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T. Seijkens · SciRah

Researcher profile · Semantic Scholar

T. Seijkens

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T. Seijkens — researcher profile on SciRah

h-index: 30
Works: 84
Citations: 3,124

Most-cited papers

Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis.
D. Lievens, A. Zernecke, T. Seijkens, O. Soehnlein +15 more
2010Blood306 citations Open access
Semantic Scholar
Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile
E. Lutgens, D. Lievens, L. Beckers, E. Wijnands +16 more
2010Journal of Experimental Medicine270 citations Open access
Semantic Scholar
Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis
T. Seijkens, C. V. van Tiel, P. Kusters, D. Atzler +32 more
2018Journal of the American College of Cardiology190 citations Open access
Semantic Scholar
Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions
M. Hoeksema, M. Gijbels, J. van den Bossche, S. van der Velden +19 more
2014EMBO Molecular Medicine187 citations Open access
Semantic Scholar
Immune Checkpoint Inhibitor Therapy Aggravates T Cell–Driven Plaque Inflammation in Atherosclerosis
K. Poels, M. V. van Leent, C. Boutros, H. Tissot +16 more
2020JACC CardioOncology151 citations Open access
Semantic Scholar
Plasmacytoid dendritic cells protect against atherosclerosis by tuning T cell proliferation and activity
I. Daissormont, A. Christ, L. Temmerman, Stefan Sampedro Millares +12 more
2011Circulation Research139 citations Open access
Semantic Scholar
Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance
A. Chatzigeorgiou, T. Seijkens, B. Zarzycka, D. Engel +32 more
2014Proceedings of the National Academy of Sciences of the United States of America133 citations Open access
Semantic Scholar
Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates
M. Lameijer, T. Binderup, M. V. van Leent, Max L. Senders +27 more
2018Nature Biomedical Engineering121 citations Open access
Semantic Scholar
Abstract 178: Platelet Cd40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes
D. Lievens, T. Seijkens, M. Kuijpers, H. Winkels +10 more
2013Arteriosclerosis, Thrombosis and Vascular Biology110 citations
Semantic Scholar
Immune Cell Crosstalk in Obesity: A Key Role for Costimulation?
T. Seijkens, P. Kusters, A. Chatzigeorgiou, T. Chavakis +1 more
2014Diabetes99 citations
Semantic Scholar
Diet‐induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow
S. M. Berg, T. Seijkens, Pascal J. H. Kusters, L. Beckers +5 more
2016The FASEB Journal90 citations Open access
Semantic Scholar
The immunobiology of CD154-CD40-TRAF interactions in atherosclerosis.
D. Engel, T. Seijkens, M. Poggi, Maryam Sanati +5 more
2009Seminars in Immunology84 citations
Semantic Scholar
Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice
K. Poels, M. V. van Leent, Myrthe E. Reiche, P. Kusters +5 more
2020Cells83 citations Open access
Semantic Scholar
Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease
M. Lacy, Christin Bürger, A. Shami, M. Ahmadsei +21 more
2021Nature Communications78 citations Open access
Semantic Scholar
Exploring immune checkpoints as potential therapeutic targets in atherosclerosis
Pascal J. H. Kusters, E. Lutgens, T. Seijkens
2018Cardiovascular Research75 citations Open access
Semantic Scholar
The CD40–CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis
S. Aarts, T. Seijkens, Koos J. F. van Dorst, C. Dijkstra +2 more
2017Frontiers in Immunology69 citations Open access
Semantic Scholar
Discovery of Small Molecule CD40-TRAF6 Inhibitors
B. Zarzycka, T. Seijkens, S. Nabuurs, T. Ritschel +11 more
2015Journal of Chemical Information and Modeling64 citations Open access
Semantic Scholar
Inhibition of PFKFB3 Hampers the Progression of Atherosclerosis and Promotes Plaque Stability
K. Poels, J. Schnitzler, F. Waissi, J. Levels +7 more
2020Frontiers in Cell and Developmental Biology61 citations Open access
Semantic Scholar
Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death
T. Seijkens, K. Poels, Svenja U. Meiler, C. V. van Tiel +20 more
2018European Heart Journal60 citations Open access
Semantic Scholar
The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease
L. Bosmans, L. Bosch, P. Kusters, E. Lutgens +1 more
2020Journal of Cardiovascular Translational Research57 citations Open access
Semantic Scholar
Immune checkpoint inhibitor treatment and atherosclerotic cardiovascular disease: an emerging clinical problem
K. Poels, S. Neppelenbroek, M. Kersten, M. L. Antoni +2 more
2021Journal for ImmunoTherapy of Cancer55 citations Open access
Semantic Scholar
Cancer patients receiving immune checkpoint inhibitor therapy are at an increased risk for atherosclerotic cardiovascular disease
E. Lutgens, T. Seijkens
2020Journal for ImmunoTherapy of Cancer55 citations Open access
Semantic Scholar
Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice
S. M. van den Berg, T. Seijkens, P. Kusters, B. Zarzycka +9 more
2014International Journal of Obesity55 citations Open access
Semantic Scholar
Caveolin‐1 deficiency decreases atherosclerosis by hampering leukocyte influx into the arterial wall and generating a regulatory T‐cell response
D. Engel, L. Beckers, E. Wijnands, T. Seijkens +8 more
2011The FASEB Journal55 citations Open access
Semantic Scholar
CD40–CD40L: Linking pancreatic, adipose tissue and vascular inflammation in type 2 diabetes and its complications
