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T. Werfel · SciRah

Researcher profile · Semantic Scholar

T. Werfel

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T. Werfel — researcher profile on SciRah

h-index: 53
Works: 186
Citations: 7,885

Most-cited papers

Cell protective, ABC triblock polymer-based thermoresponsive hydrogels with ROS-triggered degradation and drug release.
M. Gupta, John R. Martin, T. Werfel, Tianwei Shen +2 more
2014Journal of the American Chemical Society241 citations
Semantic Scholar
Efferocytosis in the tumor microenvironment
T. Werfel, R. Cook
2018Seminars in Immunopathology138 citations Open access
Semantic Scholar
Tuning PEGylation of mixed micelles to overcome intracellular and systemic siRNA delivery barriers
M. Miteva, Kellye C. Kirkbride, Kameron V. Kilchrist, T. Werfel +5 more
2014Biomaterials131 citations Open access
Semantic Scholar
Gal8 Visualization of Endosome Disruption Predicts Carrier-Mediated Biologic Drug Intracellular Bioavailability
Kameron V. Kilchrist, Somtochukwu C. Dimobi, Meredith A. Jackson, Brian C. Evans +5 more
2019ACS Nano128 citations Open access
Semantic Scholar
Zwitterionic Nanocarrier Surface Chemistry Improves siRNA Tumor Delivery and Silencing Activity Relative to Polyethylene Glycol
Meredith A. Jackson, T. Werfel, Elizabeth J. Curvino, Fang Yu +7 more
2017ACS Nano117 citations Open access
Semantic Scholar
Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing
Samantha M. Sarett, T. Werfel, Linus H Lee, Meredith A. Jackson +3 more
2017Proceedings of the National Academy of Sciences of the United States of America112 citations Open access
Semantic Scholar
Matrix Metalloproteinase Responsive, Proximity-activated Polymeric Nanoparticles for siRNA Delivery
Hongmei Li, Shann S. Yu, M. Miteva, Christopher E. Nelson +3 more
2013Advanced Functional Materials112 citations Open access
Semantic Scholar
Anxiety, depression and impaired health‐related quality of life in patients with occupational hand eczema
D. Boehm, G. Schmid-Ott, F. Finkeldey, S. M. John +4 more
2012Contact Dermatitis110 citations
Semantic Scholar
Functional effects of interleukin 31 in human primary keratinocytes
S. Kasraie, M. Niebuhr, K. Baumert, T. Werfel
2011Allergy. European Journal of Allergy and Clinical Immunology101 citations
Semantic Scholar
Histamine induces proliferation in keratinocytes from atopic dermatitis patients
Franziska Glatzer, M. Gschwandtner, Sarah Ehling, K. Rossbach +6 more
2013Journal of Allergy and Clinical Immunology85 citations Open access
Semantic Scholar
Human memory Th17 cells express a functional histamine H4 receptor.
S. Mommert, M. Gschwandtner, B. Koether, R. Gutzmer +1 more
2012American Journal of Pathology71 citations Open access
Semantic Scholar
Treatment-Induced Tumor Cell Apoptosis and Secondary Necrosis Drive Tumor Progression in the Residual Tumor Microenvironment through MerTK and IDO1.
T. Werfel, David L. Elion, Bushra Rahman, D. Hicks +8 more
2018Cancer Research70 citations
Semantic Scholar
Particle Based Technologies for Osteoarthritis Detection and Therapy
T. Kavanaugh, T. Werfel, Hongsik Cho, K. Hasty +1 more
2015Drug Delivery and Translational Research70 citations Open access
Semantic Scholar
Evidence for a regulatory loop between IFN‐γ and IL‐33 in skin inflammation
J. Seltmann, T. Werfel, M. Wittmann
2013Experimental Dermatology70 citations
Semantic Scholar
Human keratinocytes express AIM2 and respond to dsDNA with IL‐1β secretion
V. Kopfnagel, M. Wittmann, T. Werfel
2011Experimental Dermatology70 citations Open access
Semantic Scholar
The role of the histamine H4 receptor in atopic dermatitis and psoriasis
K. Schaper-Gerhardt, K. Rossbach, Eirini Nikolouli, T. Werfel +2 more
2020British Journal of Pharmacology63 citations Open access
Semantic Scholar
Selective mTORC2 inhibitor therapeutically blocks breast cancer cell growth and survival
