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Tien L. Huang · SciRah

Researcher profile · Semantic Scholar

Tien L. Huang

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Tien L. Huang — researcher profile on SciRah

h-index: 18
Works: 49
Citations: 1,362

Most-cited papers

Histone Deacetylase Inhibitors in Clinical Studies as Templates for New Anticancer Agents
Madhusoodanan Mottamal, Shi-Long Zheng, Tien L. Huang, Guangdi Wang
2015Molecules635 citations Open access
Semantic Scholar
Hydrolysis of Carbonates, Thiocarbonates, Carbamates, and Carboxylic Esters of α-Naphthol, β-Naphthol, and p-Nitrophenol by Human, Rat, and Mouse Liver Carboxylesterases
Tien L. Huang, A. Székács, T. Uematsu, E. Kuwano +2 more
1993Pharmaceutical Research58 citations
Semantic Scholar
Piperazine-linked bisbenzamidines: a novel class of antileishmanial agents.
A. Mayence, J. V. Eynde, Louis F. LeCour, L. Walker +2 more
2004European journal of medicinal chemistry52 citations
Semantic Scholar
Trypanocidal activity of conformationally restricted pentamidine congeners.
I. Donkor, Tien L. Huang, B. Tao, D. Rattendi +4 more
2003Journal of Medicinal Chemistry47 citations
Semantic Scholar
Novel bisbenzimidazoles with antileishmanial effectiveness.
A. Mayence, A. Pietka, M. Collins, M. Cushion +3 more
2008Bioorganic & Medicinal Chemistry Letters33 citations
Semantic Scholar
Fragment-based design of symmetrical bis-benzimidazoles as selective inhibitors of the trimethoprim-resistant, type II R67 dihydrofolate reductase.
Dominic Bastien, M. Ebert, D. Forge, Jacynthe L. Toulouse +6 more
2012Journal of Medicinal Chemistry32 citations
Semantic Scholar
Pneumonia in Mice Pneumocystis Bisbenzamidines against Piperazine-and Alkanediamide-Linked In Vitro Selection and In Vivo Efficacy of
A. Mayence, Tien L. Huang, Sandra L. Rebholz, Ronald Brubaker +4 more
200631 citations
Semantic Scholar
Parallel solution-phase synthesis of conformationally restricted congeners of pentamidine and evaluation of their antiplasmodial activities.
A. Mayence, J. V. Vanden Eynde, Frances M. Krogstad, D. Krogstad +2 more
2004Journal of Medicinal Chemistry31 citations
Semantic Scholar
Synthesis and anti-Pneumocystis carinii activity of conformationally restricted analogues of pentamidine
B. Tao, Tien L. Huang, Qian Zhang, Latasha Jackson +2 more
199931 citations
Semantic Scholar
Highly Active Anti-Pneumocystis carinii Compounds in a Library of Novel Piperazine-Linked Bisbenzamidines and Related Compounds
M. Cushion, P. Walzer, M. Collins, Sandra L. Rebholz +3 more
2004Antimicrobial Agents and Chemotherapy28 citations Open access
Semantic Scholar
Structure-Activity Relationships for Substrates and Inhibitors of Mammalian Liver Microsomal Carboxylesterases
Tien L. Huang, T. Shiotsuki, T. Uematsu, B. Borhan +2 more
1996Pharmaceutical Research26 citations
Semantic Scholar
Hepatic and pulmonary enzyme activities in horses.
J. Lakritz, Bruce S. Winder, Jaffar Noorouz-Zadeh, Tien L. Huang +3 more
2000American Journal of Veterinary Research25 citations Open access
Semantic Scholar
Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity
Tien L. Huang, J.‐J. Vanden Eynde, A. Mayence, M. Collins +6 more
2009Bioorganic & Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics.
Shi-Long Zheng, Jia-Wang Liu, Yan-Yuan Wu, Tien L. Huang +1 more
2015Future Medicinal Chemistry22 citations Open access
Semantic Scholar
Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia.
J. V. Vanden Eynde, A. Mayence, Tien L. Huang, M. Collins +3 more
2004Bioorganic & Medicinal Chemistry Letters22 citations
