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S. Tso · SciRah

Researcher profile · Semantic Scholar

S. Tso

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S. Tso — researcher profile on SciRah

h-index: 16
Works: 55
Citations: 1,488

Most-cited papers

The BCKDH kinase and phosphatase integrate BCAA and lipid metabolism via regulation of ATP-citrate lyase
P. White, R. McGarrah, Paul A. Grimsrud, S. Tso +17 more
2018Cell Metabolism326 citations Open access
Semantic Scholar
The intrinsic substrate specificity of the human tyrosine kinome
Tomer M. Yaron-Barir, B. Joughin, Emily M. Huntsman, Alexander Kerelsky +32 more
2024Nature139 citations Open access
Semantic Scholar
Structural Basis for Inactivation of the Human Pyruvate Dehydrogenase Complex by Phosphorylation: Role of Disordered Phosphorylation Loops
M. Kato, R. Wynn, J. Chuang, S. Tso +3 more
2008Structure123 citations Open access
Semantic Scholar
Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex
M. Kato, J. Chuang, S. Tso, R. Wynn +1 more
2005EMBO Journal104 citations Open access
Semantic Scholar
Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase*
S. Tso, Wenjun Gui, Cheng-Yang Wu, J. Chuang +12 more
2014Journal of Biological Chemistry98 citations Open access
Semantic Scholar
Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket*
S. Tso, Xiang-Bing Qi, Wenjun Gui, Cheng-Yang Wu +9 more
2013Journal of Biological Chemistry89 citations Open access
Semantic Scholar
A new locus for X-linked dominant Charcot-Marie-Tooth disease (CMTX6) is caused by mutations in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene.
M. Kennerson, E. Yiu, David T. Chuang, A. Kidambi +9 more
2013Human Molecular Genetics84 citations Open access
Semantic Scholar
Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase
S. Tso, Xiang-Bing Qi, Wenjun Gui, J. Chuang +12 more
2013Proceedings of the National Academy of Sciences of the United States of America75 citations Open access
Semantic Scholar
Pyruvate Dehydrogenase Kinase-4 Structures Reveal a Metastable Open Conformation Fostering Robust Core-free Basal Activity*
R. Wynn, M. Kato, J. Chuang, S. Tso +2 more
2008Journal of Biological Chemistry75 citations Open access
Semantic Scholar
Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice
Cheng-Yang Wu, S. Tso, J. Chuang, Wenjun Gui +6 more
2018Molecular Metabolism43 citations Open access
Semantic Scholar
Reconstitution of Mitochondrial Processing Peptidase from the Core Proteins (Subunits I and II) of Bovine Heart Mitochondrial Cytochrome bc 1 Complex*
Kai-Ping Deng, Sudha K. Shenoy, S. Tso, Linda P. C. Yu +1 more
2001Journal of Biological Chemistry43 citations Open access
Semantic Scholar
Mitochondrial NADPH fuels mitochondrial fatty acid synthesis and lipoylation to power oxidative metabolism
Dohun Kim, Rushendhiran Kesavan, Kevin Ryu, Trishna Dey +17 more
2025Nature Cell Biology38 citations
Semantic Scholar
An isolated CLASP TOG domain suppresses microtubule catastrophe and promotes rescue
S. Majumdar, Tae Kim, Zhe Chen, Sarah Munyoki +3 more
2018Molecular Biology of the Cell38 citations Open access
Semantic Scholar
Using two-site binding models to analyze microscale thermophoresis data
S. Tso, Qiuyan Chen, S. Vishnivetskiy, V. Gurevich +2 more
2017Analytical Biochemistry37 citations Open access
Semantic Scholar
Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-targeting Pyruvate Dehydrogenase Kinase Inhibitors
S. Tso, Mingliang Lou, Cheng-Yang Wu, Wenjun Gui +6 more
