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Shinji Kobuchi · SciRah

Researcher profile · Semantic Scholar

Shinji Kobuchi

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Shinji Kobuchi — researcher profile on SciRah

h-index: 14
Works: 80
Citations: 665

Most-cited papers

Therapeutic Drug Monitoring of Vancomycin in Dermal Interstitial Fluid Using Dissolving Microneedles
Yukako Ito, Yuto Inagaki, Shinji Kobuchi, K. Takada +1 more
2016International Journal of Medical Sciences57 citations Open access
Semantic Scholar
A validated LC-MS/MS method for the determination of canagliflozin, a sodium-glucose co-transporter 2 (SGLT-2) inhibitor, in a lower volume of rat plasma: application to pharmacokinetic studies in rats.
Shinji Kobuchi, K. Yano, Yukako Ito, T. Sakaeda
2016Biomedical chromotography39 citations
Semantic Scholar
Population pharmacokinetics of afatinib and exposure-safety relationships in Japanese patients with EGFR mutation-positive non-small cell lung cancer
Keiko Nakao, Shinji Kobuchi, Shuhei Marutani, Ayano Iwazaki +9 more
2019Scientific Reports35 citations Open access
Semantic Scholar
Susceptibility to serious skin and subcutaneous tissue disorders and skin tissue distribution of sodium-dependent glucose co-transporter type 2 (SGLT2) inhibitors
T. Sakaeda, Shinji Kobuchi, Ryosuke Yoshioka, M. Haruna +9 more
2018International Journal of Medical Sciences33 citations Open access
Semantic Scholar
Circadian variations in the pharmacokinetics of capecitabine and its metabolites in rats
Shinji Kobuchi, Y. Yazaki, Yukako Ito, T. Sakaeda
2018European Journal of Pharmaceutical Sciences25 citations
Semantic Scholar
Effect of serum lipids on the pharmacokinetics of atazanavir in hyperlipidemic rats.
Keizo Fukushima, Masakazu Shibata, Kazunori Mizuhara, H. Aoyama +4 more
2009Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie23 citations
Semantic Scholar
Application of Pharmacometrics of 5-Fluorouracil to Personalized Medicine: A Tool for Predicting Pharmacokinetic–Pharmacodynamic/Toxicodynamic Responses
Shinji Kobuchi, Yukako Ito
2020Anticancer Research22 citations Open access
Semantic Scholar
Pharmacokinetics of Macrolide Antibiotics and Transport into the Interstitial Fluid: Comparison among Erythromycin, Clarithromycin, and Azithromycin
Shinji Kobuchi, T. Kabata, K. Maeda, Yukako Ito +1 more
2020Antibiotics22 citations Open access
Semantic Scholar
Dissolving Microneedles as Skin Allergy Test Device.
Yukako Ito, Kengo Matsumoto, Noriyuki Osakama, Ryosuke Yoshioka +3 more
2017Biological and Pharmaceutical Bulletin19 citations Open access
Semantic Scholar
Application of dissolving microneedles to glucose monitoring through dermal interstitial fluid.
Yukako Ito, Mayu Taniguchi, Asuka Hayashi, Miku Anai +7 more
2014Biological and Pharmaceutical Bulletin19 citations Open access
Semantic Scholar
Pharmacokinetics of clomipramine, an antidepressant, in poloxamer 407‐induced hyperlipidaemic model rats
Shinji Kobuchi, Keizo Fukushima, Masakazu Shibata, Yukako Ito +2 more
2011The Journal of pharmacy and pharmacology18 citations
Semantic Scholar
A quantitative LC-MS/MS method for determining ipragliflozin, a sodium-glucose co-transporter 2 (SGLT-2) inhibitor, and its application to a pharmacokinetic study in rats.
Shinji Kobuchi, Yukako Ito, K. Yano, T. Sakaeda
2015Journal of chromatography. B, Analytical technologies in the biomedical and life sciences15 citations
Semantic Scholar
Time-dependent interaction of ritonavir in chronic use: the power balance between inhibition and induction of P-glycoprotein and cytochrome P450 3A.
Keizo Fukushima, Shinji Kobuchi, Kazunori Mizuhara, H. Aoyama +2 more
2013Journal of Pharmacy and Science15 citations
