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C. van Roomen · SciRah

Researcher profile · Semantic Scholar

C. van Roomen

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C. van Roomen — researcher profile on SciRah

h-index: 29
Works: 86
Citations: 3,479

Most-cited papers

Elevated globotriaosylsphingosine is a hallmark of Fabry disease
J. Aerts, J. Groener, S. Kuiper, W. Donker-Koopman +14 more
2008Proceedings of the National Academy of Sciences of the United States of America715 citations Open access
Semantic Scholar
Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity.
M. van Eijk, C. van Roomen, G. Renkema, Anton P. Bussink +6 more
2005International Immunology328 citations
Semantic Scholar
High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages
Willianne Hoepel, Hung-Jen Chen, C. Geyer, Sona Allahverdiyeva +32 more
2021Science Translational Medicine223 citations Open access
Semantic Scholar
Cytokine-mediated modulation of leptin and adiponectin secretion during in vitro adipogenesis: evidence that tumor necrosis factor-alpha- and interleukin-1beta-treated human preadipocytes are potent leptin producers.
Peter J. Simons, P. S. van den Pangaart, C. van Roomen, J. Aerts +1 more
2005Cytokine129 citations
Semantic Scholar
Novel activity-based probes for broad-spectrum profiling of retaining β-exoglucosidases in situ and in vivo.
W. Kallemeijn, Kah-Yee Li, M. Witte, André R. A. Marques +15 more
2012Angewandte Chemie128 citations Open access
Semantic Scholar
Reducing Glycosphingolipid Content in Adipose Tissue of Obese Mice Restores Insulin Sensitivity, Adipogenesis and Reduces Inflammation
M. van Eijk, J. Aten, N. Bijl, R. Ottenhoff +8 more
2009PLoS ONE125 citations Open access
Semantic Scholar
Glycosphingolipids and insulin resistance.
J. Aerts, R. Boot, M. van Eijk, J. Groener +12 more
2011Advances in Experimental Medicine and Biology120 citations Open access
Semantic Scholar
Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques
J. Baardman, S. Verberk, S. van der Velden, M. Gijbels +16 more
2020Nature Communications119 citations Open access
Semantic Scholar
Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice
N. Bijl, M. Sokolović, C. Vrins, M. Langeveld +9 more
2009Hepatology105 citations Open access
Semantic Scholar
Nanoparticle-Aided Characterization of Arterial Endothelial Architecture during Atherosclerosis Progression and Metabolic Therapy
Thijs J. Beldman, T. Malinova, E. Desclos, A. Grootemaat +15 more
2019ACS Nano96 citations Open access
Semantic Scholar
Aortic microcalcification is associated with elastin fragmentation in Marfan syndrome
S. Wanga, S. Hibender, Y. Ridwan, C. van Roomen +11 more
2017Journal of Pathology78 citations Open access
Semantic Scholar
Impact of obesity on taste receptor expression in extra-oral tissues: emphasis on hypothalamus and brainstem
D. H. Chao, Carmen A. Argmann, M. van Eijk, R. Boot +7 more
2016Scientific Reports77 citations Open access
Semantic Scholar
Regulation of adiponectin secretion by insulin and amino acids in 3T3-L1 adipocytes.
R. Blümer, C. van Roomen, A. Meijer, J. Houben-Weerts +2 more
2008Metabolism: Clinical and Experimental75 citations
Semantic Scholar
Inhibition of Glycosphingolipid Synthesis Induces a Profound Reduction of Plasma Cholesterol and Inhibits Atherosclerosis Development in APOE*3 Leiden and Low-Density Lipoprotein Receptor−/− Mice
Florence M. Bietrix, E. Lombardo, C. van Roomen, R. Ottenhoff +5 more
2010Arteriosclerosis, Thrombosis and Vascular Biology73 citations
Semantic Scholar
Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases[S]
A. Marques, M. Mirzaian, Hisako Akiyama, P. Wisse +23 more
2016Journal of Lipid Research71 citations Open access
