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H. Akita · SciRah

Researcher profile · Semantic Scholar

H. Akita

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H. Akita — researcher profile on SciRah

h-index: 56
Works: 314
Citations: 13K

Most-cited papers

Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan
T. Adachi, J. Chong, N. Nakajima, M. Sano +12 more
2020Emerging Infectious Diseases122 citations Open access
Semantic Scholar
Self‐Degradable Lipid‐Like Materials Based on “Hydrolysis accelerated by the intra‐Particle Enrichment of Reactant (HyPER)” for Messenger RNA Delivery
Hiroki Tanaka, Tatsunari Takahashi, M. Konishi, Nae Takata +20 more
2020Advanced Functional Materials102 citations Open access
Semantic Scholar
Development of a lipoplex-type mRNA carrier composed of an ionizable lipid with a vitamin E scaffold and the KALA peptide for use as an ex vivo dendritic cell-based cancer vaccine.
Naho Tateshita, Naoya Miura, Hiroki Tanaka, Takeshi Masuda +5 more
2019Journal of Controlled Release79 citations
Semantic Scholar
In Vivo Introduction of mRNA Encapsulated in Lipid Nanoparticles to Brain Neuronal Cells and Astrocytes via Intracerebroventricular Administration.
Hiroki Tanaka, Taichi Nakatani, Tomomi Furihata, Kota Tange +4 more
2018Molecular Pharmaceutics71 citations Open access
Semantic Scholar
Delivering mRNA to Secondary Lymphoid Tissues by Phosphatidylserine‐Loaded Lipid Nanoparticles
Masaki Gomi, Y. Sakurai, Mina Sato, Hiroki Tanaka +8 more
2022Advanced Healthcare Materials56 citations
Semantic Scholar
A human immortalized cell-based blood-brain barrier tri-culture model: development and characterization as a promising tool for drug brain permeability studies.
Ryo Ito, Kenta Umehara, Shota Suzuki, K. Kitamura +9 more
2019Molecular Pharmaceutics50 citations
Semantic Scholar
An Ionizable Lipid Material with a Vitamin E Scaffold as an mRNA Vaccine Platform for Efficient Cytotoxic T Cell Responses
Ryotaro Oyama, H. Ishigame, Hiroki Tanaka, Naho Tateshita +14 more
2023ACS Nano46 citations Open access
Semantic Scholar
Development of lipid-like materials for RNA delivery based on intracellular environment-responsive membrane destabilization and spontaneous collapse.
Hiroki Tanaka, Y. Sakurai, Jessica Anindita, H. Akita
2020Advanced Drug Delivery Reviews43 citations Open access
Semantic Scholar
Targeting Tumor Endothelial Cells with Nanoparticles
Y. Sakurai, H. Akita, H. Harashima
2019International Journal of Molecular Sciences43 citations Open access
Semantic Scholar
Modulating Immunogenicity and Reactogenicity in mRNA-Lipid Nanoparticle Vaccines through Lipid Component Optimization
Yoshino Kawaguchi, M. Kimura, Tatsuya Karaki, Hiroki Tanaka +7 more
2025ACS Nano41 citations
Semantic Scholar
A New Conditionally Immortalized Human Fetal Brain Pericyte Cell Line: Establishment and Functional Characterization as a Promising Tool for Human Brain Pericyte Studies
Kenta Umehara, Yuchen Sun, S. Hiura, Koki Hamada +9 more
2018Molecular Neurobiology41 citations
Semantic Scholar
Targeted delivery of lipid nanoparticle to lymphatic endothelial cells via anti-podoplanin antibody.
Y. Sakurai, Nodoka Abe, Keito Yoshikawa, Ryotaro Oyama +6 more
2022Journal of Controlled Release40 citations Open access
Semantic Scholar
Low-inflammatory lipid nanoparticle-based mRNA vaccine elicits protective immunity against H5N1 influenza virus with reduced adverse reactions
