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B. Crews · SciRah

Researcher profile · Semantic Scholar

B. Crews

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B. Crews — researcher profile on SciRah

h-index: 37
Works: 108
Citations: 5,294

Most-cited papers

Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis.
L. Landino, B. Crews, Michael D. Timmons, J. Morrow +1 more
1996Proceedings of the National Academy of Sciences of the United States of America412 citations Open access
Semantic Scholar
Metabolism of the Endocannabinoids, 2-Arachidonylglycerol and Anandamide, into Prostaglandin, Thromboxane, and Prostacyclin Glycerol Esters and Ethanolamides*
K. Kozak, B. Crews, Jason D. Morrow, Lee-Ho Wang +4 more
2002Journal of Biological Chemistry386 citations Open access
Semantic Scholar
Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors.
A. Kalgutkar, Alan B. Marnett, B. Crews, R. Remmel +1 more
2000Journal of Medicinal Chemistry321 citations Open access
Semantic Scholar
Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis.
T. O. Daniel, Hua Liu, Jason D. Morrow, B. Crews +1 more
1999Cancer Research316 citations
Semantic Scholar
Elevated CSF prostaglandin E2 levels in patients with probable AD.
T. Montine, K. Sidell, B. Crews, W. Markesbery +3 more
1999Neurology287 citations
Semantic Scholar
Aspirin-like molecules that covalently inactivate cyclooxygenase-2.
A. Kalgutkar, B. Crews, S. Rowlinson, C. Garner +2 more
1998Science268 citations
Semantic Scholar
Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.
A. Kalgutkar, B. Crews, S. Rowlinson, Alan B. Marnett +3 more
2000Proceedings of the National Academy of Sciences of the United States of America249 citations Open access
Semantic Scholar
Selective Visualization of Cyclooxygenase-2 in Inflammation and Cancer by Targeted Fluorescent Imaging Agents
M. Uddin, B. Crews, A. L. Blobaum, Philip J. Kingsley +7 more
2010Cancer Research153 citations Open access
Semantic Scholar
Regulation of Prostaglandin Biosynthesis by Nitric Oxide Is Revealed by Targeted Deletion of Inducible Nitric-oxide Synthase*
L. Marnett, T. L. Wright, B. Crews, S. Tannenbaum +1 more
2000Journal of Biological Chemistry147 citations Open access
Semantic Scholar
Metabolism of Prostaglandin Glycerol Esters and Prostaglandin Ethanolamides in Vitro and in Vivo *
K. Kozak, B. Crews, Jennifer Ray, H. Tai +2 more
2001Journal of Biological Chemistry141 citations Open access
Semantic Scholar
Nitric Oxide Trapping of Tyrosyl Radicals Generated during Prostaglandin Endoperoxide Synthase Turnover
D. Goodwin, M. Gunther, L. Hsi, B. Crews +3 more
1998Journal of Biological Chemistry123 citations Open access
Semantic Scholar
The glyceryl ester of prostaglandin E2 mobilizes calcium and activates signal transduction in RAW264.7 cells
C. Nirodi, B. Crews, K. Kozak, J. Morrow +1 more
2004Proceedings of the National Academy of Sciences of the United States of America120 citations Open access
Semantic Scholar
The Binding of Arachidonic Acid in the Cyclooxygenase Active Site of Mouse Prostaglandin Endoperoxide Synthase-2 (COX-2)
S. Rowlinson, B. Crews, C. Lanzo, L. Marnett
1999Journal of Biological Chemistry120 citations Open access
Semantic Scholar
Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators.
A. Kalgutkar, K. Kozak, B. Crews, G. Phillip Hochgesang +1 more
1998Journal of Medicinal Chemistry105 citations Open access
Semantic Scholar
Conjugation of Cisplatin Analogues and Cyclooxygenase Inhibitors to Overcome Cisplatin Resistance
Wilma Neumann, B. Crews, Menyhárt B. Sárosi, Cristina M. Daniel +4 more
2014ChemMedChem100 citations Open access
Semantic Scholar
Indolyl esters and amides related to indomethacin are selective COX-2 inhibitors.
A. Kalgutkar, B. Crews, S. Saleh, Daniel R. Prudhomme +1 more