Semantic Scholar
Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice
A. Marques, J. Aten, R. Ottenhoff, C. van Roomen +11 more
2015PLoS ONE71 citations Open access
Semantic Scholar
Resveratrol Inhibits Aortic Root Dilatation in the Fbn1C1039G/+ Marfan Mouse Model
S. Hibender, Romy Franken, C. van Roomen, A. T. ter Braake +11 more
2016Arteriosclerosis, Thrombosis and Vascular Biology65 citations Open access
Semantic Scholar
Lysosomal Stress in Obese Adipose Tissue Macrophages Contributes to MITF-Dependent Gpnmb Induction
T. Gabriel, M. Tol, R. Ottenhof, C. van Roomen +9 more
2014Diabetes63 citations Open access
Semantic Scholar
Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease
A. Marques, T. Gabriel, J. Aten, C. van Roomen +7 more
2016PLoS ONE54 citations Open access
Semantic Scholar
A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity
M. Tol, R. Ottenhoff, M. van Eijk, N. Zelcer +12 more
2016Diabetes53 citations Open access
Semantic Scholar
Ezetimibe stimulates faecal neutral sterol excretion depending on abcg8 function in mice
L. Jakulj, M. N. Vissers, C. van Roomen, Jelske N. van der Veen +5 more
2010FEBS Letters51 citations Open access
Semantic Scholar
TLR‐ and NOD2‐dependent regulation of human phagocyte‐specific chitotriosidase
M. van Eijk, S. Scheij, C. van Roomen, D. Speijer +2 more
2007FEBS Letters47 citations
Semantic Scholar
Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes
Daniela Herrera Moro Chao, W. Kallemeijn, A. Marques, M. Orre +13 more
2015PLoS ONE41 citations Open access
Semantic Scholar
Lyso-glycosphingolipid abnormalities in different murine models of lysosomal storage disorders.
M. J. Ferraz, A. Marques, P. Gaspar, M. Mirzaian +9 more
2016Molecular Genetics and Metabolism40 citations Open access
Semantic Scholar
Unexpected effects of fasting on murine lipid homeostasis--transcriptomic and lipid profiling.
M. Sokolović, Aleksandar Sokolović, C. van Roomen, A. Gruber +5 more
2010Journal of Hepatology39 citations
Semantic Scholar
DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability.
Lisa Willemsen, K. Prange, A. Neele, C. van Roomen +14 more
2022Cell Reports35 citations Open access
Semantic Scholar
Integrated metabolic-transcriptomic network identifies immunometabolic modulations in human macrophages.
Hung-Jen Chen, Daniel Sevin, G. Griffith, J. Vappiani +10 more
2024Cell Reports31 citations Open access
Semantic Scholar
Myeloid Kdm6b deficiency results in advanced atherosclerosis.
A. Neele, M. Gijbels, S. van der Velden, M. Hoeksema +12 more
2018Atherosclerosis31 citations Open access
Semantic Scholar
Humanized Anti-IgE mAb Hu-901 Prevents the Activation of Allergen-Specific T Cells
R. V. van Neerven, C. van Roomen, W. R. Thomas, M. de Boer +2 more
2001International Archives of Allergy and Immunology31 citations
Semantic Scholar
Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice
N. Bijl, C. van Roomen, V. Triantis, M. Sokolović +6 more
2009Hepatology29 citations Open access
Semantic Scholar
Nur77 protects against adverse cardiac remodelling by limiting neuropeptide Y signalling in the sympathoadrenal-cardiac axis
L. Medzikovic, C. van Roomen, A. Baartscheer, P. V. van Loenen +8 more
2018Cardiovascular Research28 citations Open access
Semantic Scholar
Targeting the ACOD1-itaconate axis stabilizes atherosclerotic plaques
Karl J. Harber, A. Neele, C. van Roomen, Marion J. M. Gijbels +17 more
2024Redox Biology26 citations Open access
Semantic Scholar
Dyscholesterolemia Protects Against Ischemia-Induced Ventricular Arrhythmias
A. Baartscheer, C. Schumacher, V. Wekker, A. Verkerk +7 more
2015Circulation: Arrhythmia and Electrophysiology26 citations Open access
Semantic Scholar