Atsushi Kawai, Taro Shimizu, Hiroki Tanaka, Shintaro Shichinohe +14 more
2024Molecular Therapy39 citations Open access
Semantic Scholar
Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material
Hiroki Tanaka, Nae Takata, Y. Sakurai, Tokuyuki Yoshida +8 more
2021Pharmaceutics39 citations Open access
Semantic Scholar
Ready-to-Use-Type Lyophilized Lipid Nanoparticle Formulation for the Postencapsulation of Messenger RNA.
Hiroki Tanaka, Shinya Hagiwara, Daiki Shirane, Takuma Yamakawa +17 more
2023ACS Nano36 citations
Semantic Scholar
A study of the endocytosis mechanism and transendothelial activity of lung-targeted GALA-modified liposomes.
Sarochin Santiwarangkool, H. Akita, I. Khalil, Mahmoud M. Abd Elwakil +3 more
2019Journal of Controlled Release36 citations
Semantic Scholar
Development of a mouse model for the visual and quantitative assessment of lymphatic trafficking and function by in vivo imaging
Yoshihisa Yamaji, Shinsuke Akita, H. Akita, Naoya Miura +4 more
2018Scientific Reports33 citations Open access
Semantic Scholar
DNA-loaded nano-adjuvant formed with a vitamin E-scaffold intracellular environmentally-responsive lipid-like material for cancer immunotherapy.
Minori Kawai, Takashi Nakamura, Naoya Miura, Mio Maeta +9 more
2018Nanomedicine : nanotechnology, biology, and medicine32 citations
Semantic Scholar
Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
Y. Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani +12 more
2018Drug Metabolism And Disposition31 citations Open access
Semantic Scholar
Improvement of mRNA Delivery Efficiency to a T Cell Line by Modulating PEG-Lipid Content and Phospholipid Components of Lipid Nanoparticles
Hiroki Tanaka, Ryo Miyama, Y. Sakurai, Shinya Tamagawa +4 more
2021Pharmaceutics30 citations Open access
Semantic Scholar
Development of an Alcohol Dilution-Lyophilization Method for Preparing Lipid Nanoparticles Containing Encapsulated siRNA.
Daiki Shirane, Hiroki Tanaka, Yuta Nakai, H. Yoshioka +1 more
2018Biological and Pharmaceutical Bulletin30 citations Open access
Semantic Scholar
Development of an Alcohol Dilution–Lyophilization Method for the Preparation of mRNA-LNPs with Improved Storage Stability
Daiki Shirane, Hiroki Tanaka, Y. Sakurai, Sakura Taneichi +4 more
2023Pharmaceutics29 citations Open access
Semantic Scholar
Tolerogenic Lipid Nanoparticles for Delivering Self-Antigen mRNA for the Treatment of Experimental Autoimmune Encephalomyelitis
Masaki Gomi, Yuka Nakayama, Yu Sakurai, Ryotaro Oyama +10 more
2023Pharmaceuticals28 citations Open access
Semantic Scholar
siRNA delivery to lymphatic endothelial cells via ApoE-mediated uptake by lipid nanoparticles.
Y. Sakurai, Keito Yoshikawa, K. Arai, A. Kazaoka +7 more
2022Journal of Controlled Release28 citations Open access
Semantic Scholar
Silencing of VEGFR2 by RGD-Modified Lipid Nanoparticles Enhanced the Efficacy of Anti-PD-1 Antibody by Accelerating Vascular Normalization and Infiltration of T Cells in Tumors
Riki Cho, Y. Sakurai, H. Jones, H. Akita +2 more
2020Cancers28 citations Open access
Semantic Scholar
Inhibition of the Inflammatory Pathway Enhances Both the in Vitro and in Vivo Transfection Activity of Exogenous in Vitro-Transcribed mRNAs Delivered by Lipid Nanoparticles.
Takara Ohto, M. Konishi, Hiroki Tanaka, K. Onomoto +5 more
2019Biological and Pharmaceutical Bulletin27 citations Open access
Semantic Scholar
