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P. Laise · SciRah

Researcher profile · Semantic Scholar

P. Laise

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P. Laise — researcher profile on SciRah

h-index: 8
Works: 39
Citations: 2,640

Most-cited papers

Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts
Ela Elyada, M. Bolisetty, P. Laise, W. F. Flynn +18 more
2019Cancer Discovery1,833 citations Open access
Semantic Scholar
Single-cell genomics reveals a novel cell state during smooth muscle cell phenotypic switching and potential therapeutic targets for atherosclerosis in mouse and human
Huize Pan, Chenyi Xue, Benjamin J. Auerbach, Jiaxin Fan +18 more
2020Circulation496 citations Open access
Semantic Scholar
Experimental microdissection enables functional harmonization of pancreatic cancer subtypes
Carlo Maurer, Sam R. Holmstrom, Jing He, P. Laise +12 more
2019Gut194 citations Open access
Semantic Scholar
Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis
Zheng-Yu Jiang, Fei-Jin Wu, P. Laise, Takayuki Tanaka +24 more
2023Cell Stem Cell26 citations
Semantic Scholar
Developmental and MAPK-responsive transcription factors drive distinct malignant subtypes and genetic dependencies in pancreatic cancer
P. Laise, M. Turunen, Á. C. García, L. Tomassoni +21 more
2020bioRxiv21 citations Open access
Semantic Scholar
Systematic, Protein Activity-based Characterization of Single Cell State
Lukas J. Vlahos, A. Obradovic, Jeremy Worley, Xiang-Tian Tan +5 more
2021bioRxiv16 citations Open access
Semantic Scholar
The Host Cell ViroCheckpoint: Identification and Pharmacologic Targeting of Novel Mechanistic Determinants of Coronavirus-Mediated Hijacked Cell States
P. Laise, G. Bosker, Xiao-Yun Sun, Yao Shen +6 more
2020bioRxiv16 citations Open access
Semantic Scholar
PISCES: A pipeline for the Systematic, Protein Activity-based Analysis of Single Cell RNA Sequencing Data
A. Obradovic, Lukas J. Vlahos, P. Laise, Jeremy Worley +3 more
202111 citations
Semantic Scholar
Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer
H. C. Maurer, Álvaro Curiel-García, Sam R. Holmstrom, P. Laise +24 more
2023bioRxiv7 citations Open access
Semantic Scholar
Single-cell based elucidation of molecularly-distinct glioblastoma states and drug sensitivity
Hongxu Ding, Danielle M. Burgenske, Wen-Ting Zhao, P. Subramaniam +17 more
2019bioRxiv7 citations Open access
Semantic Scholar
A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection
P. Laise, M. Stanifer, G. Bosker, Xiao-Yun Sun +12 more
2022Research Square6 citations Open access
Semantic Scholar
Systematic identification and targeting of master regulator checkpoints (MRC) governing tumor microenvironment-mediated immune evasion
P. Laise, G. Bosker, Mariana Babor, Xiaoyu Sun +4 more
2025Journal for ImmunoTherapy of Cancer5 citations Open access
Semantic Scholar
Systematic design of combination therapy by targeting master regulators of coexisting diffuse midline glioma cell states
Ester Calvo Fernández, L. Tomassoni, Xu Zhang, Jun-Qiang Wang +22 more
2026Nature Genetics3 citations Open access
Semantic Scholar
Elucidation and Pharmacologic Targeting of Master Regulator Dependencies in Coexisting Diffuse Midline Glioma Subpopulations
E. Fernández, L. Tomassoni, Xu Zhang, Jun-Qiang Wang +22 more
2024bioRxiv3 citations Open access
Semantic Scholar
A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection
P. Laise, M. Stanifer, G. Bosker, Xiao-Yun Sun +12 more
2022Communications Biology3 citations Open access
Semantic Scholar
Adult enteric Dclk1-positive glial and neuronal cells reveal distinct responses to acute intestinal injury.
M. Middelhoff, G. Valenti, L. Tomassoni, Y. Ochiai +17 more
2022American Journal of Physiology - Gastrointestinal and Liver Physiology2 citations Open access
Semantic Scholar
Developmental and MAPK-responsive transcription factors regulate distinct malignant cell states and associated genetic dependencies in pancreatic cancer
P. Laise, Mikko M. Turunen, Álvaro Curiel-García, L. Tomassoni +23 more
2026Nature Genetics1 citations Open access
Semantic Scholar
Regulatory network analysis of Dclk1 gene expression reveals a tuft cell-ILC2 axis that inhibits pancreatic tumor progression
G. Valenti, P. Laise, Fei-Jin Wu, Ryota Takahashi +14 more
2025Cell Reports1 citations Open access
Semantic Scholar
Regulatory network analysis of Dclk1 gene expression reveals a tuft cell-ILC2 axis that inhibits pancreatic tumor progression
G. Valenti, P. Laise, Ryota Takahashi, Fei-Jin Wu +12 more
2024bioRxiv1 citations Open access
Semantic Scholar