T. Seijkens, P. Kusters, D. Engel, E. Lutgens
2013Diabetes & vascular disease research52 citations Open access
Semantic Scholar
Liposomal prednisolone promotes macrophage lipotoxicity in experimental atherosclerosis.
F. M. van der Valk, D. Schulte, Svenja U. Meiler, Jun Tang +12 more
2016Nanomedicine: Nanotechnology, Biology and Medicine38 citations Open access
Semantic Scholar
Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans
A. Shami, D. Atzler, L. Bosmans, H. Winkels +20 more
2020European Heart Journal36 citations Open access
Semantic Scholar
Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation
S. Aarts, T. Seijkens, P. Kusters, S. V. D. van der Pol +12 more
2017Journal of Neuroinflammation36 citations Open access
Semantic Scholar
‘Nur'turing tumor T cell tolerance and exhaustion: novel function for Nuclear Receptor Nur77 in immunity
Sanne C. Lith, B. V. van Os, T. Seijkens, C. D. de Vries
2020European Journal of Immunology35 citations Open access
Semantic Scholar
The role of CD154 in haematopoietic development
T. Seijkens, D. Engel, M. Tjwa, E. Lutgens
2010Thrombosis and Haemostasis35 citations
Semantic Scholar
Ablation of CD8α+ dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice
B. Legein, Edith M. Janssen, T. Theelen, M. Gijbels +12 more
2015Scientific Reports23 citations Open access
Semantic Scholar
CD40L Deficiency Protects Against Aneurysm Formation
P. Kusters, T. Seijkens, L. Beckers, D. Lievens +9 more
2018Arteriosclerosis, Thrombosis and Vascular Biology22 citations Open access
Semantic Scholar
Accelerated atherosclerosis associated with immune checkpoint inhibitors: a systematic review and meta-analysis of pre-clinical studies.
A. Strijdhorst, W. Vos, L. Bosmans, K. Dzobo +7 more
2025Atherosclerosis20 citations Open access
Semantic Scholar
Statins and immune checkpoint inhibitors: a strategy to improve the efficacy of immunotherapy for cancer?
W. Vos, E. Lutgens, T. Seijkens
2022Journal for ImmunoTherapy of Cancer20 citations Open access
Semantic Scholar
Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure.
L. Bosch, J. de Haan, T. Seijkens, C. V. van Tiel +4 more
2019International Journal of Cardiology20 citations Open access
Semantic Scholar
Hematopoietic G‐protein‐coupled receptor kinase 2 deficiency decreases atherosclerotic lesion formation in LDL receptor‐knockout mice
J. Otten, S. C. A. Jager, A. Kavelaars, T. Seijkens +10 more
2013The FASEB Journal20 citations Open access
Semantic Scholar
Short-term regulation of hematopoiesis by lipoprotein(a) results in the production of pro-inflammatory monocytes.
J. Schnitzler, K. Poels, Lotte C. A. Stiekema, C. Yeang +5 more
2020International Journal of Cardiology16 citations Open access
Semantic Scholar
Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis
S. Aarts, T. Seijkens, P. Kusters, C. V. van Tiel +7 more
2019Journal of Pathology16 citations Open access
Semantic Scholar
Interruption of the CXCL13/CXCR5 Chemokine Axis Enhances Plasma IgM Levels and Attenuates Atherosclerosis Development
Emiel P. C. van der Vorst, I. Daissormont, Maria Aslani, T. Seijkens +10 more
2019Thrombosis and Haemostasis16 citations Open access
Semantic Scholar
Cardiovascular oncology: exploring the effects of targeted cancer therapies on atherosclerosis
T. Seijkens, E. Lutgens
2018Current Opinion in Lipidology16 citations
Semantic Scholar
Immuno-PET Imaging of Atherosclerotic Plaques with [89Zr]Zr-Anti-CD40 mAb—Proof of Concept
K. Poels, M. Schreurs, Matthijs F. Jansen, D. Vugts +4 more
2022Biology14 citations Open access
Semantic Scholar
Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption.
P. Kusters, T. Seijkens, Christin Bürger, B. Legein +11 more
2017American Journal of Pathology13 citations Open access
Semantic Scholar
E3 Ubiquitin Ligases as Immunotherapeutic Target in Atherosclerotic Cardiovascular Disease
K. Poels, W. Vos, E. Lutgens, T. Seijkens
2020Frontiers in Cardiovascular Medicine10 citations Open access
Semantic Scholar
T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation
W. Vos, B. V. van Os, M. den Toom, L. Beckers +11 more
2024Frontiers in Immunology6 citations Open access
Semantic Scholar
Peritoneal Metastases From Prostate Carcinoma Treated With 177Lu-PSMA-I&T.
L. W. van Golen, T. Seijkens, J. D. de Feijter, W. Vogel
2023Clinical Nuclear Medicine5 citations
Semantic Scholar
The emerging role for CAR T cells in solid tumor oncology.
S. Klobuch, T. Seijkens, J. Haanen
2023Chinese Clinical Oncology3 citations Open access
Semantic Scholar
Hyperlipidemia Induces A Hyperinflammatory Response In T-Cells
C. V. van Tiel, B. V. van Os, T. Seijkens, E. Lutgens
2019Atherosclerosis2 citations
Semantic Scholar
Author Correction: Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates
M. Lameijer, T. Binderup, M. V. van Leent, Max L. Senders +27 more
2018Nature Biomedical Engineering2 citations Open access
Semantic Scholar
Caveolin-1 deﬁciency decreases atherosclerosis by hampering leukocyte inﬂux into the arterial wall and generating a regulatory T-cell response
D. Engel, L. Beckers, E. Wijnands, T. Seijkens +8 more
20132 citations
Semantic Scholar
The CXCL13-CXCR5 axis contributes to atherosclerosis development in LDLr-/- mice by regulating myeloid development (149.1)
I. Daissormont, T. Seijkens, B. Halvorsen, Uta Hopken +4 more
2011Journal of Immunology2 citations
Semantic Scholar

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