Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

M. Aleo · SciRah

Researcher profile · Semantic Scholar

M. Aleo

Share profile

M. Aleo — researcher profile on SciRah

h-index: 24
Works: 63
Citations: 2,431

Most-cited papers

Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States.
A. Stepan, Daniel P. Walker, J. Bauman, David A. Price +3 more
2011Chemical Research in Toxicology597 citations
Semantic Scholar
Human drug‐induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump
M. Aleo, Yi Luo, Rachel L Swiss, P. Bonin +2 more
2014Hepatology206 citations Open access
Semantic Scholar
Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans.
S. Khetani, Chitra Kanchagar, O. Ukairo, Stacy Krzyzewski +5 more
2013Toxicological Sciences201 citations Open access
Semantic Scholar
Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanistic in vitro Assays.
Falgun Shah, Louis Y. Leung, H. Barton, Y. Will +3 more
2015Toxicological Sciences127 citations
Semantic Scholar
Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development
A. Hill, N. Mesens, M. Steemans, J. Xu +1 more
2012Drug metabolism reviews (Softcover ed.)104 citations
Semantic Scholar
Mitochondrial dysfunction is an early event in ochratoxin A but not oosporein toxicity to rat renal proximal tubules.
M. Aleo, R. D. Wyatt, Rick G. Schnellmann
1991Toxicology and Applied Pharmacology89 citations
Semantic Scholar
Evaluation of in Vitro Mitochondrial Toxicity Assays and Physicochemical Properties for Prediction of Organ Toxicity Using 228 Pharmaceutical Drugs.
Payal Rana, M. Aleo, M. Gosink, Y. Will
2018Chemical Research in Toxicology69 citations
Semantic Scholar
Using an in vitro cytotoxicity assay to aid in compound selection for in vivo safety studies.
N. Greene, M. Aleo, S. Louise-May, David A. Price +1 more
2010Bioorganic & Medicinal Chemistry Letters66 citations
Semantic Scholar
Endoplasmic reticulum Ca2+ signaling and calpains mediate renal cell death
J. Harriman, X.-L. Liu, M. Aleo, K. Machaca +1 more
2002Cell Death and Differentiation59 citations
Semantic Scholar
MOVING BEYOND BINARY PREDICTIONS OF HUMAN DRUG-INDUCED LIVER INJURY (DILI) TOWARDS CONTRASTING RELATIVE RISK POTENTIAL.
M. Aleo, Falgun Shah, S. Allen, H. Barton +7 more
2020Chemical Research in Toxicology50 citations
Semantic Scholar
Predicting safety toleration of pharmaceutical chemical leads: cytotoxicity correlations to exploratory toxicity studies.
J. Benbow, J. Aubrecht, Michael J. Banker, D. Nettleton +1 more
2010Toxicology Letters49 citations
Semantic Scholar
The role of altered mitochondrial function in citrinin-induced toxicity to rat renal proximal tubule suspensions.
M. Aleo, R. D. Wyatt, Rick G. Schnellmann
1991Toxicology and Applied Pharmacology49 citations
Semantic Scholar
Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes.
S. Nadanaciva, M. Aleo, C. Strock, D. Stedman +2 more
2013Toxicology and Applied Pharmacology47 citations
Semantic Scholar
Hepatotoxicity reports in the FDA adverse event reporting system database: A comparison of drugs that cause injury via mitochondrial or other mechanisms
Payal Rana, M. Aleo, Xuerong Wen, S. Kogut
2021Acta Pharmaceutica Sinica B46 citations Open access
Semantic Scholar
Neurosteroid inhibition of cell death.
Shayla L. Waters, Gary W. Miller, M. Aleo, R. G. Schnellmann
1997American Journal of Physiology39 citations Open access
Semantic Scholar
Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.
M. Aleo, Falgun Shah, K. He, P. Bonin +1 more
2017Chemical Research in Toxicology37 citations
Semantic Scholar
Mechanism and Implications of Brown Adipose Tissue Proliferation in Rats and Monkeys Treated with the Thiazolidinedione Darglitazone, a Potent Peroxisome Proliferator-Activated Receptor-γ Agonist
M. Aleo, G. Lundeen, D. Blackwell, Ward M. Smith +3 more
2003Journal of Pharmacology and Experimental Therapeutics37 citations
