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Sreekanth Kokkonda · SciRah

Researcher profile · Semantic Scholar

Sreekanth Kokkonda

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Sreekanth Kokkonda — researcher profile on SciRah

h-index: 11
Works: 16
Citations: 1,102

Most-cited papers

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria
M. Phillips, J. Lotharius, K. Marsh, John White +49 more
2015Science Translational Medicine355 citations Open access
Semantic Scholar
Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential
J. Coterón, Maria Marco, J. Esquivias, Xiao-Yi Deng +21 more
2011Journal of Medicinal Chemistry284 citations Open access
Semantic Scholar
Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors
Xiao-Yi Deng, Sreekanth Kokkonda, Farah El Mazouni, John White +6 more
2014Journal of Medicinal Chemistry102 citations Open access
Semantic Scholar
A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria
M. Phillips, K. White, Sreekanth Kokkonda, Xiao-Yi Deng +32 more
2016ACS Infectious Diseases81 citations Open access
Semantic Scholar
Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase
A. Marwaha, John White, Farah El Mazouni, Sharon A. Creason +5 more
2012Journal of Medicinal Chemistry66 citations Open access
Semantic Scholar
Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity
Sreekanth Kokkonda, Xiao-Yi Deng, K. White, J. Coterón +22 more
2016Journal of Medicinal Chemistry56 citations Open access
Semantic Scholar
Potent antimalarials with development potential identified by structure-guided computational optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series
M. J. Palmer, Xiao-Yi Deng, Shawn Watts, Goran Krilov +40 more
2021Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
Lead optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series for the treatment of Malaria
Sreekanth Kokkonda, Xiao-Yi Deng, K. White, Farah El Mazouni +25 more
2020Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity
Sreekanth Kokkonda, Farah El Mazouni, K. White, John White +14 more
2018ACS Omega29 citations Open access
Semantic Scholar
Topoisomerase II from Human Malaria Parasites
D. G. Mudeppa, Shiva Kumar, Sreekanth Kokkonda, John White +1 more
2015Journal of Biological Chemistry19 citations Open access
Semantic Scholar
Properties of Plasmodium falciparum with a Deleted Apicoplast DNA Gyrase
S. Tan, D. G. Mudeppa, Sreekanth Kokkonda, John White +2 more
2021Antimicrobial Agents and Chemotherapy13 citations Open access
Semantic Scholar
Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention
Zhe Nie, Roger Bonnert, Jet Tsien, Xiao-Yi Deng +40 more
2024Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii
T. Russo, T. Umland, Xiao-Yi Deng, Farah El Mazouni +12 more
2022Proceedings of the National Academy of Sciences of the United States of America11 citations Open access
Semantic Scholar
Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual Plasmodium falciparum
Laura Chery-Karschney, Rapatbhorn Patrapuvich, D. G. Mudeppa, Sreekanth Kokkonda +5 more
2024Antimicrobial Agents and Chemotherapy5 citations Open access
Semantic Scholar
A robust in vitro liver cell model for long-term study of Plasmodium vivax hypnozoites
Araya Jivapetthai, Yongyut Pewkliang, Sreekanth Kokkonda, Paviga Limudompon +8 more
20190 citations Open access
Semantic Scholar
SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW HYBRIDS OF PYRROLO[2,1-C][1,4]BENZODIAZEPINES AND COMBINATORIAL SYNTHESIS OF CHALCONE-TRIAZOLE DERIVATIVES
Sreekanth Kokkonda
20090 citations
Semantic Scholar

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