C. Greider

Most-cited papers

Longevity, stress response, and cancer in aging telomerase-deficient mice.
K. Rudolph, Sandy Chang, Han Lee, M. Blasco +3 more
1999Cell1,398 citations Open access
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Essential role of mouse telomerase in highly proliferative organs
Han-Woong Lee, M. Blasco, G. Gottlieb, James W. Ii Horner +2 more
1998Nature1,333 citations
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Telomerase mutations in families with idiopathic pulmonary fibrosis.
M. Armanios, J. J. Chen, J. Cogan, J. Alder +9 more
2007New England Journal of Medicine1,323 citations Open access
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The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability.
M. Hemann, Margaret A. Strong, Ling-Yang Hao, C. Greider
2001Cell1,231 citations Open access
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Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging
E. Blackburn, C. Greider, J. Szostak
2006Nature Medicine944 citations
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p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis.
Lynda Chin, S. Artandi, Qiong Shen, A. Tam +4 more
1999Cell825 citations Open access
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Secondary structure of vertebrate telomerase RNA.
Jiunn-Liang Chen, M. Blasco, C. Greider
2000Cell627 citations Open access
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Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita.
M. Armanios, Jiunn-Liang Chen, Yen-Pei C. Chang, R. Brodsky +7 more
2005Proceedings of the National Academy of Sciences of the United States of America495 citations Open access
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RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase.
Si-Yuan Le, J. Moore, J. Haber, C. Greider
1999Genetics414 citations
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Telomerase activity, cell proliferation, and cancer.
C. Greider
1998Proceedings of the National Academy of Sciences of the United States of America410 citations Open access
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Telomere dysfunction increases mutation rate and genomic instability.
J. Hackett, D. Feldser, C. Greider
2001Cell373 citations Open access
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Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aD2/3 Cancer-Prone Mouse
R. Greenberg, L. Chin, A. Femino, Kee-Ho Lee +4 more
1999373 citations
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Short telomeres limit tumor progression in vivo by inducing senescence.
D. Feldser, C. Greider
2007Cancer Cell335 citations Open access
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Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.
Ling-Yang Hao, M. Armanios, Margaret A. Strong, Baktiar O. Karim +3 more
2005Cell315 citations Open access
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Two Survivor Pathways That Allow Growth in the Absence of Telomerase Are Generated by Distinct Telomere Recombination Events
Qi-Jun Chen, A. IJpma, C. Greider
2001Molecular and Cellular Biology282 citations Open access
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Short telomeres are sufficient to cause the degenerative defects associated with aging.
M. Armanios, J. Alder, E. Parry, Baktiar O. Karim +2 more
2009American Journal of Human Genetics269 citations Open access
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Telomeres do D-loop-T-loop.
C. Greider
1999Cell264 citations Open access
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Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis
J. Hackett, C. Greider
2002Oncogene261 citations Open access
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Telomere dysfunction and the initiation of genome instability
D. Feldser, J. Hackett, C. Greider
2003Nature Reviews. Cancer239 citations
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Wild-derived inbred mouse strains have short telomeres.
M. Hemann, C. Greider
2000Nucleic Acids Research230 citations Open access
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Diagnostic utility of telomere length testing in a hospital-based setting
J. Alder, Vidya Sagar Hanumanthu, Margaret A. Strong, Amy E. DeZern +11 more
2018Proceedings of the National Academy of Sciences of the United States of America221 citations Open access
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Telomeres and senescence: the history, the experiment, the future.
C. Greider
1998Current Biology185 citations Open access
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Short telomeres induce a DNA damage response in Saccharomyces cerevisiae.
A. IJpma, C. Greider
2003Molecular Biology of the Cell180 citations Open access
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Telomere dysfunction triggers developmentally regulated germ cell apoptosis.
M. Hemann, K. Rudolph, Margaret A. Strong, R. DePinho +2 more
2001Molecular Biology of the Cell174 citations Open access
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A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA.
Jiunn-Liang Chen, K. Opperman, C. Greider
2002Nucleic Acids Research165 citations Open access
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Template boundary definition in mammalian telomerase.
Jiunn-Liang Chen, C. Greider
2003Genes & Development162 citations Open access
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Telomerase RNA structure and function: implications for dyskeratosis congenita.