A Patient‐to‐Model‐to‐Patient (PMP) Cancer Drug Discovery Protocol for Identifying and Validating Therapeutic Agents Targeting Tumor Regulatory Architecture
P. Laise, G. Bosker, A. Califano, Mariano J. Alvarez
2022Current Protocols1 citations Open access
Semantic Scholar
Plasticity in adult Dclk1+ intestinal neuronal and glial cells facilitates regeneration and ganglionic cellular homeostasis
M. Middelhoff, G. Valenti, L. Tomassoni, P. Laise +12 more
2020Zeitschrift für Gastroenterologie - German Journal of Gastroenterology1 citations
Semantic Scholar
Using genomicInstability, a package for inferring the genomic instability of cells from scRNA-Seq data
P. Laise, Mariano J. Alvarez
1 citations
Semantic Scholar
Pancreatic adenocarcinoma comprises six universally coexisting cell states
Andrea Califano, K. Olive, P. Laise, N. Genet
2026Nature Genetics0 citations
Semantic Scholar
Abstract NG04: BMAL2 is a KRAS-driven master regulator of hypoxic adaptation and EMT in pancreatic ductal adenocarcinoma
Á. C. García, Sam R. Holmstrom, Melina Chen, Diana V. Morales +24 more
2026Cancer Research0 citations
Semantic Scholar
Abstract IA02: Single-cell regulatory network analysis of therapy-associated cell state remodeling to inform combination strategies in osteosarcoma
J. Pavisic, Chelsey M. Burke, Dao-Qi You, P. Laise +13 more
2026Cancer Research0 citations
Semantic Scholar
Morphogenesis and regeneration share a conserved core transition cell state program that controls lung epithelial cell fate
Xiang-Yi Ke, Benjamin van Soldt, Lukas J. Vlahos, Yi-Zhuo Zhou +8 more
2025Developmental Cell0 citations
Semantic Scholar
Abstract A047: Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer
Á. C. García, Carlo Maurer, Sam R. Holmstrom, Cristina Castillo +26 more
2025Cancer Research0 citations
Semantic Scholar
Abstract 1501: Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer
Á. C. García, Carlo Maurer, Cristina Castillo, R. M. Schmid +26 more
2025Cancer Research0 citations
Semantic Scholar
Abstract 5072: Single cell-based elucidation of molecularly distinct glioblastoma states and drug sensitivity
L. Tomassoni, Wen-Ting Zhao, Hongxu Ding, Kenneth Egbuji +9 more
2025Cancer Research0 citations
Semantic Scholar
Abstract 3874: Adaptive heterogeneity enables the survival of residual malignant PDAC cells in response to RAS-GTP inhibition
L. Tomassoni, Urszula N. Wasko, Á. C. García, Tanner C. Dalton +5 more
2024Cancer Research0 citations
Semantic Scholar
Abstract 1403: The role of Dclk1-expression cells in normal pancreas and in pancreatic tumor progression
G. Valenti, P. Laise, Fei-Jin Wu, Hiroki Kobayashi +7 more
2024Cancer Research0 citations
Semantic Scholar
Abstract 5460: Discovery and validation of effective combination therapies targeting cell state-specific master regulator vulnerabilities by network-based protein activity inference in diffuse midline glioma
E. Fernández, L. Tomassoni, Xu Zhang, Aleksandar Z. Obradovic +16 more
2024Cancer Research0 citations
Semantic Scholar
Abstract 4803: BMAL2 is a KRAS-dependent master regulator of hypoxic response in pancreatic ductal adenocarcinoma
Á. C. García, Carlo Maurer, Kate E. R. Hollinshead, P. Laise +13 more
2023Cancer Research0 citations
Semantic Scholar
Abstract B002: ARNTL2 is a Kras-dependent master regulator of hypoxic response in pancreatic ductal adenocarcinoma
H. C. Maurer, Álvaro Curiel-García, P. Laise, Carmine F. Palermo +8 more
2022Cancer Research0 citations
Semantic Scholar
Abstract 2359: Identifying synergistic master regulators of pancreatic ductal adenocarcinoma tumorigenesis through CRISPR/Cas9 combinatorial genetic screens
Aaron T. Griffin, Mikko M. Turunen, L. Tomassoni, K. Olive +2 more
2022Cancer Research0 citations
Semantic Scholar
Abstract A007: Pancreatic cancer comprises co-existing transcriptional states regulated by distinct master regulator programs
P. Laise, Mikko M. Turunen, H. C. Maurer, Á. C. García +20 more
2022Cancer Research0 citations
Semantic Scholar
Abstract PO-001: ARNTL2 is a hypoxia-responsive master regulator of PDAC malignancy
Álvaro Curiel-García, Carlo Maurer, P. Laise, Irina Sagalovskiy +6 more
2021Big Data0 citations
Semantic Scholar
Network-based identification and pharmacological targeting of host cell master regulators induced by SARS-CoV-2 infection
P. Laise, M. Stanifer, G. Bosker, Xiao-Yun Sun +12 more
2021bioRxiv0 citations Open access
Semantic Scholar
72 Repeated Eradications of Pseudomonas aeruginosa in Cystic Fibrosis Patients
G. Taccetti, P. Laise, M. Cavicchi, L. Zavataro +2 more
20070 citations Open access
Semantic Scholar

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Á. C. García×7

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