Semantic Scholar
Circadian variations in the pharmacokinetics of the oral anticancer agent tegafur‐uracil (UFT) and its metabolites in rats
Shinji Kobuchi, Yukako Ito, Daiki Takamatsu, T. Sakaeda
2018European Journal of Pharmaceutical Sciences14 citations
Semantic Scholar
Dissolving microneedles for enhanced local delivery of capsaicin to rat skin tissue
Yukako Ito, Shinji Kobuchi, Genta Inoue, Eisaku Kakumu +3 more
2017Journal of drug targeting (Print)14 citations
Semantic Scholar
Mechanism-based pharmacokinetic–pharmacodynamic (PK–PD) modeling and simulation of oxaliplatin for hematological toxicity in rats
Shinji Kobuchi, Y. Katsuyama, Yukako Ito
2019Xenobiotica; the fate of foreign compounds in biological systems13 citations
Semantic Scholar
Pharmacokinetic/pharmacodynamic modeling of 5-fluorouracil by using a biomarker to predict tumor growth in a rat model of colorectal cancer.
Shinji Kobuchi, Yukako Ito, K. Okada, K. Imoto +2 more
2013Journal of Pharmacy and Science13 citations
Semantic Scholar
Pharmacokinetic and toxicodynamic evaluation of oxaliplatin-induced neuropathy and hematological toxicity in rats
Yukako Ito, Shinji Kobuchi, Risa Shimizu, Y. Katsuyama
2017Cancer Chemotherapy and Pharmacology12 citations
Semantic Scholar
Semi-physiological pharmacokinetic–pharmacodynamic modeling and simulation of 5-fluorouracil for the whole time course of alterations in leukocyte, neutrophil and lymphocyte counts in rats
Shinji Kobuchi, Yukako Ito, Taro Hayakawa, S. Kuwano +5 more
2014Xenobiotica; the fate of foreign compounds in biological systems12 citations
Semantic Scholar
Pharmacokinetic-pharmacodynamic (PK-PD) modeling and simulation of 5-fluorouracil for erythropenia in rats.
Shinji Kobuchi, Yukako Ito, Taro Hayakawa, Asako Nishimura +3 more
2014Journal of pharmacological and toxicological methods12 citations
Semantic Scholar
Pharmacokinetics and lung distribution of macrolide antibiotics in sepsis model rats
Shinji Kobuchi, Akihiro Fujita, Akihito Kato, H. Kobayashi +2 more
2020Xenobiotica; the fate of foreign compounds in biological systems11 citations
Semantic Scholar
Population pharmacokinetic modelling and simulation of 5-fluorouracil incorporating a circadian rhythm in rats
Shinji Kobuchi, Yukako Ito, Yuya Nakano, T. Sakaeda
2016Xenobiotica; the fate of foreign compounds in biological systems11 citations
Semantic Scholar
Pre-therapeutic assessment of plasma dihydrouracil/uracil ratio for predicting the pharmacokinetic parameters of 5-fluorouracil and tumor growth in a rat model of colorectal cancer.
Shinji Kobuchi, Yukako Ito, K. Okada, K. Imoto +2 more
2013Biological and Pharmaceutical Bulletin11 citations Open access
Semantic Scholar
Development and validation of an LC-MS/MS method for the determination of tofogliflozin in plasma and its application to a pharmacokinetic study in rats.
Shinji Kobuchi, Megumi Matsuno, Etsuko Fukuda, Yukako Ito +1 more
2016Journal of chromatography. B, Analytical technologies in the biomedical and life sciences10 citations
Semantic Scholar
A predictive biomarker for altered 5‐fluorouracil pharmacokinetics following repeated administration in a rat model of colorectal cancer
Shinji Kobuchi, S. Kuwano, K. Imoto, K. Okada +4 more
2013Biopharmaceutics & drug disposition10 citations
Semantic Scholar
Pharmacokinetics of 5-fluorouracil and increased hepatic dihydropyrimidine dehydrogenase activity levels in 1,2-dimethylhydrazine-induced colorectal cancer model rats
Shinji Kobuchi, Yukako Ito, K. Okada, K. Imoto +1 more
2012European journal of drug metabolism and pharmacokinetics10 citations
Semantic Scholar