2005Bioorganic & Medicinal Chemistry87 citations
Semantic Scholar
Spatial Requirements for 15-(R)-Hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic Acid Synthesis within the Cyclooxygenase Active Site of Murine COX-2
S. Rowlinson, B. Crews, D. Goodwin, C. Schneider +2 more
2000Journal of Biological Chemistry86 citations Open access
Semantic Scholar
Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.
A. Kalgutkar, S. Rowlinson, B. Crews, L. Marnett
2002Bioorganic & Medicinal Chemistry Letters76 citations Open access
Semantic Scholar
In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG.
M. Otteneder, Charles G. Knutson, J. Daniels, M. Hashim +5 more
2006Proceedings of the National Academy of Sciences of the United States of America73 citations
Semantic Scholar
Mutational Analysis of the Role of the Distal Histidine and Glutamine Residues of Prostaglandin-Endoperoxide Synthase-2 in Peroxidase Catalysis, Hydroperoxide Reduction, and Cyclooxygenase Activation*
L. Landino, B. Crews, J. Gierse, S. Hauser +1 more
1997Journal of Biological Chemistry71 citations Open access
Semantic Scholar
Design, Synthesis, and Structure−Activity Relationship Studies of Fluorescent Inhibitors of Cycloxygenase‐2 as Targeted Optical Imaging Agents
M. Uddin, B. Crews, K. Ghebreselasie, L. Marnett
201370 citations
Semantic Scholar
Conjugates of Cisplatin and Cyclooxygenase Inhibitors as Potent Antitumor Agents Overcoming Cisplatin Resistance
Wilma Neumann, B. Crews, L. Marnett, E. Hey-Hawkins
2014ChemMedChem69 citations Open access
Semantic Scholar
Cyclooxygenase-1-Selective Inhibitors Based on the (E)-2′-Des-methyl-sulindac Sulfide Scaffold
A. Liedtke, B. Crews, Cristina M. Daniel, A. L. Blobaum +3 more
2012Journal of Medicinal Chemistry69 citations Open access
Semantic Scholar
Transmission of conformational change from the heparin binding site to the reactive center of antithrombin.
P. Gettins, Bing-Qi Fan, B. Crews, I. Turko +2 more
1993Biochemistry69 citations
Semantic Scholar
Catalytic Consumption of Nitric Oxide by Prostaglandin H Synthase-1 Regulates Platelet Function*
V. O'Donnell, B. Coles, M. J. Lewis, B. Crews +2 more
2000Journal of Biological Chemistry68 citations Open access
Semantic Scholar
Fluorinated Cyclooxygenase-2 Inhibitors as Agents in PET Imaging of Inflammation and Cancer
M. Uddin, B. Crews, K. Ghebreselasie, Imran Huda +5 more
2011Cancer Prevention Research64 citations Open access
Semantic Scholar
The 2′-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor
A. L. Blobaum, M. Uddin, Andrew S. Felts, B. Crews +2 more
2013ACS Medicinal Chemistry Letters63 citations Open access
Semantic Scholar
nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2
Wilma Neumann, Shu Xu, Menyhárt B. Sárosi, Matthias S. Scholz +5 more
2015ChemMedChem51 citations Open access
Semantic Scholar
Inhibition of the biosynthesis of prostaglandin E2 by low dose aspirin: implications for adenocarcinoma metastasis
O. Boutaud, I. Sosa, Taneem Amin, D. Oram +11 more
2016Cancer Prevention Research49 citations Open access
Semantic Scholar
Design, synthesis, and biochemical evaluation of N-substituted maleimides as inhibitors of prostaglandin endoperoxide synthases.
Amit S. Kalgutkar, B. Crews, L. Marnett
1996Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
[123I]-Celecoxib Analogues as SPECT Tracers of Cyclooxygenase-2 in Inflammation
M. Uddin, B. Crews, K. Ghebreselasie, M. Tantawy +1 more
2010ACS Medicinal Chemistry Letters43 citations Open access
Semantic Scholar
Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer
A. Wilson, O. Fadare, A. Beeghly-Fadiel, D. Son +11 more
2015OncoTarget41 citations Open access
Semantic Scholar
Total synthesis and biological evaluation of tambjamine K and a library of unnatural analogs.
L. Aldrich, Sydney L. Stoops, B. Crews, L. Marnett +1 more