Stabilization of Glucocerebrosidase by Active Site Occupancy
F. Ben Bdira, W. Kallemeijn, S. Oussoren, S. Scheij +11 more
2017ACS Chemical Biology25 citations Open access
Semantic Scholar
Nuclear Receptor Nur77 Controls Cardiac Fibrosis through Distinct Actions on Fibroblasts and Cardiomyocytes
L. Medzikovic, Hylja Heese, P. V. van Loenen, C. van Roomen +5 more
2021International Journal of Molecular Sciences23 citations Open access
Semantic Scholar
Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis
Rosario Luque-Martin, J. van den Bossche, Rebecca Furze, A. Neele +10 more
2019Frontiers in Pharmacology21 citations Open access
Semantic Scholar
Monocyte and Macrophage Lipid Accumulation Results in Down-Regulated Type-I Interferon Responses
Lisa Willemsen, Hung-Jen Chen, C. van Roomen, G. Griffith +5 more
2022Frontiers in Cardiovascular Medicine19 citations Open access
Semantic Scholar
Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival
T. Gabriel, M. Mirzaian, B. Hooibrink, R. Ottenhoff +3 more
2017PLoS ONE19 citations Open access
Semantic Scholar
A Specific Activity‐Based Probe to Monitor Family GH59 Galactosylceramidase, the Enzyme Deficient in Krabbe Disease
A. Marques, L. Willems, Daniela Herrera Moro, B. Florea +14 more
2017ChemBioChem17 citations Open access
Semantic Scholar
Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard.
M. Mirzaian, P. Wisse, M. J. Ferraz, A. Marques +8 more
2016Clinica chimica acta; international journal of clinical chemistry17 citations
Semantic Scholar
Correction of Liver Steatosis by a Hydrophobic Iminosugar Modulating Glycosphingolipids Metabolism
E. Lombardo, C. van Roomen, G. V. van Puijvelde, R. Ottenhoff +8 more
2012PLoS ONE17 citations Open access
Semantic Scholar
Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis
S. Aarts, T. Seijkens, P. Kusters, C. V. van Tiel +7 more
2019Journal of Pathology16 citations Open access
Semantic Scholar
Novel Activity-Based Probes for Broad-Spectrum Profiling of Retaining b-Exoglucosidases In Situ and In Vivo * *
W. Kallemeijn, Kah-Yee Li, M. Witte, R. A. Marques +15 more
201216 citations
Semantic Scholar
Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes
W. Kallemeijn, S. Scheij, S. Hoogendoorn, M. Witte +6 more
2017PLoS ONE13 citations Open access
Semantic Scholar
Fasting reduces liver fibrosis in a mouse model for chronic cholangiopathies.
Aleksandar Sokolović, C. van Roomen, R. Ottenhoff, S. Scheij +6 more
2013Biochimica et Biophysica Acta13 citations Open access
Semantic Scholar
Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss
Lisa Willemsen, A. Neele, S. van der Velden, K. Prange +7 more
2019BMJ Open Diabetes Research & Care12 citations Open access
Semantic Scholar
Carotid plaque macrophage burden and inflammatory lipid-associated macrophage markers predict secondary major adverse cardiovascular events after endarterectomy
K. Prange, G. Bel-Bordes, M. Depuydt, Panos Barlampas +26 more
2026European Heart Journal9 citations Open access
Semantic Scholar
Treatment of genetically obese mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin reduces body weight by decreasing food intake and increasing fat oxidation.
M. Langeveld, S. V. D. van den Berg, N. Bijl, S. Bijland +9 more
2012Metabolism: Clinical and Experimental7 citations
Semantic Scholar
T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation
W. Vos, B. V. van Os, M. den Toom, L. Beckers +11 more
2024Frontiers in Immunology6 citations Open access
Semantic Scholar
The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1
Daniela Herrera Moro Chao, Ya-Nan Wang, E. Foppen, R. Ottenhoff +19 more
2019Diabetes5 citations Open access
Semantic Scholar

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