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P. Beernink · SciRah

Researcher profile · Semantic Scholar

P. Beernink

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P. Beernink — researcher profile on SciRah

h-index: 26
Works: 76
Citations: 1,761

Most-cited papers

Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism.
P. Beernink, B. Segelke, M. Hadi, J. Erzberger +2 more
2001Journal of Molecular Biology186 citations
Semantic Scholar
A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination
P. Beernink, Jutamas Shaughnessy, E. M. Braga, Qin Liu +3 more
2011Journal of Immunology140 citations Open access
Semantic Scholar
Fine Antigenic Specificity and Cooperative Bactericidal Activity of Monoclonal Antibodies Directed at the Meningococcal Vaccine Candidate Factor H-Binding Protein
P. Beernink, J. Welsch, M. Barlev, Oliver Koeberling +2 more
2008Infection and Immunity91 citations Open access
Semantic Scholar
Frequency of Factor H-binding Protein Modular Groups and Susceptibility to Cross-reactive Bactericidal Activity in Invasive Meningococcal Isolates
R. Pajon, P. Beernink, L. Harrison, D. Granoff
2009Vaccine84 citations Open access
Semantic Scholar
Meningococcal Factor H–Binding Protein Variants Expressed by Epidemic Capsular Group A, W-135, and X Strains from Africa
P. Beernink, D. Caugant, J. Welsch, Oliver Koeberling +1 more
2009Journal of Infectious Diseases73 citations Open access
Semantic Scholar
Bactericidal Antibody Responses Induced by Meningococcal Recombinant Chimeric Factor H-Binding Protein Vaccines
P. Beernink, D. Granoff
2008Infection and Immunity73 citations Open access
Semantic Scholar
A modular architecture of meningococcal factor H-binding protein*
P. Beernink, D. Granoff
2009Microbiology67 citations Open access
Semantic Scholar
Prevalence of factor H-binding protein variants and NadA among meningococcal group B isolates from the United States: implications for the development of a multicomponent group B vaccine.
P. Beernink, J. Welsch, L. Harrison, A. Leipus +2 more
2007Journal of Infectious Diseases66 citations Open access
Semantic Scholar
Specificity of Protein Interactions Mediated by BRCT Domains of the XRCC1 DNA Repair Protein*
P. Beernink, M. Hwang, M. Ramirez, Michael B. Murphy +2 more
2005Journal of Biological Chemistry66 citations Open access
Semantic Scholar
A Meningococcal Native Outer Membrane Vesicle Vaccine With Attenuated Endotoxin and Overexpressed Factor H Binding Protein Elicits Gonococcal Bactericidal Antibodies
P. Beernink, Emma Ispasanie, L. Lewis, S. Ram +2 more
2018Journal of Infectious Diseases51 citations Open access
Semantic Scholar
The Effect of Human Factor H on Immunogenicity of Meningococcal Native Outer Membrane Vesicle Vaccines with Over-Expressed Factor H Binding Protein
P. Beernink, Jutamas Shaughnessy, R. Pajon, E. M. Braga +2 more
2012PLoS Pathogens44 citations Open access
Semantic Scholar
High-throughput, fluorescence-based screening for soluble protein expression.
Matthew A. Coleman, V. Lao, Brent W. Segelke, P. Beernink
2004Journal of Proteome Research40 citations
Semantic Scholar
Importance of inhibition of binding of complement factor H for serum bactericidal antibody responses to meningococcal factor H-binding protein vaccines.
M. Konar, D. Granoff, P. Beernink
2013Journal of Infectious Diseases39 citations Open access
Semantic Scholar
A Region of the N-terminal Domain of Meningococcal Factor H Binding Protein that Elicits Bactericidal Antibody across Antigenic Variant Groups
P. Beernink, Carla LoPasso, A. Angiolillo, F. Felici +1 more
2009Molecular Immunology39 citations Open access
Semantic Scholar
Meningococcal factor H-binding protein vaccines with decreased binding to human complement factor H have enhanced immunogenicity in human factor H transgenic mice
Raffaella Rossi, D. Granoff, P. Beernink
2013Vaccine38 citations Open access
Semantic Scholar
Effect of Factor H-Binding Protein Sequence Variation on Factor H Binding and Survival of Neisseria meningitidis in Human Blood
Kathleen Y. Dunphy, P. Beernink, B. Brogioni, D. Granoff