2010Bioorganic & Medicinal Chemistry Letters40 citations
Semantic Scholar
Heterogeneity of recombinant human antithrombin III expressed in baby hamster kidney cells. Effect of glycosylation differences on heparin binding and structure.
Bing-Qi Fan, B. Crews, I. Turko, J. Choay +2 more
1993Journal of Biological Chemistry39 citations
Semantic Scholar
PET radiotracer [18F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preliminary investigation
M. Perrone, Paola Malerba, J. Uddin, P. Vitale +9 more
2014European journal of medicinal chemistry38 citations Open access
Semantic Scholar
Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes
M. A. Windsor, D. Hermanson, Philip J. Kingsley, Shu Xu +6 more
2012ACS Medicinal Chemistry Letters38 citations Open access
Semantic Scholar
Kinetics of the interaction of nonsteroidal antiinflammatory drugs with prostaglandin endoperoxide synthase-1 studied by limited proteolysis.
Amit S. Kalgutkar, B. Crews, L. Marnett
1996Biochemistry37 citations
Semantic Scholar
Fluorocoxib A Loaded Nanoparticles Enable Targeted Visualization of Cyclooxygenase-2 in Inflammation and Cancer
M. Uddin, T. Werfel, B. Crews, M. Gupta +5 more
2016Biomaterials35 citations Open access
Semantic Scholar
Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6
Antje Brüser, A. Zimmermann, B. Crews, Gregory Sliwoski +6 more
2017Scientific Reports34 citations Open access
Semantic Scholar
Characterization of the lysyl adducts of prostaglandin H-synthases that are derived from oxygenation of arachidonic acid.
O. Boutaud, C. Brame, P. Chaurand, Jun-Yu Li +7 more
2001Biochemistry33 citations
Semantic Scholar
Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors.
M. Uddin, Anna V. Elleman, K. Ghebreselasie, Cristina K. Daniel +4 more
2014ACS Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Trifluoromethyl fluorocoxib a detects cyclooxygenase-2 expression in inflammatory tissues and human tumor xenografts.
M. Uddin, B. Crews, Imran Huda, K. Ghebreselasie +2 more
2014ACS Medicinal Chemistry Letters29 citations Open access
Semantic Scholar
Metabolism in vitro and in vivo of the DNA base adduct, M1G.
Charles G. Knutson, Dapo Akingbade, B. Crews, M. Voehler +2 more
2007Chemical Research in Toxicology29 citations Open access
Semantic Scholar
Role of tryptophan 49 in the heparin cofactor activity of human antithrombin III.
P. Gettins, J. Choay, B. Crews, G. Zettlmeiss
1992Journal of Biological Chemistry26 citations Open access
Semantic Scholar
Structural determinants for calcium mobilization by prostaglandin E2 and prostaglandin F2α glyceryl esters in RAW 264.7 cells and H1819 cells
Robyn Richie-Jannetta, C. Nirodi, B. Crews, D. Woodward +3 more
2010Prostaglandins & other lipid mediators25 citations Open access
Semantic Scholar
Progress toward the total synthesis of lucentamycin A: total synthesis and biological evaluation of 8-epi-lucentamycin A.
R. Daniels, B. Melancon, Emily A. Wang, B. Crews +3 more
2009Journal of Organic Chemistry25 citations
Semantic Scholar
Desmethyl derivatives of indomethacin and sulindac as probes for cyclooxygenase-dependent biology.
Andrew S. Felts, C. Ji, Jennifer B. Stafford, B. Crews +8 more
2007ACS Chemical Biology25 citations Open access
Semantic Scholar
Harmaline Analogs as Substrate-Selective Cyclooxygenase-2 Inhibitors.
M. Uddin, Shu Xu, B. Crews, Ansari M. Aleem +3 more
2020ACS Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors
M. Uddin, B. Crews, Shu Xu, K. Ghebreselasie +4 more
2016ACS Chemical Biology22 citations Open access
Semantic Scholar
2-Carbaborane-3-phenyl-1H-indoles – Synthesis via McMurry Reaction and COX Inhibition Activity
M. Laube, Wilma Neumann, Matthias S. Scholz, P. Lönnecke +5 more
2013ChemMedChem21 citations Open access
Semantic Scholar

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