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H. Hatakeyama · SciRah

Researcher profile · Semantic Scholar

H. Hatakeyama

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H. Hatakeyama — researcher profile on SciRah

h-index: 43
Works: 101
Citations: 5,867

Most-cited papers

A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma.
H. Hatakeyama, H. Akita, H. Harashima
2011Advanced Drug Delivery Reviews642 citations
Semantic Scholar
The polyethyleneglycol dilemma: advantage and disadvantage of PEGylation of liposomes for systemic genes and nucleic acids delivery to tumors.
H. Hatakeyama, H. Akita, H. Harashima
2013Biological and Pharmaceutical Bulletin443 citations Open access
Semantic Scholar
Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid
H. Hatakeyama, H. Akita, K. Kogure, M. Oishi +6 more
2007Gene Therapy396 citations Open access
Semantic Scholar
A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo.
Yusuke Sato, H. Hatakeyama, Y. Sakurai, Mamoru Hyodo +2 more
2012Journal of Controlled Release286 citations Open access
Semantic Scholar
A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.
H. Hatakeyama, E. Ito, H. Akita, M. Oishi +3 more
2009Journal of Controlled Release259 citations
Semantic Scholar
Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid.
H. Hatakeyama, H. Akita, E. Ito, Y. Hayashi +8 more
2011Biomaterials201 citations Open access
Semantic Scholar
Dual-ligand modification of PEGylated liposomes shows better cell selectivity and efficient gene delivery.
G. Kibria, H. Hatakeyama, N. Ohga, K. Hida +1 more
2011Journal of Controlled Release194 citations Open access
Semantic Scholar
Tumor targeting of doxorubicin by anti-MT1-MMP antibody-modified PEG liposomes.
H. Hatakeyama, H. Akita, Emi Ishida, K. Hashimoto +8 more
2007International journal of pharmaceutics166 citations
Semantic Scholar
Cancer multidrug resistance: mechanisms involved and strategies for circumvention using a drug delivery system
G. Kibria, H. Hatakeyama, H. Harashima
2013Archives of pharmacal research165 citations
Semantic Scholar
RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system.
Y. Sakurai, H. Hatakeyama, Yusuke Sato, Mamoru Hyodo +4 more
2014Journal of Controlled Release121 citations Open access
Semantic Scholar
2’f-OMe-phosphorodithioate modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity
S. Wu, Xianbin Yang, K. Gharpure, H. Hatakeyama +34 more
2014Nature Communications120 citations Open access
Semantic Scholar
Gene silencing via RNAi and siRNA quantification in tumor tissue using MEND, a liposomal siRNA delivery system.
Y. Sakurai, H. Hatakeyama, Yusuke Sato, Mamoru Hyodo +2 more
2013Molecular Therapy117 citations Open access
Semantic Scholar
A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer
S. Wu, R. Rupaimoole, Fang-Rong Shen, S. Pradeep +33 more
2016Nature Communications115 citations Open access
Semantic Scholar
Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA.
Y. Sakurai, H. Hatakeyama, Yusuke Sato, H. Akita +4 more
2011Biomaterials112 citations Open access
Semantic Scholar
A lipid nanoparticle for the efficient delivery of siRNA to dendritic cells.
Shota Warashina, Takashi Nakamura, Yusuke Sato, Yuki Fujiwara +3 more
2016Journal of Controlled Release106 citations Open access
Semantic Scholar
Size-controlled, dual-ligand modified liposomes that target the tumor vasculature show promise for use in drug-resistant cancer therapy.
Kazuhiro Takara, H. Hatakeyama, G. Kibria, N. Ohga +2 more
2012Journal of Controlled Release101 citations Open access
Semantic Scholar
The effect of liposomal size on the targeted delivery of doxorubicin to Integrin αvβ3-expressing tumor endothelial cells.
G. Kibria, H. Hatakeyama, N. Ohga, K. Hida +1 more
2013Biomaterials100 citations Open access
Semantic Scholar
Lipid envelope-type nanoparticle incorporating a multifunctional peptide for systemic siRNA delivery to the pulmonary endothelium.
K. Kusumoto, H. Akita, Taichi Ishitsuka, Yu Matsumoto +8 more
2013ACS Nano98 citations
Semantic Scholar
A multifunctional envelope-type nanodevice for use in nanomedicine: concept and applications.
