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S. Withoff · SciRah

Researcher profile · Semantic Scholar

S. Withoff

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S. Withoff — researcher profile on SciRah

h-index: 38
Works: 102
Citations: 7,488

Most-cited papers

Systematic identification of trans-eQTLs as putative drivers of known disease associations
H. Westra, M. Peters, T. Esko, H. Yaghootkar +55 more
2013Nature Genetics1,744 citations Open access
Semantic Scholar
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis
M. Sanjuán, C. Dillon, S. Tait, S. Moshiach +7 more
2007Nature1,362 citations
Semantic Scholar
A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans.
Yang Li, M. Oosting, S. Smeekens, M. Jaeger +19 more
2016Cell319 citations Open access
Semantic Scholar
Human Disease-Associated Genetic Variation Impacts Large Intergenic Non-Coding RNA Expression
Vinod Kumar, H. Westra, J. Karjalainen, D. Zhernakova +13 more
2013PLoS Genetics292 citations Open access
Semantic Scholar
Inflammation-associated cancer: NF-κB is the lynchpin
Qiu-Tang Li, S. Withoff, I. Verma
2005275 citations
Semantic Scholar
Genetic variation in the non-coding genome: Involvement of micro-RNAs and long non-coding RNAs in disease.
B. Hrdličková, R. D. de Almeida, Z. Borek, S. Withoff
2014Biochimica et Biophysica Acta249 citations Open access
Semantic Scholar
Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits
R. Aguirre-Gamboa, I. Joosten, Paulo C. M. Urbano, R. G. van der Molen +19 more
2016Cell Reports185 citations Open access
Semantic Scholar
From genome-wide association studies to disease mechanisms: celiac disease as a model for autoimmune diseases
Vinod Kumar, C. Wijmenga, S. Withoff
2012Seminars in Immunopathology155 citations Open access
Semantic Scholar
Clinical implications of shared genetics and pathogenesis in autoimmune diseases
A. Zhernakova, S. Withoff, C. Wijmenga
2013Nature Reviews Endocrinology150 citations
Semantic Scholar
Inflammation-associated cancer: NF-kappaB is the lynchpin.
Qiu-Tang Li, S. Withoff, I. Verma
2005Trends in immunology130 citations
Semantic Scholar
Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity
B. Hrdličková, Vinod Kumar, Kartiek Kanduri, D. Zhernakova +12 more
2014Genome Medicine127 citations Open access
Semantic Scholar
Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses
O. Bakker, R. Aguirre-Gamboa, S. Sanna, M. Oosting +15 more
2018Nature Immunology121 citations Open access
Semantic Scholar
Intestinal Barrier Function in Gluten-Related Disorders
Danielle Cardoso-Silva, D. Delbue, A. Itzlinger, R. Moerkens +3 more
2019Nutrients114 citations Open access
Semantic Scholar
NF-κB and the regulation of hematopoiesis
Virginie Bottero, S. Withoff, Inder M. Verma
2006Cell Death and Differentiation110 citations
Semantic Scholar
Fas Receptor Clustering and Involvement of the Death Receptor Pathway in Rituximab-Mediated Apoptosis with Concomitant Sensitization of Lymphoma B Cells to Fas-Induced Apoptosis1
A. Stel, B. ten Cate, Susan Jacobs, J. Kok +7 more
2007Journal of Immunology94 citations Open access
Semantic Scholar
A liver‐specific long noncoding RNA with a role in cell viability is elevated in human nonalcoholic steatohepatitis
B. Atanasovska, S. Rensen, M. R. van der Sijde, Glenn Marsman +11 more
2017Hepatology89 citations Open access
Semantic Scholar
Understanding Celiac Disease by Genomics.
S. Withoff, Yang Li, Iris H. Jonkers, C. Wijmenga
2016Trends in Genetics84 citations
Semantic Scholar
Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidemia
Vinod Kumar, Shih-Chin Cheng, Melissa D. Johnson, S. Smeekens +19 more
2014Nature Communications83 citations Open access
Semantic Scholar
A large variety of clinical features and concomitant disorders in celiac disease - A cohort study in the Netherlands.
M. Spijkerman, Ineke L. Tan, J. Kolkman, S. Withoff +3 more
2016Digestive and Liver Disease75 citations
Semantic Scholar
Selection of a subpopulation with fewer DNA topoisomerase II alpha gene copies in a doxorubicin-resistant cell line panel.
S. Withoff, Wn Keith, A. Knol, J. Coutts +3 more
1996British Journal of Cancer75 citations Open access
Semantic Scholar
Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs
I. Ricaño-Ponce, D. Zhernakova, Patrick Deelen, O. Luo +62 more
2016Journal of Autoimmunity74 citations Open access
Semantic Scholar
iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies.
Victoria Palasantzas, Isabel Tamargo-Rubio, Kieu Le, J. Slager +5 more
2023Trends in Genetics70 citations Open access
Semantic Scholar
Systematic annotation of celiac disease loci refines pathological pathways and suggests a genetic explanation for increased interferon-gamma levels.
Vinod Kumar, Javier Gutierrez-Achury, Kartiek Kanduri, Rodrigo Almeida +16 more
2015Human Molecular Genetics69 citations
Semantic Scholar
An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal and neural cells
R. Moerkens, Joram Mooiweer, Aarón D. Ramírez-Sánchez, R. Oelen +5 more
2024bioRxiv65 citations
Semantic Scholar
Resistance‐associated factors in human small‐cell lung‐carcinoma GLC4 sub‐lines with increasing adriamycin resistance
C. H. Versantvoort, S. Withoff, H. J. Broxterman, C. Kuiper +3 more
1995International Journal of Cancer65 citations
Semantic Scholar
NF-kappaB and the regulation of hematopoiesis.
V. Bottero, S. Withoff, I. Verma
2006Cell Death and Differentiation60 citations
Semantic Scholar
Differential expression of DNA topoisomerase II alpha and -beta in P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines of the human SCLC cell line GLC4.
S. Withoff, E. de Vries, W. Keith, Edith F. Nienhuis +3 more
1996British Journal of Cancer60 citations Open access
Semantic Scholar
Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease
X. Chu, M. Jaeger, J. Beumer, O. Bakker +29 more
2021Genome Biology59 citations Open access
Semantic Scholar
Ordered progression of stage-specific miRNA profiles in the mouse B2 B-cell lineage.
D. Spierings, D. Mcgoldrick, A. Hamilton-Easton, G. Neale +4 more
2011Blood59 citations Open access
Semantic Scholar
Standardizing designed and emergent quantitative features in microphysiological systems
Dennis M. Nahon, R. Moerkens, H. Aydogmus, B. Lendemeijer +29 more
2024Nature Biomedical Engineering58 citations Open access
Semantic Scholar
Deconvolution of bulk blood eQTL effects into immune cell subpopulations
R. Aguirre-Gamboa, N. de Klein, Jennifer di Tommaso, A. Claringbould +24 more
2019BMC Bioinformatics58 citations Open access
Semantic Scholar
Bi-specific antibody therapy for the treatment of cancer.
S. Withoff, W. Helfrich, L. de Leij, G. Molema
2001Current opinion in molecular therapeutics (Print)54 citations
Semantic Scholar
Human DNA topoisomerase II: biochemistry and role in chemotherapy resistance (review).
S. Withoff, S. D. De Jong, E. de Vries, N. Mulder
1996Anticancer Research52 citations
Semantic Scholar
Small and Long Regulatory RNAs in the Immune System and Immune Diseases
A. Stachurska, M. Zorro, M. R. van der Sijde, S. Withoff
2014Frontiers in Immunology45 citations Open access
Semantic Scholar
Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFNγ Signaling in Celiac Disease