2017Journal of Medicinal Chemistry33 citations Open access
Semantic Scholar
The Role of the Supernumerary Subunit of Rhodobactersphaeroides Cytochrome bc1 Complex
Linda P. C. Yu, S. Tso, Sudha K. Shenoy, B. Quinn +1 more
1999Journal of Bioenergetics and Biomembranes17 citations
Semantic Scholar
A multi-laboratory benchmark study of isothermal titration calorimetry (ITC) using Ca2+ and Mg2+ binding to EDTA
A. Velázquez-Campoy, Bárbara Claro, O. Abián, Jonas Höring +13 more
2021European Biophysics Journal16 citations
Semantic Scholar
Subunit IV of cytochrome bc1 complex from Rhodobacter sphaeroides. Localization of regions essential for interaction with the three-subunit core complex.
S. Tso, Sudha K. Shenoy, B. Quinn, Linda P. C. Yu
2000Journal of Biological Chemistry16 citations Open access
Semantic Scholar
Fast and robust quantification of detergent micellization thermodynamics from isothermal titration calorimetry.
S. Tso, Florian Mahler, Jonas Höring, S. Keller +1 more
2019Analytical Chemistry14 citations Open access
Semantic Scholar
Pathogenic mechanisms underlying X-linked Charcot-Marie-Tooth neuropathy (CMTX6) in patients with a pyruvate dehydrogenase kinase 3 mutation.
G. Perez-siles, C. Ly, A. Grant, A. Drew +6 more
2016Neurobiology of Disease14 citations Open access
Semantic Scholar
Structural Determinants for Cross-talk between Pyruvate Dehydrogenase Kinase 3 and Lipoyl Domain 2 of the Human Pyruvate Dehydrogenase Complex*
S. Tso, M. Kato, J. Chuang, David T. Chuang
2006Journal of Biological Chemistry13 citations Open access
Semantic Scholar
Effect of subunit IV on superoxide generation by Rhodobacter sphaeroides cytochrome bc(1) complex.
Ying Yin, S. Tso, Chang-An Yu, Linda P. C. Yu
2009Biochimica et Biophysica Acta9 citations Open access
Semantic Scholar
Identification of amino acid residues essential for reconstitutive activity of subunit IV of the cytochrome bc1 complex from Rhodobacter sphaeroides.
S. Tso, Ying Yin, Chang-An Yu, Linda P. C. Yu
2006Biochimica et Biophysica Acta7 citations Open access
Semantic Scholar
Structures of the multi-domain oxygen sensor DosP: remote control of a c-di-GMP phosphodiesterase by a regulatory PAS domain
Wenbi Wu, Pankaj Kumar, Chad A. Brautigam, S. Tso +3 more
2024bioRxiv6 citations Open access
Semantic Scholar
The feasibility of determining kinetic constants from isothermal titration calorimetry data.
S. Tso, T. Jowitt, Chad A. Brautigam
2022Biophysical Journal6 citations Open access
Semantic Scholar
Measuring the KD of Protein-Ligand Interactions Using Microscale Thermophoresis.
S. Tso, C. Brautigam
2021Methods in molecular biology6 citations
Semantic Scholar
Biophysical and biochemical studies support TP0094 as a phosphotransacetylase in an acetogenic energy-conservation pathway in Treponema pallidum
C. Brautigam, R. Deka, S. Tso, Wei Liu +1 more
2023PLoS ONE5 citations Open access
Semantic Scholar
Using modern approaches to sedimentation velocity to detect conformational changes in proteins
C. Brautigam, S. Tso, R. Deka, Wei Liu +1 more
2020European Biophysics Journal4 citations Open access
Semantic Scholar
Subunit IV of Cytochrome bc 1 Complex from Rhodobacter sphaeroides
S. Tso, Sudha K. Shenoy, B. Quinn, Linda P. C. Yu
2000Journal of Biological Chemistry3 citations Open access
Semantic Scholar
The labor movement in China
S. Tso
3 citations
Semantic Scholar
Author Correction: Mitochondrial NADPH fuels mitochondrial fatty acid synthesis and lipoylation to power oxidative metabolism