Semantic Scholar
Improving the odds of success in drug discovery: choosing the best compounds for in vivo toxicology studies.
Travis T. Wager, B. L. Kormos, Joseph T. Brady, Y. Will +4 more
2013Journal of Medicinal Chemistry36 citations
Semantic Scholar
Recovery of cellular functions following oxidant injury.
G. Nowak, M. Aleo, J. A. Morgan, Rick G. Schnellmann
1998AJP - Renal Physiology35 citations
Semantic Scholar
Primary cultures of rabbit renal proximal tubule cells. III. Comparative cytotoxicity of inorganic and organic mercury.
M. Aleo, M. Taub, P. Kostyniak
1992Toxicology and Applied Pharmacology35 citations
Semantic Scholar
AI/ML Models to Predict the Severity of Drug-Induced Liver Injury for Small Molecules.
Mo-Han Rao, V. Nassiri, C. Alhambra, J. Snoeys +6 more
2023Chemical Research in Toxicology31 citations
Semantic Scholar
Regulation of glycolytic metabolism during long-term primary culture of renal proximal tubule cells.
M. Aleo, Rick G. Schnellmann
1992American Journal of Physiology29 citations
Semantic Scholar
Toxicity of N-(3,5-dichlorophenyl)succinimide and metabolites to rat renal proximal tubules and mitochondria.
M. Aleo, Gary O. Rankin, Theresa J. Cross, Rick G. Schnellmann
1991Chemico-Biological Interactions27 citations
Semantic Scholar
A current practice for predicting ocular toxicity of systemically delivered drugs
C. Somps, N. Greene, J. Render, M. Aleo +3 more
2009Cutaneous and Ocular Toxicology25 citations
Semantic Scholar
High performance liquid chromatographic analysis of cholesterol in milk.
W. Hurst, M. Aleo, Robert A. Martin
1983Journal of Dairy Science24 citations Open access
Semantic Scholar
The neurotoxicants strychnine and bicuculline protect renal proximal tubules from mitochondrial inhibitor-induced cell death.
M. Aleo, R. Schnellmann
1992Life Science22 citations
Semantic Scholar
An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury
Shingo Oda, Y. Uchida, M. Aleo, P. Koza-Taylor +6 more
2020Archives of Toxicology21 citations
Semantic Scholar
Ciglitazone-Induced Lenticular Opacities in Rats: In Vivo and Whole Lens Explant Culture Evaluation
M. Aleo, Colleen M Doshna, K. Navetta
2005Journal of Pharmacology and Experimental Therapeutics21 citations
Semantic Scholar
Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity
Grant T. Generaux, Vinal V. Lakhani, Yu-Ching Yang, S. Nadanaciva +9 more
2019Pharmacology Research & Perspectives19 citations Open access
Semantic Scholar
1,2-naphthoquinone stimulates lipid peroxidation and cholesterol domain formation in model membranes.
R. Jacob, M. Aleo, Yehudi B. Self-Medlin, Colleen M. Doshna +1 more
2013Investigative Ophthalmology and Visual Science19 citations
Semantic Scholar
HPLC determination of the cholesterol content of egg noodles as an indicator of egg solids
W. Hurst, M. Aleo, Robert A. Martin
198518 citations
Semantic Scholar
Differences in enzymatic and mechanical isolated rabbit renal proximal tubules: Comparison in long-term incubation
D. Rodeheaver, M. Aleo, R. Schnellmann
1990In Vitro Cellular & Developmental Biology16 citations
Semantic Scholar
Primary cultures of rabbit renal proximal tubule cells: II. Selected phase I and phase II metabolic capacities.
M. Aleo, Mary Taub, James R. Olson, P. Kostyniak
1990Toxicology in Vitro15 citations
Semantic Scholar
Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis
M. Aleo, J. Aubrecht, P. Bonin, Deborah A. Burt +7 more
2019Pharmacology Research & Perspectives13 citations Open access
Semantic Scholar
Principles of precision medicine and its application in toxicology.
J. Cook, Hong Wu, M. Aleo, K. Adkins
2018Journal of Toxicological Sciences13 citations Open access
Semantic Scholar
Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia/Cholestasis.
K. Lapham, Jonathan J. Novak, Lisa D. Marroquin, Rachel L Swiss +8 more
