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M. Hemann · SciRah

Researcher profile · Semantic Scholar

M. Hemann

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M. Hemann — researcher profile on SciRah

h-index: 61
Works: 164
Citations: 18K

Most-cited papers

A subset of platinum-containing chemotherapeutic agents kill cells by inducing ribosome biogenesis stress rather than by engaging a DNA damage response
P. M. Bruno, Yunpeng Liu, Ga-Young Park, J. Murai +6 more
2017Nature Medicine454 citations Open access
Semantic Scholar
Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma
Christian J. Braun, M. Stanciu, Paul L. Boutz, J. C. Patterson +11 more
2017Cancer Cell205 citations Open access
Semantic Scholar
Transcription elongation factors represent in vivo cancer dependencies in glioblastoma
Tyler E. Miller, Brian B Liau, Lisa C. Wallace, A. Morton +20 more
2017Nature190 citations Open access
Semantic Scholar
A small molecule targeting mutagenic translesion synthesis improves chemotherapy
J. Wojtaszek, Nimrat Chatterjee, J. Najeeb, A. Ramos +10 more
2019Cell182 citations Open access
Semantic Scholar
A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses
E. Bent, Luke A. Gilbert, M. Hemann
2016Genes & Development165 citations Open access
Semantic Scholar
SYK Is a Critical Regulator of FLT3 In Acute Myeloid Leukemia
A. Puissant, Nina Fenouille, G. Alexe, Y. Pikman +13 more
2014Cancer Cell156 citations Open access
Semantic Scholar
The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning
P. M. Bruno, Mengrou Lu, Kady A Dennis, Haider Inam +5 more
2020Proceedings of the National Academy of Sciences of the United States of America152 citations Open access
Semantic Scholar
Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy
E. Bent, Luis R. Millán-Barea, I. Zhuang, D. Goulet +2 more
2021Nature Communications145 citations Open access
Semantic Scholar
Targeting MTHFD2 in acute myeloid leukemia
Y. Pikman, A. Puissant, G. Alexe, A. Furman +17 more
2015Journal of Experimental Medicine142 citations Open access
Semantic Scholar
A Platinum(IV) Pro-drug Preferentially Targets IDO Providing Enhanced Ovarian Cancer Immuno-Chemotherapy
Samuel G. Awuah, Yao-Rong Zheng, P. M. Bruno, M. Hemann +1 more
2015Journal of the American Chemical Society136 citations Open access
Semantic Scholar
Breast Cancer Stem Cell Potent Copper(II)-Non-Steroidal Anti-Inflammatory Drug Complexes.
Janine N. Boodram, Iain J. Mcgregor, P. M. Bruno, Paul Cressey +2 more
2016Angewandte Chemie135 citations Open access
Semantic Scholar
Exploiting temporal collateral sensitivity in tumor clonal evolution
Bo-Yang Zhao, Joseph C. Sedlak, Raja R. Srinivas, Pau Creixell +4 more
2016Cell129 citations Open access
Semantic Scholar
Minor changes in expression of the mismatch repair protein MSH2 exert a major impact on glioblastoma response to temozolomide
J. McFaline-Figueroa, Christian J. Braun, M. Stanciu, Z. Nagel +11 more
2015Cancer Research116 citations Open access
Semantic Scholar
Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance
Simona Dalin, Mark R. Sullivan, Allison N. Lau, Beatrice Grauman-Boss +8 more
2019Cancer Research114 citations Open access
Semantic Scholar
Intratumor heterogeneity alters most effective drugs in designed combinations
Bo-Yang Zhao, M. Hemann, D. Lauffenburger
2014Proceedings of the National Academy of Sciences of the United States of America108 citations Open access
Semantic Scholar
Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog selective inhibitors for use in acute myeloid leukemia
F. Wagner, L. Benajiba, Arthur J. Campbell, M. Weïwer +26 more
2018Science Translational Medicine98 citations Open access
Semantic Scholar
The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia
C. F. Bassil, I. Ben-Sahra, L. Benajiba, G. Alexe +17 more
2017Nature Medicine97 citations Open access
Semantic Scholar
Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation
Christian J. Braun, P. M. Bruno, M. Horlbeck, Luke A. Gilbert +2 more
2016Proceedings of the National Academy of Sciences of the United States of America92 citations Open access
Semantic Scholar
A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-defective Tumors to Chemotherapy
I. Cannell, Karl A. Merrick, Sandra Morandell, Chang-Qi Zhu +6 more
2014Cancer Cell88 citations Open access
Semantic Scholar
Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy?
Kinrin Yamanaka, Nimrat Chatterjee, M. Hemann, G. Walker
2017PLoS Genetics83 citations Open access
Semantic Scholar
Necroptosis-Inducing Rhenium(V) Oxo Complexes
K. Suntharalingam, Samuel G. Awuah, P. M. Bruno, T. Johnstone +6 more
2015Journal of the American Chemical Society79 citations Open access
Semantic Scholar
Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer
Ruo-Gu Qi, Yongheng Wang, P. M. Bruno, Hai-Hua Xiao +15 more
2017Nature Communications74 citations Open access
Semantic Scholar
Drugs, Bugs, and Cancer: Fusobacterium nucleatum Promotes Chemoresistance in Colorectal Cancer.
A. Ramos, M. Hemann
2017Cell73 citations Open access
Semantic Scholar
Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer
C. Dowling, Kate E. R. Hollinshead, A. Di Grande, J. Pritchard +20 more
2021Science Advances68 citations Open access
Semantic Scholar
A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth
C. Meacham, Lee N. Lawton, Yadira M. Soto-Feliciano, J. Pritchard +7 more
2015Genes & Development68 citations Open access
Semantic Scholar
Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains
Khloe S. Gordon, Taeyoon Kyung, Caleb R. Perez, P. Holec +11 more
2022Nature Biomedical Engineering63 citations Open access
Semantic Scholar
PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes
Yadira M. Soto-Feliciano, J. Bartlebaugh, Yunpeng Liu, Francisco J. Sánchez-Rivera +8 more
2017Genes & Development58 citations Open access
Semantic Scholar
Rev7 dimerization is important for assembly and function of the Rev1/Polζ translesion synthesis complex
A. Rizzo, Faye-Marie Vassel, Nimrat Chatterjee, Sanjay D’Souza +5 more
2018Proceedings of the National Academy of Sciences of the United States of America56 citations Open access
Semantic Scholar
Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small molecule inhibitor
Blandine Roux, Camille Vaganay, Jesse D. Vargas, G. Alexe +32 more
2021Science Translational Medicine55 citations Open access
Semantic Scholar
Aneuploid cell survival relies upon sphingolipid homeostasis
Yun-Chi Tang, Hui Yuwen, Kaiying Wang, P. M. Bruno +11 more
2017Cancer Research47 citations Open access
Semantic Scholar
Modeling Tumor Clonal Evolution for Drug Combinations Design
Bo-Yang Zhao, M. Hemann, D. Lauffenburger
2016Trends in Cancer45 citations Open access
Semantic Scholar
Mechanisms of lymphoma clearance induced by high-dose alkylating agents
Chen Lossos, Yunpeng Liu, Kellie E. Kolb, A. Christie +20 more
2019Cancer Discovery44 citations Open access
Semantic Scholar
Induction of Necroptosis in Cancer Stem Cells using a Nickel(II)-Dithiocarbamate Phenanthroline Complex.
Marie Flamme, Paul Cressey, Chunxin Lu, P. M. Bruno +4 more
2017Chemistry44 citations Open access
Semantic Scholar
REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks
Nimrat Chatterjee, M. Whitman, C. Harris, Sophia M. Min +8 more
2020Proceedings of the National Academy of Sciences of the United States of America42 citations Open access
Semantic Scholar