Assessment of Oxaliplatin-induced Chronic Neuropathy and Anticancer Efficacy Through Pharmacokinetic and Toxicodynamic Evaluation of a Rat Model of Colorectal Cancer
Yukako Ito, Shinji Kobuchi, Takesada Waki, Chiharu Takahashi
2019Anticancer Research8 citations Open access
Semantic Scholar
Association between circadian and chemotherapeutic cycle effects on plasma concentration of 5-fluorouracil and the clinical outcome following definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in patients with esophageal squamous cell carcinoma.
Akiko Kuwahara, Shinji Kobuchi, T. Tamura
2018Oncology Letters8 citations Open access
Semantic Scholar
Transport of Azithromycin into Extravascular Space in Rats
Shinji Kobuchi, Miki Aoki, Chiaki Inoue, Hiroyuki Murakami +6 more
2016Antimicrobial Agents and Chemotherapy8 citations Open access
Semantic Scholar
Population Pharmacokinetic–Pharmacodynamic Modeling of 5-Fluorouracil for Toxicities in Rats
Shinji Kobuchi, Yukako Ito, T. Sakaeda
2016European journal of drug metabolism and pharmacokinetics8 citations
Semantic Scholar
Semi-physiological pharmacokinetic–pharmacodynamic (PK–PD) modeling and simulation of 5-fluorouracil for thrombocytopenia in rats
Shinji Kobuchi, Yukako Ito, Taro Hayakawa, Asako Nishimura +3 more
2015Xenobiotica; the fate of foreign compounds in biological systems8 citations
Semantic Scholar
Extracellular vesicle-enriched secretome of adipose-derived stem cells upregulates clusterin to alleviate doxorubicin-induced apoptosis in cardiomyocytes
Wan-Tseng Hsu, Shinji Kobuchi, T. Chien, I-Chun Chen +6 more
2025Biology Direct7 citations Open access
Semantic Scholar
Assessment of pharmacokinetic variations of capecitabine after multiple administration in rats: a physiologically based pharmacokinetic model
Shuhei Sakai, Shinji Kobuchi, Yukako Ito, T. Sakaeda
2020Cancer Chemotherapy and Pharmacology7 citations
Semantic Scholar
Effects of oxidative stress on the pharmacokinetics and hepatic metabolism of atazanavir in rats
Shinji Kobuchi, Keizo Fukushima, H. Aoyama, Yukako Ito +2 more
2013Free radical research7 citations
Semantic Scholar
Effect of oxidative stress on the pharmacokinetics of clomipramine in rats treated with ferric-nitrilotriacetate.
Shinji Kobuchi, Keizo Fukushima, H. Aoyama, T. Matsuda +3 more
2011Drug Metabolism Letters7 citations
Semantic Scholar
Translational PK-PD/TD modeling of antitumor effects and peripheral neuropathy in gemcitabine and nab-paclitaxel chemotherapy from xenograft mice to patients for optimal dose and schedule
Shinji Kobuchi, Atsuko Morita, S. Jonan, K. Amagase +1 more
2023Cancer Chemotherapy and Pharmacology6 citations
Semantic Scholar
A Physiologically Based Pharmacokinetic–Pharmacodynamic Model for Capecitabine in Colorectal Cancer Rats: Simulation of Antitumor Efficacy at Various Administration Schedules
Shuhei Sakai, Shinji Kobuchi, Yukako Ito, T. Sakaeda
2021European journal of drug metabolism and pharmacokinetics6 citations
Semantic Scholar
Effect of intact oxaliplatin in plasma on a cold allodynia after multiple administrations in colorectal cancer model rats.
Yukako Ito, Shinji Kobuchi, Mako Takeda, M. Morimoto
2020Annals of Palliative Medicine5 citations Open access
Semantic Scholar
Effects of obesity induced by high-fat diet on the pharmacokinetics of atazanavir in rats.
Shinji Kobuchi, Keizo Fukushima, H. Aoyama, Yukako Ito +2 more
2013Drug Metabolism Letters5 citations
Semantic Scholar
Pharmacokinetics and distribution of fluvoxamine to the brain in rats under oxidative stress
Shinji Kobuchi, Keizo Fukushima, Yukako Ito, N. Sugioka +1 more
2012Free radical research5 citations
Semantic Scholar
Chronopharmacokinetic model analysis of 5-fluorouracil following S-1 administration in rats: comparison with infusion and other prodrugs for chronochemotherapy.
