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M. Tohkin · SciRah

Researcher profile · Semantic Scholar

M. Tohkin

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M. Tohkin — researcher profile on SciRah

h-index: 32
Works: 130
Citations: 5,558

Most-cited papers

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.
C. Sinal, M. Tohkin, M. Miyata, J. Ward +2 more
2000Cell1,787 citations Open access
Semantic Scholar
HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis.
N. Kaniwa, Yoshiro Saito, M. Aihara, K. Matsunaga +15 more
2008Pharmacogenomics (London)380 citations
Semantic Scholar
Targeted Disruption of Soluble Epoxide Hydrolase Reveals a Role in Blood Pressure Regulation*
C. Sinal, M. Miyata, M. Tohkin, K. Nagata +2 more
2000Journal of Biological Chemistry349 citations Open access
Semantic Scholar
HLA‐B*1511 is a risk factor for carbamazepine‐induced Stevens‐Johnson syndrome and toxic epidermal necrolysis in Japanese patients
N. Kaniwa, Yoshiro Saito, M. Aihara, K. Matsunaga +14 more
2010Epilepsia219 citations Open access
Semantic Scholar
A whole-genome association study of major determinants for allopurinol-related Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese patients
M. Tohkin, N. Kaniwa, Yoshiro Saito, E. Sugiyama +14 more
2011The Pharmacogenomics Journal174 citations Open access
Semantic Scholar
RACIAL VARIABILITY IN HAPLOTYPE FREQUENCIES OF UGT1A1 AND GLUCURONIDATION ACTIVITY OF A NOVEL SINGLE NUCLEOTIDE POLYMORPHISM 686C> T (P229L) FOUND IN AN AFRICAN-AMERICAN
N. Kaniwa, K. Kurose, H. Jinno, T. Tanaka-Kagawa +5 more
2005Drug Metabolism And Disposition154 citations
Semantic Scholar
Low-dose dioxins alter gene expression related to cholesterol biosynthesis, lipogenesis, and glucose metabolism through the aryl hydrocarbon receptor-mediated pathway in mouse liver.
Shoko Sato, Hitoshi Shirakawa, S. Tomita, Y. Ohsaki +7 more
2008Toxicology and Applied Pharmacology146 citations
Semantic Scholar
Effect of CYP2C9 genetic polymorphisms on the efficacy and pharmacokinetics of glimepiride in subjects with type 2 diabetes.
Kazuko Suzuki, T. Yanagawa, T. Shibasaki, N. Kaniwa +2 more
2006Diabetes Research and Clinical Practice87 citations
Semantic Scholar
Genetic variations and haplotypes of CYP2C19 in a Japanese population.
Hiromi Fukushima-Uesaka, Yoshiro Saito, K. Maekawa, S. Ozawa +10 more
2005Drug Metabolism and Pharmacokinetics83 citations
Semantic Scholar
Four novel defective alleles and comprehensive haplotype analysis of CYP2C9 in Japanese
K. Maekawa, Hiromi Fukushima-Uesaka, M. Tohkin, R. Hasegawa +9 more
2006Pharmacogenetics & Genomics77 citations
Semantic Scholar
Substrate-Dependent Functional Alterations of Seven CYP2C9 Variants Found in Japanese Subjects
K. Maekawa, N. Harakawa, E. Sugiyama, M. Tohkin +9 more
2009Drug Metabolism And Disposition68 citations
Semantic Scholar
Identification of the functional vitamin D response elements in the human MDR1 gene.
M. Saeki, K. Kurose, M. Tohkin, R. Hasegawa
2008Biochemical Pharmacology65 citations
Semantic Scholar
Androgens directly stimulate mineralization and increase androgen receptors in human osteoblast-like osteosarcoma cells.
M. Takeuchi, H. Kakushi, M. Tohkin
1994Biochemical and Biophysical Research Communications - BBRC65 citations
Semantic Scholar
Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects.
N. Kaniwa, E. Sugiyama, Yoshiro Saito, K. Kurose +19 more
2013Pharmacogenomics (London)62 citations
Semantic Scholar
Comprehensive UGT1A1 genotyping in a Japanese population by pyrosequencing.
M. Saeki, Yoshiro Saito, H. Jinno, M. Tohkin +8 more
2003Clinical Chemistry56 citations Open access
Semantic Scholar
CYP3A4*16 and CYP3A4*18 Alleles Found in East Asians Exhibit Differential Catalytic Activities for Seven CYP3A4 Substrate Drugs
K. Maekawa, N. Harakawa, T. Yoshimura, Su-ryang Kim +11 more
2010Drug Metabolism And Disposition53 citations
Semantic Scholar
Aryl hydrocarbon receptor is required for p300-mediated induction of DNA synthesis by adenovirus E1A.
M. Tohkin, M. Fukuhara, G. Elizondo, S. Tomita +1 more
2000Molecular Pharmacology52 citations
Semantic Scholar
Absence of ethnic differences in the pharmacokinetics of moxifloxacin, simvastatin, and meloxicam among three East Asian populations and Caucasians
T. Hasunuma, M. Tohkin, N. Kaniwa, I. Jang +8 more
2016British Journal of Clinical Pharmacology44 citations Open access
Semantic Scholar
The aryl hydrocarbon receptor and glucocorticoid receptor interact to activate human metallothionein 2A