2016Chemical Research in Toxicology12 citations
Semantic Scholar
Mechanistic Analysis ofS-(1,2-Dichlorovinyl)-l-cysteine-Induced Cataractogenesisin Vitro
Colleen M.Walsh Clang, M. Aleo
199712 citations
Semantic Scholar
A novel lipidomics-based approach to evaluating the risk of clinical hepatotoxicity potential of drugs in 3D human microtissues.
Laura Goracci, Aurora Valeri, Simone Sciabola, M. Aleo +3 more
2019Chemical Research in Toxicology11 citations Open access
Semantic Scholar
High-Content Imaging in Human and Rat Hepatocytes Using the Fluorescent Dyes CLF and CMFDA Is Not Specific Enough to Assess BSEP/Bsep and/or MRP2/Mrp2 Inhibition by Cholestatic Drugs
Luping Qiu, J. Finley, M. Taimi, M. Aleo +4 more
201510 citations
Semantic Scholar
Mechanistic analysis of S-(1,2-dichlorovinyl)-L-cysteine-induced cataractogenesis in vitro.
C. M. Walsh Clang, M. Aleo
1997Toxicology and Applied Pharmacology10 citations
Semantic Scholar
The Use of Explant Lens Culture to Assess Cataractogenic Potential
M. Aleo, Michael J. Avery, William P. Beierschmitt, Cynthia A. Drupa +5 more
2000Annals of the New York Academy of Sciences9 citations
Semantic Scholar
Most Influential Physicochemical and In Vitro Assays Descriptors for Hepatotoxicity and Nephrotoxicity Prediction.
Payal Rana, S. Kogut, Xuerong Wen, F. Akhlaghi +1 more
2020Chemical Research in Toxicology8 citations Open access
Semantic Scholar
Model development and analysis of tenidap-induced proteinuria in the rat.
M. Aleo, T. Wang, G. Giebisch, M. Sanders +2 more
1996Journal of Pharmacology and Experimental Therapeutics8 citations
Semantic Scholar
Primary cultures of rabbit renal proximal tubule cells: I. Growth and biochemical characteristics
M. Aleo, M. Taub, P. Nickerson, P. Kostyniak
1989In Vitro Cellular & Developmental Biology8 citations
Semantic Scholar
Liver safety evaluation of endothelin receptor antagonists using HepatoPac®: A single model impact assessment on hepatocellular health, function and bile acid disposition
M. Aleo, O. Ukairo, A. Moore, O. Irrechukwu +2 more
2019Journal of Applied Toxicology7 citations
Semantic Scholar
Lens cholesterol biosynthesis inhibition: A common mechanism of cataract formation in laboratory animals by pharmaceutical products
M. Aleo, Colleen M Doshna, D. Baltrukonis, J. Fortner +6 more
2019Journal of Applied Toxicology6 citations
Semantic Scholar
Interpretation, Integration, and Implementation of In Vitro Assay Data: The Predictive Toxicity Challenge
D. S. Light, M. Aleo, J. G. Kenna
20186 citations
Semantic Scholar
Mechanism-Based Markers of Drug-Induced Liver Injury to Improve the Physiological Relevance and Predictivity of In Vitro Models
C. Goldring, Alan Norris, N. Kitteringham, M. Aleo +21 more
20156 citations
Semantic Scholar
An underlying role for hepatobiliary dysfunction in cyclosporine A nephrotoxicity.
M. Aleo, Colleen M Doshna, Carol A. Fritz
2008Toxicology and Applied Pharmacology6 citations
Semantic Scholar
Recovery of cellular functions following oxidant injury
G. Nowak, M. Aleo, J. A. Morgan, R. Schnellmann
19985 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

Y. Will×10
Invite
Y. Will — researcher profile on SciRah
Rick G. Schnellmann×4
Invite
Rick G. Schnellmann — researcher profile on SciRah
Rachel L Swiss×3
Invite
Rachel L Swiss — researcher profile on SciRah
P. Bonin×3
Invite
P. Bonin — researcher profile on SciRah

×3

Invite

Falgun Shah — researcher profile on SciRah

Invite

H. Barton — researcher profile on SciRah

Invite

N. Greene — researcher profile on SciRah

Invite

Payal Rana — researcher profile on SciRah

P. Kostyniak×3

Invite

P. Kostyniak — researcher profile on SciRah

Invite

J. Fortner — researcher profile on SciRah

R. Schnellmann×3

Invite

R. Schnellmann — researcher profile on SciRah

Colleen M Doshna×3

Invite

Colleen M Doshna — researcher profile on SciRah