Using an RNAi Signature Assay To Guide the Design of Three-Drug-Conjugated Nanoparticles with Validated Mechanisms, In Vivo Efficacy, and Low Toxicity
J. C. Barnes, P. M. Bruno, H. Nguyen, L. Liao +3 more
2016Journal of the American Chemical Society42 citations Open access
Semantic Scholar
The Potent Inhibitory Effect of a Naproxen‐Appended Cobalt(III)‐Cyclam Complex on Cancer Stem Cells
Paul Cressey, A. Eskandari, P. M. Bruno, Chunxin Lu +2 more
2016ChemBioChem38 citations Open access
Semantic Scholar
Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration
Francisco J. Sánchez-Rivera, J. Ryan, Yadira M. Soto-Feliciano, Mary Clare Beytagh +7 more
2021Proceedings of the National Academy of Sciences of the United States of America35 citations Open access
Semantic Scholar
The breast cancer stem cell potency of copper(ii) complexes bearing nonsteroidal anti-inflammatory drugs and their encapsulation using polymeric nanoparticles.
A. Eskandari, Janine N. Boodram, Paul Cressey, Chunxin Lu +3 more
2016Dalton Transactions34 citations Open access
Semantic Scholar
Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints
Yi W. Kong, E. Dreaden, Sandra Morandell, Wen Zhou +14 more
2020Nature Communications31 citations Open access
Semantic Scholar
Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening
A. Ramos, Catherine E. Koch, Yunpeng Liu-Lupo, Riley D. Hellinger +19 more
2022bioRxiv30 citations Open access
Semantic Scholar
A DNA/HDAC dual-targeting drug CY190602 with significantly enhanced anticancer potency
Chuan Liu, Hong-Yu Ding, Xiao-Xi Li, C. Pallasch +8 more
2015EMBO Molecular Medicine28 citations Open access
Semantic Scholar
Rev7 loss alters cisplatin response and increases drug efficacy in chemotherapy-resistant lung cancer
Faye-Marie Vassel, Ke Bian, G. Walker, M. Hemann
2020Proceedings of the National Academy of Sciences of the United States of America26 citations Open access
Semantic Scholar
Polymerase δ promotes chromosomal rearrangements and imprecise double-strand break repair
Jacob V. Layer, Lydie L. Debaize, Alexandria Van Scoyk, N. House +8 more
2020Proceedings of the National Academy of Sciences of the United States of America24 citations Open access
Semantic Scholar
Acquired resistance to PRMT5 inhibition induces concomitant collateral sensitivity to paclitaxel
Helen S. Mueller, C. Fowler, Simona Dalin, Enrico Moiso +4 more
2021Proceedings of the National Academy of Sciences of the United States of America23 citations Open access
Semantic Scholar
Mechanistic Studies of the Anticancer Activity of An Octahedral Hexanuclear Pt(II) Cage
Yao-Rong Zheng, K. Suntharalingam, P. M. Bruno, Wei Lin +3 more
2016Inorganica Chimica Acta21 citations Open access
Semantic Scholar
Aiding and Abetting: How the Tumor Microenvironment Protects Cancer from Chemotherapy
Eleanor R. C. Fiedler, M. Hemann
2019Annual Review of Cancer Biology20 citations
Semantic Scholar
Differential selective pressure alters rate of drug resistance acquisition in heterogeneous tumor populations
Daphne S. Sun, Simona Dalin, M. Hemann, D. Lauffenburger +1 more
2016Scientific Reports17 citations Open access
Semantic Scholar
Creatine Kinase Pathway Inhibition Alters GSK3 and WNT Signaling in EVI1-positive AML
L. Benajiba, G. Alexe, Angela H Su, E. Raffoux +6 more
2018Leukemia14 citations Open access
Semantic Scholar
The Chromatin Regulator CHD8 Is a Context-Dependent Mediator of Cell Survival in Murine Hematopoietic Malignancies
Jennifer R. Shingleton, M. Hemann
2015PLoS ONE12 citations Open access
Semantic Scholar
Inherent genome instability underlies trisomy 21-associated myeloid malignancies
Chun-Chin Chen, R. Silberman, Duanduan Ma, Jennifer A. Perry +5 more
2024Leukemia11 citations Open access
Semantic Scholar

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