2010Infection and Immunity38 citations Open access
Semantic Scholar
Rapid Genetic Grouping of Factor H-Binding Protein (Genome-Derived Neisserial Antigen 1870), a Promising Group B Meningococcal Vaccine Candidate
P. Beernink, A. Leipus, D. Granoff
2006Clinical and Vaccine Immunology36 citations Open access
Semantic Scholar
Spatial Clustering of Isozyme-specific Residues Reveals Unlikely Determinants of Isozyme Specificity in Fructose-1,6-bisphosphate Aldolase*
J. A. Pezza, K. Choi, T. Berardini, P. Beernink +2 more
2003Journal of Biological Chemistry34 citations Open access
Semantic Scholar
Binding of Complement Factor H (FH) Decreases Protective Anti-FH Binding Protein Antibody Responses of Infant Rhesus Macaques Immunized With a Meningococcal Serogroup B Vaccine.
D. Granoff, I. Costa, M. Konar, S. Giuntini +2 more
2015Journal of Infectious Diseases30 citations Open access
Semantic Scholar
Structural basis for a change in substrate specificity: crystal structure of S113E isocitrate dehydrogenase in a complex with isopropylmalate, Mg2+, and NADP.
S. Doyle, P. Beernink, D. Koshland
2001Biochemistry29 citations
Semantic Scholar
Does Binding of Complement Factor H to the Meningococcal Vaccine Antigen, Factor H Binding Protein, Decrease Protective Serum Antibody Responses?
D. Granoff, S. Ram, P. Beernink
2013Clinical and Vaccine Immunology28 citations Open access
Semantic Scholar
Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: implications for allosteric regulation.
J. Endrizzi, P. Beernink, T. Alber, H. Schachman
2000Proceedings of the National Academy of Sciences of the United States of America28 citations Open access
Semantic Scholar
Enhanced protective antibody to a mutant meningococcal factor H-binding protein with low-factor H binding
D. Granoff, S. Giuntini, Flor A Gowans, Eduardo Luján +2 more
2016JCI Insight27 citations Open access
Semantic Scholar
A Meningococcal Outer Membrane Vesicle Vaccine with Overexpressed Mutant FHbp Elicits Higher Protective Antibody Responses in Infant Rhesus Macaques than a Licensed Serogroup B Vaccine
P. Beernink, Vianca V. Vianzon, L. Lewis, G. Moe +1 more
2019mBio26 citations Open access
Semantic Scholar
Susceptibility of Meningococcal Strains Responsible for Two Serogroup B Outbreaks on U.S. University Campuses to Serum Bactericidal Activity Elicited by the MenB-4C Vaccine
Raffaella Rossi, P. Beernink, S. Giuntini, D. Granoff
2015Clinical and Vaccine Immunology26 citations Open access
Semantic Scholar
Design of Meningococcal Factor H Binding Protein Mutant Vaccines That Do Not Bind Human Complement Factor H
R. Pajon, P. Beernink, D. Granoff
2012Infection and Immunity26 citations Open access
Semantic Scholar
Impaired Immunogenicity of a Meningococcal Factor H-Binding Protein Vaccine Engineered To Eliminate Factor H Binding
P. Beernink, Jutamas Shaughnessy, S. Ram, D. Granoff
2010Clinical and Vaccine Immunology25 citations Open access
Semantic Scholar
Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: implications for allosteric regulation induced cell migration.
J. Endrizzi, P. Beernink, T. Alber, H. Schachman
200023 citations
Semantic Scholar
Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp
J. López-Sagaseta, P. Beernink, F. Bianchi, L. Santini +4 more
2018Nature Communications21 citations Open access
Semantic Scholar
Construction of a high-copy "ATG vector" for expression in Escherichia coli.
P. Beernink, D. Tolan
1992Protein Expression and Purification21 citations Open access
Semantic Scholar
A Mutant Library Approach to Identify Improved Meningococcal Factor H Binding Protein Vaccine Antigens
M. Konar, Raffaella Rossi, H. Walter, R. Pajon +1 more
2015PLoS ONE19 citations Open access
Semantic Scholar
Heterogeneity in Rhesus Macaque Complement Factor H Binding to Meningococcal Factor H Binding Protein (FHbp) Informs Selection of Primates To Assess Immunogenicity of FHbp-Based Vaccines
P. Beernink, Jutamas Shaughnessy, Heather Stefek, S. Ram +1 more
2014Clinical and Vaccine Immunology19 citations Open access
Semantic Scholar