Takashi Nakamura, H. Akita, Yuma Yamada, H. Hatakeyama +1 more
2012Accounts of Chemical Research86 citations
Semantic Scholar
Relationship Between the Physicochemical Properties of Lipid Nanoparticles and the Quality of siRNA Delivery to Liver Cells.
Yusuke Sato, H. Hatakeyama, Mamoru Hyodo, H. Harashima
2016Molecular Therapy77 citations Open access
Semantic Scholar
Recent Advances in Endogenous and Exogenous Stimuli-Responsive Nanocarriers for Drug Delivery and Therapeutics.
H. Hatakeyama
2017Chemical and pharmaceutical bulletin71 citations Open access
Semantic Scholar
A Neutral Envelope‐Type Nanoparticle Containing pH‐Responsive and SS‐Cleavable Lipid‐Like Material as a Carrier for Plasmid DNA
H. Akita, R. Ishiba, H. Hatakeyama, Hiroki Tanaka +5 more
2013Advanced Healthcare Materials71 citations
Semantic Scholar
An aptamer ligand based liposomal nanocarrier system that targets tumor endothelial cells.
M. N. Ara, Takashi Matsuda, Mamoru Hyodo, Y. Sakurai +4 more
2014Biomaterials69 citations Open access
Semantic Scholar
Design of a dual-ligand system using a specific ligand and cell penetrating peptide, resulting in a synergistic effect on selectivity and cellular uptake.
Kazuhiro Takara, H. Hatakeyama, N. Ohga, K. Hida +1 more
2010International journal of pharmaceutics66 citations Open access
Semantic Scholar
A neutral lipid envelope-type nanoparticle composed of a pH-activated and vitamin E-scaffold lipid-like material as a platform for a gene carrier targeting renal cell carcinoma.
H. Akita, R. Ishiba, R. Togashi, Kota Tange +3 more
2015Journal of Controlled Release65 citations Open access
Semantic Scholar
Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection.
Naoki Yamamoto, Yusuke Sato, Tsubasa Munakata, M. Kakuni +10 more
2016Journal of Hepatology61 citations Open access
Semantic Scholar
Delivering mRNA to Secondary Lymphoid Tissues by Phosphatidylserine‐Loaded Lipid Nanoparticles
Masaki Gomi, Y. Sakurai, Mina Sato, Hiroki Tanaka +8 more
2022Advanced Healthcare Materials56 citations
Semantic Scholar
Anti-tumor effect via passive anti-angiogenesis of PEGylated liposomes encapsulating doxorubicin in drug resistant tumors.
G. Kibria, H. Hatakeyama, Yusuke Sato, H. Harashima
2016International journal of pharmaceutics51 citations Open access
Semantic Scholar
Advances in an active and passive targeting to tumor and adipose tissues
Y. Sakurai, Kazuaki Kajimoto, H. Hatakeyama, H. Harashima
2015Expert Opinion on Drug Delivery51 citations
Semantic Scholar
In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus.
Tsunamasa Watanabe, H. Hatakeyama, Chiho Matsuda-Yasui, Yusuke Sato +8 more
2014Scientific Reports51 citations Open access
Semantic Scholar
In vitro optimization of 2′-OMe-4′-thioribonucleoside–modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle
Mayumi M. Takahashi, Naoki Yamada, H. Hatakeyama, Manami Murata +4 more
2013Nucleic Acids Research50 citations Open access
Semantic Scholar
An apolipoprotein E modified liposomal nanoparticle: ligand dependent efficiency as a siRNA delivery carrier for mouse-derived brain endothelial cells.
Mina Tamaru, H. Akita, Kazuaki Kajimoto, Yusuke Sato +2 more
2014International journal of pharmaceutics48 citations
Semantic Scholar
Synthesis, structure, and biological activity of dumbbell-shaped nanocircular RNAs for RNA interference.
Naoko Abe, H. Abe, C. Nagai, Mitsuru Harada +8 more
2011Bioconjugate chemistry48 citations
Semantic Scholar
Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP)
T. Mitamura, S. Pradeep, Michael H. McGuire, S. Wu +13 more
2017Oncogene47 citations Open access
Semantic Scholar
Comparative study of the sensitivities of cancer cells to doxorubicin, and relationships between the effect of the drug-efflux pump P-gp.
G. Kibria, H. Hatakeyama, K. Akiyama, K. Hida +1 more
2014Biological and Pharmaceutical Bulletin47 citations Open access
Semantic Scholar
Efficient short interference RNA delivery to tumor cells using a combination of octaarginine, GALA and tumor-specific, cleavable polyethylene glycol system.
Y. Sakurai, H. Hatakeyama, H. Akita, M. Oishi +3 more
