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D. Ryan · SciRah

Researcher profile · Semantic Scholar

D. Ryan

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D. Ryan — researcher profile on SciRah

h-index: 18
Works: 27
Citations: 6,357

Most-cited papers

Repurposing mitochondria from ATP production to ROS generation drives a pro-inflammatory phenotype in macrophages that depends on succinate oxidation by complex II
E. Mills, B. Kelly, A. Logan, Ana S. H. Costa +16 more
2016Cell2,112 citations Open access
Semantic Scholar
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
E. Mills, D. Ryan, H. Prag, Dina Dikovskaya +31 more
2018Nature1,744 citations Open access
Semantic Scholar
Krebs Cycle Reborn in Macrophage Immunometabolism.
D. Ryan, L. O'Neill
2020Annual Review of Immunology421 citations Open access
Semantic Scholar
Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2
James O. Early, D. Menon, C. Wyse, Mariana P. Cervantes-Silva +14 more
2018Proceedings of the National Academy of Sciences of the United States of America363 citations Open access
Semantic Scholar
Coupling Krebs cycle metabolites to signalling in immunity and cancer
D. Ryan, M. Murphy, C. Frezza, H. Prag +3 more
2018Nature Metabolism348 citations Open access
Semantic Scholar
Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
D. Olagnier, Aske M. Brandtoft, Camilla Gunderstofte, Nikolaj L. Villadsen +30 more
2018Nature Communications274 citations Open access
Semantic Scholar
Targeting fumarate hydratase promotes mitochondrial RNA-mediated interferon production
A. Hooftman, Christian G. Peace, D. Ryan, Emily A. Day +24 more
2023Nature210 citations Open access
Semantic Scholar
A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia.
J. Baardman, S. Verberk, K. Prange, M. van Weeghel +14 more
2018Cell Reports172 citations Open access
Semantic Scholar
Krebs cycle rewired for macrophage and dendritic cell effector functions
D. Ryan, L. O'Neill
2017FEBS Letters134 citations Open access
Semantic Scholar
Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism
D. Ryan, Ming Yang, H. Prag, G. R. Blanco +10 more
2021bioRxiv123 citations Open access
Semantic Scholar
Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response
D. Ryan, Elena V. Knatko, A. Casey, J. Hukelmann +17 more
2022iScience100 citations Open access
Semantic Scholar
Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses
Mimmi le Lundahl, Morgane Mitermite, D. Ryan, Sarah Case +14 more
2021bioRxiv83 citations Open access
Semantic Scholar
Caspase-11 promotes allergic airway inflammation
Z. Zaslona, E. Flis, Mieszko M. Wilk, R. Carroll +18 more
2020Nature Communications70 citations Open access
Semantic Scholar
TCA cycle signalling and the evolution of eukaryotes
D. Ryan, C. Frezza, L. O'Neill
2020Current Opinion in Biotechnology57 citations Open access
Semantic Scholar
Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages
Niamh C. Williams, D. Ryan, Ana S. H. Costa, E. Mills +4 more
2021Journal of Biological Chemistry51 citations Open access
Semantic Scholar
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression
M. Sciacovelli, Aurélien J. F. Dugourd, L. V. Jimenez, Ming Yang +24 more
2022Nature Communications38 citations Open access
Semantic Scholar
Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling
M. Hughes, P. Lavrencic, R. Coll, T. Ve +8 more
2017Proceedings of the National Academy of Sciences of the United States of America35 citations Open access
Semantic Scholar
DIA label-free proteomic analysis of murine bone-marrow-derived macrophages
Christa P Baker, Iain R. Phair, Alejandro J. Brenes, A. Atrih +6 more
2022STAR Protocols19 citations Open access
Semantic Scholar
Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1 α in lipopolysaccharide-activated macrophages
Niamh C. Williams, D. Ryan, Ana S. H. Costa, E. Mills +5 more
202213 citations
Semantic Scholar
IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity
D. Ryan, C. Frezza
2021Immunometabolism8 citations Open access
Semantic Scholar
Nitrogen partitioning between branched-chain amino acids and urea cycle enzymes sustains renal cancer progression
M. Sciacovelli, Aurélien J. F. Dugourd, L. V. Jimenez, Ming Yang +24 more
2021bioRxiv4 citations Open access
Semantic Scholar
Immunometabolism at the basis of health and disease; an editorial.
J. van den Bossche, Tiffany Horng, D. Ryan
2023Biochimica et Biophysica Acta - Molecular Basis of Disease2 citations Open access
Semantic Scholar
Metabolic symbiosis in pancreatic cancer
D. Ryan, C. Frezza
2022Nature Cancer2 citations
Semantic Scholar
Nrf2 is a central regulator of the metabolic landscape in macrophages and finetunes their inflammatory response
D. Ryan, Elena V. Knatko, A. Casey, J. Hukelmann +12 more
2021bioRxiv1 citations Open access
Semantic Scholar
Author response: Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism
D. Ryan, Ming Yang, H. Prag, G. R. Blanco +10 more
20210 citations Open access
Semantic Scholar
Analysis of the role of Krebs cycle rewiring in macrophage cytokine production
D. Ryan
20190 citations
Semantic Scholar
Disruption of the TCA cycle reveals an ATF 4-dependent integration of redox 1 and amino acid metabolism 2
D. Ryan, Ming Yang, H. Prag, G. R. Blanco +11 more
0 citations
Semantic Scholar

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