Semantic Scholar
Some non-conventional biomolecular targets for diamidines. A short survey.
Tien L. Huang, A. Mayence, J. V. Vanden Eynde
2014Bioorganic & Medicinal Chemistry20 citations Open access
Semantic Scholar
Characterization of a spectrophotometric assay for juvenile hormone esterase.
Bill F. McCutchen, András Székács, Tien L. Huang, T. Shiotsuki +1 more
1995Insect Biochemistry and Molecular Biology20 citations
Semantic Scholar
Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug.
Tien L. Huang, C. Bacchi, N. Kode, Qiang Zhang +8 more
2007International Journal of Antimicrobial Agents19 citations
Semantic Scholar
Peptidyl aldehyde inhibitors of calpain incorporating P2-proline mimetics.
I. Donkor, Rajani Korukonda, Tien L. Huang, Louis F. LeCour
2003Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents.
A. Mayence, J. V. Vanden Eynde, M. Kaiser, R. Brun +2 more
2011Bioorganic & Medicinal Chemistry16 citations
Semantic Scholar
N,N'-bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents.
Tien L. Huang, B. Tao, Yvonne Quarshie, S. F. Queener +1 more
2001Bioorganic & Medicinal Chemistry Letters15 citations
Semantic Scholar
Pentamidine analogs as inhibitors of [3H]MK-801 and [3H]ifenprodil binding to rat brain NMDA receptors
M. Berger, D. Maciejewska, J. V. Vanden Eynde, Madhusoodanan Mottamal +12 more
2015Bioorganic & Medicinal Chemistry14 citations Open access
Semantic Scholar
Anti‐plasmodial and anti‐leishmanial activity of conformationally restricted pentamidine congeners
Tien L. Huang, J. Eynde, A. Mayence, I. Donkor +2 more
2006The Journal of pharmacy and pharmacology14 citations Open access
Semantic Scholar
Inhibition of N8-acetylspermidine deacetylase by active-site-directed metal coordinating inhibitors.
Tien L. Huang, Sasi A. Dredar, Victor A. Manneh, J. Blankenship +1 more
1992Journal of Medicinal Chemistry14 citations
Semantic Scholar
Novel piperazine induces apoptosis in U937 cells.
Josiah J. Sampson, I. Donkor, Tien L. Huang, S. Adunyah
2011International Journal of Biochemistry and Molecular Biology13 citations
Semantic Scholar
Synthesis and anti-pneumocystis carinii activity of piperidine-linked aromatic diimidazolines
Tien L. Huang, Qian Zhang, A. White, S. Queener +3 more
199613 citations
Semantic Scholar
Potential of bisbenzimidazole‐analogs toward metronidazole‐resistant Trichomonas vaginalis isolates
Travis Korosh, Emmanuel Bujans, Mary Morada, Canan Karaaliog̃lu +4 more
2017Chemical Biology and Drug Design12 citations
Semantic Scholar
Antitumor and Anti-Pneumocystis Carinii Activities of Novel Bisbenzamidines
J. V. Eynde, A. Mayence, Melissa T. Johnson, Tien L. Huang +5 more
2005Medicinal Chemistry Research12 citations Open access
Semantic Scholar
Design and Synthesis of N1,N5-bis[4-(5-Alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as Potential Antifungal Prodrugs
N. Kode, J. V. Vanden Eynde, A. Mayence, Guangdi Wang +1 more
2013Molecules11 citations Open access
Semantic Scholar
Novel bisbenzamidines and bisbenzimidazolines as noncompetitive NMDA receptor antagonists.
B. Tao, Tien L. Huang, Terre A. Sharma, I. Reynolds +1 more
1999Bioorganic & Medicinal Chemistry Letters9 citations
Semantic Scholar
Bisbenzamidines as Antifungal Agents. Are Both Amidine Functions Required to Observe an Anti-Pneumocystis carinii Activity?
J. Laurent, D. Stanicki, Tien L. Huang, E. Dei-cas +3 more
2009Molecules8 citations Open access
Semantic Scholar
Evidences for the formation of bisbenzamidine-heme complexes in cell-free systems.
A. Mayence, J. V. Vanden Eynde, Tien L. Huang
