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A. Spallarossa · SciRah

Researcher profile · Semantic Scholar

A. Spallarossa

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A. Spallarossa — researcher profile on SciRah

h-index: 25
Works: 95
Citations: 2,154

Most-cited papers

Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7
Vittoria Zoppi, S. Hughes, Chiara Maniaci, A. Testa +7 more
2018Journal of Medicinal Chemistry268 citations Open access
Semantic Scholar
The bovine basic pancreatic trypsin inhibitor (Kunitz inhibitor): a milestone protein.
P. Ascenzi, A. Bocedi, M. Bolognesi, A. Spallarossa +3 more
2003Current protein and peptide science189 citations
Semantic Scholar
Anthrax toxin: a tripartite lethal combination1
P. Ascenzi, P. Visca, G. Ippolito, A. Spallarossa +2 more
2002FEBS Letters144 citations
Semantic Scholar
The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity.
C. Cantoni, M. Ponassi, R. Biassoni, R. Conte +5 more
2003Structure107 citations Open access
Semantic Scholar
Identification of a novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice.
F. Manetti, A. Santucci, Giada. A. Locatelli, G. Maga +15 more
2007Journal of Medicinal Chemistry85 citations Open access
Semantic Scholar
Two novel GPER agonists induce gene expression changes and growth effects in cancer cells.
R. Lappano, C. Rosano, M. Santolla, Marco Pupo +6 more
2012Current Cancer Drug Targets75 citations
Semantic Scholar
Amino-Pyrazoles in Medicinal Chemistry: A Review
Matteo Lusardi, A. Spallarossa, C. Brullo
2023International Journal of Molecular Sciences67 citations Open access
Semantic Scholar
Escherichia coli GlpE is a prototype sulfurtransferase for the single-domain rhodanese homology superfamily.
A. Spallarossa, J. Donahue, T. Larson, M. Bolognesi +1 more
2001Structure56 citations Open access
Semantic Scholar
Btk Inhibitors: A Medicinal Chemistry and Drug Delivery Perspective
C. Brullo, Carla Villa, B. Tasso, Eleonora Russo +1 more
2021International Journal of Molecular Sciences55 citations Open access
Semantic Scholar
Valorization and Potential Antimicrobial Use of Olive Mill Wastewater (OMW) from Italian Olive Oil Production
Eleonora Russo, A. Spallarossa, A. Comite, M. Pagliero +4 more
2022Antioxidants50 citations Open access
Semantic Scholar
The Development of FAK Inhibitors: A Five-Year Update
A. Spallarossa, B. Tasso, Eleonora Russo, Carla Villa +1 more
2022International Journal of Molecular Sciences50 citations Open access
Semantic Scholar
The Development of BTK Inhibitors: A Five-Year Update
B. Tasso, A. Spallarossa, E. Russo, C. Brullo
2021Molecules49 citations Open access
Semantic Scholar
The "rhodanese" fold and catalytic mechanism of 3-mercaptopyruvate sulfurtransferases: crystal structure of SseA from Escherichia coli.
A. Spallarossa, F. Forlani, A. Carpen, A. Armirotti +3 more
2003Journal of Molecular Biology49 citations
Semantic Scholar
N-acylated and N,N'-diacylated imidazolidine-2-thione derivatives and N,N'-diacylated tetrahydropyrimidine-2(1H)-thione analogues: synthesis and antiproliferative activity.
Sara Cesarini, A. Spallarossa, A. Ranise, S. Schenone +5 more
2009European journal of medicinal chemistry45 citations
Semantic Scholar
New selective phosphodiesterase 4D inhibitors differently acting on long, short, and supershort isoforms.
O. Bruno, Alessia Romussi, A. Spallarossa, C. Brullo +4 more
2009Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Structure-based design, parallel synthesis, structure-activity relationship, and molecular modeling studies of thiocarbamates, new potent non-nucleoside HIV-1 reverse transcriptase inhibitor isosteres of phenethylthiazolylthiourea derivatives.
A. Ranise, A. Spallarossa, Sara Cesarini, F. Bondavalli +14 more
2005Journal of Medicinal Chemistry41 citations Open access
Semantic Scholar
Synthesis of N-substituted-N-acylthioureas of 4-substituted piperazines endowed with local anaesthetic, antihyperlipidemic, antiproliferative activities and antiarrythmic, analgesic, antiaggregating actions.
A. Ranise, A. Spallarossa, O. Bruno, S. Schenone +8 more