2009Biological and Pharmaceutical Bulletin47 citations Open access
Semantic Scholar
The systemic administration of an anti-miRNA oligonucleotide encapsulated pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice.
H. Hatakeyama, Manami Murata, Yusuke Sato, Mayumi M. Takahashi +3 more
2014Journal of Controlled Release46 citations
Semantic Scholar
Intracellular stability of 2′-OMe-4′-thioribonucleoside modified siRNA leads to long-term RNAi effect
Mayumi M. Takahashi, C. Nagai, H. Hatakeyama, N. Minakawa +2 more
2012Nucleic Acids Research46 citations Open access
Semantic Scholar
Molecular Tuning of a Vitamin E-Scaffold pH-Sensitive and Reductive Cleavable Lipid-like Material for Accelerated in Vivo Hepatic siRNA Delivery.
H. Akita, Yukihiro Noguchi, H. Hatakeyama, Yusuke Sato +3 more
2015ACS Biomaterials Science & Engineering45 citations
Semantic Scholar
Anti-tumor and Anti-angiogenic Effects of Aspirin-PC in Ovarian Cancer
Yan Huang, L. Lichtenberger, Morgan L. Taylor, J. Bottsford-Miller +14 more
2016Molecular Cancer Therapeutics44 citations Open access
Semantic Scholar
The systemic administration of an anti-miRNA oligonucleotide encapsulated pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice.
H. Hatakeyama, Manami Murata, Yusuke Sato, Mayumi M. Takahashi +3 more
2014Journal of Controlled Release44 citations Open access
Semantic Scholar
Improvement of doxorubicin efficacy using liposomal anti-polo-like kinase 1 siRNA in human renal cell carcinomas.
Y. Sakurai, H. Hatakeyama, H. Akita, H. Harashima
2014Molecular Pharmaceutics44 citations
Semantic Scholar
Poor outcome with anti-programmed death-ligand 1 (PD-L1) antibody due to poor pharmacokinetic properties in PD-1/PD-L1 blockade-sensitive mouse models
Taiki Kurino, Reiko Matsuda, Ayu Terui, Hiroyuki Suzuki +5 more
2020Journal for ImmunoTherapy of Cancer43 citations Open access
Semantic Scholar
Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes
Y. Hayashi, Erina Suemitsu, Kazuaki Kajimoto, Yusuke Sato +7 more
2014Molecular Therapy: Nucleic Acids43 citations Open access
Semantic Scholar
HSP70 Inhibition Synergistically Enhances the Effects of Magnetic Fluid Hyperthermia in Ovarian Cancer
Karem A. Court, H. Hatakeyama, S. Wu, Mangala S. Lingegowda +7 more
2017Molecular Cancer Therapeutics41 citations
Semantic Scholar
Induction of Antitumor Immunity in Mice by the Combination of Nanoparticle-Based Photothermolysis and Anti-PD-1 Checkpoint Inhibition
Qizhen Cao, Wanqin Wang, Min Zhou, Qian Huang +12 more
2020Nanomedicine: Nanotechnology, Biology and Medicine33 citations Open access
Semantic Scholar
[Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid].
H. Hatakeyama, H. Akita, K. Kogure, H. Harashima
2007Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan32 citations Open access
Semantic Scholar
Combined nano cancer immunotherapy based on immune status in a tumor microenvironment.
Takashi Nakamura, K. Kawakami, Momoka Nomura, Yusuke Sato +4 more
2022Journal of Controlled Release31 citations Open access
Semantic Scholar
Novel antiangiogenic therapy targeting biglycan using tumor endothelial cell‐specific liposomal siRNA delivery system
N. Maishi, Y. Sakurai, H. Hatakeyama, Yui Umeyama +13 more
2022Cancer Science29 citations Open access
Semantic Scholar
Silencing of VEGFR2 by RGD-Modified Lipid Nanoparticles Enhanced the Efficacy of Anti-PD-1 Antibody by Accelerating Vascular Normalization and Infiltration of T Cells in Tumors
Riki Cho, Y. Sakurai, H. Jones, H. Akita +2 more
2020Cancers28 citations Open access
Semantic Scholar

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H. Akita — researcher profile on SciRah
Yusuke Sato×17
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Y. Sakurai×12
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Mamoru Hyodo — researcher profile on SciRah

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N. Ohga — researcher profile on SciRah

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G. Kibria — researcher profile on SciRah

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A. Sood — researcher profile on SciRah

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