T. Werfel, Shan Wang, Meredith A. Jackson, T. Kavanaugh +11 more
2018Cancer Research62 citations Open access
Semantic Scholar
Expression of antimicrobial peptides in atopic dermatitis and possible immunoregulatory functions
V. Kopfnagel, J. Harder, T. Werfel
2013Current Opinion in Allergy and Clinical Immunology60 citations
Semantic Scholar
Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acids as anti-microRNA Therapies
K. R. Beavers, T. Werfel, Tianwei Shen, T. Kavanaugh +7 more
2016Advances in Materials57 citations Open access
Semantic Scholar
Pathogenetic and therapeutic implications of the histamine H4 receptor in inflammatory skin diseases and pruritus.
R. Gutzmer, M. Gschwandtner, K. Rossbach, S. Mommert +3 more
2011Frontiers in Bioscience55 citations Open access
Semantic Scholar
RNase 7 Strongly Promotes TLR9-Mediated DNA Sensing by Human Plasmacytoid Dendritic Cells.
V. Kopfnagel, S. Wagenknecht, J. Harder, K. Hofmann +4 more
2017Journal of Investigative Dermatology53 citations Open access
Semantic Scholar
The Antimicrobial and Immunomodulatory Function of RNase 7 in Skin
F. Rademacher, Sylvia Dreyer, V. Kopfnagel, R. Gläser +2 more
2019Frontiers in Immunology52 citations Open access
Semantic Scholar
IL-27 Regulates IL-18 Binding Protein in Skin Resident Cells
M. Wittmann, Rosella Doble, M. Bachmann, J. Pfeilschifter +2 more
2012PLoS ONE50 citations Open access
Semantic Scholar
Combinatorial Optimization of PEG Architecture and Hydrophobic Content Improves siRNA Polyplex Stability, Pharmacokinetics, and Potency In Vivo
T. Werfel, Meredith A. Jackson, T. Kavanaugh, Kellye C. Kirkbride +3 more
2017Journal of Controlled Release47 citations Open access
Semantic Scholar
Cytokines as therapeutic targets in skin inflammation.
M. Wittmann, D. McGonagle, T. Werfel
2014Cytokine & growth factor reviews43 citations
Semantic Scholar
Hydrophobic Interactions between Polymeric Carrier and Palmitic Acid-Conjugated siRNA Improve PEGylated Polyplex Stability and Enhance In Vivo Pharmacokinetics and Tumor Gene Silencing
Samantha M. Sarett, T. Werfel, Irene Chandra, Meredith A. Jackson +4 more
2016Biomaterials42 citations Open access
Semantic Scholar
GATA3 regulates FLG and FLG2 expression in human primary keratinocytes
J. Zeitvogel, N. Jokmin, S. Rieker, I. Klug +2 more
2017Scientific Reports41 citations Open access
Semantic Scholar
Differentiation of IL-26+ TH17 intermediates into IL-17A producers via epithelial crosstalk in psoriasis
A. Fries, F. Saidoune, F. Kuonen, I. Dupanloup +13 more
2023Nature Communications40 citations Open access
Semantic Scholar
Intrinsic alterations of pro‐inflammatory mediators in unstimulated and TLR‐2 stimulated keratinocytes from atopic dermatitis patients
M. Niebuhr, A. Heratizadeh, Katja Wichmann, I. Satzger +1 more
2011Experimental Dermatology40 citations
Semantic Scholar
Human thioredoxin, a damage-associated molecular pattern and Malassezia-crossreactive autoallergen, modulates immune responses via the C-type lectin receptors Dectin-1 and Dectin-2
L. Roesner, M. Ernst, W. Chen, G. Begemann +4 more
2019Scientific Reports39 citations Open access
Semantic Scholar
Autoimmunity (or Not) in Atopic Dermatitis
L. Roesner, T. Werfel
2019Frontiers in Immunology39 citations Open access
Semantic Scholar
Recommendations for pimecrolimus 1% cream in the treatment of mild-to-moderate atopic dermatitis: from medical needs to a new treatment algorithm.
T. Luger, L. D. De Raeve, C. Gelmetti, T. Kakourou +8 more
2013EJD. European journal of dermatology39 citations Open access
Semantic Scholar
The Role of the Histamine H4 Receptor in Atopic Dermatitis
S. Mommert, M. Gschwandtner, R. Gutzmer, T. Werfel
2011Current Allergy and Asthma Reports37 citations
Semantic Scholar
Fluorocoxib A Loaded Nanoparticles Enable Targeted Visualization of Cyclooxygenase-2 in Inflammation and Cancer