A. van der Graaf, M. Zorro, A. Claringbould, U. Võsa +16 more
2020bioRxiv43 citations Open access
Semantic Scholar
Gut mucosa dissociation protocols influence cell type proportions and single-cell gene expression levels
W. U. Uniken Venema, Aarón D. Ramírez-Sánchez, E. Bigaeva, S. Withoff +8 more
2022Scientific Reports40 citations Open access
Semantic Scholar
Phage display immunoprecipitation sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire
S. Andreu-Sánchez, A. Bourgonje, T. Vogl, A. Kurilshikov +18 more
2023Immunity39 citations Open access
Semantic Scholar
Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant
Rodrigo Almeida, I. Ricaño-Ponce, Vinod Kumar, Patrick Deelen +21 more
2013Human Molecular Genetics38 citations Open access
Semantic Scholar
Genetic mapping across autoimmune diseases reveals shared associations and mechanisms
M. Lincoln, N. Connally, Pierre-Paul Axisa, C. Gasperi +15 more
2024Nature Genetics33 citations Open access
Semantic Scholar
Molecular Biomarkers for Celiac Disease: Past, Present and Future
Aarón D. Ramírez-Sánchez, Ineke L. Tan, B. C. Gonera-de Jong, M. Visschedijk +2 more
2020International Journal of Molecular Sciences32 citations Open access
Semantic Scholar
THEMIS and PTPRK in celiac intestinal mucosa: coexpression in disease and after in vitro gliadin challenge
C. Bondar, Leticia Plaza-Izurieta, N. Fernández-Jiménez, I. Irastorza +4 more
2013European Journal of Human Genetics32 citations Open access
Semantic Scholar
Differential regulation of IL‐6 promoter activity in a human ovarian‐tumor cell line transfected with various p53 mutants: Involvement of AP‐1
J. G. Asschert, E. D. de Vries, S. de Jong, S. Withoff +1 more
1999International Journal of Cancer31 citations Open access
Semantic Scholar
Celiac disease-on-chip: Modeling a multifactorial disease in vitro
R. Moerkens, Joram Mooiweer, S. Withoff, C. Wijmenga
2019United European Gastroenterology journal30 citations Open access
Semantic Scholar
A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans.
M. Jaeger, V. Matzaraki, R. Aguirre-Gamboa, M. Gresnigt +14 more
2019Journal of Infectious Diseases29 citations Open access
Semantic Scholar
Activation of peritoneal cells upon in vivo transfection with a recombinant alphavirus expressing GM-CSF
A. Klimp, E. van der Vaart, PO Lansink, S. Withoff +4 more
2001Gene Therapy29 citations Open access
Semantic Scholar
Circulating miRNAs as Potential Biomarkers for Celiac Disease Development
Ineke L. Tan, Rodrigo Coutinho de Almeida, R. Modderman, A. Stachurska +21 more
2021Frontiers in Immunology28 citations Open access
Semantic Scholar
A locus at 7p14.3 predisposes to refractory celiac disease progression from celiac disease
B. Hrdličková, C. Mulder, G. Malamut, B. Meresse +19 more
2018European Journal of Gastroenterology and Hepathology27 citations Open access
Semantic Scholar
An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility
V. Matzaraki, M. Gresnigt, M. Jaeger, I. Ricaño-Ponce +13 more
2017PLoS ONE25 citations Open access
Semantic Scholar
Long Non-Coding RNAs Involved in Progression of Non-Alcoholic Fatty Liver Disease to Steatohepatitis
B. Atanasovska, S. Rensen, Glenn Marsman, R. Shiri-Sverdlov +5 more
2021Cells23 citations Open access
Semantic Scholar
Leukocyte-Released Mediators in Response to Both Bacterial and Fungal Infections Trigger IFN Pathways, Independent of IL-1 and TNF-α, in Endothelial Cells
Kieu Le, X. Chu, M. Jaeger, J. Plantinga +8 more
2019Frontiers in Immunology22 citations Open access
Semantic Scholar

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