2003Il Farmaco38 citations
Semantic Scholar
Nanotechnology of Tyrosine Kinase Inhibitors in Cancer Therapy: A Perspective
Eleonora Russo, A. Spallarossa, B. Tasso, Carla Villa +1 more
2021International Journal of Molecular Sciences37 citations Open access
Semantic Scholar
Structure of the human NK cell triggering receptor NKp46 ectodomain.
M. Ponassi, C. Cantoni, R. Biassoni, R. Conte +6 more
2003Biochemical and Biophysical Research Communications - BBRC37 citations
Semantic Scholar
Homology modeling in tandem with 3D-QSAR analyses: a computational approach to depict the agonist binding site of the human CB2 receptor.
E. Cichero, A. Ligresti, M. Allarà, V. Di Marzo +7 more
2011European journal of medicinal chemistry36 citations Open access
Semantic Scholar
Design, synthesis, SAR, and molecular modeling studies of acylthiocarbamates: a novel series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors structurally related to phenethylthiazolylthiourea derivatives.
A. Ranise, A. Spallarossa, S. Schenone, O. Bruno +6 more
2003Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
PDE4D: A Multipurpose Pharmacological Target
Matteo Lusardi, Federica Rapetti, A. Spallarossa, C. Brullo
2024International Journal of Molecular Sciences32 citations Open access
Semantic Scholar
A Persulfurated Cysteine Promotes Active Site Reactivity in Azotobacter vinelandii Rhodanese
D. Bordo, F. Forlani, A. Spallarossa, R. Colnaghi +3 more
2001Biological chemistry31 citations
Semantic Scholar
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors: docking-based CoMFA and CoMSIA analyses.
E. Cichero, Sara Cesarini, P. Fossa, A. Spallarossa +1 more
2009European journal of medicinal chemistry26 citations
Semantic Scholar
Rational design, synthesis and biological evaluation of new 1,5-diarylpyrazole derivatives as CB1 receptor antagonists, structurally related to rimonabant.
G. Menozzi, P. Fossa, E. Cichero, A. Spallarossa +2 more
2008European journal of medicinal chemistry26 citations Open access
Semantic Scholar
Successful Dendrimer and Liposome-Based Strategies to Solubilize an Antiproliferative Pyrazole Otherwise Not Clinically Applicable
S. Alfei, A. Spallarossa, Matteo Lusardi, G. Zuccari
2022Nanomaterials25 citations Open access
Semantic Scholar
Novel modifications in the series of O-(2-phthalimidoethyl)-N-substituted thiocarbamates and their ring-opened congeners as non-nucleoside HIV-1 reverse transcriptase inhibitors.
A. Spallarossa, Sara Cesarini, A. Ranise, O. Bruno +6 more
2009European journal of medicinal chemistry24 citations
Semantic Scholar
Acylthiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors: docking studies and ligand-based CoMFA and CoMSIA analyses
E. Cichero, Sara Cesarini, A. Spallarossa, L. Mosti +1 more
2009Journal of Molecular Modeling23 citations
Semantic Scholar
Synthesis and antiproliferative activity of basic thioanalogues of merbarone.
A. Ranise, A. Spallarossa, S. Schenone, O. Bruno +6 more
2003Bioorganic & Medicinal Chemistry23 citations
Semantic Scholar
Nanotechnology for Pediatric Retinoblastoma Therapy
E. Russo, A. Spallarossa, B. Tasso, Carla Villa +1 more
2022Pharmaceuticals21 citations Open access
Semantic Scholar
Hydrophilic and amphiphilic water‐soluble dendrimer prodrugs suitable for parenteral administration of a non‐soluble non‐nucleoside HIV‐1 reverse transcriptase inhibitor thiocarbamate derivative
S. Alfei, S. Catena, M. Ponassi, C. Rosano +2 more
2018European Journal of Pharmaceutical Sciences20 citations
Semantic Scholar
Parallel synthesis, molecular modelling and further structure-activity relationship studies of new acylthiocarbamates as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
A. Spallarossa, Sara Cesarini, A. Ranise, S. Schenone +8 more
2009European journal of medicinal chemistry19 citations Open access
Semantic Scholar
Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors.
A. Spallarossa, Sara Cesarini, A. Ranise, M. Ponassi +2 more
2007Biochemical and Biophysical Research Communications - BBRC19 citations
Semantic Scholar
Novel insights on the molecular mechanism of action of the anti-angiogenic pyrazolyl-urea GeGe-3 by functional proteomics.
