena, Lei Feng +9 more
2014PLoS Pathogens126 citations Open access
Semantic Scholar
The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors*
Lei Feng, Amit Sharma, Alison Slaughter, Nivedita Jena +9 more
2013Journal of Biological Chemistry96 citations Open access
Semantic Scholar
Cytochrome b Mutations That Modify the Ubiquinol-binding Pocket of the Cytochrome bc1 Complex and Confer Anti-malarial Drug Resistance in Saccharomyces cerevisiae*
J. Kessl, Kevin Ha, A. Merritt, Benjamin B. Lange +4 more
2005Journal of Biological Chemistry85 citations Open access
Semantic Scholar
Allosteric inhibition of HIV-1 integrase activity
A. Engelman, J. Kessl, M. Kvaratskhelia
2013Current Opinion in Chemical Biology81 citations Open access
Semantic Scholar
Modeling the molecular basis of atovaquone resistance in parasites and pathogenic fungi.
J. Kessl, S. Meshnick, B. Trumpower
2007Trends in Parasitology72 citations
Semantic Scholar
Molecular Basis for Atovaquone Resistance in Pneumocystis jirovecii Modeled in the Cytochrome bc1Complex of Saccharomyces cerevisiae*
J. Kessl, P. Hill, Benjamin B. Lange, S. Meshnick +2 more
2004Journal of Biological Chemistry67 citations Open access
Semantic Scholar
Recapitulation in Saccharomyces cerevisiae of Cytochrome b Mutations Conferring Resistance to Atovaquone in Pneumocystis jiroveci
P. Hill, J. Kessl, N. Fisher, S. Meshnick +2 more
2003Antimicrobial Agents and Chemotherapy67 citations Open access
Semantic Scholar
Interaction of the HIV-1 Intasome with Transportin 3 Protein (TNPO3 or TRN-SR2)*
Ross C. Larue, K. Gupta, C. Wuensch, Nikoloz Shkriabai +9 more
2012Journal of Biological Chemistry58 citations Open access
Semantic Scholar
An Allosteric Mechanism for Inhibiting HIV-1 Integrase with a Small Molecule
J. Kessl, J. Eidahl, Nikoloz Shkriabai, Zhuojun Zhao +4 more
2009Molecular Pharmacology57 citations Open access
Semantic Scholar
Subunit-specific Protein Footprinting Reveals Significant Structural Rearrangements and a Role for N-terminal Lys-14 of HIV-1 Integrase during Viral DNA Binding*
Zhuojun Zhao, Christopher J. McKee, J. Kessl, W. Santos +4 more
2008Journal of Biological Chemistry55 citations Open access
Semantic Scholar
FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75
J. Kessl, Min Li, M. E. Ignatov, Nikoloz Shkriabai +5 more
2011Nucleic Acids Research53 citations Open access
Semantic Scholar
The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase
Alison Slaughter, K. Jurado, Nan-Jie Deng, Lei Feng +11 more
2014Retrovirology40 citations Open access
Semantic Scholar
Parameters determining the relative efficacy of hydroxy-naphthoquinone inhibitors of the cytochrome bc1 complex.
J. Kessl, N. Moskalev, G. Gribble, M. Nasr +2 more
2007Biochimica et Biophysica Acta38 citations Open access
Semantic Scholar
RPL29 codes for a non-essential protein of the 60S ribosomal subunit in Saccharomyces cerevisiae and exhibits synthetic lethality with mutations in genes for proteins required for subunit coupling.
M. Delabre, J. Kessl, S. Karamanou, B. Trumpower
2002Biochimica et Biophysica Acta38 citations
Semantic Scholar
The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency
Lei Feng, V. Dharmarajan, Erik Serrao, Ashley C. Hoyte +10 more
2016ACS Chemical Biology35 citations Open access
Semantic Scholar
A Critical Role of the C-terminal Segment for Allosteric Inhibitor-induced Aberrant Multimerization of HIV-1 Integrase*
Nikoloz Shkriabai, V. Dharmarajan, Alison Slaughter, J. Kessl +5 more
2014Journal of Biological Chemistry35 citations Open access
Semantic Scholar
HIV-1 Integrase Multimerization as a Therapeutic Target
Lei Feng, Ross C. Larue, Alison Slaughter, J. Kessl +1 more
2015Current Topics in Microbiology and Immunology34 citations
Semantic Scholar
Indole-based Allosteric Inhibitors of HIV-1 Integrase
Pratiq A. Patel, Nina Kvaratskhelia, Y. Mansour, Janet Antwi +9 more
2016Bioorganic & Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Synthesis and Evaluation of Aryl Quinolines as HIV-1 Integrase Multimerization Inhibitors.
Nicholas G. Jentsch, Alison P. Hart, Jared D Hume, Jian Sun +5 more
2018ACS Medicinal Chemistry Letters30 citations Open access
Semantic Scholar
A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain*
D. Patel, Janet Antwi, P. Koneru, Erik Serrao +11 more
2016Journal of Biological Chemistry22 citations Open access
Semantic Scholar
HIV-1 Integrase-DNA Recognition Mechanisms
J. Kessl, Christopher J. McKee, J. Eidahl, Nikoloz Shkriabai +2 more
2009Viruses22 citations Open access
Semantic Scholar
Molecular basis of Toxoplasma gondii atovaquone resistance modeled in Saccharomyces cerevisiae.