M. Uddin, T. Werfel, B. Crews, M. Gupta +5 more
2016Biomaterials35 citations Open access
Semantic Scholar
Histamine down‐regulates IL‐27 production in antigen‐presenting cells
M. Gschwandtner, H. Bunk, Brigitta Köther, Robin L. Thurmond +4 more
2012Journal of Leukocyte Biology35 citations Open access
Semantic Scholar
Congenital deficiency reveals critical role of ISG15 in skin homeostasis
M. N. H. Malik, Syed F. Hassnain Waqas, J. Zeitvogel, Jingyuan Cheng +17 more
2021Journal of Clinical Investigation33 citations Open access
Semantic Scholar
Histamine Increases Th2 Cytokine-Induced CCL18 Expression in Human M2 Macrophages
S. Mommert, J. Schaper, K. Schaper-Gerhardt, R. Gutzmer +1 more
2021International Journal of Molecular Sciences32 citations Open access
Semantic Scholar
Systemic Delivery of a Gli Inhibitor via Polymeric Nanocarriers Inhibits Tumor-Induced Bone Disease
Joseph P. Vanderburgh, K. A. Kwakwa, T. Werfel, A. Merkel +5 more
2019Journal of Controlled Release32 citations Open access
Semantic Scholar
Future nanomedicine for the diagnosis and treatment of osteoarthritis
Lauren Eichaker, Hongsik Cho, C. Duvall, T. Werfel +1 more
2014Nanomedicine32 citations Open access
Semantic Scholar
Profiling of histamine H4 receptor agonists in native human monocytes
M. Gschwandtner, B. Koether, T. Werfel, H. Stark +1 more
2013British Journal of Pharmacology30 citations Open access
Semantic Scholar
Enhanced Performance of Plasmid DNA Polyplexes Stabilized by a Combination of Core Hydrophobicity and Surface PEGylation
E. Adolph, Christopher E. Nelson, T. Werfel, R. Guo +3 more
2014Journal of materials chemistry. B29 citations Open access
Semantic Scholar
RAC1 in keratinocytes regulates crosstalk to immune cells by Arp2/3-dependent control of STAT1
E. Pedersen, Zhipeng Wang, Alanna Stanley, K. Peyrollier +4 more
2012Journal of Cell Science29 citations Open access
Semantic Scholar
Stimulation of the histamine 4 receptor upregulates thymic stromal lymphopoietin (TSLP) in human and murine keratinocytes.
Katrin Schaper, K. Rossbach, Brigitta Köther, H. Stark +3 more
2016Pharmacological Research28 citations
Semantic Scholar
Molecular regulation of acute Tie2 suppression in sepsis
K. Thamm, C. Schrimpf, Jennifer Retzlaff, Temitayo O. Idowu +8 more
2018Critical Care Medicine27 citations Open access
Semantic Scholar
The Anaphylatoxin C3a Receptor Expression on Human M2 Macrophages Is Down-Regulated by Stimulating the Histamine H4 Receptor and the IL-4 Receptor
S. Mommert, D. Aslan, Lisanne Ratz, H. Stark +2 more
2018Journal of Innate Immunity27 citations Open access
Semantic Scholar
Macrophages from patients with atopic dermatitis show a reduced CXCL10 expression in response to staphylococcal α‐toxin
S. Kasraie, M. Niebuhr, Verena Kopfnagel, O. Dittrich-Breiholz +2 more
2012Allergy. European Journal of Allergy and Clinical Immunology26 citations
Semantic Scholar
Histamine up‐regulates oncostatin M expression in human M1 macrophages
S. Mommert, M. Huer, K. Schaper-Gerhardt, R. Gutzmer +1 more
2019British Journal of Pharmacology25 citations Open access
Semantic Scholar
The histamine H4 receptor modulates the differentiation process of human monocyte-derived M1 macrophages and the release of CCL4/MIP-1β from fully differentiated M1 macrophages
S. Mommert, Lisanne Ratz, H. Stark, R. Gutzmer +1 more
2018Inflammation Research24 citations
Semantic Scholar
Development of drug delivery systems for the dermal application of therapeutic DNAzymes.
T. Schmidts, Kay Marquardt, P. Schlupp, D. Dobler +7 more
2012International journal of pharmaceutics24 citations
Semantic Scholar
HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0
Niko Hensel, Verena Raker, Benjamin Förthmann, Nora T. Detering +14 more
2019Journal of Neuroinflammation23 citations Open access
Semantic Scholar

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