E. Morretta, R. Belvedere, A. Petrella, A. Spallarossa +4 more
2021Bioorganic chemistry (Print)17 citations
Semantic Scholar
Indole Antitumor Agents in Nanotechnology Formulations: An Overview
E. Russo, Carola Grondona, C. Brullo, A. Spallarossa +2 more
2023Pharmaceutics15 citations Open access
Semantic Scholar
One‐Pot Synthesis and Antiproliferative Activity of Highly Functionalized Pyrazole Derivatives
Matteo Lusardi, C. Rotolo, M. Ponassi, Erika Iervasi +2 more
2022ChemMedChem15 citations Open access
Semantic Scholar
Exploring the binding features of rimonabant analogues and acyclic CB1 antagonists: docking studies and QSAR analysis
E. Cichero, G. Menozzi, A. Spallarossa, L. Mosti +1 more
2008Journal of Molecular Modeling15 citations
Semantic Scholar
Potent and Broad-Spectrum Bactericidal Activity of a Nanotechnologically Manipulated Novel Pyrazole
S. Alfei, D. Caviglia, A. Zorzoli, D. Marimpietri +4 more
2022Biomedicines14 citations Open access
Semantic Scholar
Parallel one-pot synthesis and structure-activity relationship study of symmetric formimidoester disulfides as a novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Sara Cesarini, A. Spallarossa, A. Ranise, S. Schenone +6 more
2008Bioorganic & Medicinal Chemistry12 citations Open access
Semantic Scholar
Novel 5-aminopyrazoles endowed with anti-angiogenetic properties: Design, synthesis and biological evaluation.
Matteo Lusardi, B. Wehrle-Haller, A. Sidibé, M. Ponassi +4 more
2023European journal of medicinal chemistry11 citations Open access
Semantic Scholar
Synthesis, functional proteomics and biological evaluation of new 5-pyrazolyl ureas as potential anti-angiogenic compounds.
E. Morretta, A. Sidibé, A. Spallarossa, A. Petrella +4 more
2021European journal of medicinal chemistry11 citations
Semantic Scholar
Microbiological Screening of 5-Functionalized Pyrazoles for the Future Development of Optimized Pyrazole-Based Delivery Systems
C. Brullo, D. Caviglia, A. Spallarossa, S. Alfei +3 more
2022Pharmaceutics10 citations Open access
Semantic Scholar
Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents.
A. Spallarossa, C. Caneva, M. Caviglia, S. Alfei +13 more
2015European journal of medicinal chemistry10 citations Open access
Semantic Scholar
Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents.
A. Spallarossa, C. Rotolo, C. Sissi, Giuseppe Marson +5 more
2013Bioorganic & Medicinal Chemistry10 citations Open access
Semantic Scholar
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: Parallel synthesis, molecular modelling and structure-activity relationship studies on analogues of O-(2-phenylethyl)-N-phenylthiocarbamate.
Sara Cesarini, A. Spallarossa, A. Ranise, O. Bruno +4 more
2008Bioorganic & Medicinal Chemistry10 citations
Semantic Scholar
Insights into the Pharmacological Activity of the Imidazo−Pyrazole Scaffold
A. Spallarossa, Federica Rapetti, Maria Grazia Signorello, C. Rosano +3 more
2023ChemMedChem9 citations Open access
Semantic Scholar
Antimalarial Activity of Tri- and Tetra-Substituted Anilino Pyrazoles
Matteo Lusardi, N. Basilico, C. Rotolo, S. Parapini +1 more
2023Molecules9 citations Open access
Semantic Scholar
Regioselective Synthesis, Structural Characterization, and Antiproliferative Activity of Novel Tetra-Substituted Phenylaminopyrazole Derivatives
Matteo Lusardi, A. Profumo, C. Rotolo, Erika Iervasi +3 more
2022Molecules8 citations Open access
Semantic Scholar
Synthesis and biological evaluation of (acyl)hydrazones and thiosemicarbazones obtained via in situ condensation of iminium salts with nitrogen-containing nucleophiles
C. Caneva, S. Alfei, M. de Maria, Cristina Ibba +3 more
2015Molecular diversity8 citations
Semantic Scholar
Computational studies of the binding mode and 3D-QSAR analyses of symmetric formimidoester disulfides: a new class of non-nucleoside HIV-1 reverse transcriptase inhibitor
E. Cichero, Sara Cesarini, A. Spallarossa, L. Mosti +1 more
2009Journal of Molecular Modeling8 citations
Semantic Scholar

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