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E. Beck · SciRah

Researcher profile · Semantic Scholar

E. Beck

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E. Beck — researcher profile on SciRah

h-index: 17
Works: 31
Citations: 1,857

Most-cited papers

Oxidative Pd(II)-catalyzed C-H bond amination to carbazole at ambient temperature.
James A. Jordan‐Hore, C. Johansson, Moisés Gulías, E. Beck +1 more
2008Journal of the American Chemical Society454 citations
Semantic Scholar
Mild aerobic oxidative palladium (II) catalyzed C-H bond functionalization: regioselective and switchable C-H alkenylation and annulation of pyrroles.
E. Beck, N. Grimster, R. Hatley, M. Gaunt
2006Journal of the American Chemical Society277 citations
Semantic Scholar
Synthesis of rhazinicine by a metal-catalyzed C-H bond functionalization strategy.
E. Beck, R. Hatley, M. Gaunt
2008Angewandte Chemie190 citations
Semantic Scholar
Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligand.
Lei Zhang, A. Villalobos, E. Beck, T. Bocan +13 more
2013Journal of Medicinal Chemistry177 citations Open access
Semantic Scholar
Pd-catalyzed C-H bond functionalization on the indole and pyrrole nucleus.
E. Beck, M. Gaunt
2011Topics in current chemistry177 citations
Semantic Scholar
Chemical synthesis of Aspidosperma alkaloids inspired by the reverse of the biosynthesis of the rhazinilam family of natural products.
L. McMurray, E. Beck, M. Gaunt
2012Angewandte Chemie65 citations
Semantic Scholar
Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors
A. Zuhl, C. Nolan, Michael A. Brodney, S. Niessen +16 more
2016Nature Communications64 citations Open access
Semantic Scholar
Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors
Michael A. Brodney, E. Beck, C. Butler, G. Barreiro +27 more
2015Journal of Medicinal Chemistry63 citations Open access
Semantic Scholar
Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase.
C. Butler, E. Beck, A. Harris, Zhen Huang +18 more
2017Journal of Medicinal Chemistry59 citations Open access
Semantic Scholar
Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design.
C. Butler, Michael A. Brodney, E. Beck, G. Barreiro +21 more
2015Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
Chiral Sulfinamide/Achiral Sulfonic Acid Co-Catalyzed Enantioselective Protonation of Enol Silanes
E. Beck, A. M. Hyde, E. Jacobsen
2011Organic Letters39 citations Open access
Semantic Scholar
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.
B. O'Neill, E. Beck, C. Butler, C. Nolan +27 more
2018Journal of Medicinal Chemistry36 citations Open access
Semantic Scholar
Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality
C. Butler, Kevin Ogilvie, Luis A Martínez-Alsina, G. Barreiro +19 more
2016Journal of Medicinal Chemistry36 citations Open access
Semantic Scholar
The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH)
M. Skaddan, Lei Zhang, D. Johnson, Aijun Zhu +14 more
2012Nuclear Medicine and Biology29 citations Open access
Semantic Scholar
The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging.
Lei Zhang, L. Chen, E. Beck, T. Chappie +18 more
2017Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
Bend-ribbon forming gamma-peptides.
A. Kothari, M. K. Qureshi, E. Beck, Martin D. Smith
2007Chemical Communications25 citations
Semantic Scholar
Synthesis and Structure‐Activity Relationships of N‐(4‐Benzamidino)‐Oxazolidinones: Potent and Selective Inhibitors of Kallikrein‐Related Peptidase 6
E. De Vita, Niels Smits, Helma van den Hurk, E. Beck +11 more
2019ChemMedChem20 citations Open access
Semantic Scholar
Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1
E. Beck, Euan Parnell, A. Cowley, A. Porter +17 more
2019Cells17 citations Open access
Semantic Scholar
Oxidative Pd(II)-Catalyzed C—H Bond Amination to Carbazole at Ambient Temperature.
James A. Jordan‐Hore, C. Johansson, Moisés Gulías, E. Beck +1 more
200917 citations
Semantic Scholar
Identification of a Novel Positron Emission Tomography (PET) Ligand for Imaging β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) in Brain.
Lei Zhang, L. Chen, Jason K. Dutra, E. Beck +15 more
2018Journal of Medicinal Chemistry16 citations
Semantic Scholar
Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M4 Muscarinic Acetylcholine Receptor.
Christopher R. Butler, M. Popiolek, Laura A McAllister, Erik A. Lachapelle +21 more
2024Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Expedient Diels–Alder assembly of 4-aryl-4-phenylsulfonyl cyclohexanones ☆
Jeremy P. Scott, D. C. Hammond, E. Beck, K. Brands +3 more
200411 citations
Semantic Scholar
Utilizing CYP2D6 and BACE1 Structure Complexes to Reduce Risk of Drug-Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors
Michael A. Brodney, E. Beck, C. Butler, G. Barreiro +19 more
20151 citations
Semantic Scholar
CCDC 1532758: Experimental Crystal Structure Determination
C. Butler, Kevin Ogilvie, Luis A Martínez-Alsina, G. Barreiro +19 more
20170 citations
Semantic Scholar
Chapter 8:C–H Activation Approaches to Molecules
E. Beck, A. Stepan, Damien Webb
20160 citations
Semantic Scholar
2-AMIN0-6-METI L-4,4a, 5,6-tetrahydro [3,4-d] [1,3] thiazin-8A (8H) -yl-1,3-thiazol-4-ILAMIDAS
Michael A. Brodney, E. Beck, C. Butler, Lei Zhang +4 more
20160 citations
Semantic Scholar
P4–277: Evaluation of beta‐amyloid‐lowering efficacy of a novel BACE1 inhibitor in multiple species
C. Nolan, K. Atchison, A. Robshaw, L. Pustilnik +16 more
20130 citations
Semantic Scholar
Enantioselective Protonation of Enol Silanes by ProtonatedChiral Sulfinamides
E. Beck, A. M. Hyde, E. Jacobsen
20110 citations
Semantic Scholar
Oxidative Pd(II)-Catalyzed C-H Bond Activation Routeto Carbazoles
James A. Jordan‐Hore, C. Johansson, Moisés Gulías, E. Beck +1 more
20090 citations
Semantic Scholar
Synthesis of (±)-Rhazinicine
E. Beck, R. Hatley, M. Gaunt
20080 citations
Semantic Scholar
Mild Aerobic Oxidative Palladium (II) Catalyzed C—H Bond Functionalization: Regioselective and Switchable C—H Alkenylation and Annulation of Pyrroles.
E. Beck, N. Grimster, R. Hatley, M. Gaunt
20060 citations
Semantic Scholar

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