Shoko Sato, Hitoshi Shirakawa, S. Tomita, M. Tohkin +2 more
2013Toxicology and Applied Pharmacology43 citations Open access
Semantic Scholar
Significant association between hand-foot syndrome and efficacy of capecitabine in patients with metastatic breast cancer.
Yu-ichiro Azuma, K. Hata, K. Sai, R. Udagawa +9 more
2012Biological and Pharmaceutical Bulletin38 citations Open access
Semantic Scholar
Ethnic differences of two non-synonymous single nucleotide polymorphisms in CDA gene.
E. Sugiyama, Su-Jun Lee, Sang Seop Lee, Woo-Young Kim +10 more
2009Drug Metabolism and Pharmacokinetics37 citations
Semantic Scholar
A detection algorithm for drug‐induced liver injury in medical information databases using the Japanese diagnostic scale and its comparison with the Council for International Organizations of Medical Sciences/the Roussel Uclaf Causality Assessment Method scale
T. Hanatani, K. Sai, M. Tohkin, Katsunori Segawa +4 more
2014Pharmacoepidemiology and Drug Safety34 citations
Semantic Scholar
Development of a rapid and inexpensive assay for detecting a surrogate genetic polymorphism of HLA-B*58:01: a partially predictive but useful biomarker for allopurinol-related Stevens-Johnson syndrome/toxic epidermal necrolysis in Japanese.
K. Maekawa, J. Nishikawa, N. Kaniwa, E. Sugiyama +4 more
2012Drug Metabolism and Pharmacokinetics34 citations
Semantic Scholar
Susceptibility to serious skin and subcutaneous tissue disorders and skin tissue distribution of sodium-dependent glucose co-transporter type 2 (SGLT2) inhibitors
T. Sakaeda, Shinji Kobuchi, Ryosuke Yoshioka, M. Haruna +9 more
2018International Journal of Medical Sciences33 citations Open access
Semantic Scholar
Comparison of the developmental/reproductive toxicity and hepatotoxicity of phthalate esters in rats using an open toxicity data source.
Kaori Ambe, Yuko Sakakibara, Aya Sakabe, Hayato Makino +2 more
2019Journal of Toxicological Sciences31 citations Open access
Semantic Scholar
Prediction of severe adverse drug reactions using pharmacogenetic biomarkers.
M. Tohkin, Akihiro Ishiguro, N. Kaniwa, Yoshiro Saito +2 more
2010Drug Metabolism and Pharmacokinetics31 citations
Semantic Scholar
Serum lipidomics for exploring biomarkers of bortezomib therapy in patients with multiple myeloma
K. Maekawa, Masaki Ri, M. Nakajima, A. Sekine +5 more
2019Cancer Science26 citations Open access
Semantic Scholar
Genetic variations of the ABC transporter gene ABCC3 in a Japanese population.
Hiromi Fukushima-Uesaka, Yoshiro Saito, K. Maekawa, R. Hasegawa +8 more
2007Drug Metabolism and Pharmacokinetics24 citations
Semantic Scholar
Development of quantitative model of a local lymph node assay for evaluating skin sensitization potency applying machine learning CatBoost.
Kaori Ambe, Masaharu Suzuki, T. Ashikaga, M. Tohkin
2021Regulatory toxicology and pharmacology : RTP23 citations Open access
Semantic Scholar
Expression, mutation, and methylation of cereblon‐pathway genes at pre‐ and post‐lenalidomide treatment in multiple myeloma
T. Tachita, Shiori Kinoshita, Masaki Ri, Sho Aoki +12 more
2020Cancer Science23 citations Open access
Semantic Scholar
In Silico Prediction of Chemical-Induced Hepatocellular Hypertrophy Using Molecular Descriptors
Kaori Ambe, Kana Ishihara, Tatsuya Ochibe, Kazuyuki Ohya +4 more
2018Toxicological Sciences21 citations
Semantic Scholar
Thyroid hormone receptor mediates human MDR1 gene expression-Identification of the response region essential for gene expression.
K. Kurose, M. Saeki, M. Tohkin, R. Hasegawa
2008Archives of Biochemistry and Biophysics20 citations
Semantic Scholar
Reconstitution of CYP3A4 active site through assembly of ligand interactions as a grid-template: Solving the modes of the metabolism and inhibition.
Y. Yamazoe, Takahiro Goto, M. Tohkin
2019Drug Metabolism and Pharmacokinetics19 citations
Semantic Scholar
5′ Diversity of human hepatic PXR (NR1I2) transcripts and identification of the major transcription initiation site
K. Kurose, Satoru Koyano, S. Ikeda, M. Tohkin +2 more
2005Molecular and Cellular Biochemistry19 citations
Semantic Scholar
Allopurinol suppresses expression of the regulatory T‐cell migration factors TARC/CCL17 and MDC/CCL22 in HaCaT keratinocytes via restriction of nuclear factor‐κB activation
M. Osabe, T. Tajika, M. Tohkin
2018Journal of Applied Toxicology16 citations
Semantic Scholar
No Contribution of the ABCB11 p.444A Polymorphism in Japanese Patients with Drug-Induced Cholestasis
T. Kagawa, Shunji Hirose, Yoshitaka Arase, A. Oka +21 more
2015Drug Metabolism And Disposition15 citations Open access