Vitamin E Scaffolds of pH-Responsive Lipid Nanoparticles as DNA Vaccines in Cancer and Protozoan Infection.
Mio Maeta, Naoya Miura, Hiroki Tanaka, Takashi Nakamura +10 more
2020Molecular Pharmaceutics26 citations Open access
Semantic Scholar
Effect of Anti-PEG Antibody on Immune Response of mRNA-Loaded Lipid Nanoparticles
D. Omata, Eigo Kawahara, Lisa Munakata, Hiroki Tanaka +3 more
2024Molecular Pharmaceutics25 citations Open access
Semantic Scholar
Lipid nanoparticles-encapsulated brain-derived neurotrophic factor mRNA delivered through the round window niche in the cochleae of guinea pigs
T. Miwa, Haruki Saito, H. Akita
2020Experimental Brain Research23 citations Open access
Semantic Scholar
A hepatic pDNA delivery system based on an intracellular environment sensitive vitamin E‐scaffold lipid‐like material with the aid of an anti‐inflammatory drug
R. Togashi, Hiroki Tanaka, S. Nakamura, H. Yokota +5 more
2018Journal of Controlled Release22 citations Open access
Semantic Scholar
The delivery of mRNA to colon inflammatory lesions by lipid-nano-particles containing environmentally-sensitive lipid-like materials with oleic acid scaffolds
Hiroki Tanaka, Ayaka Watanabe, M. Konishi, Yuta Nakai +5 more
2018Heliyon22 citations Open access
Semantic Scholar
A Post-Encapsulation Method for the Preparation of mRNA-LNPs via the Nucleic Acid-Bridged Fusion of mRNA-Free LNPs
Hiroki Tanaka, Yuka Sato, T. Nakabayashi, Akari Tanaka +11 more
2025Nano letters (Print)20 citations Open access
Semantic Scholar
Dietary 7-ketocholesterol exacerbates myocardial ischemia–reperfusion injury in mice through monocyte/macrophage-mediated inflammation
Tomoki Uchikawa, T. Matoba, Takuro Kawahara, Isashi Baba +7 more
2022Scientific Reports20 citations Open access
Semantic Scholar
Development, characterization and potential applications of a multicellular spheroidal human blood-brain barrier model integrating three conditionally immortalized cell lines.
K. Kitamura, Kenta Umehara, Ryo Ito, Y. Yamaura +4 more
2021Biological and Pharmaceutical Bulletin20 citations Open access
Semantic Scholar
The Effect of Cholesterol Content on the Adjuvant Activity of Nucleic-Acid-Free Lipid Nanoparticles
Jessica Anindita, Hiroki Tanaka, Takuma Yamakawa, Yuka Sato +13 more
2024Pharmaceutics18 citations Open access
Semantic Scholar
Comprehensive Evaluation of Lipid Nanoparticles and Polyplex Nanomicelles for Muscle-Targeted mRNA Delivery
Xuan Du, Erica Yada, Yuki Terai, Takuya Takahashi +4 more
2023Pharmaceutics18 citations Open access
Semantic Scholar
pH-Responsive Lipid Nanoparticles Achieve Efficient mRNA Transfection in Brain Capillary Endothelial Cells
Y. Sakurai, H. Watanabe, Kazuma Nishio, Kohei Hashimoto +13 more
2022Pharmaceutics18 citations Open access
Semantic Scholar
Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice
Shin-ichiro Nitta, Mari Hashimoto, Y. Kazuki, Shoko Takehara +5 more
2018AAPS Journal18 citations
Semantic Scholar
Cancer-Type OATP1B3 mRNA in Extracellular Vesicles as a Promising Candidate for a Serum-Based Colorectal Cancer Biomarker.
Hanae Morio, Yuchen Sun, Manami Harada, H. Ide +11 more
2018Biological and Pharmaceutical Bulletin18 citations Open access
Semantic Scholar
EVs-miR-17-5p attenuates the osteogenic differentiation of vascular smooth muscle cells potentially via inhibition of TGF-β signaling under high glucose conditions
Isashi Baba, Tetsuya Matoba, Shunsuke Katsuki, Jun-ichiro Koga +4 more
2024Scientific Reports17 citations Open access