Shinji Kobuchi, Tomoki Satake, Yukako Ito
2025Journal of Pharmacy and Science4 citations
Semantic Scholar
Translational Pharmacokinetic-Toxicodynamic Model of Myelosuppression for Dose Optimization in Combination Chemotherapy of Capecitabine and Oxaliplatin from Rats to Humans
Shinji Kobuchi, Mayuka Arimoto, Yukako Ito
2024Journal of Pharmacology and Experimental Therapeutics4 citations
Semantic Scholar
Mobilization of Circulating Tumor Cells after Short- and Long-Term FOLFIRINOX and GEM/nab-PTX Chemotherapy in Xenograft Mouse Models of Human Pancreatic Cancer
Yukako Ito, Shinji Kobuchi, Amiri Kawakita, Kazuki Tosaka +8 more
2023Cancers4 citations Open access
Semantic Scholar
A Pharmacokinetic-Pharmacodynamic Model Predicts Uracil-tegafur Effect on Tumor Shrinkage and Myelosuppression in a Colorectal Cancer Rat Model
Shinji Kobuchi, M. Tsuda, M. Okamura, Takanori Nakamura +1 more
2023Anticancer Research4 citations
Semantic Scholar
Assessment of drug-drug interaction and optimization in capecitabine and irinotecan combination regimen using a physiologically based pharmacokinetic model.
Shuhei Sakai, Shinji Kobuchi, Yukako Ito, T. Sakaeda
2021Journal of Pharmacy and Science4 citations
Semantic Scholar
Population Pharmacokinetic Model-Based Evaluation of Intact Oxaliplatin in Rats with Acute Kidney Injury
Shinji Kobuchi, Miyu Kai, Yukako Ito
2021Cancers4 citations Open access
Semantic Scholar
Semi-Mechanism-Based Pharmacokinetic-Toxicodynamic Model of Oxaliplatin-Induced Acute and Chronic Neuropathy
Shinji Kobuchi, Risa Shimizu, Yukako Ito
2020Pharmaceutics4 citations Open access
Semantic Scholar
Cytology-based Detection of Circulating Tumour Cells in Human Pancreatic Cancer Xenograft Models With KRAS Mutation
Yukako Ito, Eriko Inoue, Y. Matsui, Shinji Kobuchi +6 more
2020Anticancer Research4 citations Open access
Semantic Scholar
A simple and rapid LC-MS/MS method for quantitation of luseogliflozin in rat plasma and its application to a PK study.
Shinji Kobuchi, Megumi Matsuno, Momoko Kawamoto, N. Kojima +3 more
2017Bioanalysis4 citations
Semantic Scholar
Effects of Cholestasis on Whole Blood Concentration of Tacrolimus, an Immunosuppressant, in Living-Related Liver Transplant Recipients
Shinji Kobuchi, Keizo Fukushima, Yu Maeda, T. Kokuhu +4 more
20134 citations Open access
Semantic Scholar

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Yukako Ito×44
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Yukako Ito — researcher profile on SciRah
T. Sakaeda×22
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T. Sakaeda — researcher profile on SciRah
K. Takada×19
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K. Takada — researcher profile on SciRah
Keizo Fukushima×8
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Keizo Fukushima — researcher profile on SciRah

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N. Sugioka — researcher profile on SciRah

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H. Aoyama — researcher profile on SciRah

Taro Hayakawa×4

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Taro Hayakawa — researcher profile on SciRah

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K. Okada — researcher profile on SciRah

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K. Imoto — researcher profile on SciRah

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S. Kuwano — researcher profile on SciRah

Asako Nishimura×4

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Asako Nishimura — researcher profile on SciRah

Nobuhito Shibata×4

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Nobuhito Shibata — researcher profile on SciRah