Jiunn-Liang Chen, C. Greider
2004TIBS -Trends in Biochemical Sciences. Regular ed160 citations
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Preprints for the life sciences
J. Berg, Needhi Bhalla, P. Bourne, M. Chalfie +21 more
2016Science154 citations
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Identification of two RNA-binding proteins associated with human telomerase RNA.
Si-Yuan Le, Rolf Sternglanz, C. Greider
2000Molecular Biology of the Cell141 citations Open access
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Phenotypes in mTERT+/− and mTERT−/− Mice Are Due to Short Telomeres, Not Telomere-Independent Functions of Telomerase Reverse Transcriptase
Margaret A. Strong, S. Vidal-Cardenas, Baktiar O. Karim, Hui-Min Yu +2 more
2011Molecular and Cellular Biology139 citations Open access
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Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross‐species incompatibility
Jiunn-Liang Chen, C. Greider
2003EMBO Journal133 citations Open access
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Haploinsufficiency of mTR results in defects in telomere elongation
K. Hathcock, M. Hemann, K. Opperman, Margaret A. Strong +2 more
2002Proceedings of the National Academy of Sciences of the United States of America114 citations Open access
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Regulation of telomere elongation by the cyclin-dependent kinase CDK1.
Christopher J. Frank, M. Hyde, C. Greider
2006Molecules and Cells113 citations Open access
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End Resection Initiates Genomic Instability in the Absence of Telomerase
J. Hackett, C. Greider
2003Molecular and Cellular Biology105 citations Open access
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ATM kinase is required for telomere elongation in mouse and human cells
Stella S. Lee, Craig L. Bohrson, Alexandra M. Pike, S. Wheelan +1 more
2015Cell Reports103 citations Open access
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Recombination in telomere-length maintenance.
Alyson Kass-Eisler, C. Greider
2000TIBS -Trends in Biochemical Sciences. Regular ed102 citations
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G-strand overhangs on telomeres in telomerase-deficient mouse cells.
Michael T. Hemann, C. Greider
1999Nucleic Acids Research101 citations Open access
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Regulation of Telomere Length Requires a Conserved N-Terminal Domain of Rif2 in Saccharomyces cerevisiae
H. Kaizer, C. Connelly, Kelsey Bettridge, C. Viggiani +1 more
2015Genetics84 citations Open access
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Short Telomeres Initiate Telomere Recombination in Primary and Tumor Cells
T. Morrish, C. Greider
2009PLoS Genetics81 citations Open access
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Regulating telomere length from the inside out: the replication fork model
C. Greider
2016bioRxiv80 citations Open access
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Phosphorylation of H2AX at Short Telomeres in T Cells and Fibroblasts*
Ling-Yang Hao, Margaret A. Strong, C. Greider
2004Journal of Biological Chemistry80 citations Open access
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Telomerase and cancer stem cells.
M. Armanios, C. Greider
2005Cold Spring Harbor Symposia on Quantitative Biology79 citations Open access
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Increasing gender diversity in the STEM research workforce
C. Greider, J. Sheltzer, N. C. Cantalupo, W. Copeland +17 more
2019Science76 citations
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Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.
Ling Qi, Margaret A. Strong, Baktiar O. Karim, M. Armanios +2 more
2003Cancer Research74 citations
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Telomerase activity in human gliomas.
Si-Yuan Le, Jay-Jiguang Zhu, D. Anthony, C. Greider +1 more
1998Neurosurgery69 citations
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Stem-Loop IV of Tetrahymena Telomerase RNA Stimulates Processivity in trans
Douglas X. Mason, Elizabeth Goneska, C. Greider
2003Molecular and Cellular Biology68 citations Open access
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Chromosome-specific telomere lengths and the minimal functional telomere revealed by nanopore sequencing
Samantha L. Sholes, K. Karimian, Ariel Gershman, Thomas Jerome Kelly +2 more
2021bioRxiv63 citations Open access
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An emerging consensus for telomerase RNA structure.
Jiunn-Liang Chen, C. Greider
2004Proceedings of the National Academy of Sciences of the United States of America55 citations Open access
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Telomerase RNA levels limit the telomere length equilibrium.
C. Greider
2006Cold Spring Harbor Symposia on Quantitative Biology52 citations Open access
Semantic Scholar
Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse.
Roger A. Greenberg, Lynda Chin, A. Femino, Kee-Ho Lee +4 more
1999Cell50 citations Open access
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