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Sharadha Dayalan Naidu · SciRah

Researcher profile · Semantic Scholar

Sharadha Dayalan Naidu

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Sharadha Dayalan Naidu — researcher profile on SciRah

h-index: 18
Works: 32
Citations: 5,393

Most-cited papers

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
D. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, M. Abdellatif +496 more
2021Autophagy4,016 citations Open access
Semantic Scholar
Regulation of the mammalian heat shock factor 1
Sharadha Dayalan Naidu, A. Dinkova-Kostova
2017The FEBS Journal158 citations Open access
Semantic Scholar
KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy
T. Shekh-Ahmad, R. Eckel, Sharadha Dayalan Naidu, M. Higgins +5 more
2018Brain : a journal of neurology137 citations Open access
Semantic Scholar
KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease
Sharadha Dayalan Naidu, A. Dinkova-Kostova
2020Open Biology132 citations Open access
Semantic Scholar
Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection.
Sharadha Dayalan Naidu, Rumen V. Kostov, A. Dinkova-Kostova
2015TIPS - Trends in Pharmacological Sciences129 citations
Semantic Scholar
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients
L. Quinti, Sharadha Dayalan Naidu, U. Träger, Xi-Qun Chen +35 more
2017Proceedings of the National Academy of Sciences of the United States of America127 citations Open access
Semantic Scholar
Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response
D. Ryan, Elena V. Knatko, A. Casey, J. Hukelmann +17 more
2022iScience100 citations Open access
Semantic Scholar
Regulating Nrf2 activity: ubiquitin ligases and signaling molecules in redox homeostasis.
John D. Hayes, Sharadha Dayalan Naidu, A. Dinkova-Kostova
2025TIBS -Trends in Biochemical Sciences. Regular ed95 citations Open access
Semantic Scholar
C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape
Sharadha Dayalan Naidu, A. Muramatsu, Ryota Saito, Soichiro Asami +6 more
2018Scientific Reports95 citations Open access
Semantic Scholar
Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases
Sharadha Dayalan Naidu, C. Sutherland, Ying Zhang, A. Risco +10 more
2016Molecular and Cellular Biology75 citations Open access
Semantic Scholar
Phenethyl Isothiocyanate, a Dual Activator of Transcription Factors NRF2 and HSF1
Sharadha Dayalan Naidu, Takafumi Suzuki, M. Yamamoto, J. Fahey +1 more
2018Molecular Nutrition & Food Research51 citations Open access
Semantic Scholar
Omaveloxolone (SkyclarysTM) for patients with Friedreich's ataxia.
Sharadha Dayalan Naidu, A. Dinkova-Kostova
2023TIPS - Trends in Pharmacological Sciences39 citations Open access
Semantic Scholar
Transcription factors NRF2 and HSF1 have opposing functions in autophagy
Sharadha Dayalan Naidu, Dina Dikovskaya, E. Gaurilcikaite, Elena V. Knatko +10 more
2017Scientific Reports38 citations Open access
Semantic Scholar
The Cell-Permeable Derivative of the Immunoregulatory Metabolite Itaconate, 4-Octyl Itaconate, Is Anti-Fibrotic in Systemic Sclerosis
J. Henderson, Sharadha Dayalan Naidu, A. Dinkova-Kostova, S. Przyborski +2 more
2021Cells34 citations Open access
Semantic Scholar
The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity
Laura Casares, R. Moreno, K. Ali, M. Higgins +13 more
2022Redox Biology27 citations Open access
Semantic Scholar
The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2
Sharadha Dayalan Naidu, Takafumi Suzuki, Dina Dikovskaya, Elena V. Knatko +7 more
2021iScience27 citations Open access
Semantic Scholar
Downregulation of Keap1 Confers Features of a Fasted Metabolic State
Elena V. Knatko, M. Tatham, Ying Zhang, Cecilia Castro +8 more
