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G. Dear · SciRah

Researcher profile · Semantic Scholar

G. Dear

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G. Dear — researcher profile on SciRah

h-index: 22
Works: 38
Citations: 1,507

Most-cited papers

Metabonomics: the use of electrospray mass spectrometry coupled to reversed-phase liquid chromatography shows potential for the screening of rat urine in drug development.
R. Plumb, C. Stumpf, M. Gorenstein, J. Castro-Pérez +5 more
2002Rapid Communications in Mass Spectrometry184 citations
Semantic Scholar
Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids.
R. Plumb, C. Stumpf, Jennifer H. Granger, J. Castro-Pérez +2 more
2003Rapid Communications in Mass Spectrometry172 citations Open access
Semantic Scholar
The use of turbulent flow chromatography/mass spectrometry for the rapid, direct analysis of a novel pharmaceutical compound in plasma.
J. Ayrton, G. Dear, W. J. Leavens, D. Mallett +1 more
1997Rapid Communications in Mass Spectrometry151 citations
Semantic Scholar
Application of a generic fast gradient liquid chromatography tandem mass spectrometry method for the analysis of cytochrome P450 probe substrates.
J. Ayrton, R. Plumb, W. J. Leavens, D. Mallett +2 more
1998Rapid Communications in Mass Spectrometry96 citations
Semantic Scholar
Hyperpolarisation through reversible interactions with parahydrogen
Lyrelle S. Lloyd, Azizi Asghar, M. Burns, A. Charlton +14 more
201477 citations Open access
Semantic Scholar
Sites of metabolic substitution: investigating metabolite structures utilising ion mobility and molecular modelling.
G. Dear, J. Muñoz-Muriedas, C. Beaumont, Andrew Roberts +3 more
2010Rapid Communications in Mass Spectrometry77 citations
Semantic Scholar
Optimizing drug discovery by Investigative Toxicology: Current and future trends.
Mario Beilmann, H. Boonen, A. Czich, G. Dear +30 more
2018ALTEX64 citations Open access
Semantic Scholar
Use of monolithic silica columns to increase analytical throughput for metabolite identification by liquid chromatography/tandem mass spectrometry
G. Dear, R. Plumb, D. Mallett
200161 citations
Semantic Scholar
Analysis of microcystins from cyanobacteria by liquid chromatography with mass spectrometry using atmospheric-pressure ionization
C. Edwards, L. Lawton, K. Beattie, G. Codd +2 more
199356 citations
Semantic Scholar
Elucidation of Drug Metabolite Structural Isomers Using Molecular Modeling Coupled with Ion Mobility Mass Spectrometry.
E. Reading, J. Muñoz-Muriedas, Andrew Roberts, G. Dear +2 more
2016Analytical Chemistry55 citations Open access
Semantic Scholar
Evaluation of preparative high performance liquid chromatography and cryoprobe-nuclear magnetic resonance spectroscopy for the early quantitative estimation of drug metabolites in human plasma.
G. Dear, Andrew Roberts, C. Beaumont, Stephanie E. North
2008Journal of chromatography. B, Analytical technologies in the biomedical and life sciences51 citations
Semantic Scholar
A gender-specific discriminator in Sprague-Dawley rat urine: the deployment of a metabolic profiling strategy for biomarker discovery and identification.
M. Hodson, G. Dear, A. Roberts, C. Haylock +5 more
2007Analytical Biochemistry47 citations
Semantic Scholar
From definition to implementation: a cross-industry perspective of past, current and future MIST strategies
A. Nedderman, G. Dear, Stephanie E. North, R. Obach +1 more
2011Xenobiotica; the fate of foreign compounds in biological systems44 citations
Semantic Scholar
Quantitative analysis of pharmaceuticals in biological fluids using high-performance liquid chromatography coupled to mass spectrometry: a review
Robert S. Plumb, G. Dear, D. Mallett, D. Higton +2 more
2001Xenobiotica; the fate of foreign compounds in biological systems43 citations
Semantic Scholar
Mass directed peak selection, an efficient method of drug metabolite identification using directly coupled liquid chromatography-mass spectrometry-nuclear magnetic resonance spectroscopy.
G. Dear, R. Plumb, B. Sweatman, J. Ayrton +3 more
2000Journal of Chromatography B: Biomedical Sciences and Applications37 citations
Semantic Scholar
A rapid and efficient approach to metabolite identification using nuclear magnetic resonance spectroscopy, liquid chromatography/mass spectrometry and liquid chromatography/nuclear magnetic resonance spectroscopy/sequential mass spectrometry
G. Dear, J. Ayrton, R. Plumb, B. Sweatman +3 more
199836 citations
Semantic Scholar
Urinary metabolites of a novel quinoxaline non-nucleoside reverse transcriptase inhibitor in rabbit, mouse and human: identification of fluorine NIH shift metabolites using NMR and tandem MS
G. Dear, I. Ismail, P. Mutch, Robert S. Plumb +2 more
2000Xenobiotica; the fate of foreign compounds in biological systems30 citations
Semantic Scholar