Dohun Kim, Rushendhiran Kesavan, Kevin Ryu, Trishna Dey +17 more
2025Nature Cell Biology2 citations
Semantic Scholar
Biophysical insights into a highly selective L-arginine-binding lipoprotein of a pathogenic treponeme
R. Deka, Wei Liu, S. Tso, M. Norgard +1 more
2018bioRxiv2 citations Open access
Semantic Scholar
Biophysical and biochemical evidence for the role of acetate kinases (AckAs) in an acetogenic pathway in pathogenic spirochetes
R. Deka, S. Tso, Wei Liu, Chad A. Brautigam
2024bioRxiv1 citations Open access
Semantic Scholar
Structures of branched-chain alpha-ketoacid dehydrogenase kinase-inhibitor complexes
S. Tso, J. Chuang, Wenjun Gui, R. Wynn +2 more
20131 citations
Semantic Scholar
A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin
Alex C Sternisha, Haocheng Li, Kumar Gajendra, Yi Xiao +30 more
2026Science0 citations Open access
Semantic Scholar
Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS35
Wenjun Gui, S. Tso, J. Chuang, C.-Y. Wu +3 more
20170 citations
Semantic Scholar
Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS46
Wenjun Gui, S. Tso, J. Chuang, C.-Y. Wu +3 more
20170 citations
Semantic Scholar
Understanding the pathogenic mechanisms underlying the X-linked Charcot-Marie-Tooth neuropathy (CMTX6) caused by the R158H PDK3 mutation
G. Perez-Sues, E. Yiu, M. Ryan, David T. Chuang +4 more
20150 citations
Semantic Scholar
Novel Allosteric Inhibitors of Benzothiophene Carboxylate Derivatives as Metabolism
David T. Chuang, U. Tambar, R. Max, S. Strom +8 more
20140 citations
Semantic Scholar
Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS10
Wenjun Gui, S. Tso, J. Chuang, C.-Y. Wu +4 more
20140 citations
Semantic Scholar
Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PA1
Wenjun Gui, S. Tso, J. Chuang, Cheng-Yang Wu +4 more
20140 citations
Semantic Scholar
Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with AMPPNP
S. Tso, J. Chuang, Wenjun Gui, R. Wynn +2 more
20130 citations
Semantic Scholar
Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase in complex with alpha-ketoisocaproic acid and ADP
S. Tso, J. Chuang, Wenjun Gui, R. Wynn +2 more
20130 citations
Semantic Scholar
Crystal structure of I170F mutant branched-chain alpha-ketoacid dehydrogenase kinase in complex with 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid
K. Ahmed, Wenjun Gui, S. Tso, J. Chuang +2 more
20130 citations
Semantic Scholar
A Combination of Linkage Analysis and Exome Sequencing Identifies a New Gene for X-linked Charcot-Marie-Tooth Neuropathy (S26.007)
M. Kennerson, E. Yiu, David T. Chuang, A. Kidambi +9 more
2013Neurology0 citations
Semantic Scholar
Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(R)-alpha-chloroisocaproate complex with ADP
S. Tso, J. Chuang, Wenjun Gui, R. Wynn +2 more
20120 citations
Semantic Scholar
Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/phenylbutyrate complex with ADP
S. Tso, J. Chuang, Wenjun Gui, R. Wynn +2 more
20120 citations
Semantic Scholar
Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/S-alpha-chloroisocaproate complex
S. Tso, J. Chuang, Wenjun Gui, R. Wynn +2 more
20120 citations
Semantic Scholar
D.O.5 A combination of linkage analysis and exome sequencing identifies a new gene for X-linked Charcot–Marie–Tooth neuropathy
M. Kennerson, E. Yiu, David T. Chuang, S. Tso +4 more
20120 citations
Semantic Scholar
Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex
M. Kato, R. Wynn, J. Chuang, S. Tso +3 more
20080 citations
Semantic Scholar

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