2004Bioorganic & Medicinal Chemistry Letters8 citations
Semantic Scholar
Evaluation of bisbenzamidines as inhibitors for matriptase-2.
Anna Beckmann, Erik Gilberg, Susanne Gattner, Tien L. Huang +5 more
2016Bioorganic & Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Synthesis, antituberculosis activity, and DNA binding affinity of a highly diverse library of 1,4-diarylpiperazines
J. V. Eynde, A. Mayence, Louis F. LeCour, Tien L. Huang
20037 citations
Semantic Scholar
Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents
J. V. Vanden Eynde, A. Mayence, Madhusoodanan Mottamal, C. Bacchi +4 more
2016Pharmaceuticals6 citations Open access
Semantic Scholar
Affinity purification of mouse liver carboxylesterases with trifluoromethyl ketones as ligands
T. Shiotsuki, Tien L. Huang, B. Hammock
19945 citations Open access
Semantic Scholar
N,N′‐Bis[4‐(N‐Alkylamidino)phenyl]homopiperazines as Anti‐Pneumocystis carinii Agents.
Tien L. Huang, B. Tao, Y. Quarshie, S. Queener +1 more
20023 citations
Semantic Scholar
Characterization of the symmetrical benzimidazole twin drug TL1228: the role as viral entry inhibitor for fighting COVID-19
M. Murdocca, Osvaldo Andrade Santos-Filho, C. De Masi, Edivaldo dos Santos Rodrigues +15 more
2024Biology Direct2 citations
Semantic Scholar
Evaluation of aryl amidines/benzimidazoles as potential anti-COVID-19 agents: A computational study
O. Santos-Filho, J. V. Vanden Eynde, Tien L. Huang, Annie Mayence
20200 citations Open access
Semantic Scholar
Identification of a Novel Potent and SelectiveAnti-Trichomonas vaginalis Agent among Libraries of Bisbenzimidazoles
J. V. Eynde, A. Mayence, Tien L. Huang, N. Yarlett
20170 citations Open access
Semantic Scholar
Identification of a Hit in a Small Library of Potential Antiplasmodial Imidazo[4,5-b]pyridines
T. Honoré, A. Mayence, Tien L. Huang, J. V. Eynde
20150 citations Open access
Semantic Scholar
Evaluation of Alkanediamide-Linked Bisbenzamidines as Potential Antiparasitic Agents
J. V. Eynde, A. Mayence, Madhusoodanan Mottamal, C. Bacchi +4 more
20150 citations Open access
Semantic Scholar
The identification of small molecules that alter the activity of the LINE1 endonuclease (LB253)
Lindsey Maurice-Walker, Idrees Ahmad, Sherry Reddix, Brittany Russell +3 more
20140 citations
Semantic Scholar
Related Compounds Piperazine-Linked Bisbenzamidines and Compounds in a Library of Novel Pneumocystis carinii Highly Active Anti-
Tien L. Huang, Sandra L. Rebholz, J. V. Eynde, T. Cushion +2 more
20140 citations
Semantic Scholar
Original Article Novel piperazine induces apoptosis in U937 cells
Josiah J. Sampson, I. Donkor, Tien L. Huang, S. Adunyah
20110 citations
Semantic Scholar
Trypanocidal activity of novel alkanediamide-linked bisbenzamidines and bisbenzamidoximes
Tien L. Huang, N. Kode, C. Bacchi, D. Rattendi +4 more
20100 citations Open access
Semantic Scholar
Synthesis and Anti-Pneumocystis carinii Activity of Conformationally Restricted Analogues of Pentamidine.
B. Tao, Tien L. Huang, Qian Zhang, Latasha Jackson +2 more
19990 citations
Semantic Scholar
Synthesis, anti-pneumocystis carinii activity, and DNA binding affinity of a new series of conformational constrained pentamidine congeners
Qian Zhang, A. White, M. Malbrue, Tien L. Huang +2 more
19970 citations
Semantic Scholar
Synthesis and Anti‐Pneumocystis carinii Activity of Piperidine‐Linked Aromatic Diimidazolines.
Tien L. Huang, Qian Zhang, A. White, S. Queener +3 more
19960 citations
Semantic Scholar

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