An approach for the development and selection of chromatographic methods for high-throughput metabolomic screening of urine by ultra pressure LC-ESI-ToF-MS
M. Hodson, G. Dear, J. Griffin, J. Haselden
2009Metabolomics28 citations
Semantic Scholar
HLA DRB1*15:01-DQB1*06:02-restricted human CD4+ T-cells are selectively activated with amoxicillin-peptide adducts.
A. Tailor, Xiaoli Meng, Kareena Adair, J. Farrell +6 more
2020Toxicological Sciences24 citations
Semantic Scholar
Determination of 4-hydroxytamoxifen in mouse plasma in the pg/mL range by gradient capillary liquid chromatography/tandem mass spectrometry.
R. Plumb, H. Warwick, D. Higton, G. Dear +1 more
2001Rapid Communications in Mass Spectrometry24 citations Open access
Semantic Scholar
The use of capillary high performance liquid chromatography with electrospray mass spectrometry for the analysis of small volume blood samples from serially bled mice to determine the pharmacokinetics of early discovery compounds.
I. Fraser, G. Dear, Robert S. Plumb, Matthew L’Affineur +2 more
1999Rapid Communications in Mass Spectrometry23 citations
Semantic Scholar
Definition of haptens derived from sulfamethoxazole: in vitro and in vivo.
A. Tailor, J. Waddington, J. Hamlett, J. Maggs +7 more
2019Chemical Research in Toxicology22 citations
Semantic Scholar
Approaches for the rapid identification of drug metabolites in early clinical studies.
G. Dear, C. Beaumont, Andrew Roberts, Bianca Squillaci +3 more
2011Bioanalysis19 citations
Semantic Scholar
Investigation into Small Molecule Isomeric Glucuronide Metabolite Differentiation Using In Silico and Experimental Collision Cross-Section Values.
John R. Connolly, J. Muñoz-Muriedas, Cris Lapthorn, D. Higton +4 more
2021Journal of the American Society for Mass Spectrometry18 citations
Semantic Scholar
Relationship between Pharmacokinetics and Pharmacodynamic Responses in Healthy Smokers Informs a Once-Daily Dosing Regimen for Nemiralisib
M. Begg, R. Wilson, J. N. Hamblin, M. Montembault +13 more
2019Journal of Pharmacology and Experimental Therapeutics17 citations Open access
Semantic Scholar
Tandem mass spectrometry linked fraction collection for the isolation of drug metabolites from biological matrices.
G. Dear, R. Plumb, B. Sweatman, I. M. Ismail +1 more
1999Rapid Communications in Mass Spectrometry16 citations
Semantic Scholar
An Inhaled PI3Kδ Inhibitor Improves Recovery in Acutely Exacerbating COPD Patients: A Randomized Trial
A. Cahn, J. N. Hamblin, Jon Robertson, M. Begg +12 more
2021International Journal of COPD14 citations Open access
Semantic Scholar
HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors.
Toru Usui, A. Tailor, L. Faulkner, Xiaoli Meng +5 more
2018Chemical Research in Toxicology9 citations Open access
Semantic Scholar
A discovery biotransformation strategy: combining in silico tools with high-resolution mass spectrometry and software-assisted data analysis for high-throughput metabolism
Daniel J. Weston, M. Dave, K. Colizza, Steve Thomas +5 more
2022Xenobiotica; the fate of foreign compounds in biological systems6 citations
Semantic Scholar
THE VALUE OF METABOLITE IDENTIFICATION AND QUANTIFICATION IN CLINICAL STUDIES. SOME CASE STUDIES ENABLING EARLY ASSESSMENT OF SAFETY IN HUMANS
J. Bloomer, C. Beaumont, G. Dear, Stephanie E. North +1 more
20163 citations
Semantic Scholar
METABOLITE TECHNOLOGY: QUALITATIVE AND QUANTITATIVE
G. Dear, A. Mcewen
20162 citations
Semantic Scholar
Retrospective use of PBPK modelling to understand a clinical drug–drug interaction between dextromethorphan and GSK1034702
M. Hobbs, J. Bloomer, G. Dear
2017Xenobiotica; the fate of foreign compounds in biological systems1 citations
Semantic Scholar
Applications of Capillary LC(-MS) to Drug Metabolism Studies
G. Dear, D. Mallett, Robert S. Plumb
20011 citations
Semantic Scholar
Development of a high content imaging assay to assess drug induced lysosome perturbation
I. Baines, Luther J. Davis, M. G. Lennon, C. Taylor +6 more
2018Toxicology Letters0 citations
Semantic Scholar
An in-vitro investigation in rat L6 and mouse C2C12 cell lines into the skeletal muscle toxicity observed in the mouse of Trypanosoma Cruzi whole cell inhibitor compounds
D. Grimsditch, Gino Brunori, J. Armitage, C. Taylor +7 more
2018Toxicology Letters0 citations
Semantic Scholar
“MIST” AND OTHER METABOLITE GUIDELINES IN THE CONTEXT OF INDUSTRIAL DRUG METABOLISM
G. Dear, A. Nedderman
20160 citations
Semantic Scholar
Identification Of Drug Metabolites In Biological Fluids Using Qualitative Spectroscopic And Chromatographic Techniques
I. Ismail, G. Dear
20040 citations
Semantic Scholar
DRUGS AND METABOLITES | Liquid Chromatography–Nuclear Magnetic Resonance–Mass Spectrometry
R. Plumb, G. Dear, I. Ismail, B. Sweatman
20000 citations
Semantic Scholar

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