2020iScience27 citations Open access
Semantic Scholar
Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein–Protein Interaction Inhibitors with an Alternative Binding Mode
Nikolaos D. Georgakopoulos, S. Talapatra, Dina Dikovskaya, Sharadha Dayalan Naidu +10 more
2022Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
Pirin, an Nrf2-Regulated Protein, Is Overexpressed in Human Colorectal Tumors
Ying Zhang, Elena V. Knatko, M. Higgins, Sharadha Dayalan Naidu +4 more
2022Antioxidants18 citations Open access
Semantic Scholar
Detection of thermal shift in cellular Keap1 by protein-protein interaction inhibitors using immunoblot- and fluorescence microplate-based assays
Sharadha Dayalan Naidu, Dina Dikovskaya, T. Moore, A. Dinkova-Kostova
2022STAR Protocols17 citations Open access
Semantic Scholar
Laminin-α2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms
Susana G. Martins, Vanessa Ribeiro, Catarina Melo, Cláudia Paulino-Cavaco +14 more
2024Life Science Alliance12 citations Open access
Semantic Scholar
Nrf2 depletion in the context of loss-of-function Keap1 leads to mitolysosome accumulation.
Sharadha Dayalan Naidu, Plamena R. Angelova, Elena V. Knatko, Chiara Leonardi +5 more
2023Free Radical Biology & Medicine7 citations Open access
Semantic Scholar
Keap1-Kelch-targeting protein–protein interaction inhibitors, but not reversibly-binding electrophiles, increase the thermostability of Keap1 in the cellular environment
Sharadha Dayalan Naidu, Dina Dikovskaya, J. M. Walker, C. Yee +10 more
2026RSC Chemical Biology5 citations Open access
Semantic Scholar
The Chemopreventive Power of Isothiocyanates
Sharadha Dayalan Naidu, Lidia Brodziak-Jarosz, C. Gerhäuser, A. Dinkova-Kostova
20205 citations
Semantic Scholar
The electrophilic metabolite of kynurenine, kynurenine-CKA, requires C151 in Keap1 to derepress Nrf2
Jia-Lin Feng, Mara Carreño, Hannah Jung, Sharadha Dayalan Naidu +13 more
2026Redox Biology4 citations Open access
Semantic Scholar
CD5L is a target of transcription factor Nrf2.
Sharadha Dayalan Naidu, Abel D. Ang, Charlotte Lim Jia Yee, O. Read +10 more
2025Biochemical and Biophysical Research Communications - BBRC2 citations Open access
Semantic Scholar
Sulforaphane Decreases the Burden of AKT1-Expressing Pre-Neoplastic Cells in a Zebrafish Model of Glioblastoma Initiation
Manana Kutsia, O. Read, Sharadha Dayalan Naidu, A. Dinkova-Kostova +1 more
2026Nutrients1 citations Open access
Semantic Scholar
Genetic Deletion of RHAMM Alleviates Hepatic Oxidative Stress, Reversing Thyroid Stimulating Hormone Elevation in Male Obese Mice
Tianzhen Wang, He-Lin Sun, Ayman K. Banah, X. Weng +6 more
2025Cells1 citations Open access
Semantic Scholar
The CNC-bZIP transcription factor Nrf2 controls expression of matrix metalloproteases in murine macrophages.
Abel D. Ang, Sharadha Dayalan Naidu, O. Read, Ping-Ting Bian +13 more
2026Journal of Leukocyte Biology0 citations Open access
Semantic Scholar
Genetic and pharmacologic inhibition of Keap1 dampens the pro-fibrotic program in human hepatic stellate cells
Sharadha Dayalan Naidu, R. Madsen, Boushra Bathish, Ping-Ting Bian +11 more
2026Scientific Reports0 citations Open access
Semantic Scholar
Tetrazole-containing naphthalene bis-sulfonamide Keap1-Nrf2 interaction inhibitors with unexpected binding modes
Nikolaos D. Georgakopoulos, S. Talapatra, Sharadha Dayalan Naidu, Dina Dikovskaya +10 more
2025Redox Biology0 citations Open access
Semantic Scholar
Author Correction: C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape
Sharadha Dayalan Naidu, Aki Muramatsu, Ryota Saito, Soichiro Asami +6 more
2024Scientific Reports0 citations Open access
Semantic Scholar

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