J. Kessl, Kevin Ha, A. Merritt, S. Meshnick +1 more
2006Molecular and biochemical parasitology (Print)18 citations
Semantic Scholar
Mass spectrometry-based footprinting of protein–protein interactions
Christopher J. McKee, J. Kessl, Jocelyn O Norris, Nikoloz Shkriabai +1 more
2008Methods16 citations Open access
Semantic Scholar
Optimized binding of substituted quinoline ALLINIs within the HIV-1 integrase oligomer
Jian Sun, Krunal Patel, Jared D Hume, Julie A. Pigza +2 more
2021Journal of Biological Chemistry14 citations Open access
Semantic Scholar
The Aquila Digital Community The Aquila Digital Community Quinolines from the Cyclocondensation of Isatoic Anhydride With Quinolines from the Cyclocondensation of Isatoic Anhydride With Ethyl Acetoacetate: Preparation of Ethyl Ethyl Acetoacetate: Preparation of Ethyl 4-Hydroxy-2-Methylquinoline-3-Ca
Nicholas G. Jentsch, Jared D Hume, Emily B Crull, Samer M Beauti +4 more
12 citations
Semantic Scholar
The AUG start codon of the Saccharomyces cerevisiae NFS1 gene can be substituted for by UUG without increased initiation of translation at downstream codons.
J. Nett, J. Kessl, Tina Wenz, B. Trumpower
2001European Journal of Biochemistry11 citations Open access
Semantic Scholar
Molecular Basis for Atovaquone Binding to the Cytochrome bc 1 Complex *
J. Kessl, Benjamin B. Lange, Torsten Merbitz-Zahradnik, K. Zwicker +6 more
11 citations
Semantic Scholar
Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase
J. Kessl, Amit Sharma, M. Kvaratskhelia
2016Methods in molecular biology9 citations Open access
Semantic Scholar
Optimizing the Multimerization Properties of Quinoline-Based Allosteric HIV-1 Integrase Inhibitors
Jian-yi Sun, J. Kessl
2024Viruses8 citations Open access
Semantic Scholar
Identification and Optimization of a Novel HIV-1 Integrase Inhibitor
Daniel Adu-Ampratwum, Yu-Min Pan, P. Koneru, Janet Antwi +6 more
2022ACS Omega7 citations Open access
Semantic Scholar
Interaction of the HIV-1 intasome with Transportin 3 ( TNPO 3 or TRN-SR 2 )
Ross C. Larue, K. Gupta, C. Wuensch, Nikoloz Shkriabai +9 more
20127 citations
Semantic Scholar
Multi-Substituted Quinolines as HIV-1 Integrase Allosteric Inhibitors
Long P. Dinh, Jian Sun, Courtney D Glenn, K. Patel +4 more
2022Viruses6 citations Open access
Semantic Scholar
Quinolines from the cyclocondensation of isatoic anhydride with ethyl acetoacetate: preparation of ethyl 4-hydroxy-2-methylquinoline-3-carboxylate and derivatives
Nicholas G. Jentsch, Jared D Hume, Emily B Crull, Samer M Beauti +4 more
2018Beilstein Journal of Organic Chemistry6 citations Open access
Semantic Scholar
The Aquila Digital Community The Aquila Digital Community HIV-1 Integrase-Targeted Short Peptides Derived from a Viral HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence Protein R Sequence
Xue-Zhi Zhao, Mathieu M. É. Tifiot, E. Kiselev, J. Kessl +5 more
4 citations
Semantic Scholar
Exploring Residue-Level Interactions between the Biofilm-Driving R2ab Protein and Polystyrene Nanoparticles
Radha P. Somarathne, Sandeep K. Misra, Chathuri S. Kariyawasam, J. Kessl +2 more
2024Langmuir3 citations
Semantic Scholar
BET proteins target murine leukemia virus integration to transcription start sites
Amit Sharma, Ross C. Larue, Matthew R. Plumb, Nirav Malani +11 more
2013Retrovirology3 citations Open access
Semantic Scholar
Mapping the TAR vRNA Interaction with HIV-1 Integrase
Jian Sun, Rahul Yadav, Tolga Catmakas, Luke Fisher +2 more
2026Viruses0 citations Open access
Semantic Scholar
Mapping the vRNA Interaction with HIV-1 Integrase
Jian Sun, Rahul Yadav, Tolga Catmakas, Luke Fisher +2 more
2026bioRxiv0 citations Open access
Semantic Scholar
HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence
Xue-Zhi Zhao, M. Métifiot, E. Kiselev, J. Kessl +5 more
2018Molecules0 citations Open access
Semantic Scholar
BET proteins target murine leukemia virus integration to transcription start sites
Amit Kumar Sharma, Ross C. Larue, Matthew R. Plumb, Nirav Malani +11 more
2013Retrovirology0 citations Open access
Semantic Scholar
HIV-1 Integrase Inhibitors Primary Mechanism of Action of Allosteric Aberrant Protein Multimerization as the The A 128 T Resistance Mutation Reveals Molecular Bases of Disease :
Lei Feng, Amit Sharma, Alison Slaughter, Nivedita Jena +9 more
20130 citations
Semantic Scholar
Expressions de la dopamine beta hydroxylase humaine chez la bactérie E. Coli et la levure S. Cerevisiae
J. Kessl
19980 citations
Semantic Scholar
Human DBH cDNA expression in E. coli and Saccharomyces cerevisiae.
M. Réglier, J. Kessl, M. Pierrot, J. Chaix +3 more
19920 citations
Semantic Scholar

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