Semantic Scholar
Intranasal immunization with an RBD-hemagglutinin fusion protein harnesses preexisting immunity to enhance antigen-specific responses
Atsushi Kawai, Nagisa Tokunoh, Eigo Kawahara, Shigeyuki Tamiya +11 more
2023Journal of Clinical Investigation17 citations Open access
Semantic Scholar
A nasal vaccine with inactivated whole-virion elicits protective mucosal immunity against SARS-CoV-2 in mice
Nagisa Tokunoh, Shigeyuki Tamiya, Masato Watanabe, Toru Okamoto +7 more
2023Frontiers in Immunology17 citations Open access
Semantic Scholar
Development of an SS-Cleavable pH-Activated Lipid-Like Material (ssPalm) as a Nucleic Acid Delivery Device.
H. Akita
2020Biological and Pharmaceutical Bulletin17 citations Open access
Semantic Scholar
Delivery of aPD-L1 antibody to i.p. tumors via direct penetration by i.p. route: Beyond EPR effect.
Mayu Yamamoto, Taiki Kurino, Reiko Matsuda, H. Jones +16 more
2022Journal of Controlled Release14 citations Open access
Semantic Scholar
Differentiated HASTR/ci35 cells: A promising in vitro human astrocyte model for facilitating CNS drug development studies.
K. Kitamura, Ryo Ito, Kenta Umehara, Hanae Morio +8 more
2018Journal of Pharmacological Sciences12 citations Open access
Semantic Scholar
Cancer-type organic anion transporting polypeptide 1B3 is a target for cancer suicide gene therapy using RNA trans-splicing technology.
Yuchen Sun, Josefina Piñón Hofbauer, Manami Harada, K. Wöss +12 more
2018Cancer Letters12 citations
Semantic Scholar
Logistics and distribution of small extracellular vesicles from the subcutaneous space to the lymphatic system.
Y. Sakurai, Asa Ohtani, Yuka Nakayama, Masaki Gomi +4 more
2023Journal of Controlled Release11 citations Open access
Semantic Scholar
Human Immortalized Cell-Based Blood-Brain Barrier Spheroid Models Offer an Evaluation Tool for the Brain Penetration Properties of Macromolecules.
K. Kitamura, Ayaka Okamoto, Hanae Morio, Ryuto Isogai +8 more
2022Molecular Pharmaceutics11 citations
Semantic Scholar
Development of Sentinel LN Imaging with a Combination of HAase Based on a Comprehensive Analysis of the Intra-lymphatic Kinetics of LPs
Masaki Gomi, Y. Sakurai, T. Okada, Naoya Miura +2 more
2020Molecular Therapy11 citations Open access
Semantic Scholar
Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies.
Y. Ishizaki, Tomomi Furihata, Yusuke Oyama, Kayoko Ohura +4 more
2018Biological and Pharmaceutical Bulletin11 citations Open access
Semantic Scholar

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Hiroki Tanaka — researcher profile on SciRah
Yuta Nakai×20
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Yuta Nakai — researcher profile on SciRah
Kota Tange×18
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Kota Tange — researcher profile on SciRah
Y. Sakurai×15
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H. Yoshioka — researcher profile on SciRah

Tomomi Furihata×10

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Masaki Gomi — researcher profile on SciRah

H. Harashima×7

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H. Harashima — researcher profile on SciRah

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K. Chiba — researcher profile on SciRah

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K. Kitamura — researcher profile on SciRah

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Keisuke Ueda — researcher profile on SciRah