Semantic Scholar
Impact of Japanese regulatory action on metformin-associated lactic acidosis in type II diabetes patients
T. Hanatani, K. Sai, M. Tohkin, Katsunori Segawa +1 more
2015International Journal of Clinical Pharmacy15 citations
Semantic Scholar
Points to Consider for Implementation of the ICH E17 Guideline: Learning from Past Multiregional Clinical Trials in Japan
K. Asano, Y. Aoi, Shuji Kamada, Y. Uyama +1 more
2020Clinical pharmacology and therapy14 citations Open access
Semantic Scholar
Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template.
Y. Yamazoe, M. Tohkin
2020Drug Metabolism and Pharmacokinetics14 citations
Semantic Scholar
Functional analysis of genetic variations in the 5'-flanking region of the human MDR1 gene.
M. Saeki, K. Kurose, R. Hasegawa, M. Tohkin
2011Molecular Genetics and Metabolism14 citations
Semantic Scholar
Cloning and Characterization of Syrian Hamster Testosterone 7α-Hydroxylase, CYP2A9
K. Kurose, M. Tohkin, F. Ushio, M. Fukuhara
199814 citations
Semantic Scholar
Versatile applicability of a grid-based CYP3A4 Template to understand the interacting mechanisms with the small-size ligands; part 3 of CYP3A4 Template study.
Y. Yamazoe, Takahiro Goto, M. Tohkin
2020Drug Metabolism and Pharmacokinetics13 citations
Semantic Scholar
Factors Affecting Drug‐Development Strategies in Asian Global Clinical Trials for Drug Approval in Japan
K. Asano, Y. Uyama, M. Tohkin
2017Clinical and Translational Science13 citations Open access
Semantic Scholar
Pharmacokinetics and Pharmacodynamics of Meloxicam in East Asian Populations: The Role of Ethnicity on Drug Response
T. Aoyama, Y. Ishida, M. Kaneko, A. Miyamoto +4 more
2017CPT: Pharmacometrics & Systems Pharmacology13 citations Open access
Semantic Scholar
Significant association between HLA‐B*35:01 and onset of drug‐induced liver injury caused by Kampo medicines in Japanese patients
R. Nakamura, Noriaki Arakawa, Yoichi Tanaka, N. Uchiyama +16 more
2022Hepatology Research12 citations
Semantic Scholar
Hepatitis B infection reported with cancer chemotherapy: analyzing the US FDA Adverse Event Reporting System
A. Sanagawa, Y. Hotta, T. Kataoka, Yasuhiro Maeda +6 more
2018Cancer Medicine12 citations Open access
Semantic Scholar
Cross-Classification of Human Urinary Lipidome by Sex, Age, and Body Mass Index
Kazuo Okemoto, K. Maekawa, Y. Tajima, M. Tohkin +1 more
2016PLoS ONE12 citations Open access
Semantic Scholar
[Basic principles of interpretation of hepatocellular hypertrophy in risk assessment in Japan].
Midori Yoshida, T. Umemura, Hiroyuki Kojima, Kaoru Inoue +7 more
2015Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan12 citations Open access
Semantic Scholar
Real‐world evidence of population differences in allopurinol‐related severe cutaneous adverse reactions in East Asians: A population‐based cohort study
Tsugumichi Sato, Ching-Lan Cheng, Heung-Woo Park, Yea-Huei Kao Yang +6 more
2020Clinical and Translational Science11 citations Open access
Semantic Scholar
Genetic variations and haplotype structures of the ABC transporter gene ABCC1 in a Japanese population.
Hiromi Fukushima-Uesaka, Yoshiro Saito, M. Tohkin, K. Maekawa +9 more
2007Drug Metabolism and Pharmacokinetics10 citations
Semantic Scholar

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Yoshiro Saito×24
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Yoshiro Saito — researcher profile on SciRah
R. Hasegawa×18
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R. Hasegawa — researcher profile on SciRah
K. Kurose×13
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K. Kurose — researcher profile on SciRah
N. Kaniwa×12
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N. Kaniwa — researcher profile on SciRah

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K. Maekawa — researcher profile on SciRah

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J. Sawada — researcher profile on SciRah

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F. Gonzalez — researcher profile on SciRah

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E. Sugiyama — researcher profile on SciRah

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M. Saeki — researcher profile on SciRah

Kazuko Suzuki×5

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Kazuko Suzuki — researcher profile on SciRah

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T. Yanagawa — researcher profile on SciRah

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K. Yasuda — researcher profile on SciRah