Monoclonal Antibodies to Meningococcal Factor H Binding Protein with Overlapping Epitopes and Discordant Functional Activity
S. Giuntini, P. Beernink, D. Reason, D. Granoff
2012PLoS ONE19 citations Open access
Semantic Scholar
Broad vaccine protection against Neisseria meningitidis using factor H binding protein
J. Findlow, C. Bayliss, P. Beernink, R. Borrow +2 more
2020Vaccine18 citations Open access
Semantic Scholar
Neisseria meningitidis factor H binding protein bound to monoclonal antibody JAR5: implications for antibody synergy
E. Malito, Paola Lo Surdo, D. Veggi, L. Santini +6 more
2016Biochemical Journal18 citations Open access
Semantic Scholar
A meningococcal vaccine antigen engineered to increase thermal stability and stabilize protective epitopes
M. Konar, R. Pajon, P. Beernink
2015Proceedings of the National Academy of Sciences of the United States of America18 citations Open access
Semantic Scholar
Effect of Complement Factor H on anti-FHbp Serum Bactericidal Antibody Responses of Infant Rhesus Macaques Boosted with a Licensed Meningococcal Serogroup B Vaccine
S. Giuntini, P. Beernink, D. Granoff
2015Vaccine17 citations Open access
Semantic Scholar
Functional Analysis of the Human Antibody Response to Meningococcal Factor H Binding Protein
P. Beernink, S. Giuntini, I. Costa, A. Lucas +1 more
2015mBio17 citations Open access
Semantic Scholar
Thermodynamic Analysis of the Dissociation of the Aldolase Tetramer Substituted at One or Both of the Subunit Interfaces
D. Tolan, B. Schuler, P. Beernink, R. Jaenicke
2003Biological chemistry16 citations
Semantic Scholar
Meningococcal Factor H Binding Protein Vaccine Antigens with Increased Thermal Stability and Decreased Binding of Human Factor H
Raffaella Rossi, M. Konar, P. Beernink
2016Infection and Immunity15 citations Open access
Semantic Scholar
Anti-Factor H Antibody Reactivity in Young Adults Vaccinated with a Meningococcal Serogroup B Vaccine Containing Factor H Binding Protein
K. Sharkey, P. Beernink, J. Langley, S. Gantt +5 more
2019Msphere12 citations Open access
Semantic Scholar
A Newly-Identified Polymorphism in Rhesus Macaque Complement Factor H Modulates Binding Affinity for Meningococcal FHbp
M. Konar, P. Beernink, D. Granoff
2015PLoS ONE11 citations Open access
Semantic Scholar
An adenoviral-vectored vaccine confers seroprotection against capsular group B meningococcal disease
C. Dold, L. Marsay, Nelson Y. Wang, L. Silva-Reyes +8 more
2023Science Translational Medicine9 citations Open access
Semantic Scholar
Applications of functional protein microarrays: identifying protein-protein interactions in an array format.
M. Coleman, P. Beernink, J. A. Camarero, J. Albala
2007Methods in molecular biology9 citations
Semantic Scholar
Methods to evaluate the performance of a multicomponent meningococcal serogroup B vaccine
R. Borrow, Laura Tomasi Cont, D. Toneatto, S. Bambini +6 more
2025Msphere4 citations Open access
Semantic Scholar
A phase 1/2a clinical trial to assess safety and immunogenicity of an adenoviral-vectored capsular group B meningococcal vaccine.
C. Dold, B. Oguti, L. Silva-Reyes, A. Stanzelova +18 more
2025Science Translational Medicine4 citations
Semantic Scholar
Gonococcal Mimitope Vaccine Candidate Forms a Beta-Hairpin Turn and Binds Hydrophobically to a Therapeutic Monoclonal Antibody
P. Beernink, Cristina Di Carluccio, R. Marchetti, L. Cerofolini +13 more
2024JACS Au4 citations Open access
Semantic Scholar
Two human antibodies to a meningococcal serogroup B vaccine antigen enhance binding of complement Factor H by stabilizing the Factor H binding site
N. Sands, P. Beernink
2021PLoS Pathogens3 citations Open access
Semantic Scholar
Design of Meningococcal Factor H Binding Protein Mutant Vaccines That Do Not Bind Human Complement Factor H
R. Pajon, P. Beernink, D. Granoff
2014Infection and Immunity3 citations Open access
Semantic Scholar
Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: Implications for allosteric regulation
T. Alber, J. Endrizzi, H. Schachman, P. Beernink
20063 citations
Semantic Scholar

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